From genes to cognition: Octodon degus, an animal model for AD translational research

Autores
Mugnaini, Matías; Deacon, Robert; Sampieri, Guido; Vanderklish, Peter; Angione, Claudio; Kropff, Emilio; Cogram, Patricia
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Octodon degus (O. degus), a long-lived rodent, provides us with a unique opportunity to search for molecular pathways that are associated with enhanced longevity in mammals. This rodent from Chile spontaneously develops an analog of sporadic AD at behavioral and neurobiological levels. It is a diurnal rodent that makes wide use of spatial memory to find and hide food. This cognitive ability is thought to be rooted in what is commonly known as the GPS of the mammalian brain, a collection of structures centred around the hippocampus and neighbouring cortical areas. A fraction of the aged O. degus population not only exhibits amyloid-beta oligomers, tau hyperphosphorylation, neurofibrillary tangle formation, cell death and cognitive decline but also several other conditions comorbid to AD like diabetes mellitus type 2, macular and retinal degeneration and atherosclerosis. Method: In this study, we used the Octodon degus. Behavioural assessment of a population (N = 150) of degu was performed using the tests of daily living (burrowing test, marble burying and nesting), Novel Object Recognition and the Open Field. All Degus were chronically implanted with a four-tetrode microdrive, which was originally developed for mice (Versadrive-4, Neuralynx, USA). Result: These model features call for research efforts to be put on studying the degu GPS from both the basic and applied science perspectives, with a multilaboratory and multidisciplinary perspective. In response to this, we here present the first multidisciplinary study including i) Recording 69 CA1 principal cells while O. degus explored a 1 m wide square environment, finding that O. degus exhibited extreme place cell behaviour. ii)We performed a genome-wide association study in O. degus and report the identification of SNVs in genes associated with AD (APP, BACE1, MAPT, Psen1 and Psen2, grn and SORL1. iii) Some of the variants identified in AD associated genes showed significant association with behavioural performance in Hardy-Weinberg equilibrium. Conclusion: All together these findings provide an important path toward the understanding how AD related mutations in the O. degus prove this model to be an important translational tool for aging and Alzheimer’s research.
Fil: Mugnaini, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Deacon, Robert. Universidad de Chile; Chile
Fil: Sampieri, Guido. Teesside University; Reino Unido
Fil: Vanderklish, Peter. The Scripps Research Institute; Estados Unidos
Fil: Angione, Claudio. Teesside University; Reino Unido
Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Cogram, Patricia. No especifíca;
Materia
ALZHEIMER
OCTODON DEGUS
PLACE CELLS
SPATIAL MEMORY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/138712

id CONICETDig_f541eb32e42938e5881fdab3d36379d5
oai_identifier_str oai:ri.conicet.gov.ar:11336/138712
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling From genes to cognition: Octodon degus, an animal model for AD translational researchMugnaini, MatíasDeacon, RobertSampieri, GuidoVanderklish, PeterAngione, ClaudioKropff, EmilioCogram, PatriciaALZHEIMEROCTODON DEGUSPLACE CELLSSPATIAL MEMORYhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Background: Octodon degus (O. degus), a long-lived rodent, provides us with a unique opportunity to search for molecular pathways that are associated with enhanced longevity in mammals. This rodent from Chile spontaneously develops an analog of sporadic AD at behavioral and neurobiological levels. It is a diurnal rodent that makes wide use of spatial memory to find and hide food. This cognitive ability is thought to be rooted in what is commonly known as the GPS of the mammalian brain, a collection of structures centred around the hippocampus and neighbouring cortical areas. A fraction of the aged O. degus population not only exhibits amyloid-beta oligomers, tau hyperphosphorylation, neurofibrillary tangle formation, cell death and cognitive decline but also several other conditions comorbid to AD like diabetes mellitus type 2, macular and retinal degeneration and atherosclerosis. Method: In this study, we used the Octodon degus. Behavioural assessment of a population (N = 150) of degu was performed using the tests of daily living (burrowing test, marble burying and nesting), Novel Object Recognition and the Open Field. All Degus were chronically implanted with a four-tetrode microdrive, which was originally developed for mice (Versadrive-4, Neuralynx, USA). Result: These model features call for research efforts to be put on studying the degu GPS from both the basic and applied science perspectives, with a multilaboratory and multidisciplinary perspective. In response to this, we here present the first multidisciplinary study including i) Recording 69 CA1 principal cells while O. degus explored a 1 m wide square environment, finding that O. degus exhibited extreme place cell behaviour. ii)We performed a genome-wide association study in O. degus and