From genes to cognition: Octodon degus, an animal model for AD translational research
- Autores
- Mugnaini, Matías; Deacon, Robert; Sampieri, Guido; Vanderklish, Peter; Angione, Claudio; Kropff, Emilio; Cogram, Patricia
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Octodon degus (O. degus), a long-lived rodent, provides us with a unique opportunity to search for molecular pathways that are associated with enhanced longevity in mammals. This rodent from Chile spontaneously develops an analog of sporadic AD at behavioral and neurobiological levels. It is a diurnal rodent that makes wide use of spatial memory to find and hide food. This cognitive ability is thought to be rooted in what is commonly known as the GPS of the mammalian brain, a collection of structures centred around the hippocampus and neighbouring cortical areas. A fraction of the aged O. degus population not only exhibits amyloid-beta oligomers, tau hyperphosphorylation, neurofibrillary tangle formation, cell death and cognitive decline but also several other conditions comorbid to AD like diabetes mellitus type 2, macular and retinal degeneration and atherosclerosis. Method: In this study, we used the Octodon degus. Behavioural assessment of a population (N = 150) of degu was performed using the tests of daily living (burrowing test, marble burying and nesting), Novel Object Recognition and the Open Field. All Degus were chronically implanted with a four-tetrode microdrive, which was originally developed for mice (Versadrive-4, Neuralynx, USA). Result: These model features call for research efforts to be put on studying the degu GPS from both the basic and applied science perspectives, with a multilaboratory and multidisciplinary perspective. In response to this, we here present the first multidisciplinary study including i) Recording 69 CA1 principal cells while O. degus explored a 1 m wide square environment, finding that O. degus exhibited extreme place cell behaviour. ii)We performed a genome-wide association study in O. degus and report the identification of SNVs in genes associated with AD (APP, BACE1, MAPT, Psen1 and Psen2, grn and SORL1. iii) Some of the variants identified in AD associated genes showed significant association with behavioural performance in Hardy-Weinberg equilibrium. Conclusion: All together these findings provide an important path toward the understanding how AD related mutations in the O. degus prove this model to be an important translational tool for aging and Alzheimer’s research.
Fil: Mugnaini, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Deacon, Robert. Universidad de Chile; Chile
Fil: Sampieri, Guido. Teesside University; Reino Unido
Fil: Vanderklish, Peter. The Scripps Research Institute; Estados Unidos
Fil: Angione, Claudio. Teesside University; Reino Unido
Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Cogram, Patricia. No especifíca; - Materia
-
ALZHEIMER
OCTODON DEGUS
PLACE CELLS
SPATIAL MEMORY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/138712
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From genes to cognition: Octodon degus, an animal model for AD translational researchMugnaini, MatíasDeacon, RobertSampieri, GuidoVanderklish, PeterAngione, ClaudioKropff, EmilioCogram, PatriciaALZHEIMEROCTODON DEGUSPLACE CELLSSPATIAL MEMORYhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Background: Octodon degus (O. degus), a long-lived rodent, provides us with a unique opportunity to search for molecular pathways that are associated with enhanced longevity in mammals. This rodent from Chile spontaneously develops an analog of sporadic AD at behavioral and neurobiological levels. It is a diurnal rodent that makes wide use of spatial memory to find and hide food. This cognitive ability is thought to be rooted in what is commonly known as the GPS of the mammalian brain, a collection of structures centred around the hippocampus and neighbouring cortical areas. A fraction of the aged O. degus population not only exhibits amyloid-beta oligomers, tau hyperphosphorylation, neurofibrillary tangle formation, cell death and cognitive decline but also several other conditions comorbid to AD like diabetes mellitus type 2, macular and retinal degeneration and atherosclerosis. Method: In this study, we used the Octodon degus. Behavioural assessment of a population (N = 150) of degu was performed using the tests of daily living (burrowing test, marble burying and nesting), Novel Object Recognition and the Open Field. All Degus were chronically implanted with a four-tetrode microdrive, which was originally developed for mice (Versadrive-4, Neuralynx, USA). Result: These model features call for research efforts to be put on studying the degu GPS from both the