Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?

Autores
Rukavina Mikusic, Natalia Lucía; Silva, Mauro Gastón; Pineda, Angélica M.; Gironacci, Mariela Mercedes
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
G-protein–coupled receptors (GPCRs) are targets for around one third of currently approved and clinical prescribed drugs and represent the largest and most structurally diverse family of transmembrane signaling proteins, with almost 1000 members identified in the human genome. Upon agonist stimulation, GPCRs are internalized and trafficked inside the cell: they may be targeted to different organelles, recycled back to the plasma membrane or be degraded. Once inside the cell, the receptors may initiate other signaling pathways leading to different biological responses. GPCRs’ biological function may also be influenced by interaction with other receptors. Thus, the ultimate cellular response may depend not only on the activation of the receptor from the cell membrane, but also from receptor trafficking and/or the interaction with other receptors. This review is focused on angiotensin receptors and how their biological function is influenced by trafficking and interaction with others receptors.
Fil: Rukavina Mikusic, Natalia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Silva, Mauro Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Pineda, Angélica M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Materia
ANGIOTENSIN TYPE 1 RECEPTOR
ANGIOTENSIN TYPE 2 RECEPTOR
G-PROTEIN–COUPLED RECEPTOR
HETEROMERIZATION
MAS RECEPTOR
NUCLEUS
TRAFFICKING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/148924
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/148924
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?Rukavina Mikusic, Natalia LucíaSilva, Mauro GastónPineda, Angélica M.Gironacci, Mariela MercedesANGIOTENSIN TYPE 1 RECEPTORANGIOTENSIN TYPE 2 RECEPTORG-PROTEIN–COUPLED RECEPTORHETEROMERIZATIONMAS RECEPTORNUCLEUSTRAFFICKINGhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1G-protein–coupled receptors (GPCRs) are targets for around one third of currently approved and clinical prescribed drugs and represent the largest and most structurally diverse family of transmembrane signaling proteins, with almost 1000 members identified in the human genome. Upon agonist stimulation, GPCRs are internalized and trafficked inside the cell: they may be targeted to different organelles, recycled back to the plasma membrane or be degraded. Once inside the cell, the receptors may initiate other signaling pathways leading to different biological responses. GPCRs’ biological function may also be influenced by interaction with other receptors. Thus, the ultimate cellular response may depend not only on the activation of the receptor from the cell membrane, but also from receptor trafficking and/or the interaction with other receptors. This review is focused on angiotensin receptors and how their biological function is influenced by trafficking and interaction with others receptors.Fil: Rukavina Mikusic, Natalia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Silva, Mauro Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Pineda, Angélica M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFrontiers Media2020-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/148924Rukavina Mikusic, Natalia Lucía; Silva, Mauro Gastón; Pineda, Angélica M.; Gironacci, Mariela Mercedes; Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?; Frontiers Media; Frontiers in Pharmacology; 11; 8-2020; 1-201663-9812CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fphar.2020.01179/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphar.2020.01179info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:00Zoai:ri.conicet.gov.ar:11336/148924instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:00.279CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?
title Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?
spellingShingle Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?
Rukavina Mikusic, Natalia Lucía
ANGIOTENSIN TYPE 1 RECEPTOR
ANGIOTENSIN TYPE 2 RECEPTOR
G-PROTEIN–COUPLED RECEPTOR
HETEROMERIZATION
MAS RECEPTOR
NUCLEUS
TRAFFICKING
title_short Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?
title_full Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?
title_fullStr Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?
title_full_unstemmed Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?
title_sort Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?
dc.creator.none.fl_str_mv Rukavina Mikusic, Natalia Lucía
Silva, Mauro Gastón
Pineda, Angélica M.
Gironacci, Mariela Mercedes
author Rukavina Mikusic, Natalia Lucía
author_facet Rukavina Mikusic, Natalia Lucía
Silva, Mauro Gastón
Pineda, Angélica M.
Gironacci, Mariela Mercedes
author_role author
author2 Silva, Mauro Gastón
Pineda, Angélica M.
Gironacci, Mariela Mercedes
author2_role author
author
author
dc.subject.none.fl_str_mv ANGIOTENSIN TYPE 1 RECEPTOR
ANGIOTENSIN TYPE 2 RECEPTOR
G-PROTEIN–COUPLED RECEPTOR
HETEROMERIZATION
MAS RECEPTOR
NUCLEUS
TRAFFICKING
topic ANGIOTENSIN TYPE 1 RECEPTOR
ANGIOTENSIN TYPE 2 RECEPTOR
G-PROTEIN–COUPLED RECEPTOR
HETEROMERIZATION
MAS RECEPTOR
NUCLEUS
TRAFFICKING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv G-protein–coupled receptors (GPCRs) are targets for around one third of currently approved and clinical prescribed drugs and represent the largest and most structurally diverse family of transmembrane signaling proteins, with almost 1000 members identified in the human genome. Upon agonist stimulation, GPCRs are internalized and trafficked inside the cell: they may be targeted to different organelles, recycled back to the plasma membrane or be degraded. Once inside the cell, the receptors may initiate other signaling pathways leading to different biological responses. GPCRs’ biological function may also be influenced by interaction with other receptors. Thus, the ultimate cellular response may depend not only on the activation of the receptor from the cell membrane, but also from receptor trafficking and/or the interaction with other receptors. This review is focused on angiotensin receptors and how their biological function is influenced by trafficking and interaction with others receptors.
Fil: Rukavina Mikusic, Natalia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Silva, Mauro Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Pineda, Angélica M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
description G-protein–coupled receptors (GPCRs) are targets for around one third of currently approved and clinical prescribed drugs and represent the largest and most structurally diverse family of transmembrane signaling proteins, with almost 1000 members identified in the human genome. Upon agonist stimulation, GPCRs are internalized and trafficked inside the cell: they may be targeted to different organelles, recycled back to the plasma membrane or be degraded. Once inside the cell, the receptors may initiate other signaling pathways leading to different biological responses. GPCRs’ biological function may also be influenced by interaction with other receptors. Thus, the ultimate cellular response may depend not only on the activation of the receptor from the cell membrane, but also from receptor trafficking and/or the interaction with other receptors. This review is focused on angiotensin receptors and how their biological function is influenced by trafficking and interaction with others receptors.
publishDate 2020
dc.date.none.fl_str_mv 2020-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/148924
Rukavina Mikusic, Natalia Lucía; Silva, Mauro Gastón; Pineda, Angélica M.; Gironacci, Mariela Mercedes; Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?; Frontiers Media; Frontiers in Pharmacology; 11; 8-2020; 1-20
1663-9812
CONICET Digital
CONICET
url http://hdl.handle.net/11336/148924
identifier_str_mv Rukavina Mikusic, Natalia Lucía; Silva, Mauro Gastón; Pineda, Angélica M.; Gironacci, Mariela Mercedes; Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?; Frontiers Media; Frontiers in Pharmacology; 11; 8-2020; 1-20
1663-9812
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fphar.2020.01179/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fphar.2020.01179
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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