Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies

Autores
Crossley, Nicolas A.; Alliende, Luz Maria; Ossandon, Tomas; Castañeda, Carmen Paz; González Valderrama, Alfonso; Undurraga, Juan; Castro, Mariana Nair; Guinjoan, Salvador Martín; Díaz Zuluaga, Ana M.; Pineda-Zapata, Julián A.; López-Jaramillo, Carlos; Reyes Madrigal, Francisco; León-Ortíz, Pablo; de la Fuente-Sandoval, Camilo; Czepielewski, Leticia Sanguinetti; Gama, Clarissa S.; Zugman, Andre; Gadelha, Ary; Jackowski, Andrea; Bressan, Rodrigo
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Social and environmental factors are known risk factors and modulators of mental health disorders. We here conducted a nonsystematic review of the neuroimaging literature studying the effects of poverty, urbanicity, and community violence, highlighting the opportunities of studying non-Western developing societies such as those in Latin America. Social and environmental factors in these communities are widespread and have a large magnitude, as well as an unequal distribution, providing a good opportunity for their characterization. Studying the effect of poverty in these settings could help to explore the brain effect of economic improvements, disentangle the effect of absolute and relative poverty, and characterize the modulating impact of poverty on the underlying biology of mental health disorders. Exploring urbanicity effects in highly unequal cities could help identify the specific factors that modulate this effect as well as examine a possible dose–response effect by studying megacities. Studying brain changes in those living among violence, which is particularly high in places such as Latin America, could help to characterize the interplay between brain predisposition and exposure to violence. Furthermore, exploring the brain in an adverse environment should shed light on the mechanisms underlying resilience. We finally provide examples of two methodological approaches that could contribute to this field, namely a big cohort study in the developing world and a consortium-based meta-analytic approach, and argue about the potential translational value of this research on the development of effective social policies and successful personalized medicine in disadvantaged societies.
Fil: Crossley, Nicolas A.. Pontificia Universidad Católica de Chile; Chile
Fil: Alliende, Luz Maria. Pontificia Universidad Católica de Chile; Chile
Fil: Ossandon, Tomas. Pontificia Universidad Católica de Chile; Chile
Fil: Castañeda, Carmen Paz. Instituto Psiquiátrico Dr. José Horwitz Barak; Chile
Fil: González Valderrama, Alfonso. Instituto Psiquiátrico Dr. José Horwitz Barak; Chile. Universidad Finis Terrae.; Chile
Fil: Undurraga, Juan. Universidad del Desarrollo; Chile. Instituto Psiquiátrico Dr. José Horwitz Barak; Chile
Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Díaz Zuluaga, Ana M.. Universidad de Antioquia; Colombia
Fil: Pineda-Zapata, Julián A.. Instituto de Alta Tecnología Médica; Colombia
Fil: López-Jaramillo, Carlos. Hospital Universitario San Vicente Fundación; Colombia. Universidad de Antioquia; Colombia
Fil: Reyes Madrigal, Francisco. Instituto Nacional de Neurología y Neurocirugía; México
Fil: León-Ortíz, Pablo. Instituto Nacional de Neurología y Neurocirugía; México
Fil: de la Fuente-Sandoval, Camilo. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Czepielewski, Leticia Sanguinetti. Hospital de Clinicas de Porto Alegre; Brasil
Fil: Gama, Clarissa S.. Hospital de Clinicas de Porto Alegre; Brasil
Fil: Zugman, Andre. Universidade Federal de Sao Paulo; Brasil
Fil: Gadelha, Ary. Universidade Federal de Sao Paulo; Brasil
Fil: Jackowski, Andrea. Universidade Federal de Sao Paulo; Brasil
Fil: Bressan, Rodrigo. Universidade Federal de Sao Paulo; Brasil
Materia
DEVELOPING WORLD
NEUROIMAGING
POVERTY
PSYCHIATRIC DISORDERS
URBANICITY
VIOLENCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117246