basic and applied science perspectives, with a multilaboratory and multidisciplinary perspective. In response to this, we here present the first multidisciplinary study including i) Recording 69 CA1 principal cells while O. degus explored a 1 m wide square environment, finding that O. degus exhibited extreme place cell behaviour. ii)We performed a genome-wide association study in O. degus and report the identification of SNVs in genes associated with AD (APP, BACE1, MAPT, Psen1 and Psen2, grn and SORL1. iii) Some of the variants identified in AD associated genes showed significant association with behavioural performance in Hardy-Weinberg equilibrium. Conclusion: All together these findings provide an important path toward the understanding how AD related mutations in the O. degus prove this model to be an important translational tool for aging and Alzheimer’s research.Fil: Mugnaini, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Deacon, Robert. Universidad de Chile; ChileFil: Sampieri, Guido. Teesside University; Reino UnidoFil: Vanderklish, Peter. The Scripps Research Institute; Estados UnidosFil: Angione, Claudio. Teesside University; Reino UnidoFil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Cogram, Patricia. No especifíca;Willey2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138712Mugnaini, Matías; Deacon, Robert; Sampieri, Guido; Vanderklish, Peter; Angione, Claudio; et al.; From genes to cognition: Octodon degus, an animal model for AD translational research; Willey; Alzheimers & Dementia; 16; S3; 12-2020; 1-21552-52601552-5279CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/alz.047726info:eu-repo/semantics/altIdentifier/doi/10.1002/alz.047726info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:16Zoai:ri.conicet.gov.ar:11336/138712instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:16.878CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
From genes to cognition: Octodon degus, an animal model for AD translational research |
title |
From genes to cognition: Octodon degus, an animal model for AD translational research |
spellingShingle |
From genes to cognition: Octodon degus, an animal model for AD translational research Mugnaini, Matías ALZHEIMER OCTODON DEGUS PLACE CELLS SPATIAL MEMORY |
title_short |
From genes to cognition: Octodon degus, an animal model for AD translational research |
title_full |
From genes to cognition: Octodon degus, an animal model for AD translational research |
title_fullStr |
From genes to cognition: Octodon degus, an animal model for AD translational research |
title_full_unstemmed |
From genes to cognition: Octodon degus, an animal model for AD translational research |
title_sort |
From genes to cognition: Octodon degus, an animal model for AD translational research |
dc.creator.none.fl_str_mv |
Mugnaini, Matías Deacon, Robert Sampieri, Guido Vanderklish, Peter Angione, Claudio Kropff, Emilio Cogram, Patricia |
author |
Mugnaini, Matías |
author_facet |
Mugnaini, Matías Deacon, Robert Sampieri, Guido Vanderklish, Peter Angione, Claudio Kropff, Emilio Cogram, Patricia |
author_role |
author |
author2 |
Deacon, Robert Sampieri, Guido Vanderklish, Peter Angione, Claudio Kropff, Emilio Cogram, Patricia |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
ALZHEIMER OCTODON DEGUS PLACE CELLS SPATIAL MEMORY |
topic |
ALZHEIMER OCTODON DEGUS PLACE CELLS SPATIAL MEMORY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.5 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background: Octodon degus (O. degus), a long-lived rodent, provides us with a unique opportunity to search for molecular pathways that are associated with enhanced longevity in mammals. This rodent from Chile spontaneously develops an analog of sporadic AD at behavioral and neurobiological levels. It is a diurnal rodent that makes wide use of spatial memory to find and hide food. This cognitive ability is thought to be rooted in what is commonly known as the GPS of the mammalian brain, a collection of structures centred around the hippocampus and neighbouring cortical areas. A fraction of the aged O. degus population not only exhibits amyloid-beta oligomers, tau hyperphosphorylation, neurofibrillary tangle formation, cell death and cognitive decline but also several other conditions comorbid to AD like diabetes mellitus type 2, macular and retinal degeneration and atherosclerosis. Method: In this study, we used the Octodon degus. Behavioural assessment of a population (N = 150) of degu was performed using the tests of daily living (burrowing test, marble burying and nesting), Novel Object Recognition and the Open Field. All Degus were chronically implanted with a four-tetrode microdrive, which was originally developed for mice (Versadrive-4, Neuralynx, USA). Result: These model features call for research efforts to be put on studying the degu GPS from both the basic and applied science perspectives, with a multilaboratory and multidisciplinary perspective. In response to this, we here present the first multidisciplinary study including i) Recording 69 CA1 principal cells while O. degus explored a 1 m wide square environment, finding that O. degus exhibited extreme place cell behaviour. ii)We performed a genome-wide association study in O. degus and report the identification of SNVs in genes associated with AD (APP, BACE1, MAPT, Psen1 and Psen2, grn and SORL1. iii) Some of the variants identified in AD associated genes showed significant association with behavioural performance in Hardy-Weinberg equilibrium. Conclusion: All together these findings provide an important path toward the understanding how AD related mutations in the O. degus prove this model to be an important translational tool for aging and Alzheimer’s research. Fil: Mugnaini, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Deacon, Robert. Universidad de Chile; Chile Fil: Sampieri, Guido. Teesside University; Reino Unido Fil: Vanderklish, Peter. The Scripps Research Institute; Estados Unidos Fil: Angione, Claudio. Teesside University; Reino Unido Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Cogram, Patricia. No especifíca; |
description |
Background: Octodon degus (O. degus), a long-lived rodent, provides us with a unique opportunity to search for molecular pathways that are associated with enhanced longevity in mammals. This rodent from Chile spontaneously develops an analog of sporadic AD at behavioral and neurobiological levels. It is a diurnal rodent that makes wide use of spatial memory to find and hide food. This cognitive ability is thought to be rooted in what is commonly known as the GPS of the mammalian brain, a collection of structures centred around the hippocampus and neighbouring cortical areas. A fraction of the aged O. degus population not only exhibits amyloid-beta oligomers, tau hyperphosphorylation, neurofibrillary tangle formation, cell death and cognitive decline but also several other conditions comorbid to AD like diabetes mellitus type 2, macular and retinal degeneration and atherosclerosis. Method: In this study, we used the Octodon degus. Behavioural assessment of a population (N = 150) of degu was performed using the tests of daily living (burrowing test, marble burying and nesting), Novel Object Recognition and the Open Field. All Degus were chronically implanted with a four-tetrode microdrive, which was originally developed for mice (Versadrive-4, Neuralynx, USA). Result: These model features call for research efforts to be put on studying the degu GPS from both the basic and applied science perspectives, with a multilaboratory and multidisciplinary perspective. In response to this, we here present the first multidisciplinary study including i) Recording 69 CA1 principal cells while O. degus explored a 1 m wide square environment, finding that O. degus exhibited extreme place cell behaviour. ii)We performed a genome-wide association study in O. degus and report the identification of SNVs in genes associated with AD (APP, BACE1, MAPT, Psen1 and Psen2, grn and SORL1. iii) Some of the variants identified in AD associated genes showed significant association with behavioural performance in Hardy-Weinberg equilibrium. Conclusion: All together these findings provide an important path toward the understanding how AD related mutations in the O. degus prove this model to be an important translational tool for aging and Alzheimer’s research. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/138712 Mugnaini, Matías; Deacon, Robert; Sampieri, Guido; Vanderklish, Peter; Angione, Claudio; et al.; From genes to cognition: Octodon degus, an animal model for AD translational research; Willey; Alzheimers & Dementia; 16; S3; 12-2020; 1-2 1552-5260 1552-5279 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/138712 |
identifier_str_mv |
Mugnaini, Matías; Deacon, Robert; Sampieri, Guido; Vanderklish, Peter; Angione, Claudio; et al.; From genes to cognition: Octodon degus, an animal model for AD translational research; Willey; Alzheimers & Dementia; 16; S3; 12-2020; 1-2 1552-5260 1552-5279 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
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eng |
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application/pdf application/pdf |
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Willey |
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Willey |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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