Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes
- Autores
- Salva, Maria Susana; Kolling, Yanina Noralí; Argañaraz, Nicolás; Rocchia Novillo, María Pía; Rocchia Novillo, María del Milagro; Albarracin, Leonardo; Charubi, Jacqueline Elizabeth; Casen, Alejandra; Gobbato, Nadia Margarita; Rachid, Mirta Maria; Alvarez, Susana; Villena, Julio Cesar; Valdéz, Juan Carlos
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Elderly individuals, especially those with pre-existing conditions like diabetes mellitus (DM), have a high risk for developing severe cases of COVID-19. The aim of this work was to characterize the alterations of blood immune cells (BIC) in patients with symptomatic COVID-19 and confirmed SARS-CoV-2 infection, ≥ 60 years and who needed hospitalization in the Centro de Salud Hospital of Tucuman during the second peak of the pandemic. Blood samples were taken at the time of admission (d0) and five days after (d5) for routine laboratory tests and the characterization of BIC by flow cytometry. Most of the patients were men (70%) aged between 60 and 78 years. The 70% of patients had DM while 50% had arterial hypertension. At d0, all the patients had increased neutrophils and inflammatory markers (C reactive protein and D-dimers) and reduced numbers of lymphocytes, HLA-DRhi monocytes, CD16+CD56+ NK cells, CD3+HLA-DR+CD25+ cells, CD4+ and CD8+ T cells in blood. Patients received a standard treatment for COVID-19 care (O2, corticosteroids and antibiotics). The treatment normalized the levels of BIC (d5) in 30% of patients who were those with no comorbidities. In patients with DM, BIC recovery was variable. In DM patients who required administration of plasma (30%), prolonged O2 therapy (40%) or referral to the intensive care unit (10%) significant reductions of CD16+CD56+, CD3+HLA-DR+CD25+, CD4+ and CD8+ cells were observed between d0 and d5. In line with previous studies, our results shows that absolute counts of major lymphocyte subsets in blood are significantly and substantially decreased during the course of severe COVID-19 disease in elderly patients. These BIC alterations may persist despite clinical care in elderly patients with DM. Further studies are needed to investigate the utility of early lymphocyte subset measurements as prognostic biomarkers of disease severity, mortality, and response to treatment in COVID-19 elderly patients with DM.
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Kolling, Yanina Noralí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán; Argentina
Fil: Argañaraz, Nicolás. Universidad Nacional de Tucumán; Argentina
Fil: Rocchia Novillo, María Pía. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; Argentina
Fil: Rocchia Novillo, María del Milagro. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; Argentina
Fil: Albarracin, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Charubi, Jacqueline Elizabeth. Instituto de Maternidad “Ntra. Sra. De las Mercedes”; Argentina
Fil: Casen, Alejandra. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; Argentina
Fil: Gobbato, Nadia Margarita. Universidad Nacional de Tucumán; Argentina
Fil: Rachid, Mirta Maria. Universidad Nacional de Tucumán; Argentina
Fil: Alvarez, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Valdéz, Juan Carlos. Universidad Nacional de Tucumán; Argentina
Annual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar)
Buenos Aires
Argentina
Sociedad Argentina de Inmunología
Asociación Argentina de Farmacología Experimental
Sociedad Argentina de Investigación Clínica
Asociación Argentina de Nanomedicina - Materia
-
BLOOD IMMUNE CELLS
COVID-19
ELDERLY
TYPE 2 DIABETES
FLOW CYTOMETRY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/152964
Ver los metadatos del registro completo
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Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetesSalva, Maria SusanaKolling, Yanina NoralíArgañaraz, NicolásRocchia Novillo, María PíaRocchia Novillo, María del MilagroAlbarracin, LeonardoCharubi, Jacqueline ElizabethCasen, AlejandraGobbato, Nadia MargaritaRachid, Mirta MariaAlvarez, SusanaVillena, Julio CesarValdéz, Juan CarlosBLOOD IMMUNE CELLSCOVID-19ELDERLYTYPE 2 DIABETESFLOW CYTOMETRYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Elderly individuals, especially those with pre-existing conditions like diabetes mellitus (DM), have a high risk for developing severe cases of COVID-19. The aim of this work was to characterize the alterations of blood immune cells (BIC) in patients with symptomatic COVID-19 and confirmed SARS-CoV-2 infection, ≥ 60 years and who needed hospitalization in the Centro de Salud Hospital of Tucuman during the second peak of the pandemic. Blood samples were taken at the time of admission (d0) and five days after (d5) for routine laboratory tests and the characterization of BIC by flow cytometry. Most of the patients were men (70%) aged between 60 and 78 years. The 70% of patients had DM while 50% had arterial hypertension. At d0, all the patients had increased neutrophils and inflammatory markers (C reactive protein and D-dimers) and reduced numbers of lymphocytes, HLA-DRhi monocytes, CD16+CD56+ NK cells, CD3+HLA-DR+CD25+ cells, CD4+ and CD8+ T cells in blood. Patients received a standard treatment