Facial shape manifestations of growth faltering in Tanzanian children

Autores
Cole, Joanne B.; Manyama, Mange F.; Nikitovic, Dejana; Gonzalez, Paula Natalia; Liberton, Denise; Wilson, Warren M.; Rolian, Campbell; Larson, Jacinda R.; Kimwaga, Emmanuel; Mathayo, Joshua; Roseman, Charles C.; Santorico, Stephanie A.; Lukowiak, Ken; Spritz, Richard A.; Hallgrimsson, Benedikt
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Variation in the shape of the human face and in stature is determined by complex interactions between genetic and environmental influences. One such environmental influence is malnourishment, which can result in growth faltering, usually diagnosed by means of comparing an individual's stature with a set of age-appropriate standards. These standards for stature, however, are typically ascertained in groups where people are at low risk for growth faltering. Moreover, genetic differences among populations with respect to stature are well established, further complicating the generalizability of stature-based diagnostic tools. In a large sample of children aged 5–19 years, we obtained high-resolution genomic data, anthropometric measures and 3D facial images from individuals within and around the city of Mwanza, Tanzania. With genome-wide complex trait analysis, we partitioned genetic and environmental variance for growth outcomes and facial shape. We found that children with growth faltering have faces that look like those of older and taller children, in a direction opposite to the expected allometric trajectory, and in ways predicted by the environmental portion of covariance at the community and individual levels. The environmental variance for facial shape varied subtly but significantly among communities, whereas genetic differences were minimal. These results reveal that facial shape preserves information about exposure to undernourishment, with important implications for refining assessments of nutritional status in children and the developmental-genetics of craniofacial variation alike.
Fil: Cole, Joanne B.. University of Colorado; Estados Unidos
Fil: Manyama, Mange F.. Weill‐Cornell Medicine; Qatar. Catholic University of Health and Allied Sciences; Tanzania
Fil: Nikitovic, Dejana. University of Calgary; Canadá
Fil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios En Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad En Red El Cruce Dr. Nestor Carlos Kirchner Samic. Unidad Ejecutora de Estudios En Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Unidad Ejecutora de Estudios En Neurociencias y Sistemas Complejos.; Argentina
Fil: Liberton, Denise. National Institutes of Health; Estados Unidos
Fil: Wilson, Warren M.. University of Calgary; Canadá
Fil: Rolian, Campbell. University of Calgary; Canadá
Fil: Larson, Jacinda R.. University of Calgary; Canadá
Fil: Kimwaga, Emmanuel. Catholic University of Health and Allied Sciences; Tanzania
Fil: Mathayo, Joshua. Catholic University of Health and Allied Sciences; Tanzania
Fil: Roseman, Charles C.. University of Illinois at Urbana; Estados Unidos
Fil: Santorico, Stephanie A.. University of Colorado; Estados Unidos
Fil: Lukowiak, Ken. University of Calgary; Canadá
Fil: Spritz, Richard A.. University of Colorado; Estados Unidos
Fil: Hallgrimsson, Benedikt. University of Calgary; Canadá
Materia
Childhood Growth
Complex Traits
Craniofacial
Facial Imaging
Growth Faltering
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/57469
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/57469
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Facial shape manifestations of growth faltering in Tanzanian childrenCole, Joanne B.Manyama, Mange F.Nikitovic, DejanaGonzalez, Paula NataliaLiberton, DeniseWilson, Warren M.Rolian, CampbellLarson, Jacinda R.Kimwaga, EmmanuelMathayo, JoshuaRoseman, Charles C.Santorico, Stephanie A.Lukowiak, KenSpritz, Richard A.Hallgrimsson, BenediktChildhood GrowthComplex TraitsCraniofacialFacial ImagingGrowth Falteringhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Variation in the shape of the human face and in stature is determined by complex interactions between genetic and environmental influences. One such environmental influence is malnourishment, which can result in growth faltering, usually diagnosed by means of comparing an individual's stature with a set of age-appropriate standards. These standards for stature, however, are typically ascertained in groups where people are at low risk for growth faltering. Moreover, genetic differences among populations with respect to stature are well established, further complicating the