Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disorders

Autores
Rodriguez, Amaia; Marinelli, Raul Alberto; Tesse, Angela; Frühbeck, Gema; Calamita, Giuseppe
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gender differences in the relative risk of developing metabolic complications, such as insulin resistance or non-alcoholic fatty liver disease (NAFLD), have been reported. The deregulation of glycerol metabolism partly contributes to the onset of these metabolic diseases, since glycerol constitutes a key substrate for the synthesis of triacylglycerols (TAGs) as well as for hepatic gluconeogenesis. The present mini-review covers the sex-­related differences in glycerol metabolism and aquaglyceroporins (AQPs) and its impact in the control of adipose and hepatic fat accumulation as well as in whole-body glucose homeostasis. Plasma glycerol concentrations are increased in women compared to men probably due to the higher lipolytic rate and larger AQP7 amounts in visceral fat as well as the well-known sexual dimorphism in fat mass with women showing higher adiposity. AQP9 represents the primary route for glycerol uptake in hepatocytes, where glycerol is converted by the glycerol-kinase enzyme into glycerol-3-phosphate, a key substrate for de novo synthesis of glucose and TAG. In spite of showing similar hepatic AQP9 protein, women exhibit lower hepatocyte glycerol permeability than men, which might contribute to their lower prevalence of insulin resistance and NAFLD.
Fil: Rodriguez, Amaia. Universidad de Navarra; España
Fil: Marinelli, Raul Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Tesse, Angela. Universite de Nantes; Francia
Fil: Frühbeck, Gema. Universidad de Navarra; España
Fil: Calamita, Giuseppe. Universita Degli Studi Di Bari; Italia
Materia
Sexual dimorphism
Aquaglyceroporins
Glycerol
Metabolism
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15410
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disordersRodriguez, AmaiaMarinelli, Raul AlbertoTesse, AngelaFrühbeck, GemaCalamita, GiuseppeSexual dimorphismAquaglyceroporinsGlycerolMetabolismhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Gender differences in the relative risk of developing metabolic complications, such as insulin resistance or non-alcoholic fatty liver disease (NAFLD), have been reported. The deregulation of glycerol metabolism partly contributes to the onset of these metabolic diseases, since glycerol constitutes a key substrate for the synthesis of triacylglycerols (TAGs) as well as for hepatic gluconeogenesis. The present mini-review covers the sex-­related differences in glycerol metabolism and aquaglyceroporins (AQPs) and its impact in the control of adipose and hepatic fat accumulation as well as in whole-body glucose homeostasis. Plasma glycerol concentrations are increased in women compared to men probably due to the higher lipolytic rate and larger AQP7 amounts in visceral fat as well as the well-known sexual dimorphism in fat mass with women showing higher adiposity. AQP9 represents the primary route for glycerol uptake in hepatocytes, where glycerol is converted by the glycerol-kinase enzyme into glycerol-3-phosphate, a key substrate for de novo synthesis of glucose and TAG. In spite of showing similar hepatic AQP9 protein, women exhibit lower hepatocyte glycerol permeability than men, which might contribute to their lower prevalence of insulin resistance and NAFLD.Fil: Rodriguez, Amaia. Universidad de Navarra; EspañaFil: Marinelli, Raul Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Tesse, Angela. Universite de Nantes; FranciaFil: Frühbeck, Gema. Universidad de Navarra; EspañaFil: Calamita, Giuseppe. Universita Degli Studi Di Bari; ItaliaFrontiers2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15410Rodriguez, Amaia; Marinelli, Raul Alberto; Tesse, Angela; Frühbeck, Gema; Calamita, Giuseppe; Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disorders; Frontiers; Frontiers in Endocrinology; 6; 11-2015; 1-7; 1711664-2392enginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2015.00171info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fendo.2015.00171/fullinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633488/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:10Zoai:ri.conicet.gov.ar:11336/15410instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:11.224CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disorders
title Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disorders
spellingShingle Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disorders
Rodriguez, Amaia
Sexual dimorphism
Aquaglyceroporins
Glycerol
Metabolism
title_short Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disorders
