Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues

Autores
Jones, Leandro Roberto; Moretti, Franco; Calvo, Andrea Yamila; Dilernia, Dario Alberto; Manrique, Julieta Marina; Gómez Carrillo, Manuel; Salomon, Horacio Eduardo
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We studied drug resistance mutations (DRMs) in 2623 pol sequences. Out of 94,828 amino acid substitutions that were detected, 8749 corresponded to nucleoside reverse transcriptase inhibitor (NRTI), 3765 to nonnucleoside reverse transcriptase inhibitor (NNRTI), and 7141 to protease inhibitor (PI) resistance-associated mutations. The most common DRMs were L10I, I54V, L90M, V82A, A71V, L10V, M46I, M184V, M41L, T215Y, D67N, L210W, K70R, N348I, V118I, K103N, Y181C, G190A, K101E, V108I, L100I, V90I, K101Q, and A98G. As expected, DRMs frequencies depended on viral genotype. The amounts of NRTI and PI resistance mutations among B and BF sequences from children were higher than among sequences from adults. The frequencies of PI and NRTI resistance mutations among B and BF sequences from adult men were higher than among sequences from women. Some of these observations can be explained in light of the available epidemiological information, but some cannot, indicating that further studies are needed to understand the antiretroviral resistance epidemics in Argentina.
Fil: Jones, Leandro Roberto. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moretti, Franco. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina
Fil: Calvo, Andrea Yamila. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dilernia, Dario Alberto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Manrique, Julieta Marina. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gómez Carrillo, Manuel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salomon, Horacio Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Hiv/Aids
Drug Resistance
Molecular Epidemiology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16267
Acceder
id CONICETDig_f7319f740173008d640d0bd29bcfe735
oai_identifier_str oai:ri.conicet.gov.ar:11336/16267
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issuesJones, Leandro RobertoMoretti, FrancoCalvo, Andrea YamilaDilernia, Dario AlbertoManrique, Julieta MarinaGómez Carrillo, ManuelSalomon, Horacio EduardoHiv/AidsDrug ResistanceMolecular Epidemiologyhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3We studied drug resistance mutations (DRMs) in 2623 pol sequences. Out of 94,828 amino acid substitutions that were detected, 8749 corresponded to nucleoside reverse transcriptase inhibitor (NRTI), 3765 to nonnucleoside reverse transcriptase inhibitor (NNRTI), and 7141 to protease inhibitor (PI) resistance-associated mutations. The most common DRMs were L10I, I54V, L90M, V82A, A71V, L10V, M46I, M184V, M41L, T215Y, D67N, L210W, K70R, N348I, V118I, K103N, Y181C, G190A, K101E, V108I, L100I, V90I, K101Q, and A98G. As expected, DRMs frequencies depended on viral genotype. The amounts of NRTI and PI resistance mutations among B and BF sequences from children were higher than among sequences from adults. The frequencies of PI and NRTI resistance mutations among B and BF sequences from adult men were higher than among sequences from women. Some of these observations can be explained in light of the available epidemiological information, but some cannot, indicating that further studies are needed to understand the antiretroviral resistance epidemics in Argentina.Fil: Jones, Leandro Roberto. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Moretti, Franco. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; ArgentinaFil: Calvo, Andrea Yamila. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Dilernia, Dario Alberto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Manrique, Julieta Marina. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gómez Carrillo, Manuel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Salomon, Horacio Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMary Ann Liebert Inc2011-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16267Jones, Leandro Roberto; Moretti, Franco; Calvo, Andrea Yamila; Dilernia, Dario Alberto; Manrique, Julieta Marina; et al.; Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues; Mary Ann Liebert Inc; Aids Research And Human Retroviruses; 28; 8; 12-2011; 949-9550889-2229enginfo:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/aid.2011.0287info:eu-repo/semantics/altIdentifier/doi/10.1089/aid.2011.0287info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:57Zoai:ri.conicet.gov.ar:11336/16267instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:57.92CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues
title Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues
spellingShingle Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues
Jones, Leandro Roberto
