Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American Adults

Autores
Fernandez Machulsky, Nahuel Hernan; Colla, Julian; Gonzalez, Diego Javier; Fortuna, Federico; Ibar, Carolina; Jamardo, Juan; Gagliardi, Juan Alberto; Fabre, Bibiana; Berg, Gabriela Alicia
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Chronic and psychosocial stresses are the emerging factors linked to cardiovascular disease. Assessment of cortisol levels in hair can serve as an indicator of an individual’s exposure to prolonged stressful events. For its evaluation, mass spectrometry is the reference method. However, because of its limitations for clinical laboratories, an automated chemiluminescent method was developed in our laboratory. The objective of the study is to evaluate the hair cortisol levels measured by an automated method and its association with psychosocial stress and cardiometabolic risk factors in a Latin American population. Materials and Methods: Hair samples were obtained from 56 consecutive patients hospitalized with an ST‑segment elevation acute myocardial infarction (STEMI) and 56 consecutive controls randomly recruited in routine consultation. Perceived stress and social support were evaluated by the validated questionnaires. Hair cortisol was measured by an automated chemiluminescent method. Glycemia and lipoprotein profile were measured in serum samples. Results: Hair cortisol was significantly higher in patients than in controls (175 [40–424] vs. 60.5 [40–155] pg of cortisol/mg of hair [P < 0.001]). Hair cortisol was not related to age or body mass index; however, it was related to glycemia (r = 0.461, P < 0.001) and triglycerides/high‑density lipoprotein cholesterol (TGs/ HDL‑c) index (r = 0.398, P = 0.001). Perceived stress was related to hair cortisol (r = 0.425, P < 0.001), age (r = 0.321, P = 0.01), and social support (r = −0.208, P = 0.028). TGs/HDL‑c index and perceived stress partially explain hair cortisol variation ([F = 8.69, P = 0.004] and [F = 24.9, P < 0.001], respectively). Conclusion: We observed higher hair cortisol concentrations, measured by an automated method, in STEMI patients than in controls in a Latin American population. In addition, it was related to perceived stress and cardiometabolic parameters.
Fil: Fernandez Machulsky, Nahuel Hernan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Colla, Julian. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich.; Argentina
Fil: Gonzalez, Diego Javier. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Fortuna, Federico. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Ibar, Carolina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Jamardo, Juan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Gagliardi, Juan Alberto. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich.; Argentina
Fil: Fabre, Bibiana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Berg, Gabriela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Materia
Hair cortisol
Acute myocardial infarction
Automated method
Perceived stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/272289
Acceder
id CONICETDig_f67af8b538e179b0577085aa713f4e93
oai_identifier_str oai:ri.conicet.gov.ar:11336/272289
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American AdultsFernandez Machulsky, Nahuel HernanColla, JulianGonzalez, Diego JavierFortuna, FedericoIbar, CarolinaJamardo, JuanGagliardi, Juan AlbertoFabre, BibianaBerg, Gabriela AliciaHair cortisolAcute myocardial infarctionAutomated methodPerceived stresshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Chronic and psychosocial stresses are the emerging factors linked to cardiovascular disease. Assessment of cortisol levels in hair can serve as an indicator of an individual’s exposure to prolonged stressful events. For its evaluation, mass spectrometry is the reference method. However, because of its limitations for clinical laboratories, an automated chemiluminescent method was developed in our laboratory. The objective of the study is to evaluate the hair cortisol levels measured by an automated method and its association with psychosocial stress and cardiometabolic risk factors in a Latin American population. Materials and Methods: Hair samples were obtained from 56 consecutive patients hospitalized with an ST‑segment elevation acute myocardial infarction (STEMI) and 56 consecutive controls randomly recruited in routine consultation. Perceived stress and social support were evaluated by the validated questionnaires. Hair cortisol was measured by an automated chemiluminescent method. Glycemia and lipoprotein profile were measured in serum samples. Results: Hair cortisol was significantly higher in patients than in controls (175 [40–424] vs. 60.5 [40–155] pg of cortisol/mg of hair [P < 0.001]). Hair cortisol was not related to age or body mass index; however, it was related to glycemia (r = 0.461, P < 0.001) and triglycerides/high‑density lipoprotein cholesterol (TGs/ HDL‑c) index (r = 0.398, P = 0.001). Perceived stress was related to hair cortisol (r = 0.425, P < 0.001), age (r = 0.321, P = 0.01), and social support (r = −0.208, P = 0.028). TGs/HDL‑c index and perceived stress partially explain hair cortisol variation ([F = 8.69, P = 0.004] and [F = 24.9, P < 0.001], respectively). Conclusion: We observed higher hair cortisol concentrations, measured by an automated method, in STEMI patients than in controls in a Latin American population. In addition, it was related to perceived stress and cardiometabolic parameters.Fil: Fernandez Machulsky, Nahuel Hernan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Colla, Julian. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich.; ArgentinaFil: Gonzalez, Diego Javier. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Fortuna, Federico. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Ibar, Carolina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Jamardo, Juan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Gagliardi, Juan Alberto. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich.; ArgentinaFil: Fabre, Bibiana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Berg, Gabriela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaWolters Kluwer2025-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/272289Fernandez Machulsky, Nahuel Hernan; Colla, Julian; Gonzalez, Diego Javier; Fortuna, Federico; Ibar, Carolina; et al.; Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American Adults; Wolters Kluwer; Heart and Mind; 9; 1; 1-2025; 13-202468-64762468-6484CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/10.4103/hm.HM-D-24-00099info:eu-repo/semantics/altIdentifier/doi/10.4103/hm.HM-D-24-00099info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:50:02Zoai:ri.conicet.gov.ar:11336/272289instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:50:02.526CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American Adults
title Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American Adults
spellingShingle Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American Adults
Fernandez Machulsky, Nahuel Hernan
Hair cortisol
Acute myocardial infarction
Automated method
Perceived stress
title_short Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American Adults
title_full Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American Adults
title_fullStr Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American Adults
title_full_unstemmed Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American Adults
title_sort Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American Adults
dc.creator.none.fl_str_mv Fernandez Machulsky, Nahuel Hernan
Colla, Julian
Gonzalez, Diego Javier
Fortuna, Federico
Ibar, Carolina
Jamardo, Juan
Gagliardi, Juan Alberto
Fabre, Bibiana
Berg, Gabriela Alicia
author Fernandez Machulsky, Nahuel Hernan
author_facet Fernandez Machulsky, Nahuel Hernan
Colla, Julian
Gonzalez, Diego Javier
Fortuna, Federico
Ibar, Carolina
Jamardo, Juan
Gagliardi, Juan Alberto
Fabre, Bibiana
Berg, Gabriela Alicia
author_role author
author2 Colla, Julian
Gonzalez, Diego Javier
Fortuna, Federico
Ibar, Carolina
Jamardo, Juan
Gagliardi, Juan Alberto
Fabre, Bibiana
Berg, Gabriela Alicia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hair cortisol
Acute myocardial infarction
Automated method
Perceived stress
topic Hair cortisol
Acute myocardial infarction
Automated method
Perceived stress
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Chronic and psychosocial stresses are the emerging factors linked to cardiovascular disease. Assessment of cortisol levels in hair can serve as an indicator of an individual’s exposure to prolonged stressful events. For its evaluation, mass spectrometry is the reference method. However, because of its limitations for clinical laboratories, an automated chemiluminescent method was developed in our laboratory. The objective of the study is to evaluate the hair cortisol levels measured by an automated method and its association with psychosocial stress and cardiometabolic risk factors in a Latin American population. Materials and Methods: Hair samples were obtained from 56 consecutive patients hospitalized with an ST‑segment elevation acute myocardial infarction (STEMI) and 56 consecutive controls randomly recruited in routine consultation. Perceived stress and social support were evaluated by the validated questionnaires. Hair cortisol was measured by an automated chemiluminescent method. Glycemia and lipoprotein profile were measured in serum samples. Results: Hair cortisol was significantly higher in patients than in controls (175 [40–424] vs. 60.5 [40–155] pg of cortisol/mg of hair [P < 0.001]). Hair cortisol was not related to age or body mass index; however, it was related to glycemia (r = 0.461, P < 0.001) and triglycerides/high‑density lipoprotein cholesterol (TGs/ HDL‑c) index (r = 0.398, P = 0.001). Perceived stress was related to hair cortisol (r = 0.425, P < 0.001), age (r = 0.321, P = 0.01), and social support (r = −0.208, P = 0.028). TGs/HDL‑c index and perceived stress partially explain hair cortisol variation ([F = 8.69, P = 0.004] and [F = 24.9, P < 0.001], respectively). Conclusion: We observed higher hair cortisol concentrations, measured by an automated method, in STEMI patients than in controls in a Latin American population. In addition, it was related to perceived stress and cardiometabolic parameters.
