A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility
- Autores
- Alejandro, Gabriela; Longhino, Juan Manuel; Alvarez, Nadia Roxana; Pawlak, Eva; Butera, Alejandro Ricardo
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Standard commercial L-alanine pellets and specially prepared natural lithium formate monohydrate powder samples of specific granulometry were irradiated in a 60Co gamma-ray irradiation plant and in the mixed field (thermal neutrons and gamma photons) of a boron neutron capture therapy (BNCT) experimental facility. The γ-doses applied with the 60Co source range from 0.1 to 50 kGy, while those in the BNCT facility go from ∼7 Gy to 150 Gy. The thermal neutron fluences range from 1012 neutrons cm-2 to 2 1013 neutrons cm-2. The irradiation of materials promotes the creation of stable electronic defects (generally free radicals) which constitute paramagnetic centers that can be detected and quantified by electron paramagnetic resonance (EPR). After irradiation, the EPR characterization of the samples was performed by determining the EPR intensity of the spectrum relative to a reference standard constituted by Mn2+ impurities diluted into a MgO single crystal. As expected, L-alanine has revealed to be largely insensitive to thermal neutrons fluence in the investigated range. On the contrary, it is shown that the EPR intensity of irradiated natural lithium formate monohydrate powders is clearly sensitive to thermal neutrons and has a linear dependence with the γ-dose. We propose a dual dosimeter by combining L-alanine pellets and formate powders that would allow to determine the γ-dose and thermal neutron fluence in a selected position of the BNCT irradiation facility. Moreover, we demonstrate that the 6Li enrichment that has been proposed in the literature to enhance the performance of lithium-based EPR dosimeters is not crucial in our case. Instead, the natural isotopic abundance of lithium is large enough to obtain a satisfactory sensibility to thermal neutrons in our BNCT facility for fluencies >1012 neutrons cm-2.
Fil: Alejandro, Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina
Fil: Longhino, Juan Manuel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina
Fil: Alvarez, Nadia Roxana. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear; Argentina
Fil: Pawlak, Eva. Comisión Nacional de Energía Atómica; Argentina
Fil: Butera, Alejandro Ricardo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina - Materia
-
BORON NEUTRON CAPTURE THERAPY
ELECTRON PARAMAGNETIC RESONANCE DOSIMETRY
L-ALAINE
LITHIUM FORMATE
MIXED RADIATION FIELDS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/146132
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spelling |
A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facilityAlejandro, GabrielaLonghino, Juan ManuelAlvarez, Nadia RoxanaPawlak, EvaButera, Alejandro RicardoBORON NEUTRON CAPTURE THERAPYELECTRON PARAMAGNETIC RESONANCE DOSIMETRYL-ALAINELITHIUM FORMATEMIXED RADIATION FIELDShttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Standard commercial L-alanine pellets and specially prepared natural lithium formate monohydrate powder samples of specific granulometry were irradiated in a 60Co gamma-ray irradiation plant and in the mixed field (thermal neutrons and gamma photons) of a boron neutron capture therapy (BNCT) experimental facility. The γ-doses applied with the 60Co source range from 0.1 to 50 kGy, while those in the BNCT facility go from ∼7 Gy to 150 Gy. The thermal neutron fluences range from 1012 neutrons cm-2 to 2 1013 neutrons cm-2. The irradiation of materials promotes the creation of stable electronic defects (generally free radicals) which constitute paramagnetic centers that can be detected and quantified by electron paramagnetic resonance (EPR). After irradiation, the EPR characterization of the samples was performed by determining the EPR intensity of the spectrum relative to a reference standard constituted by Mn2+ impurities diluted into a MgO single crystal. As expected, L-alanine has revealed to be largely insensitive to thermal neutrons fluence in the investigated range. On the contrary, it is shown that the EPR intensity of irradiated natural lithium formate monohydrate powders is clearly sensitive to thermal neutrons and has a linear dependence with the γ-dose. We propose a dual dosimeter by combining L-alanine pellets and formate powders that would allow to determine the γ-dose and thermal neutron fluence in a selected position of the BNCT irradiation facility. Moreover, we demonstrate that the 6Li enrichment that has been proposed in the literature to enhance the performance of lithium-based EPR dosimeters is not crucial in our case. Instead, the natural isotopic abundance of lithium is large enough to obtain a satisfactory sensibility to thermal neutrons in our BNCT facility for fluencies >1012 neutrons cm-2.Fil: Alejandro, Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; ArgentinaFil: Longhino, Juan Manuel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; ArgentinaFil: Alvarez, Nadia Roxana. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear; ArgentinaFil: Pawlak, Eva. Comisión Nacional de Energía Atómica; ArgentinaFil: Butera, Alejandro Ricardo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; ArgentinaIOP Publishing2020-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/146132Alejandro, Gabriela; Longhino, Juan Manuel; Alvarez, Nadia Roxana; Pawlak, Eva; Butera, Alejandro Ricardo; A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility; IOP Publishing; Journal of Physics D: Applied Physics; 53; 16; 4-2020; 1-100022-3727CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1088/1361-6463/ab6e45info:eu-repo/semantics/altIdentifier/url/https://iopscience.iop.org/article/10.1088/1361-6463/ab6e45info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:52:22Zoai:ri.conicet.gov.ar:11336/146132instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:52:22.355CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility |
title |
A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility |
spellingShingle |
