Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms

Autores
Calvo, Daniel Juan; Beltrán González, Andrea Natalia
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Oxidizing and reducing agents, which are currently involved in cell metabolism and signaling pathways, can regulate fast inhibitory neurotransmission mediated by γ-aminobutyric acid (GABA) receptors in the nervous system. A number of in vitro studies have shown that diverse redox compounds, including redox metabolites and reactive oxygen and nitrogen species, modulate phasic and tonic responses mediated by neuronal GABAA receptors through both pre- and postsynaptic mechanisms. We review experimental data showing that many redox agents, which are normally present in neurons and glia or are endogenously generated in these cells under physiological states or during oxidative stress (e.g: hydrogen peroxide, superoxide and hydroxyl radicals, nitric oxide, ascorbic acid, glutathione), induce potentiating or inhibiting actions on different native and recombinant GABAA receptor subtypes. Based on these results, it is thought that redox signaling might represent a homeostatic mechanism that regulates the function of synaptic and extrasynaptic GABAA receptors in physiological and pathological conditions.
Fil: Calvo, Daniel Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; Argentina
Fil: Beltrán González, Andrea Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; Argentina
Materia
Gabaa Receptors
Redox Modulation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/44186
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Dynamic Regulation of the GABAA Receptor Function by Redox MechanismsCalvo, Daniel JuanBeltrán González, Andrea NataliaGabaa ReceptorsRedox Modulationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Oxidizing and reducing agents, which are currently involved in cell metabolism and signaling pathways, can regulate fast inhibitory neurotransmission mediated by γ-aminobutyric acid (GABA) receptors in the nervous system. A number of in vitro studies have shown that diverse redox compounds, including redox metabolites and reactive oxygen and nitrogen species, modulate phasic and tonic responses mediated by neuronal GABAA receptors through both pre- and postsynaptic mechanisms. We review experimental data showing that many redox agents, which are normally present in neurons and glia or are endogenously generated in these cells under physiological states or during oxidative stress (e.g: hydrogen peroxide, superoxide and hydroxyl radicals, nitric oxide, ascorbic acid, glutathione), induce potentiating or inhibiting actions on different native and recombinant GABAA receptor subtypes. Based on these results, it is thought that redox signaling might represent a homeostatic mechanism that regulates the function of synaptic and extrasynaptic GABAA receptors in physiological and pathological conditions.Fil: Calvo, Daniel Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; ArgentinaFil: Beltrán González, Andrea Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; ArgentinaAmerican Society for Pharmacology and Experimental Therapeutics2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44186Calvo, Daniel Juan; Beltrán González, Andrea Natalia; Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms; American Society for Pharmacology and Experimental Therapeutics; Molecular Pharmacology; 90; 3; 7-2016; 326-3331521-0111CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://molpharm.aspetjournals.org/content/early/recent#content-blockinfo:eu-repo/semantics/altIdentifier/doi/10.1124/mol.116.105205info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:44:49Zoai:ri.conicet.gov.ar:11336/44186instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:44:49.347CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms
title Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms
spellingShingle Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms
Calvo, Daniel Juan
Gabaa Receptors
Redox Modulation
title_short Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms
title_full Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms
title_fullStr Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms
title_full_unstemmed Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms
title_sort Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms
dc.creator.none.fl_str_mv Calvo, Daniel Juan
Beltrán González, Andrea Natalia
author Calvo, Daniel Juan
author_facet Calvo, Daniel Juan
Beltrán González, Andrea Natalia
author_role author
author2 Beltrán González, Andrea Natalia
author2_role author
dc.subject.none.fl_str_mv Gabaa Receptors
Redox Modulation
topic Gabaa Receptors
Redox Modulation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Oxidizing and reducing agents, which are currently involved in cell metabolism and signaling pathways, can regulate fast inhibitory neurotransmission mediated by γ-aminobutyric acid (GABA) receptors in the nervous system. A number of in vitro studies have shown that diverse redox compounds, including redox metabolites and reactive oxygen and nitrogen species, modulate phasic and tonic responses mediated by neuronal GABAA receptors through both pre- and postsynaptic mechanisms. We review experimental data showing that many redox agents, which are normally present in neurons and glia or are endogenously generated in these cells under physiological states or during oxidative stress (e.g: hydrogen peroxide, superoxide and hydroxyl radicals, nitric oxide, ascorbic acid, glutathione), induce potentiating or inhibiting actions on different native and recombinant GABAA receptor subtypes. Based on these results, it is thought that redox signaling might represent a homeostatic mechanism that regulates the function of synaptic and extrasynaptic GABAA receptors in physiological and pathological conditions.
Fil: Calvo, Daniel Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; Argentina
Fil: Beltrán González, Andrea Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; Argentina
description Oxidizing and reducing agents, which are currently involved in cell metabolism and signaling pathways, can regulate fast inhibitory neurotransmission mediated by γ-aminobutyric acid (GABA) receptors in the nervous system. A number of in vitro studies have shown that diverse redox compounds, including redox metabolites and reactive oxygen and nitrogen species, modulate phasic and tonic responses mediated by neuronal GABAA receptors through both pre- and postsynaptic mechanisms. We review experimental data showing that many redox agents, which are normally present in neurons and glia or are endogenously generated in these cells under physiological states or during oxidative stress (e.g: hydrogen peroxide, superoxide and hydroxyl radicals, nitric oxide, ascorbic acid, glutathione), induce potentiating or inhibiting actions on different native and recombinant GABAA receptor subtypes. Based on these results, it is thought that redox signaling might represent a homeostatic mechanism that regulates the function of synaptic and extrasynaptic GABAA receptors in physiological and pathological conditions.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/44186
Calvo, Daniel Juan; Beltrán González, Andrea Natalia; Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms; American Society for Pharmacology and Experimental Therapeutics; Molecular Pharmacology; 90; 3; 7-2016; 326-333
1521-0111
CONICET Digital
CONICET
url http://hdl.handle.net/11336/44186
identifier_str_mv Calvo, Daniel Juan; Beltrán González, Andrea Natalia; Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms; American Society for Pharmacology and Experimental Therapeutics; Molecular Pharmacology; 90; 3; 7-2016; 326-333
1521-0111
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://molpharm.aspetjournals.org/content/early/recent#content-block
info:eu-repo/semantics/altIdentifier/doi/10.1124/mol.116.105205
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Pharmacology and Experimental Therapeutics
publisher.none.fl_str_mv American Society for Pharmacology and Experimental Therapeutics
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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