Nuclear genetic diversity of head lice sheds light on human dispersal around the world

Autores
Ascunce, Marina Sofia; Toloza, Ariel Ceferino; González Oliver, Angélica; Reed, David L.
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The human louse, Pediculus humanus, is an obligate blood-sucking ectoparasite that has coevolved with humans for millennia. Because of the intimate relationship between this parasite and the human host, the study of human lice has the potential to shed light on aspects of the human evolution that are obscured or difficult to interpret using other biological evidence. In this study, we analyzed the genetic variation in 274 human lice from 25 geographic sites around the world by using nuclear microsatellite loci and female-inherited mitochondrial DNA sequences. Nuclear genetic diversity analysis revealed the presence of two distinct genetic clusters I and II, which are subdivided into subclusters: Ia-Ib and IIa-IIb, respectively. Among these samples, we observed the presence of the two most common louse mitochondrial haplogroups: A and B. Both mitochondrial haplotypes were found in nuclear Clusters I and II. Evidence of nuclear admixture was uncommon (33 lice) and was predominately found in the New World potentially mirroring the pattern of very recent host admixture between Native Americans and Europeans. These findings were supported by novel DIYABC-simulations that were built using both host and parasite data to define parameters and models. In addition to providing new evolutionary knowledge about this human parasite, our study could guide the development of new analyses in other host-parasite systems.
Fil: Ascunce, Marina Sofia. University Of Florida. Florida Museum Of History. Departamento Of Biology; Estados Unidos
Fil: Toloza, Ariel Ceferino. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina
Fil: González Oliver, Angélica. Universidad Nacional Autónoma de México. Instituto de Biología; México
Fil: Reed, David L.. University Of Florida. Florida Museum Of History. Departamento Of Biology; Estados Unidos
Materia
Evolution
Head lice
Microsatellites
Human migrations
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/240938
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Nuclear genetic diversity of head lice sheds light on human dispersal around the worldAscunce, Marina SofiaToloza, Ariel CeferinoGonzález Oliver, AngélicaReed, David L.EvolutionHead liceMicrosatellitesHuman migrationshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The human louse, Pediculus humanus, is an obligate blood-sucking ectoparasite that has coevolved with humans for millennia. Because of the intimate relationship between this parasite and the human host, the study of human lice has the potential to shed light on aspects of the human evolution that are obscured or difficult to interpret using other biological evidence. In this study, we analyzed the genetic variation in 274 human lice from 25 geographic sites around the world by using nuclear microsatellite loci and female-inherited mitochondrial DNA sequences. Nuclear genetic diversity analysis revealed the presence of two distinct genetic clusters I and II, which are subdivided into subclusters: Ia-Ib and IIa-IIb, respectively. Among these samples, we observed the presence of the two most common louse mitochondrial haplogroups: A and B. Both mitochondrial haplotypes were found in nuclear Clusters I and II. Evidence of nuclear admixture was uncommon (33 lice) and was predominately found in the New World potentially mirroring the pattern of very recent host admixture between Native Americans and Europeans. These findings were supported by novel DIYABC-simulations that were built using both host and parasite data to define parameters and models. In addition to providing new evolutionary knowledge about this human parasite, our study could guide the development of new analyses in other host-parasite systems.Fil: Ascunce, Marina Sofia. University Of Florida. Florida Museum Of History. Departamento Of Biology; Estados UnidosFil: Toloza, Ariel Ceferino. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; ArgentinaFil: González Oliver, Angélica. Universidad Nacional Autónoma de México. Instituto de Biología; MéxicoFil: Reed, David L.. University Of Florida. Florida Museum Of History. Departamento Of Biology; Estados UnidosPublic Library of Science2023-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/240938Ascunce, Marina Sofia; Toloza, Ariel Ceferino; González Oliver, Angélica; Reed, David L.; Nuclear genetic diversity of head lice sheds light on human dispersal around the world; Public Library of Science; Plos One; 18; 11; 11-2023; 1-301932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0293409info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:39:27Zoai:ri.conicet.gov.ar:11336/240938instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:39:27.438CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nuclear genetic diversity of head lice sheds light on human dispersal around the world
title Nuclear genetic diversity of head lice sheds light on human dispersal around the world
spellingShingle Nuclear genetic diversity of head lice sheds light on human dispersal around the world
Ascunce, Marina Sofia
Evolution
Head lice
Microsatellites
Human migrations
title_short Nuclear genetic diversity of head lice sheds light on human dispersal around the world
title_full Nuclear genetic diversity of head lice sheds light on human dispersal around the world
title_fullStr Nuclear genetic diversity of head lice sheds light on human dispersal around the world
title_full_unstemmed Nuclear genetic diversity of head lice sheds light on human dispersal around the world
title_sort Nuclear genetic diversity of head lice sheds light on human dispersal around the world
dc.creator.none.fl_str_mv Ascunce, Marina Sofia
Toloza, Ariel Ceferino
González Oliver, Angélica
Reed, David L.
