Ultradeformable phospholipid vesicles as a drug delivery system: a review

Autores
Romero, Eder Lilia; Morilla, María José
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ultradeformable vesicles are highly deformable (elastic/flexible) liposomes made of phospholipids plus highly mobile hydrophilic detergents capable of penetrating the intact skin across the stratum corneum and reach the viable epidermis. Ultradeformable vesicles are more effective than conventional liposomes in delivering drugs into and across the mammalian skin, and have been tested for local delivery of non-steroidal anti-inflammatory agents against musculoskeletal-articular disorders such as osteoarthritis, to treat atopic dermatitis, to deliver anti-infective drugs against epithelial infections and to avoid the first pass effect of oral antihypertensive drugs. Currently a single ultradeformable vesicle anti-inflammatory formulation has reached phase III clinical trials, but no commercial product based on this technology is yet available.
Fil: Romero, Eder Lilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Morilla, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Materia
ELASTIC LIPOSOMES
ANTI-INFLAMMATORY AGENTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/72169
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Ultradeformable phospholipid vesicles as a drug delivery system: a reviewRomero, Eder LiliaMorilla, María JoséELASTIC LIPOSOMESANTI-INFLAMMATORY AGENTShttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Ultradeformable vesicles are highly deformable (elastic/flexible) liposomes made of phospholipids plus highly mobile hydrophilic detergents capable of penetrating the intact skin across the stratum corneum and reach the viable epidermis. Ultradeformable vesicles are more effective than conventional liposomes in delivering drugs into and across the mammalian skin, and have been tested for local delivery of non-steroidal anti-inflammatory agents against musculoskeletal-articular disorders such as osteoarthritis, to treat atopic dermatitis, to deliver anti-infective drugs against epithelial infections and to avoid the first pass effect of oral antihypertensive drugs. Currently a single ultradeformable vesicle anti-inflammatory formulation has reached phase III clinical trials, but no commercial product based on this technology is yet available.Fil: Romero, Eder Lilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Morilla, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaDove Medical Press Ltd2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/72169Romero, Eder Lilia; Morilla, María José; Ultradeformable phospholipid vesicles as a drug delivery system: a review; Dove Medical Press Ltd; Research and Reports in Transdermal Drug Delivery; 4; 12-2015; 55-692253-1580CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2147/RRTD.S50370info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/ultradeformable-phospholipid-vesicles-as-a-drug-delivery-system-a-revi-peer-reviewed-article-RRTDinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:07:49Zoai:ri.conicet.gov.ar:11336/72169instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:07:49.855CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ultradeformable phospholipid vesicles as a drug delivery system: a review
title Ultradeformable phospholipid vesicles as a drug delivery system: a review
spellingShingle Ultradeformable phospholipid vesicles as a drug delivery system: a review
Romero, Eder Lilia
ELASTIC LIPOSOMES
ANTI-INFLAMMATORY AGENTS
title_short Ultradeformable phospholipid vesicles as a drug delivery system: a review
title_full Ultradeformable phospholipid vesicles as a drug delivery system: a review
title_fullStr Ultradeformable phospholipid vesicles as a drug delivery system: a review
title_full_unstemmed Ultradeformable phospholipid vesicles as a drug delivery system: a review
title_sort Ultradeformable phospholipid vesicles as a drug delivery system: a review
dc.creator.none.fl_str_mv Romero, Eder Lilia
Morilla, María José
author Romero, Eder Lilia
author_facet Romero, Eder Lilia
Morilla, María José
author_role author
author2 Morilla, María José
author2_role author
dc.subject.none.fl_str_mv ELASTIC LIPOSOMES
ANTI-INFLAMMATORY AGENTS
topic ELASTIC LIPOSOMES
ANTI-INFLAMMATORY AGENTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Ultradeformable vesicles are highly deformable (elastic/flexible) liposomes made of phospholipids plus highly mobile hydrophilic detergents capable of penetrating the intact skin across the stratum corneum and reach the viable epidermis. Ultradeformable vesicles are more effective than conventional liposomes in delivering drugs into and across the mammalian skin, and have been tested for local delivery of non-steroidal anti-inflammatory agents against musculoskeletal-articular disorders such as osteoarthritis, to treat atopic dermatitis, to deliver anti-infective drugs against epithelial infections and to avoid the first pass effect of oral antihypertensive drugs. Currently a single ultradeformable vesicle anti-inflammatory formulation has reached phase III clinical trials, but no commercial product based on this technology is yet available.
Fil: Romero, Eder Lilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Morilla, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
description Ultradeformable vesicles are highly deformable (elastic/flexible) liposomes made of phospholipids plus highly mobile hydrophilic detergents capable of penetrating the intact skin across the stratum corneum and reach the viable epidermis. Ultradeformable vesicles are more effective than conventional liposomes in delivering drugs into and across the mammalian skin, and have been tested for local delivery of non-steroidal anti-inflammatory agents against musculoskeletal-articular disorders such as osteoarthritis, to treat atopic dermatitis, to deliver anti-infective drugs against epithelial infections and to avoid the first pass effect of oral antihypertensive drugs. Currently a single ultradeformable vesicle anti-inflammatory formulation has reached phase III clinical trials, but no commercial product based on this technology is yet available.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/72169
Romero, Eder Lilia; Morilla, María José; Ultradeformable phospholipid vesicles as a drug delivery system: a review; Dove Medical Press Ltd; Research and Reports in Transdermal Drug Delivery; 4; 12-2015; 55-69
2253-1580
CONICET Digital
CONICET
url http://hdl.handle.net/11336/72169
identifier_str_mv Romero, Eder Lilia; Morilla, María José; Ultradeformable phospholipid vesicles as a drug delivery system: a review; Dove Medical Press Ltd; Research and Reports in Transdermal Drug Delivery; 4; 12-2015; 55-69
2253-1580
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2147/RRTD.S50370
info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/ultradeformable-phospholipid-vesicles-as-a-drug-delivery-system-a-revi-peer-reviewed-article-RRTD
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press Ltd
publisher.none.fl_str_mv Dove Medical Press Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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