Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions

Autores
Mujib, Ullah; Asma, Akbar; Yannarelli, Gustavo Gabriel
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Early detection of cancer has great clinical importance and potentially improves cure, survival rate and treatment outcome. RNA editing technology can be used as targeted and precise molecular scissors to cut and replace disease-causing genes with healthy ones. This is a post transcriptional modification that can lead to the recoding of proteins. RNA editing technology is in its infancy, but it can be used for early diagnoses and effective treatment of cancer. The full potential of precision medicine will be achieved by using the knowledge of RNA reversible-recoding to edit the protein. RNA editing technology could be used to expose chemo resistant cancer cells, dormant cancer stem cells and other malignant tumors. RNA editing generates RNA and protein diversity to accelerate and enhance the screening window for early detection of cancer. We propose that the RNA editing sites could be used as a novel tool for early detection of cancer.
Fil: Mujib, Ullah. University of Stanford; Estados Unidos
Fil: Asma, Akbar. University of Stanford; Estados Unidos
Fil: Yannarelli, Gustavo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
Materia
RNA EDITING
CANCER
DETECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/130710
Acceder
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spelling Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future DirectionsMujib, UllahAsma, AkbarYannarelli, Gustavo GabrielRNA EDITINGCANCERDETECTIONhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Early detection of cancer has great clinical importance and potentially improves cure, survival rate and treatment outcome. RNA editing technology can be used as targeted and precise molecular scissors to cut and replace disease-causing genes with healthy ones. This is a post transcriptional modification that can lead to the recoding of proteins. RNA editing technology is in its infancy, but it can be used for early diagnoses and effective treatment of cancer. The full potential of precision medicine will be achieved by using the knowledge of RNA reversible-recoding to edit the protein. RNA editing technology could be used to expose chemo resistant cancer cells, dormant cancer stem cells and other malignant tumors. RNA editing generates RNA and protein diversity to accelerate and enhance the screening window for early detection of cancer. We propose that the RNA editing sites could be used as a novel tool for early detection of cancer.Fil: Mujib, Ullah. University of Stanford; Estados UnidosFil: Asma, Akbar. University of Stanford; Estados UnidosFil: Yannarelli, Gustavo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; ArgentinaSAGE Publications2020-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/130710Mujib, Ullah; Asma, Akbar; Yannarelli, Gustavo Gabriel; Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions; SAGE Publications; Technology In Cancer Research & Treatment; 19; 1-2020; 1-41533-03461533-0338CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/1533033820964194info:eu-repo/semantics/altIdentifier/doi/10.1177/1533033820964194info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:37:24Zoai:ri.conicet.gov.ar:11336/130710instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:37:24.558CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions
title Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions
spellingShingle Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions
Mujib, Ullah
RNA EDITING
CANCER
DETECTION
title_short Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions
title_full Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions
title_fullStr Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions
title_full_unstemmed Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions
title_sort Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions
dc.creator.none.fl_str_mv Mujib, Ullah
Asma, Akbar
Yannarelli, Gustavo Gabriel
author Mujib, Ullah
author_facet Mujib, Ullah
Asma, Akbar
Yannarelli, Gustavo Gabriel
author_role author
author2 Asma, Akbar
Yannarelli, Gustavo Gabriel
author2_role author
author
dc.subject.none.fl_str_mv RNA EDITING
CANCER
DETECTION
topic RNA EDITING
CANCER
DETECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Early detection of cancer has great clinical importance and potentially improves cure, survival rate and treatment outcome. RNA editing technology can be used as targeted and precise molecular scissors to cut and replace disease-causing genes with healthy ones. This is a post transcriptional modification that can lead to the recoding of proteins. RNA editing technology is in its infancy, but it can be used for early diagnoses and effective treatment of cancer. The full potential of precision medicine will be achieved by using the knowledge of RNA reversible-recoding to edit the protein. RNA editing technology could be used to expose chemo resistant cancer cells, dormant cancer stem cells and other malignant tumors. RNA editing generates RNA and protein diversity to accelerate and enhance the screening window for early detection of cancer. We propose that the RNA editing sites could be used as a novel tool for early detection of cancer.
Fil: Mujib, Ullah. University of Stanford; Estados Unidos
Fil: Asma, Akbar. University of Stanford; Estados Unidos
Fil: Yannarelli, Gustavo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
description Early detection of cancer has great clinical importance and potentially improves cure, survival rate and treatment outcome. RNA editing technology can be used as targeted and precise molecular scissors to cut and replace disease-causing genes with healthy ones. This is a post transcriptional modification that can lead to the recoding of proteins. RNA editing technology is in its infancy, but it can be used for early diagnoses and effective treatment of cancer. The full potential of precision medicine will be achieved by using the knowledge of RNA reversible-recoding to edit the protein. RNA editing technology could be used to expose chemo resistant cancer cells, dormant cancer stem cells and other malignant tumors. RNA editing generates RNA and protein diversity to accelerate and enhance the screening window for early detection of cancer. We propose that the RNA editing sites could be used as a novel tool for early detection of cancer.
publishDate 2020
dc.date.none.fl_str_mv 2020-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/130710
Mujib, Ullah; Asma, Akbar; Yannarelli, Gustavo Gabriel; Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions; SAGE Publications; Technology In Cancer Research & Treatment; 19; 1-2020; 1-4
1533-0346
1533-0338
CONICET Digital
CONICET
url http://hdl.handle.net/11336/130710
identifier_str_mv Mujib, Ullah; Asma, Akbar; Yannarelli, Gustavo Gabriel; Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions; SAGE Publications; Technology In Cancer Research & Treatment; 19; 1-2020; 1-4
1533-0346
1533-0338
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/1533033820964194
info:eu-repo/semantics/altIdentifier/doi/10.1177/1533033820964194
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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