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western SocietiesCrossley, Nicolas A.Alliende, Luz MariaOssandon, TomasCastañeda, Carmen PazGonzález Valderrama, AlfonsoUndurraga, JuanCastro, Mariana NairGuinjoan, Salvador MartínDíaz Zuluaga, Ana M.Pineda-Zapata, Julián A.López-Jaramillo, CarlosReyes Madrigal, FranciscoLeón-Ortíz, Pablode la Fuente-Sandoval, CamiloCzepielewski, Leticia SanguinettiGama, Clarissa S.Zugman, AndreGadelha, AryJackowski, AndreaBressan, RodrigoDEVELOPING WORLDNEUROIMAGINGPOVERTYPSYCHIATRIC DISORDERSURBANICITYVIOLENCEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Social and environmental factors are known risk factors and modulators of mental health disorders. We here conducted a nonsystematic review of the neuroimaging literature studying the effects of poverty, urbanicity, and community violence, highlighting the opportunities of studying non-Western developing societies such as those in Latin America. Social and environmental factors in these communities are widespread and have a large magnitude, as well as an unequal distribution, providing a good opportunity for their characterization. Studying the effect of poverty in these settings could help to explore the brain effect of economic improvements, disentangle the effect of absolute and relative poverty, and characterize the modulating impact of poverty on the underlying biology of mental health disorders. Exploring urbanicity effects in highly unequal cities could help identify the specific factors that modulate this effect as well as examine a possible dose–response effect by studying megacities. Studying brain changes in those living among violence, which is particularly high in places such as Latin America, could help to characterize the interplay between brain predisposition and exposure to violence. Furthermore, exploring the brain in an adverse environment should shed light on the mechanisms underlying resilience. We finally provide examples of two methodological approaches that could contribute to this field, namely a big cohort study in the developing world and a consortium-based meta-analytic approach, and argue about the potential translational value of this research on the development of effective social policies and successful personalized medicine in disadvantaged societies.Fil: Crossley, Nicolas A.. Pontificia Universidad Católica de Chile; ChileFil: Alliende, Luz Maria. Pontificia Universidad Católica de Chile; ChileFil: Ossandon, Tomas. Pontificia Universidad Católica de Chile; ChileFil: Castañeda, Carmen Paz. Instituto Psiquiátrico Dr. José Horwitz Barak; ChileFil: González Valderrama, Alfonso. Instituto Psiquiátrico Dr. José Horwitz Barak; Chile. Universidad Finis Terrae.; ChileFil: Undurraga, Juan. Universidad del Desarrollo; Chile. Instituto Psiquiátrico Dr. José Horwitz Barak; ChileFil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Díaz Zuluaga, Ana M.. Universidad de Antioquia; ColombiaFil: Pineda-Zapata, Julián A.. Instituto de Alta Tecnología Médica; ColombiaFil: López-Jaramillo, Carlos. Hospital Universitario San Vicente Fundación; Colombia. Universidad de Antioquia; ColombiaFil: Reyes Madrigal, Francisco. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: León-Ortíz, Pablo. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: de la Fuente-Sandoval, Camilo. Instituto Nacional de Neurología y Neurocirugía; MéxicoFil: Czepielewski, Leticia Sanguinetti. Hospital de Clinicas de Porto Alegre; BrasilFil: Gama, Clarissa S.. Hospital de Clinicas de Porto Alegre; BrasilFil: Zugman, Andre. Universidade Federal de Sao Paulo; BrasilFil: Gadelha, Ary. Universidade Federal de Sao Paulo; BrasilFil: Jackowski, Andrea. Universidade Federal de Sao Paulo; BrasilFil: Bressan, Rodrigo. Universidade Federal de Sao Paulo; BrasilElsevier Inc2019-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117246Crossley, Nicolas A.; Alliende, Luz Maria; Ossandon, Tomas; Castañeda, Carmen Paz; González Valderrama, Alfonso; et al.; Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies; Elsevier Inc; Biological Psychiatry: Cognitive Neuroscience and Neuroimaging; 4; 1; 1-2019; 8-152451-90222451-9030CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bpsc.2018.09.005info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S2451902218302441info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:10:25Zoai:ri.conicet.gov.ar:11336/117246instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:10:25.574CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies
title Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies
spellingShingle Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies
Crossley, Nicolas A.