title_full Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disorders
title_fullStr Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disorders
title_full_unstemmed Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disorders
title_sort Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disorders
dc.creator.none.fl_str_mv Rodriguez, Amaia
Marinelli, Raul Alberto
Tesse, Angela
Frühbeck, Gema
Calamita, Giuseppe
author Rodriguez, Amaia
author_facet Rodriguez, Amaia
Marinelli, Raul Alberto
Tesse, Angela
Frühbeck, Gema
Calamita, Giuseppe
author_role author
author2 Marinelli, Raul Alberto
Tesse, Angela
Frühbeck, Gema
Calamita, Giuseppe
author2_role author
author
author
author
dc.subject.none.fl_str_mv Sexual dimorphism
Aquaglyceroporins
Glycerol
Metabolism
topic Sexual dimorphism
Aquaglyceroporins
Glycerol
Metabolism
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Gender differences in the relative risk of developing metabolic complications, such as insulin resistance or non-alcoholic fatty liver disease (NAFLD), have been reported. The deregulation of glycerol metabolism partly contributes to the onset of these metabolic diseases, since glycerol constitutes a key substrate for the synthesis of triacylglycerols (TAGs) as well as for hepatic gluconeogenesis. The present mini-review covers the sex-­related differences in glycerol metabolism and aquaglyceroporins (AQPs) and its impact in the control of adipose and hepatic fat accumulation as well as in whole-body glucose homeostasis. Plasma glycerol concentrations are increased in women compared to men probably due to the higher lipolytic rate and larger AQP7 amounts in visceral fat as well as the well-known sexual dimorphism in fat mass with women showing higher adiposity. AQP9 represents the primary route for glycerol uptake in hepatocytes, where glycerol is converted by the glycerol-kinase enzyme into glycerol-3-phosphate, a key substrate for de novo synthesis of glucose and TAG. In spite of showing similar hepatic AQP9 protein, women exhibit lower hepatocyte glycerol permeability than men, which might contribute to their lower prevalence of insulin resistance and NAFLD.
Fil: Rodriguez, Amaia. Universidad de Navarra; España
Fil: Marinelli, Raul Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Tesse, Angela. Universite de Nantes; Francia
Fil: Frühbeck, Gema. Universidad de Navarra; España
Fil: Calamita, Giuseppe. Universita Degli Studi Di Bari; Italia
description Gender differences in the relative risk of developing metabolic complications, such as insulin resistance or non-alcoholic fatty liver disease (NAFLD), have been reported. The deregulation of glycerol metabolism partly contributes to the onset of these metabolic diseases, since glycerol constitutes a key substrate for the synthesis of triacylglycerols (TAGs) as well as for hepatic gluconeogenesis. The present mini-review covers the sex-­related differences in glycerol metabolism and aquaglyceroporins (AQPs) and its impact in the control of adipose and hepatic fat accumulation as well as in whole-body glucose homeostasis. Plasma glycerol concentrations are increased in women compared to men probably due to the higher lipolytic rate and larger AQP7 amounts in visceral fat as well as the well-known sexual dimorphism in fat mass with women showing higher adiposity. AQP9 represents the primary route for glycerol uptake in hepatocytes, where glycerol is converted by the glycerol-kinase enzyme into glycerol-3-phosphate, a key substrate for de novo synthesis of glucose and TAG. In spite of showing similar hepatic AQP9 protein, women exhibit lower hepatocyte glycerol permeability than men, which might contribute to their lower prevalence of insulin resistance and NAFLD.
publishDate 2015
dc.date.none.fl_str_mv 2015-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15410
Rodriguez, Amaia; Marinelli, Raul Alberto; Tesse, Angela; Frühbeck, Gema; Calamita, Giuseppe; Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disorders; Frontiers; Frontiers in Endocrinology; 6; 11-2015; 1-7; 171
1664-2392
url http://hdl.handle.net/11336/15410
identifier_str_mv Rodriguez, Amaia; Marinelli, Raul Alberto; Tesse, Angela; Frühbeck, Gema; Calamita, Giuseppe; Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in health and metabolic disorders; Frontiers; Frontiers in Endocrinology; 6; 11-2015; 1-7; 171
1664-2392
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2015.00171
info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fendo.2015.00171/full
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633488/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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