generalizability of stature-based diagnostic tools. In a large sample of children aged 5–19 years, we obtained high-resolution genomic data, anthropometric measures and 3D facial images from individuals within and around the city of Mwanza, Tanzania. With genome-wide complex trait analysis, we partitioned genetic and environmental variance for growth outcomes and facial shape. We found that children with growth faltering have faces that look like those of older and taller children, in a direction opposite to the expected allometric trajectory, and in ways predicted by the environmental portion of covariance at the community and individual levels. The environmental variance for facial shape varied subtly but significantly among communities, whereas genetic differences were minimal. These results reveal that facial shape preserves information about exposure to undernourishment, with important implications for refining assessments of nutritional status in children and the developmental-genetics of craniofacial variation alike.Fil: Cole, Joanne B.. University of Colorado; Estados UnidosFil: Manyama, Mange F.. Weill‐Cornell Medicine; Qatar. Catholic University of Health and Allied Sciences; TanzaniaFil: Nikitovic, Dejana. University of Calgary; CanadáFil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios En Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad En Red El Cruce Dr. Nestor Carlos Kirchner Samic. Unidad Ejecutora de Estudios En Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Unidad Ejecutora de Estudios En Neurociencias y Sistemas Complejos.; ArgentinaFil: Liberton, Denise. National Institutes of Health; Estados UnidosFil: Wilson, Warren M.. University of Calgary; CanadáFil: Rolian, Campbell. University of Calgary; CanadáFil: Larson, Jacinda R.. University of Calgary; CanadáFil: Kimwaga, Emmanuel. Catholic University of Health and Allied Sciences; TanzaniaFil: Mathayo, Joshua. Catholic University of Health and Allied Sciences; TanzaniaFil: Roseman, Charles C.. University of Illinois at Urbana; Estados UnidosFil: Santorico, Stephanie A.. University of Colorado; Estados UnidosFil: Lukowiak, Ken. University of Calgary; CanadáFil: Spritz, Richard A.. University of Colorado; Estados UnidosFil: Hallgrimsson, Benedikt. University of Calgary; CanadáWiley Blackwell Publishing, Inc2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/57469Cole, Joanne B.; Manyama, Mange F.; Nikitovic, Dejana; Gonzalez, Paula Natalia; Liberton, Denise; et al.; Facial shape manifestations of growth faltering in Tanzanian children; Wiley Blackwell Publishing, Inc; Journal of Anatomy; 232; 2; 2-2018; 250-2620021-8782CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/joa.12748info:eu-repo/semantics/altIdentifier/doi/10.1111/joa.12748info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:38Zoai:ri.conicet.gov.ar:11336/57469instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:38.44CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Facial shape manifestations of growth faltering in Tanzanian children
title Facial shape manifestations of growth faltering in Tanzanian children
spellingShingle Facial shape manifestations of growth faltering in Tanzanian children
Cole, Joanne B.
Childhood Growth
Complex Traits
Craniofacial
Facial Imaging
Growth Faltering
title_short Facial shape manifestations of growth faltering in Tanzanian children
title_full Facial shape manifestations of growth faltering in Tanzanian children
title_fullStr Facial shape manifestations of growth faltering in Tanzanian children
title_full_unstemmed Facial shape manifestations of growth faltering in Tanzanian children
title_sort Facial shape manifestations of growth faltering in Tanzanian children
dc.creator.none.fl_str_mv Cole, Joanne B.
Manyama, Mange F.
Nikitovic, Dejana
Gonzalez, Paula Natalia
Liberton, Denise
Wilson, Warren M.
Rolian, Campbell
Larson, Jacinda R.
Kimwaga, Emmanuel
Mathayo, Joshua
Roseman, Charles C.
Santorico, Stephanie A.
Lukowiak, Ken
Spritz, Richard A.
Hallgrimsson, Benedikt
author Cole, Joanne B.
author_facet Cole, Joanne B.
Manyama, Mange F.
Nikitovic, Dejana
Gonzalez, Paula Natalia
Liberton, Denise
Wilson, Warren M.
Rolian, Campbell
Larson, Jacinda R.
Kimwaga, Emmanuel
Mathayo, Joshua
Roseman, Charles C.
Santorico, Stephanie A.
Lukowiak, Ken
Spritz, Richard A.
Hallgrimsson, Benedikt
author_role author
author2 Manyama, Mange F.
Nikitovic, Dejana
Gonzalez, Paula Natalia
Liberton, Denise
Wilson, Warren M.
Rolian, Campbell
Larson, Jacinda R.
Kimwaga, Emmanuel
Mathayo, Joshua
Roseman, Charles C.
Santorico, Stephanie A.
Lukowiak, Ken
Spritz, Richard A.