DEVELOPING WORLD
NEUROIMAGING
POVERTY
PSYCHIATRIC DISORDERS
URBANICITY
VIOLENCE
title_short Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies
title_full Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies
title_fullStr Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies
title_full_unstemmed Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies
title_sort Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies
dc.creator.none.fl_str_mv Crossley, Nicolas A.
Alliende, Luz Maria
Ossandon, Tomas
Castañeda, Carmen Paz
González Valderrama, Alfonso
Undurraga, Juan
Castro, Mariana Nair
Guinjoan, Salvador Martín
Díaz Zuluaga, Ana M.
Pineda-Zapata, Julián A.
López-Jaramillo, Carlos
Reyes Madrigal, Francisco
León-Ortíz, Pablo
de la Fuente-Sandoval, Camilo
Czepielewski, Leticia Sanguinetti
Gama, Clarissa S.
Zugman, Andre
Gadelha, Ary
Jackowski, Andrea
Bressan, Rodrigo
author Crossley, Nicolas A.
author_facet Crossley, Nicolas A.
Alliende, Luz Maria
Ossandon, Tomas
Castañeda, Carmen Paz
González Valderrama, Alfonso
Undurraga, Juan
Castro, Mariana Nair
Guinjoan, Salvador Martín
Díaz Zuluaga, Ana M.
Pineda-Zapata, Julián A.
López-Jaramillo, Carlos
Reyes Madrigal, Francisco
León-Ortíz, Pablo
de la Fuente-Sandoval, Camilo
Czepielewski, Leticia Sanguinetti
Gama, Clarissa S.
Zugman, Andre
Gadelha, Ary
Jackowski, Andrea
Bressan, Rodrigo
author_role author
author2 Alliende, Luz Maria
Ossandon, Tomas
Castañeda, Carmen Paz
González Valderrama, Alfonso
Undurraga, Juan
Castro, Mariana Nair
Guinjoan, Salvador Martín
Díaz Zuluaga, Ana M.
Pineda-Zapata, Julián A.
López-Jaramillo, Carlos
Reyes Madrigal, Francisco
León-Ortíz, Pablo
de la Fuente-Sandoval, Camilo
Czepielewski, Leticia Sanguinetti
Gama, Clarissa S.
Zugman, Andre
Gadelha, Ary
Jackowski, Andrea
Bressan, Rodrigo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DEVELOPING WORLD
NEUROIMAGING
POVERTY
PSYCHIATRIC DISORDERS
URBANICITY
VIOLENCE
topic DEVELOPING WORLD
NEUROIMAGING
POVERTY
PSYCHIATRIC DISORDERS
URBANICITY
VIOLENCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Social and environmental factors are known risk factors and modulators of mental health disorders. We here conducted a nonsystematic review of the neuroimaging literature studying the effects of poverty, urbanicity, and community violence, highlighting the opportunities of studying non-Western developing societies such as those in Latin America. Social and environmental factors in these communities are widespread and have a large magnitude, as well as an unequal distribution, providing a good opportunity for their characterization. Studying the effect of poverty in these settings could help to explore the brain effect of economic improvements, disentangle the effect of absolute and relative poverty, and characterize the modulating impact of poverty on the underlying biology of mental health disorders. Exploring urbanicity effects in highly unequal cities could help identify the specific factors that modulate this effect as well as examine a possible dose–response effect by studying megacities. Studying brain changes in those living among violence, which is particularly high in places such as Latin America, could help to characterize the interplay between brain predisposition and exposure to violence. Furthermore, exploring the brain in an adverse environment should shed light on the mechanisms underlying resilience. We finally provide examples of two methodological approaches that could contribute to this field, namely a big cohort study in the developing world and a consortium-based meta-analytic approach, and argue about the potential translational value of this research on the development of effective social policies and successful personalized medicine in disadvantaged societies.