Hiv/Aids
Drug Resistance
Molecular Epidemiology
title_short Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues
title_full Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues
title_fullStr Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues
title_full_unstemmed Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues
title_sort Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues
dc.creator.none.fl_str_mv Jones, Leandro Roberto
Moretti, Franco
Calvo, Andrea Yamila
Dilernia, Dario Alberto
Manrique, Julieta Marina
Gómez Carrillo, Manuel
Salomon, Horacio Eduardo
author Jones, Leandro Roberto
author_facet Jones, Leandro Roberto
Moretti, Franco
Calvo, Andrea Yamila
Dilernia, Dario Alberto
Manrique, Julieta Marina
Gómez Carrillo, Manuel
Salomon, Horacio Eduardo
author_role author
author2 Moretti, Franco
Calvo, Andrea Yamila
Dilernia, Dario Alberto
Manrique, Julieta Marina
Gómez Carrillo, Manuel
Salomon, Horacio Eduardo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Hiv/Aids
Drug Resistance
Molecular Epidemiology
topic Hiv/Aids
Drug Resistance
Molecular Epidemiology
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We studied drug resistance mutations (DRMs) in 2623 pol sequences. Out of 94,828 amino acid substitutions that were detected, 8749 corresponded to nucleoside reverse transcriptase inhibitor (NRTI), 3765 to nonnucleoside reverse transcriptase inhibitor (NNRTI), and 7141 to protease inhibitor (PI) resistance-associated mutations. The most common DRMs were L10I, I54V, L90M, V82A, A71V, L10V, M46I, M184V, M41L, T215Y, D67N, L210W, K70R, N348I, V118I, K103N, Y181C, G190A, K101E, V108I, L100I, V90I, K101Q, and A98G. As expected, DRMs frequencies depended on viral genotype. The amounts of NRTI and PI resistance mutations among B and BF sequences from children were higher than among sequences from adults. The frequencies of PI and NRTI resistance mutations among B and BF sequences from adult men were higher than among sequences from women. Some of these observations can be explained in light of the available epidemiological information, but some cannot, indicating that further studies are needed to understand the antiretroviral resistance epidemics in Argentina.
Fil: Jones, Leandro Roberto. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moretti, Franco. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina
Fil: Calvo, Andrea Yamila. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dilernia, Dario Alberto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Manrique, Julieta Marina. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gómez Carrillo, Manuel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salomon, Horacio Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description We studied drug resistance mutations (DRMs) in 2623 pol sequences. Out of 94,828 amino acid substitutions that were detected, 8749 corresponded to nucleoside reverse transcriptase inhibitor (NRTI), 3765 to nonnucleoside reverse transcriptase inhibitor (NNRTI), and 7141 to protease inhibitor (PI) resistance-associated mutations. The most common DRMs were L10I, I54V, L90M, V82A, A71V, L10V, M46I, M184V, M41L, T215Y, D67N, L210W, K70R, N348I, V118I, K103N, Y181C, G190A, K101E, V108I, L100I, V90I, K101Q, and A98G. As expected, DRMs frequencies depended on viral genotype. The amounts of NRTI and PI resistance mutations among B and BF sequences from children were higher than among sequences from adults. The frequencies of PI and NRTI resistance mutations among B and BF sequences from adult men were higher than among sequences from women. Some of these observations can be explained in light of the available epidemiological information, but some cannot, indicating that further studies are needed to understand the antiretroviral resistance epidemics in Argentina.
publishDate 2011
dc.date.none.fl_str_mv 2011-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16267
Jones, Leandro Roberto; Moretti, Franco; Calvo, Andrea Yamila; Dilernia, Dario Alberto; Manrique, Julieta Marina; et al.; Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues; Mary Ann Liebert Inc; Aids Research And Human Retroviruses; 28; 8; 12-2011; 949-955
0889-2229
url http://hdl.handle.net/11336/16267
identifier_str_mv Jones, Leandro Roberto; Moretti, Franco; Calvo, Andrea Yamila; Dilernia, Dario Alberto; Manrique, Julieta Marina; et al.; Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues; Mary Ann Liebert Inc; Aids Research And Human Retroviruses; 28; 8; 12-2011; 949-955
0889-2229
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/aid.2011.0287
info:eu-repo/semantics/altIdentifier/doi/10.1089/aid.2011.0287
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert Inc
publisher.none.fl_str_mv Mary Ann Liebert Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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