Hallgrimsson, Benedikt
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Childhood Growth
Complex Traits
Craniofacial
Facial Imaging
Growth Faltering
topic Childhood Growth
Complex Traits
Craniofacial
Facial Imaging
Growth Faltering
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Variation in the shape of the human face and in stature is determined by complex interactions between genetic and environmental influences. One such environmental influence is malnourishment, which can result in growth faltering, usually diagnosed by means of comparing an individual's stature with a set of age-appropriate standards. These standards for stature, however, are typically ascertained in groups where people are at low risk for growth faltering. Moreover, genetic differences among populations with respect to stature are well established, further complicating the generalizability of stature-based diagnostic tools. In a large sample of children aged 5–19 years, we obtained high-resolution genomic data, anthropometric measures and 3D facial images from individuals within and around the city of Mwanza, Tanzania. With genome-wide complex trait analysis, we partitioned genetic and environmental variance for growth outcomes and facial shape. We found that children with growth faltering have faces that look like those of older and taller children, in a direction opposite to the expected allometric trajectory, and in ways predicted by the environmental portion of covariance at the community and individual levels. The environmental variance for facial shape varied subtly but significantly among communities, whereas genetic differences were minimal. These results reveal that facial shape preserves information about exposure to undernourishment, with important implications for refining assessments of nutritional status in children and the developmental-genetics of craniofacial variation alike.
Fil: Cole, Joanne B.. University of Colorado; Estados Unidos
Fil: Manyama, Mange F.. Weill‐Cornell Medicine; Qatar. Catholic University of Health and Allied Sciences; Tanzania
Fil: Nikitovic, Dejana. University of Calgary; Canadá
Fil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios En Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad En Red El Cruce Dr. Nestor Carlos Kirchner Samic. Unidad Ejecutora de Estudios En Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Unidad Ejecutora de Estudios En Neurociencias y Sistemas Complejos.; Argentina
Fil: Liberton, Denise. National Institutes of Health; Estados Unidos
Fil: Wilson, Warren M.. University of Calgary; Canadá
Fil: Rolian, Campbell. University of Calgary; Canadá
Fil: Larson, Jacinda R.. University of Calgary; Canadá
Fil: Kimwaga, Emmanuel. Catholic University of Health and Allied Sciences; Tanzania
Fil: Mathayo, Joshua. Catholic University of Health and Allied Sciences; Tanzania
Fil: Roseman, Charles C.. University of Illinois at Urbana; Estados Unidos
Fil: Santorico, Stephanie A.. University of Colorado; Estados Unidos
Fil: Lukowiak, Ken. University of Calgary; Canadá
Fil: Spritz, Richard A.. University of Colorado; Estados Unidos
Fil: Hallgrimsson, Benedikt. University of Calgary; Canadá
description Variation in the shape of the human face and in stature is determined by complex interactions between genetic and environmental influences. One such environmental influence is malnourishment, which can result in growth faltering, usually diagnosed by means of comparing an individual's stature with a set of age-appropriate standards. These standards for stature, however, are typically ascertained in groups where people are at low risk for growth faltering. Moreover, genetic differences among populations with respect to stature are well established, further complicating the generalizability of stature-based diagnostic tools. In a large sample of children aged 5–19 years, we obtained high-resolution genomic data, anthropometric measures and 3D facial images from individuals within and around the city of Mwanza, Tanzania. With genome-wide complex trait analysis, we partitioned genetic and environmental variance for growth outcomes and facial shape. We found that children with growth faltering have faces that look like those of older and taller children, in a direction opposite to the expected allometric trajectory, and in ways predicted by the environmental portion of covariance at the community and individual levels. The environmental variance for facial shape varied subtly but significantly among communities, whereas genetic differences were minimal. These results reveal that facial shape preserves information about exposure to undernourishment, with important implications for refining assessments of nutritional status in children and the developmental-genetics of craniofacial variation alike.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/57469
Cole, Joanne B.; Manyama, Mange F.; Nikitovic, Dejana; Gonzalez, Paula Natalia; Liberton, Denise; et al.; Facial shape manifestations of growth faltering in Tanzanian children; Wiley Blackwell Publishing, Inc; Journal of Anatomy; 232; 2; 2-2018; 250-262
0021-8782
CONICET Digital
CONICET
url http://hdl.handle.net/11336/57469
identifier_str_mv Cole, Joanne B.; Manyama, Mange F.; Nikitovic, Dejana; Gonzalez, Paula Natalia; Liberton, Denise; et al.; Facial shape manifestations of growth faltering in Tanzanian children; Wiley Blackwell Publishing, Inc; Journal of Anatomy; 232; 2; 2-2018; 250-262
0021-8782
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/joa.12748
info:eu-repo/semantics/altIdentifier/doi/10.1111/joa.12748
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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