A portable and affordable aligner for the assembly of microfluidic devices

Autores
Guglielmotti, Victoria; Saffioti, Nicolas Andres; Tohmé, Ana Laura; Gambarotta, Martín; Corthey, Gastón; Pallarola, Diego Andres
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The incorporation of sophisticated capabilities within microfluidic devices often requires the assembly of different layers in a correct arrangement. For example, when it is desired to include electrodes inside microfluidic channels or to create 3D microfluidic structures. However, the alignment between different substrates at the microscale requires expensive equipment not available for all research groups. In this work, we present an affordable, compact and portable aligner for assembling multilayered composite microfluidic chips. The instrument is composed of aluminum machined pieces combined with precision stages and includes a digital microscope with a LED illumination system for monitoring the alignment process. An interchangeable holder was created for substrate fixing, allowing the bonding of PDMS with other materials. Microscopic visualization is achieved through any device with internet access, avoiding the need of a computer attached to the aligner. To test the performance of the aligner, the center of an indium tin oxide microelectrode on a glass substrate was aligned with the center of a microchannel in a PDMS chip. The accuracy and precision of the instrument are suited for many microfluidic applications. The small and inexpensive design of the aligner makes it a cost-effective option for small groups working in microfluidics.
Fil: Guglielmotti, Victoria. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Saffioti, Nicolas Andres. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tohmé, Ana Laura. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Gambarotta, Martín. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Corthey, Gastón. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pallarola, Diego Andres. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ELECTROCHEMISTRY
MASK ALIGNER
MICROFABRICATION
SENSORS
SOFT LITHOGRAPHY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/206028
Acceder
id CONICETDig_f5edb6c8637501c7d485cf1f09831d14
oai_identifier_str oai:ri.conicet.gov.ar:11336/206028
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A portable and affordable aligner for the assembly of microfluidic devicesGuglielmotti, VictoriaSaffioti, Nicolas AndresTohmé, Ana LauraGambarotta, MartínCorthey, GastónPallarola, Diego AndresELECTROCHEMISTRYMASK ALIGNERMICROFABRICATIONSENSORSSOFT LITHOGRAPHYhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3The incorporation of sophisticated capabilities within microfluidic devices often requires the assembly of different layers in a correct arrangement. For example, when it is desired to include electrodes inside microfluidic channels or to create 3D microfluidic structures. However, the alignment between different substrates at the microscale requires expensive equipment not available for all research groups. In this work, we present an affordable, compact and portable aligner for assembling multilayered composite microfluidic chips. The instrument is composed of aluminum machined pieces combined with precision stages and includes a digital microscope with a LED illumination system for monitoring the alignment process. An interchangeable holder was created for substrate fixing, allowing the bonding of PDMS with other materials. Microscopic visualization is achieved through any device with internet access, avoiding the need of a computer attached to the aligner. To test the performance of the aligner, the center of an indium tin oxide microelectrode on a glass substrate was aligned with the center of a microchannel in a PDMS chip. The accuracy and precision of the instrument are suited for many microfluidic applications. The small and inexpensive design of the aligner makes it a cost-effective option for small groups working in microfluidics.Fil: Guglielmotti, Victoria. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Saffioti, Nicolas Andres. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tohmé, Ana Laura. Universidad Nacional de San Martin. Instituto de Nanosistemas; ArgentinaFil: Gambarotta, Martín. Universidad Nacional de San Martin. Instituto de Nanosistemas; ArgentinaFil: Corthey, Gastón. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pallarola, Diego Andres. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Ltd2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/206028Guglielmotti, Victoria; Saffioti, Nicolas Andres; Tohmé, Ana Laura; Gambarotta, Martín; Corthey, Gastón; et al.; A portable and affordable aligner for the assembly of microfluidic devices; Elsevier Ltd; HardwareX; 12; 10-2022; 1-11; E003482468-0672CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hardware-x.com/article/S2468-0672(22)00093-1/fulltextinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ohx.2022.e00348info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:14:13Zoai:ri.conicet.gov.ar:11336/206028instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:14:13.864CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A portable and affordable aligner for the assembly of microfluidic devices
title A portable and affordable aligner for the assembly of microfluidic devices
spellingShingle A portable and affordable aligner for the assembly of microfluidic devices