for COVID-19 care (O2, corticosteroids and antibiotics). The treatment normalized the levels of BIC (d5) in 30% of patients who were those with no comorbidities. In patients with DM, BIC recovery was variable. In DM patients who required administration of plasma (30%), prolonged O2 therapy (40%) or referral to the intensive care unit (10%) significant reductions of CD16+CD56+, CD3+HLA-DR+CD25+, CD4+ and CD8+ cells were observed between d0 and d5. In line with previous studies, our results shows that absolute counts of major lymphocyte subsets in blood are significantly and substantially decreased during the course of severe COVID-19 disease in elderly patients. These BIC alterations may persist despite clinical care in elderly patients with DM. Further studies are needed to investigate the utility of early lymphocyte subset measurements as prognostic biomarkers of disease severity, mortality, and response to treatment in COVID-19 elderly patients with DM.Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Kolling, Yanina Noralí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán; ArgentinaFil: Argañaraz, Nicolás. Universidad Nacional de Tucumán; ArgentinaFil: Rocchia Novillo, María Pía. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; ArgentinaFil: Rocchia Novillo, María del Milagro. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; ArgentinaFil: Albarracin, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Charubi, Jacqueline Elizabeth. Instituto de Maternidad “Ntra. Sra. De las Mercedes”; ArgentinaFil: Casen, Alejandra. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; ArgentinaFil: Gobbato, Nadia Margarita. Universidad Nacional de Tucumán; ArgentinaFil: Rachid, Mirta Maria. Universidad Nacional de Tucumán; ArgentinaFil: Alvarez, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Valdéz, Juan Carlos. Universidad Nacional de Tucumán; ArgentinaAnnual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar)Buenos AiresArgentinaSociedad Argentina de InmunologíaAsociación Argentina de Farmacología ExperimentalSociedad Argentina de Investigación ClínicaAsociación Argentina de NanomedicinaFundación Revista Medicina2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152964Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes; Annual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar); Buenos Aires; Argentina; 2021; 165-1661669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.medicinabuenosaires.com/indices-de-2020/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:54:09Zoai:ri.conicet.gov.ar:11336/152964instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:54:09.901CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes |
| title |
Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes |
| spellingShingle |
Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes Salva, Maria Susana BLOOD IMMUNE CELLS COVID-19 ELDERLY TYPE 2 DIABETES FLOW CYTOMETRY |
| title_short |
Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes |
| title_full |
Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes |
| title_fullStr |
Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes |
| title_full_unstemmed |
Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes |
| title_sort |
Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes |
| dc.creator.none.fl_str_mv |
Salva, Maria Susana Kolling, Yanina Noralí Argañaraz, Nicolás Rocchia Novillo, María Pía Rocchia Novillo, María del Milagro Albarracin, Leonardo Charubi, Jacqueline Elizabeth Casen, Alejandra Gobbato, Nadia Margarita Rachid, Mirta Maria Alvarez, Susana Villena, Julio Cesar Valdéz, Juan Carlos |
| author |
Salva, Maria Susana |
| author_facet |
Salva, Maria Susana Kolling, Yanina Noralí Argañaraz, Nicolás Rocchia Novillo, María Pía Rocchia Novillo, María del Milagro Albarracin, Leonardo Charubi, Jacqueline Elizabeth Casen, Alejandra Gobbato, Nadia Margarita Rachid, Mirta Maria Alvarez, Susana Villena, Julio Cesar Valdéz, Juan Carlos |
| author_role |
author |
| author2 |
Kolling, Yanina Noralí Argañaraz, Nicolás Rocchia Novillo, María Pía Rocchia Novillo, María del Milagro Albarracin, Leonardo Charubi, Jacqueline Elizabeth Casen, Alejandra Gobbato, Nadia Margarita Rachid, Mirta Maria Alvarez, Susana Villena, Julio Cesar Valdéz, Juan Carlos |
| author2_role |
author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
BLOOD IMMUNE CELLS COVID-19 ELDERLY TYPE 2 DIABETES FLOW CYTOMETRY |
| topic |
BLOOD IMMUNE CELLS COVID-19 ELDERLY TYPE 2 DIABETES FLOW CYTOMETRY |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Elderly individuals, especially those with pre-existing conditions like diabetes mellitus (DM), have a high risk for developing severe cases of COVID-19. The aim of this work was to characterize the alterations of blood immune cells (BIC) in patients with symptomatic COVID-19 and confirmed SARS-CoV-2 infection, ≥ 60 years and who needed hospitalization in the Centro de Salud Hospital of Tucuman during the second peak of the pandemic. Blood samples were taken at the time of admission (d0) and five days after (d5) for routine laboratory tests and the characterization of BIC by flow cytometry. Most of the patients were men (70%) aged between 60 and 78 years. The 70% of patients had DM while 50% had