Fil: Fernandez Machulsky, Nahuel Hernan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Colla, Julian. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich.; Argentina
Fil: Gonzalez, Diego Javier. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Fortuna, Federico. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Ibar, Carolina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Jamardo, Juan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Gagliardi, Juan Alberto. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich.; Argentina
Fil: Fabre, Bibiana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Berg, Gabriela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
description Background: Chronic and psychosocial stresses are the emerging factors linked to cardiovascular disease. Assessment of cortisol levels in hair can serve as an indicator of an individual’s exposure to prolonged stressful events. For its evaluation, mass spectrometry is the reference method. However, because of its limitations for clinical laboratories, an automated chemiluminescent method was developed in our laboratory. The objective of the study is to evaluate the hair cortisol levels measured by an automated method and its association with psychosocial stress and cardiometabolic risk factors in a Latin American population. Materials and Methods: Hair samples were obtained from 56 consecutive patients hospitalized with an ST‑segment elevation acute myocardial infarction (STEMI) and 56 consecutive controls randomly recruited in routine consultation. Perceived stress and social support were evaluated by the validated questionnaires. Hair cortisol was measured by an automated chemiluminescent method. Glycemia and lipoprotein profile were measured in serum samples. Results: Hair cortisol was significantly higher in patients than in controls (175 [40–424] vs. 60.5 [40–155] pg of cortisol/mg of hair [P < 0.001]). Hair cortisol was not related to age or body mass index; however, it was related to glycemia (r = 0.461, P < 0.001) and triglycerides/high‑density lipoprotein cholesterol (TGs/ HDL‑c) index (r = 0.398, P = 0.001). Perceived stress was related to hair cortisol (r = 0.425, P < 0.001), age (r = 0.321, P = 0.01), and social support (r = −0.208, P = 0.028). TGs/HDL‑c index and perceived stress partially explain hair cortisol variation ([F = 8.69, P = 0.004] and [F = 24.9, P < 0.001], respectively). Conclusion: We observed higher hair cortisol concentrations, measured by an automated method, in STEMI patients than in controls in a Latin American population. In addition, it was related to perceived stress and cardiometabolic parameters.
publishDate 2025
dc.date.none.fl_str_mv 2025-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/272289
Fernandez Machulsky, Nahuel Hernan; Colla, Julian; Gonzalez, Diego Javier; Fortuna, Federico; Ibar, Carolina; et al.; Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American Adults; Wolters Kluwer; Heart and Mind; 9; 1; 1-2025; 13-20
2468-6476
2468-6484
CONICET Digital
CONICET
url http://hdl.handle.net/11336/272289
identifier_str_mv Fernandez Machulsky, Nahuel Hernan; Colla, Julian; Gonzalez, Diego Javier; Fortuna, Federico; Ibar, Carolina; et al.; Automated Chemiluminescent Hair Cortisol Measurement and Its Association with Acute Myocardial Infarction: A Case-Control Study in Latin American Adults; Wolters Kluwer; Heart and Mind; 9; 1; 1-2025; 13-20
2468-6476
2468-6484
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/10.4103/hm.HM-D-24-00099
info:eu-repo/semantics/altIdentifier/doi/10.4103/hm.HM-D-24-00099
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer
publisher.none.fl_str_mv Wolters Kluwer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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