report the identification of SNVs in genes associated with AD (APP, BACE1, MAPT, Psen1 and Psen2, grn and SORL1. iii) Some of the variants identified in AD associated genes showed significant association with behavioural performance in Hardy-Weinberg equilibrium. Conclusion: All together these findings provide an important path toward the understanding how AD related mutations in the O. degus prove this model to be an important translational tool for aging and Alzheimer’s research.Fil: Mugnaini, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Deacon, Robert. Universidad de Chile; ChileFil: Sampieri, Guido. Teesside University; Reino UnidoFil: Vanderklish, Peter. The Scripps Research Institute; Estados UnidosFil: Angione, Claudio. Teesside University; Reino UnidoFil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Cogram, Patricia. No especifíca;Willey2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138712Mugnaini, Matías; Deacon, Robert; Sampieri, Guido; Vanderklish, Peter; Angione, Claudio; et al.; From genes to cognition: Octodon degus, an animal model for AD translational research; Willey; Alzheimers & Dementia; 16; S3; 12-2020; 1-21552-52601552-5279CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/alz.047726info:eu-repo/semantics/altIdentifier/doi/10.1002/alz.047726info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:16Zoai:ri.conicet.gov.ar:11336/138712instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:16.878CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv From genes to cognition: Octodon degus, an animal model for AD translational research
title From genes to cognition: Octodon degus, an animal model for AD translational research
spellingShingle From genes to cognition: Octodon degus, an animal model for AD translational research
Mugnaini, Matías
ALZHEIMER
OCTODON DEGUS
PLACE CELLS
SPATIAL MEMORY
title_short From genes to cognition: Octodon degus, an animal model for AD translational research
title_full From genes to cognition: Octodon degus, an animal model for AD translational research
title_fullStr From genes to cognition: Octodon degus, an animal model for AD translational research
title_full_unstemmed From genes to cognition: Octodon degus, an animal model for AD translational research
title_sort From genes to cognition: Octodon degus, an animal model for AD translational research
dc.creator.none.fl_str_mv Mugnaini, Matías
Deacon, Robert
Sampieri, Guido
Vanderklish, Peter
Angione, Claudio
Kropff, Emilio
Cogram, Patricia
author Mugnaini, Matías
author_facet Mugnaini, Matías
Deacon, Robert
Sampieri, Guido
Vanderklish, Peter
Angione, Claudio
Kropff, Emilio
Cogram, Patricia
author_role author
author2 Deacon, Robert
Sampieri, Guido
Vanderklish, Peter
Angione, Claudio
Kropff, Emilio
Cogram, Patricia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ALZHEIMER
OCTODON DEGUS
PLACE CELLS
SPATIAL MEMORY
topic ALZHEIMER
OCTODON DEGUS
PLACE CELLS
SPATIAL MEMORY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Octodon degus (O. degus), a long-lived rodent, provides us with a unique opportunity to search for molecular pathways that are associated with enhanced longevity in mammals. This rodent from Chile spontaneously develops an analog of sporadic AD at behavioral and neurobiological levels. It is a diurnal rodent that makes wide use of spatial memory to find and hide food. This cognitive ability is thought to be rooted in what is commonly known as the GPS of the mammalian brain, a collection of structures centred around the hippocampus and neighbouring cortical areas. A fraction of the aged O. degus population not only exhibits amyloid-beta oligomers, tau hyperphosphorylation, neurofibrillary tangle formation, cell death and cognitive decline but also several other conditions comorbid to AD like diabetes mellitus type 2, macular and retinal degeneration and atherosclerosis. Method: In this study, we used the Octodon degus. Behavioural assessment of a population (N = 150) of degu was performed using the tests of daily living (burrowing test, marble burying and nesting), Novel Object Recognition and the Open Field. All Degus were chronically implanted with a four-tetrode microdrive, which was originally developed for mice (Versadrive-4, Neuralynx, USA). Result: These model features call for research efforts to be put on studying the degu GPS from both the basic and applied science perspectives, with a multilaboratory and multidisciplinary perspective. In response to this, we here present the first multidisciplinary study including i) Recording 69 CA1 principal cells while O. degus explored a 1 m wide square environment, finding that O. degus exhibited extreme place cell behaviour. ii)We performed a genome-wide association study in O. degus and report the identification of SNVs in genes associated with AD (APP, BACE1, MAPT, Psen1 and Psen2, grn and SORL1. iii) Some of the variants identified in AD associated genes showed significant association with behavioural performance in Hardy-Weinberg equilibrium. Conclusion: All together these findings provide an important path toward the understanding how AD related mutations in the O. degus prove this model to be an important translational tool for aging and Alzheimer’s research.
