Translational medicine in obstructive sleep apnea

Autores
Larrateguy, Luis Darío; Milone, Diego Humberto; Di Persia, Leandro Ezequiel; Schlotthauer, Gaston; Pais, Carlos Marcelo
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: The Obstructive Sleep Apnea (OSA ) is highly prevalent in the population and the "gold standard " for diagnosis is polysomnography (PSG ). This is not always available, so a validated alternative to find and to treat severe cases is the use of simplified studies at home. 1 Translational medicine is the transfer of basic science to the medical practice from the translation of scientific findings or developments made in laboratories to products or methodologies using everyday in medical practice. Objective: Develop a diagnostic home device that uses an automatic algorithm from the pulse oximetry signal (SaO2). Materials and methods: We designed a hardware, with an automatic algorithm that uses the SaO2 signal. We create an Oxygen Desaturation Index ( ODI) that estimated an apnea / hypopnea index (AHI ) was compared with AHI calculated by an expert in 25 studies PSG and then compared with the AHI calculated automatically in 80 records obtained with a validated polygraph, the ApneaLink ® ( AL). SaO2 signals were analyzed with the two detection techniques that we named M1 and M2.2We have begun to use the hardware with this algorithm in people. Results: The Area Under Curve (AUC) for ODI M1/IAH PSG was 0,97. The AUC for ODI M2/ IAH PSG: 0,94. The AUC for ODI (AL) /IAH (AL) was 0,92 (0,85 - 0,96). The AUC for ODI M1/IAH AL was 0,94 (0,87-0,97) and the AUC for IDH M2/ IAH AL was 0,95 (0,88 – 0,98). Conclusions: There is a good correlation between AHI estimated by the new hardware and algorithm compared to PSG and PR. The hardware works properly with this algorithm.This is an example of translational medicine in sleep medicine.
Fil: Larrateguy, Luis Darío. No especifíca;
Fil: Milone, Diego Humberto. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Di Persia, Leandro Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas; Argentina
Fil: Schlotthauer, Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Pais, Carlos Marcelo. Cardiocom. Departamento Respiratorio; Argentina
Materia
Sleep Disorders
Sleep Studies
Experimental Approaches
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38032
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/38032
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Translational medicine in obstructive sleep apneaLarrateguy, Luis DaríoMilone, Diego HumbertoDi Persia, Leandro EzequielSchlotthauer, GastonPais, Carlos MarceloSleep DisordersSleep StudiesExperimental Approacheshttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2Introduction: The Obstructive Sleep Apnea (OSA ) is highly prevalent in the population and the "gold standard " for diagnosis is polysomnography (PSG ). This is not always available, so a validated alternative to find and to treat severe cases is the use of simplified studies at home. 1 Translational medicine is the transfer of basic science to the medical practice from the translation of scientific findings or developments made in laboratories to products or methodologies using everyday in medical practice. Objective: Develop a diagnostic home device that uses an automatic algorithm from the pulse oximetry signal (SaO2). Materials and methods: We designed a hardware, with an automatic algorithm that uses the SaO2 signal. We create an Oxygen Desaturation Index ( ODI) that estimated an apnea / hypopnea index (AHI ) was compared with AHI calculated by an expert in 25 studies PSG and then compared with the AHI calculated automatically in 80 records obtained with a validated polygraph, the ApneaLink ® ( AL). SaO2 signals were analyzed with the two detection techniques that we named M1 and M2.2We have begun to use the hardware with this algorithm in people. Results: The Area Under Curve (AUC) for ODI M1/IAH PSG was 0,97. The AUC for ODI M2/ IAH PSG: 0,94. The AUC for ODI (AL) /IAH (AL) was 0,92 (0,85 - 0,96). The AUC for ODI M1/IAH AL was 0,94 (0,87-0,97) and the AUC for IDH M2/ IAH AL was 0,95 (0,88 – 0,98). Conclusions: There is a good correlation between AHI estimated by the new hardware and algorithm compared to PSG and PR. The hardware works properly with this algorithm.This is an example of translational medicine in sleep medicine.Fil: Larrateguy, Luis Darío. No especifíca;Fil: Milone, Diego Humberto. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Di Persia, Leandro Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas; ArgentinaFil: Schlotthauer, Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaFil: Pais, Carlos Marcelo. Cardiocom. Departamento Respiratorio; ArgentinaEuropean Respiratory Society2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38032Larrateguy, Luis Darío; Milone, Diego Humberto; Di Persia, Leandro Ezequiel; Schlotthauer, Gaston; Pais, Carlos Marcelo; Translational medicine in obstructive sleep apnea; European Respiratory Society; European Respiratory Journal; 44; 58; 12-2014; 1-30903-19361399-3003CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://erj.ersjournals.com/content/44/Suppl_58/P2267info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T10:54:48Zoai:ri.conicet.gov.ar:11336/38032instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 10:54:49.141CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Translational medicine in obstructive sleep apnea
title Translational medicine in obstructive sleep apnea
spellingShingle Translational medicine in obstructive sleep apnea
Larrateguy, Luis Darío
Sleep Disorders
Sleep Studies
Experimental Approaches