arterial hypertension. At d0, all the patients had increased neutrophils and inflammatory markers (C reactive protein and D-dimers) and reduced numbers of lymphocytes, HLA-DRhi monocytes, CD16+CD56+ NK cells, CD3+HLA-DR+CD25+ cells, CD4+ and CD8+ T cells in blood. Patients received a standard treatment for COVID-19 care (O2, corticosteroids and antibiotics). The treatment normalized the levels of BIC (d5) in 30% of patients who were those with no comorbidities. In patients with DM, BIC recovery was variable. In DM patients who required administration of plasma (30%), prolonged O2 therapy (40%) or referral to the intensive care unit (10%) significant reductions of CD16+CD56+, CD3+HLA-DR+CD25+, CD4+ and CD8+ cells were observed between d0 and d5. In line with previous studies, our results shows that absolute counts of major lymphocyte subsets in blood are significantly and substantially decreased during the course of severe COVID-19 disease in elderly patients. These BIC alterations may persist despite clinical care in elderly patients with DM. Further studies are needed to investigate the utility of early lymphocyte subset measurements as prognostic biomarkers of disease severity, mortality, and response to treatment in COVID-19 elderly patients with DM. Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Kolling, Yanina Noralí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán; Argentina Fil: Argañaraz, Nicolás. Universidad Nacional de Tucumán; Argentina Fil: Rocchia Novillo, María Pía. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; Argentina Fil: Rocchia Novillo, María del Milagro. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; Argentina Fil: Albarracin, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Charubi, Jacqueline Elizabeth. Instituto de Maternidad “Ntra. Sra. De las Mercedes”; Argentina Fil: Casen, Alejandra. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; Argentina Fil: Gobbato, Nadia Margarita. Universidad Nacional de Tucumán; Argentina Fil: Rachid, Mirta Maria. Universidad Nacional de Tucumán; Argentina Fil: Alvarez, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Valdéz, Juan Carlos. Universidad Nacional de Tucumán; Argentina Annual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar) Buenos Aires Argentina Sociedad Argentina de Inmunología Asociación Argentina de Farmacología Experimental Sociedad Argentina de Investigación Clínica Asociación Argentina de Nanomedicina |
| description |
Elderly individuals, especially those with pre-existing conditions like diabetes mellitus (DM), have a high risk for developing severe cases of COVID-19. The aim of this work was to characterize the alterations of blood immune cells (BIC) in patients with symptomatic COVID-19 and confirmed SARS-CoV-2 infection, ≥ 60 years and who needed hospitalization in the Centro de Salud Hospital of Tucuman during the second peak of the pandemic. Blood samples were taken at the time of admission (d0) and five days after (d5) for routine laboratory tests and the characterization of BIC by flow cytometry. Most of the patients were men (70%) aged between 60 and 78 years. The 70% of patients had DM while 50% had arterial hypertension. At d0, all the patients had increased neutrophils and inflammatory markers (C reactive protein and D-dimers) and reduced numbers of lymphocytes, HLA-DRhi monocytes, CD16+CD56+ NK cells, CD3+HLA-DR+CD25+ cells, CD4+ and CD8+ T cells in blood. Patients received a standard treatment for COVID-19 care (O2, corticosteroids and antibiotics). The treatment normalized the levels of BIC (d5) in 30% of patients who were those with no comorbidities. In patients with DM, BIC recovery was variable. In DM patients who required administration of plasma (30%), prolonged O2 therapy (40%) or referral to the intensive care unit (10%) significant reductions of CD16+CD56+, CD3+HLA-DR+CD25+, CD4+ and CD8+ cells were observed between d0 and d5. In line with previous studies, our results shows that absolute counts of major lymphocyte subsets in blood are significantly and substantially decreased during the course of severe COVID-19 disease in elderly patients. These BIC alterations may persist despite clinical care in elderly patients with DM. Further studies are needed to investigate the utility of early lymphocyte subset measurements as prognostic biomarkers of disease severity, mortality, and response to treatment in COVID-19 elderly patients with DM. |
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2021 |
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2021 |
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http://hdl.handle.net/11336/152964 Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes; Annual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar); Buenos Aires; Argentina; 2021; 165-166 1669-9106 CONICET Digital CONICET |
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Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes; Annual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar); Buenos Aires; Argentina; 2021; 165-166 1669-9106 CONICET Digital CONICET |
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eng |
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eng |
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