author Ascunce, Marina Sofia
author_facet Ascunce, Marina Sofia
Toloza, Ariel Ceferino
González Oliver, Angélica
Reed, David L.
author_role author
author2 Toloza, Ariel Ceferino
González Oliver, Angélica
Reed, David L.
author2_role author
author
author
dc.subject.none.fl_str_mv Evolution
Head lice
Microsatellites
Human migrations
topic Evolution
Head lice
Microsatellites
Human migrations
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The human louse, Pediculus humanus, is an obligate blood-sucking ectoparasite that has coevolved with humans for millennia. Because of the intimate relationship between this parasite and the human host, the study of human lice has the potential to shed light on aspects of the human evolution that are obscured or difficult to interpret using other biological evidence. In this study, we analyzed the genetic variation in 274 human lice from 25 geographic sites around the world by using nuclear microsatellite loci and female-inherited mitochondrial DNA sequences. Nuclear genetic diversity analysis revealed the presence of two distinct genetic clusters I and II, which are subdivided into subclusters: Ia-Ib and IIa-IIb, respectively. Among these samples, we observed the presence of the two most common louse mitochondrial haplogroups: A and B. Both mitochondrial haplotypes were found in nuclear Clusters I and II. Evidence of nuclear admixture was uncommon (33 lice) and was predominately found in the New World potentially mirroring the pattern of very recent host admixture between Native Americans and Europeans. These findings were supported by novel DIYABC-simulations that were built using both host and parasite data to define parameters and models. In addition to providing new evolutionary knowledge about this human parasite, our study could guide the development of new analyses in other host-parasite systems.
Fil: Ascunce, Marina Sofia. University Of Florida. Florida Museum Of History. Departamento Of Biology; Estados Unidos
Fil: Toloza, Ariel Ceferino. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina
Fil: González Oliver, Angélica. Universidad Nacional Autónoma de México. Instituto de Biología; México
Fil: Reed, David L.. University Of Florida. Florida Museum Of History. Departamento Of Biology; Estados Unidos
description The human louse, Pediculus humanus, is an obligate blood-sucking ectoparasite that has coevolved with humans for millennia. Because of the intimate relationship between this parasite and the human host, the study of human lice has the potential to shed light on aspects of the human evolution that are obscured or difficult to interpret using other biological evidence. In this study, we analyzed the genetic variation in 274 human lice from 25 geographic sites around the world by using nuclear microsatellite loci and female-inherited mitochondrial DNA sequences. Nuclear genetic diversity analysis revealed the presence of two distinct genetic clusters I and II, which are subdivided into subclusters: Ia-Ib and IIa-IIb, respectively. Among these samples, we observed the presence of the two most common louse mitochondrial haplogroups: A and B. Both mitochondrial haplotypes were found in nuclear Clusters I and II. Evidence of nuclear admixture was uncommon (33 lice) and was predominately found in the New World potentially mirroring the pattern of very recent host admixture between Native Americans and Europeans. These findings were supported by novel DIYABC-simulations that were built using both host and parasite data to define parameters and models. In addition to providing new evolutionary knowledge about this human parasite, our study could guide the development of new analyses in other host-parasite systems.
publishDate 2023
dc.date.none.fl_str_mv 2023-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/240938
Ascunce, Marina Sofia; Toloza, Ariel Ceferino; González Oliver, Angélica; Reed, David L.; Nuclear genetic diversity of head lice sheds light on human dispersal around the world; Public Library of Science; Plos One; 18; 11; 11-2023; 1-30
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/240938
identifier_str_mv Ascunce, Marina Sofia; Toloza, Ariel Ceferino; González Oliver, Angélica; Reed, David L.; Nuclear genetic diversity of head lice sheds light on human dispersal around the world; Public Library of Science; Plos One; 18; 11; 11-2023; 1-30
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0293409
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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