Guglielmotti, Victoria
ELECTROCHEMISTRY
MASK ALIGNER
MICROFABRICATION
SENSORS
SOFT LITHOGRAPHY
title_short A portable and affordable aligner for the assembly of microfluidic devices
title_full A portable and affordable aligner for the assembly of microfluidic devices
title_fullStr A portable and affordable aligner for the assembly of microfluidic devices
title_full_unstemmed A portable and affordable aligner for the assembly of microfluidic devices
title_sort A portable and affordable aligner for the assembly of microfluidic devices
dc.creator.none.fl_str_mv Guglielmotti, Victoria
Saffioti, Nicolas Andres
Tohmé, Ana Laura
Gambarotta, Martín
Corthey, Gastón
Pallarola, Diego Andres
author Guglielmotti, Victoria
author_facet Guglielmotti, Victoria
Saffioti, Nicolas Andres
Tohmé, Ana Laura
Gambarotta, Martín
Corthey, Gastón
Pallarola, Diego Andres
author_role author
author2 Saffioti, Nicolas Andres
Tohmé, Ana Laura
Gambarotta, Martín
Corthey, Gastón
Pallarola, Diego Andres
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ELECTROCHEMISTRY
MASK ALIGNER
MICROFABRICATION
SENSORS
SOFT LITHOGRAPHY
topic ELECTROCHEMISTRY
MASK ALIGNER
MICROFABRICATION
SENSORS
SOFT LITHOGRAPHY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The incorporation of sophisticated capabilities within microfluidic devices often requires the assembly of different layers in a correct arrangement. For example, when it is desired to include electrodes inside microfluidic channels or to create 3D microfluidic structures. However, the alignment between different substrates at the microscale requires expensive equipment not available for all research groups. In this work, we present an affordable, compact and portable aligner for assembling multilayered composite microfluidic chips. The instrument is composed of aluminum machined pieces combined with precision stages and includes a digital microscope with a LED illumination system for monitoring the alignment process. An interchangeable holder was created for substrate fixing, allowing the bonding of PDMS with other materials. Microscopic visualization is achieved through any device with internet access, avoiding the need of a computer attached to the aligner. To test the performance of the aligner, the center of an indium tin oxide microelectrode on a glass substrate was aligned with the center of a microchannel in a PDMS chip. The accuracy and precision of the instrument are suited for many microfluidic applications. The small and inexpensive design of the aligner makes it a cost-effective option for small groups working in microfluidics.
Fil: Guglielmotti, Victoria. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Saffioti, Nicolas Andres. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tohmé, Ana Laura. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Gambarotta, Martín. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Corthey, Gastón. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pallarola, Diego Andres. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The incorporation of sophisticated capabilities within microfluidic devices often requires the assembly of different layers in a correct arrangement. For example, when it is desired to include electrodes inside microfluidic channels or to create 3D microfluidic structures. However, the alignment between different substrates at the microscale requires expensive equipment not available for all research groups. In this work, we present an affordable, compact and portable aligner for assembling multilayered composite microfluidic chips. The instrument is composed of aluminum machined pieces combined with precision stages and includes a digital microscope with a LED illumination system for monitoring the alignment process. An interchangeable holder was created for substrate fixing, allowing the bonding of PDMS with other materials. Microscopic visualization is achieved through any device with internet access, avoiding the need of a computer attached to the aligner. To test the performance of the aligner, the center of an indium tin oxide microelectrode on a glass substrate was aligned with the center of a microchannel in a PDMS chip. The accuracy and precision of the instrument are suited for many microfluidic applications. The small and inexpensive design of the aligner makes it a cost-effective option for small groups working in microfluidics.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/206028
Guglielmotti, Victoria; Saffioti, Nicolas Andres; Tohmé, Ana Laura; Gambarotta, Martín; Corthey, Gastón; et al.; A portable and affordable aligner for the assembly of microfluidic devices; Elsevier Ltd; HardwareX; 12; 10-2022; 1-11; E00348
2468-0672
CONICET Digital
CONICET
url http://hdl.handle.net/11336/206028
identifier_str_mv Guglielmotti, Victoria; Saffioti, Nicolas Andres; Tohmé, Ana Laura; Gambarotta, Martín; Corthey, Gastón; et al.; A portable and affordable aligner for the assembly of microfluidic devices; Elsevier Ltd; HardwareX; 12; 10-2022; 1-11; E00348
2468-0672
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hardware-x.com/article/S2468-0672(22)00093-1/fulltext
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ohx.2022.e00348
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ltd
publisher.none.fl_str_mv Elsevier Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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