Fil: Crossley, Nicolas A.. Pontificia Universidad Católica de Chile; Chile
Fil: Alliende, Luz Maria. Pontificia Universidad Católica de Chile; Chile
Fil: Ossandon, Tomas. Pontificia Universidad Católica de Chile; Chile
Fil: Castañeda, Carmen Paz. Instituto Psiquiátrico Dr. José Horwitz Barak; Chile
Fil: González Valderrama, Alfonso. Instituto Psiquiátrico Dr. José Horwitz Barak; Chile. Universidad Finis Terrae.; Chile
Fil: Undurraga, Juan. Universidad del Desarrollo; Chile. Instituto Psiquiátrico Dr. José Horwitz Barak; Chile
Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Díaz Zuluaga, Ana M.. Universidad de Antioquia; Colombia
Fil: Pineda-Zapata, Julián A.. Instituto de Alta Tecnología Médica; Colombia
Fil: López-Jaramillo, Carlos. Hospital Universitario San Vicente Fundación; Colombia. Universidad de Antioquia; Colombia
Fil: Reyes Madrigal, Francisco. Instituto Nacional de Neurología y Neurocirugía; México
Fil: León-Ortíz, Pablo. Instituto Nacional de Neurología y Neurocirugía; México
Fil: de la Fuente-Sandoval, Camilo. Instituto Nacional de Neurología y Neurocirugía; México
Fil: Czepielewski, Leticia Sanguinetti. Hospital de Clinicas de Porto Alegre; Brasil
Fil: Gama, Clarissa S.. Hospital de Clinicas de Porto Alegre; Brasil
Fil: Zugman, Andre. Universidade Federal de Sao Paulo; Brasil
Fil: Gadelha, Ary. Universidade Federal de Sao Paulo; Brasil
Fil: Jackowski, Andrea. Universidade Federal de Sao Paulo; Brasil
Fil: Bressan, Rodrigo. Universidade Federal de Sao Paulo; Brasil
description Social and environmental factors are known risk factors and modulators of mental health disorders. We here conducted a nonsystematic review of the neuroimaging literature studying the effects of poverty, urbanicity, and community violence, highlighting the opportunities of studying non-Western developing societies such as those in Latin America. Social and environmental factors in these communities are widespread and have a large magnitude, as well as an unequal distribution, providing a good opportunity for their characterization. Studying the effect of poverty in these settings could help to explore the brain effect of economic improvements, disentangle the effect of absolute and relative poverty, and characterize the modulating impact of poverty on the underlying biology of mental health disorders. Exploring urbanicity effects in highly unequal cities could help identify the specific factors that modulate this effect as well as examine a possible dose–response effect by studying megacities. Studying brain changes in those living among violence, which is particularly high in places such as Latin America, could help to characterize the interplay between brain predisposition and exposure to violence. Furthermore, exploring the brain in an adverse environment should shed light on the mechanisms underlying resilience. We finally provide examples of two methodological approaches that could contribute to this field, namely a big cohort study in the developing world and a consortium-based meta-analytic approach, and argue about the potential translational value of this research on the development of effective social policies and successful personalized medicine in disadvantaged societies.
publishDate 2019
dc.date.none.fl_str_mv 2019-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117246
Crossley, Nicolas A.; Alliende, Luz Maria; Ossandon, Tomas; Castañeda, Carmen Paz; González Valderrama, Alfonso; et al.; Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies; Elsevier Inc; Biological Psychiatry: Cognitive Neuroscience and Neuroimaging; 4; 1; 1-2019; 8-15
2451-9022
2451-9030
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117246
identifier_str_mv Crossley, Nicolas A.; Alliende, Luz Maria; Ossandon, Tomas; Castañeda, Carmen Paz; González Valderrama, Alfonso; et al.; Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies; Elsevier Inc; Biological Psychiatry: Cognitive Neuroscience and Neuroimaging; 4; 1; 1-2019; 8-15
2451-9022
2451-9030
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bpsc.2018.09.005
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S2451902218302441
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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