Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes

Autores
Arias, Hugo Rubén; Blanton, Michael P.
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.
Fil: Arias, Hugo Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Texas Tech University Health Sciences Center; Estados Unidos
Fil: Blanton, Michael P.. Texas Tech University Health Sciences Center; Estados Unidos
Materia
Local Anesthesics
Nicotinic Acetylcholine Receptors
Mechanism of Inhibition
Achrs Memrane
Open-Channel-Blocking Mechanism
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/78991
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/78991
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing MembranesArias, Hugo RubénBlanton, Michael P.Local AnesthesicsNicotinic Acetylcholine ReceptorsMechanism of InhibitionAchrs MemraneOpen-Channel-Blocking Mechanismhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.Fil: Arias, Hugo Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Texas Tech University Health Sciences Center; Estados UnidosFil: Blanton, Michael P.. Texas Tech University Health Sciences Center; Estados UnidosBentham Science Publishers2002-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/78991Arias, Hugo Rubén; Blanton, Michael P.; Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 2; 4; 4-2002; 385-4101389-5575CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/81400/article/molecular-and-physicochemical-aspects-local-anesthetics-acting-nicotinic-acetylcholineinfo:eu-repo/semantics/altIdentifier/doi/10.2174/1389557023406025info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-03-31T14:56:59Zoai:ri.conicet.gov.ar:11336/78991instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-03-31 14:57:00.046CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes
title Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes
spellingShingle Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes
Arias, Hugo Rubén
Local Anesthesics
Nicotinic Acetylcholine Receptors
Mechanism of Inhibition
Achrs Memrane
Open-Channel-Blocking Mechanism
title_short Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes
title_full Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes
title_fullStr Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes
title_full_unstemmed Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes
title_sort Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes
dc.creator.none.fl_str_mv Arias, Hugo Rubén
Blanton, Michael P.
author Arias, Hugo Rubén
author_facet Arias, Hugo Rubén
Blanton, Michael P.
author_role author
author2 Blanton, Michael P.
author2_role author
dc.subject.none.fl_str_mv Local Anesthesics
Nicotinic Acetylcholine Receptors
Mechanism of Inhibition
Achrs Memrane
Open-Channel-Blocking Mechanism
topic Local Anesthesics
Nicotinic Acetylcholine Receptors
Mechanism of Inhibition
Achrs Memrane
Open-Channel-Blocking Mechanism
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.
Fil: Arias, Hugo Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Texas Tech University Health Sciences Center; Estados Unidos
Fil: Blanton, Michael P.. Texas Tech University Health Sciences Center; Estados Unidos
description Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.
publishDate 2002
dc.date.none.fl_str_mv 2002-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/78991
Arias, Hugo Rubén; Blanton, Michael P.; Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 2; 4; 4-2002; 385-410
1389-5575
CONICET Digital
CONICET
url http://hdl.handle.net/11336/78991
identifier_str_mv Arias, Hugo Rubén; Blanton, Michael P.; Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 2; 4; 4-2002; 385-410
1389-5575
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/81400/article/molecular-and-physicochemical-aspects-local-anesthetics-acting-nicotinic-acetylcholine
info:eu-repo/semantics/altIdentifier/doi/10.2174/1389557023406025
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1861213962889068544
score 12.720982

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