Platelet TLR4 at the crossroads of thrombosis and the innate immune response

Autores
Schattner, Mirta Ana
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Platelet TLR-4 activation by pathogen- or damage-associated molecular pattern molecules triggers pro-thrombotic, proinflammatory, and pro-coagulant effector responses. Moreover, platelet TLR4 has a prominent role as a sensor of high lipopolysaccharide circulating levels during sepsis and in the clearance of pathogens mediated by neutrophils. This review presents evidence pointing to TLR4 as a bridge connecting thrombosis and innate immunity.
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
HMGB-1
LPS
NETS
PLATELETS
SEPSIS
THROMBOSIS
TLRS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/127868
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/127868
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Platelet TLR4 at the crossroads of thrombosis and the innate immune responseSchattner, Mirta AnaHMGB-1LPSNETSPLATELETSSEPSISTHROMBOSISTLRShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Platelet TLR-4 activation by pathogen- or damage-associated molecular pattern molecules triggers pro-thrombotic, proinflammatory, and pro-coagulant effector responses. Moreover, platelet TLR4 has a prominent role as a sensor of high lipopolysaccharide circulating levels during sepsis and in the clearance of pathogens mediated by neutrophils. This review presents evidence pointing to TLR4 as a bridge connecting thrombosis and innate immunity.Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFederation of American Societies for Experimental Biology2018-12-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/127868Schattner, Mirta Ana; Platelet TLR4 at the crossroads of thrombosis and the innate immune response; Federation of American Societies for Experimental Biology; Journal of Leukocyte Biology; 105; 5; 4-12-2018; 873-8800741-5400CONICET DigitalCONICETenginfo:eu-repo/semantics/reference/url/http://dx.doi.org/10.1002/ajh.24097info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/JLB.MR0618-213Rinfo:eu-repo/semantics/altIdentifier/doi/10.1002/JLB.MR0618-213Rinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:03Zoai:ri.conicet.gov.ar:11336/127868instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:04.188CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Platelet TLR4 at the crossroads of thrombosis and the innate immune response
title Platelet TLR4 at the crossroads of thrombosis and the innate immune response
spellingShingle Platelet TLR4 at the crossroads of thrombosis and the innate immune response
Schattner, Mirta Ana
HMGB-1
LPS
NETS
PLATELETS
SEPSIS
THROMBOSIS
TLRS
title_short Platelet TLR4 at the crossroads of thrombosis and the innate immune response
title_full Platelet TLR4 at the crossroads of thrombosis and the innate immune response
title_fullStr Platelet TLR4 at the crossroads of thrombosis and the innate immune response
title_full_unstemmed Platelet TLR4 at the crossroads of thrombosis and the innate immune response
title_sort Platelet TLR4 at the crossroads of thrombosis and the innate immune response
dc.creator.none.fl_str_mv Schattner, Mirta Ana
author Schattner, Mirta Ana
author_facet Schattner, Mirta Ana
author_role author
dc.subject.none.fl_str_mv HMGB-1
LPS
NETS
PLATELETS
SEPSIS
THROMBOSIS
TLRS
topic HMGB-1
LPS
NETS
PLATELETS
SEPSIS
THROMBOSIS
TLRS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Platelet TLR-4 activation by pathogen- or damage-associated molecular pattern molecules triggers pro-thrombotic, proinflammatory, and pro-coagulant effector responses. Moreover, platelet TLR4 has a prominent role as a sensor of high lipopolysaccharide circulating levels during sepsis and in the clearance of pathogens mediated by neutrophils. This review presents evidence pointing to TLR4 as a bridge connecting thrombosis and innate immunity.
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description Platelet TLR-4 activation by pathogen- or damage-associated molecular pattern molecules triggers pro-thrombotic, proinflammatory, and pro-coagulant effector responses. Moreover, platelet TLR4 has a prominent role as a sensor of high lipopolysaccharide circulating levels during sepsis and in the clearance of pathogens mediated by neutrophils. This review presents evidence pointing to TLR4 as a bridge connecting thrombosis and innate immunity.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/127868
Schattner, Mirta Ana; Platelet TLR4 at the crossroads of thrombosis and the innate immune response; Federation of American Societies for Experimental Biology; Journal of Leukocyte Biology; 105; 5; 4-12-2018; 873-880
0741-5400
CONICET Digital
CONICET
url http://hdl.handle.net/11336/127868
identifier_str_mv Schattner, Mirta Ana; Platelet TLR4 at the crossroads of thrombosis and the innate immune response; Federation of American Societies for Experimental Biology; Journal of Leukocyte Biology; 105; 5; 4-12-2018; 873-880
0741-5400
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/reference/url/http://dx.doi.org/10.1002/ajh.24097
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/JLB.MR0618-213R
info:eu-repo/semantics/altIdentifier/doi/10.1002/JLB.MR0618-213R
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Federation of American Societies for Experimental Biology
publisher.none.fl_str_mv Federation of American Societies for Experimental Biology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269010695028736
score 13.13397

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