title_short Translational medicine in obstructive sleep apnea
title_full Translational medicine in obstructive sleep apnea
title_fullStr Translational medicine in obstructive sleep apnea
title_full_unstemmed Translational medicine in obstructive sleep apnea
title_sort Translational medicine in obstructive sleep apnea
dc.creator.none.fl_str_mv Larrateguy, Luis Darío
Milone, Diego Humberto
Di Persia, Leandro Ezequiel
Schlotthauer, Gaston
Pais, Carlos Marcelo
author Larrateguy, Luis Darío
author_facet Larrateguy, Luis Darío
Milone, Diego Humberto
Di Persia, Leandro Ezequiel
Schlotthauer, Gaston
Pais, Carlos Marcelo
author_role author
author2 Milone, Diego Humberto
Di Persia, Leandro Ezequiel
Schlotthauer, Gaston
Pais, Carlos Marcelo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Sleep Disorders
Sleep Studies
Experimental Approaches
topic Sleep Disorders
Sleep Studies
Experimental Approaches
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Introduction: The Obstructive Sleep Apnea (OSA ) is highly prevalent in the population and the "gold standard " for diagnosis is polysomnography (PSG ). This is not always available, so a validated alternative to find and to treat severe cases is the use of simplified studies at home. 1 Translational medicine is the transfer of basic science to the medical practice from the translation of scientific findings or developments made in laboratories to products or methodologies using everyday in medical practice. Objective: Develop a diagnostic home device that uses an automatic algorithm from the pulse oximetry signal (SaO2). Materials and methods: We designed a hardware, with an automatic algorithm that uses the SaO2 signal. We create an Oxygen Desaturation Index ( ODI) that estimated an apnea / hypopnea index (AHI ) was compared with AHI calculated by an expert in 25 studies PSG and then compared with the AHI calculated automatically in 80 records obtained with a validated polygraph, the ApneaLink ® ( AL). SaO2 signals were analyzed with the two detection techniques that we named M1 and M2.2We have begun to use the hardware with this algorithm in people. Results: The Area Under Curve (AUC) for ODI M1/IAH PSG was 0,97. The AUC for ODI M2/ IAH PSG: 0,94. The AUC for ODI (AL) /IAH (AL) was 0,92 (0,85 - 0,96). The AUC for ODI M1/IAH AL was 0,94 (0,87-0,97) and the AUC for IDH M2/ IAH AL was 0,95 (0,88 – 0,98). Conclusions: There is a good correlation between AHI estimated by the new hardware and algorithm compared to PSG and PR. The hardware works properly with this algorithm.This is an example of translational medicine in sleep medicine.
Fil: Larrateguy, Luis Darío. No especifíca;
Fil: Milone, Diego Humberto. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Di Persia, Leandro Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas; Argentina
Fil: Schlotthauer, Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Fil: Pais, Carlos Marcelo. Cardiocom. Departamento Respiratorio; Argentina
description Introduction: The Obstructive Sleep Apnea (OSA ) is highly prevalent in the population and the "gold standard " for diagnosis is polysomnography (PSG ). This is not always available, so a validated alternative to find and to treat severe cases is the use of simplified studies at home. 1 Translational medicine is the transfer of basic science to the medical practice from the translation of scientific findings or developments made in laboratories to products or methodologies using everyday in medical practice. Objective: Develop a diagnostic home device that uses an automatic algorithm from the pulse oximetry signal (SaO2). Materials and methods: We designed a hardware, with an automatic algorithm that uses the SaO2 signal. We create an Oxygen Desaturation Index ( ODI) that estimated an apnea / hypopnea index (AHI ) was compared with AHI calculated by an expert in 25 studies PSG and then compared with the AHI calculated automatically in 80 records obtained with a validated polygraph, the ApneaLink ® ( AL). SaO2 signals were analyzed with the two detection techniques that we named M1 and M2.2We have begun to use the hardware with this algorithm in people. Results: The Area Under Curve (AUC) for ODI M1/IAH PSG was 0,97. The AUC for ODI M2/ IAH PSG: 0,94. The AUC for ODI (AL) /IAH (AL) was 0,92 (0,85 - 0,96). The AUC for ODI M1/IAH AL was 0,94 (0,87-0,97) and the AUC for IDH M2/ IAH AL was 0,95 (0,88 – 0,98). Conclusions: There is a good correlation between AHI estimated by the new hardware and algorithm compared to PSG and PR. The hardware works properly with this algorithm.This is an example of translational medicine in sleep medicine.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38032
Larrateguy, Luis Darío; Milone, Diego Humberto; Di Persia, Leandro Ezequiel; Schlotthauer, Gaston; Pais, Carlos Marcelo; Translational medicine in obstructive sleep apnea; European Respiratory Society; European Respiratory Journal; 44; 58; 12-2014; 1-3
0903-1936
1399-3003
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38032
identifier_str_mv Larrateguy, Luis Darío; Milone, Diego Humberto; Di Persia, Leandro Ezequiel; Schlotthauer, Gaston; Pais, Carlos Marcelo; Translational medicine in obstructive sleep apnea; European Respiratory Society; European Respiratory Journal; 44; 58; 12-2014; 1-3
0903-1936
1399-3003
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://erj.ersjournals.com/content/44/Suppl_58/P2267
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv European Respiratory Society
publisher.none.fl_str_mv European Respiratory Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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