Fil: Mugnaini, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Deacon, Robert. Universidad de Chile; Chile
Fil: Sampieri, Guido. Teesside University; Reino Unido
Fil: Vanderklish, Peter. The Scripps Research Institute; Estados Unidos
Fil: Angione, Claudio. Teesside University; Reino Unido
Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Cogram, Patricia. No especifíca;
description Background: Octodon degus (O. degus), a long-lived rodent, provides us with a unique opportunity to search for molecular pathways that are associated with enhanced longevity in mammals. This rodent from Chile spontaneously develops an analog of sporadic AD at behavioral and neurobiological levels. It is a diurnal rodent that makes wide use of spatial memory to find and hide food. This cognitive ability is thought to be rooted in what is commonly known as the GPS of the mammalian brain, a collection of structures centred around the hippocampus and neighbouring cortical areas. A fraction of the aged O. degus population not only exhibits amyloid-beta oligomers, tau hyperphosphorylation, neurofibrillary tangle formation, cell death and cognitive decline but also several other conditions comorbid to AD like diabetes mellitus type 2, macular and retinal degeneration and atherosclerosis. Method: In this study, we used the Octodon degus. Behavioural assessment of a population (N = 150) of degu was performed using the tests of daily living (burrowing test, marble burying and nesting), Novel Object Recognition and the Open Field. All Degus were chronically implanted with a four-tetrode microdrive, which was originally developed for mice (Versadrive-4, Neuralynx, USA). Result: These model features call for research efforts to be put on studying the degu GPS from both the basic and applied science perspectives, with a multilaboratory and multidisciplinary perspective. In response to this, we here present the first multidisciplinary study including i) Recording 69 CA1 principal cells while O. degus explored a 1 m wide square environment, finding that O. degus exhibited extreme place cell behaviour. ii)We performed a genome-wide association study in O. degus and report the identification of SNVs in genes associated with AD (APP, BACE1, MAPT, Psen1 and Psen2, grn and SORL1. iii) Some of the variants identified in AD associated genes showed significant association with behavioural performance in Hardy-Weinberg equilibrium. Conclusion: All together these findings provide an important path toward the understanding how AD related mutations in the O. degus prove this model to be an important translational tool for aging and Alzheimer’s research.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/138712
Mugnaini, Matías; Deacon, Robert; Sampieri, Guido; Vanderklish, Peter; Angione, Claudio; et al.; From genes to cognition: Octodon degus, an animal model for AD translational research; Willey; Alzheimers & Dementia; 16; S3; 12-2020; 1-2
1552-5260
1552-5279
CONICET Digital
CONICET
url http://hdl.handle.net/11336/138712
identifier_str_mv Mugnaini, Matías; Deacon, Robert; Sampieri, Guido; Vanderklish, Peter; Angione, Claudio; et al.; From genes to cognition: Octodon degus, an animal model for AD translational research; Willey; Alzheimers & Dementia; 16; S3; 12-2020; 1-2
1552-5260
1552-5279
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/alz.047726
info:eu-repo/semantics/altIdentifier/doi/10.1002/alz.047726
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Willey
publisher.none.fl_str_mv Willey
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269571970498560
score 13.13397