A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility Alejandro, Gabriela BORON NEUTRON CAPTURE THERAPY ELECTRON PARAMAGNETIC RESONANCE DOSIMETRY L-ALAINE LITHIUM FORMATE MIXED RADIATION FIELDS |
title_short |
A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility |
title_full |
A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility |
title_fullStr |
A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility |
title_full_unstemmed |
A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility |
title_sort |
A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility |
dc.creator.none.fl_str_mv |
Alejandro, Gabriela Longhino, Juan Manuel Alvarez, Nadia Roxana Pawlak, Eva Butera, Alejandro Ricardo |
author |
Alejandro, Gabriela |
author_facet |
Alejandro, Gabriela Longhino, Juan Manuel Alvarez, Nadia Roxana Pawlak, Eva Butera, Alejandro Ricardo |
author_role |
author |
author2 |
Longhino, Juan Manuel Alvarez, Nadia Roxana Pawlak, Eva Butera, Alejandro Ricardo |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
BORON NEUTRON CAPTURE THERAPY ELECTRON PARAMAGNETIC RESONANCE DOSIMETRY L-ALAINE LITHIUM FORMATE MIXED RADIATION FIELDS |
topic |
BORON NEUTRON CAPTURE THERAPY ELECTRON PARAMAGNETIC RESONANCE DOSIMETRY L-ALAINE LITHIUM FORMATE MIXED RADIATION FIELDS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.3 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Standard commercial L-alanine pellets and specially prepared natural lithium formate monohydrate powder samples of specific granulometry were irradiated in a 60Co gamma-ray irradiation plant and in the mixed field (thermal neutrons and gamma photons) of a boron neutron capture therapy (BNCT) experimental facility. The γ-doses applied with the 60Co source range from 0.1 to 50 kGy, while those in the BNCT facility go from ∼7 Gy to 150 Gy. The thermal neutron fluences range from 1012 neutrons cm-2 to 2 1013 neutrons cm-2. The irradiation of materials promotes the creation of stable electronic defects (generally free radicals) which constitute paramagnetic centers that can be detected and quantified by electron paramagnetic resonance (EPR). After irradiation, the EPR characterization of the samples was performed by determining the EPR intensity of the spectrum relative to a reference standard constituted by Mn2+ impurities diluted into a MgO single crystal. As expected, L-alanine has revealed to be largely insensitive to thermal neutrons fluence in the investigated range. On the contrary, it is shown that the EPR intensity of irradiated natural lithium formate monohydrate powders is clearly sensitive to thermal neutrons and has a linear dependence with the γ-dose. We propose a dual dosimeter by combining L-alanine pellets and formate powders that would allow to determine the γ-dose and thermal neutron fluence in a selected position of the BNCT irradiation facility. Moreover, we demonstrate that the 6Li enrichment that has been proposed in the literature to enhance the performance of lithium-based EPR dosimeters is not crucial in our case. Instead, the natural isotopic abundance of lithium is large enough to obtain a satisfactory sensibility to thermal neutrons in our BNCT facility for fluencies >1012 neutrons cm-2. Fil: Alejandro, Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina Fil: Longhino, Juan Manuel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina Fil: Alvarez, Nadia Roxana. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear; Argentina Fil: Pawlak, Eva. Comisión Nacional de Energía Atómica; Argentina Fil: Butera, Alejandro Ricardo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina |
description |
Standard commercial L-alanine pellets and specially prepared natural lithium formate monohydrate powder samples of specific granulometry were irradiated in a 60Co gamma-ray irradiation plant and in the mixed field (thermal neutrons and gamma photons) of a boron neutron capture therapy (BNCT) experimental facility. The γ-doses applied with the 60Co source range from 0.1 to 50 kGy, while those in the BNCT facility go from ∼7 Gy to 150 Gy. The thermal neutron fluences range from 1012 neutrons cm-2 to 2 1013 neutrons cm-2. The irradiation of materials promotes the creation of stable electronic defects (generally free radicals) which constitute paramagnetic centers that can be detected and quantified by electron paramagnetic resonance (EPR). After irradiation, the EPR characterization of the samples was performed by determining the EPR intensity of the spectrum relative to a reference standard constituted by Mn2+ impurities diluted into a MgO single crystal. As expected, L-alanine has revealed to be largely insensitive to thermal neutrons fluence in the investigated range. On the contrary, it is shown that the EPR intensity of irradiated natural lithium formate monohydrate powders is clearly sensitive to thermal neutrons and has a linear dependence with the γ-dose. We propose a dual dosimeter by combining L-alanine pellets and formate powders that would allow to determine the γ-dose and thermal neutron fluence in a selected position of the BNCT irradiation facility. Moreover, we demonstrate that the 6Li enrichment that has been proposed in the literature to enhance the performance of lithium-based EPR dosimeters is not crucial in our case. Instead, the natural isotopic abundance of lithium is large enough to obtain a satisfactory sensibility to thermal neutrons in our BNCT facility for fluencies >1012 neutrons cm-2. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/146132 Alejandro, Gabriela; Longhino, Juan Manuel; Alvarez, Nadia Roxana; Pawlak, Eva; Butera, Alejandro Ricardo; A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility; IOP Publishing; Journal of Physics D: Applied Physics; 53; 16; 4-2020; 1-10 0022-3727 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/146132 |
identifier_str_mv |
Alejandro, Gabriela; Longhino, Juan Manuel; Alvarez, Nadia Roxana; Pawlak, Eva; Butera, Alejandro Ricardo; A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility; IOP Publishing; Journal of Physics D: Applied Physics; 53; 16; 4-2020; 1-10 0022-3727 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1088/1361-6463/ab6e45 info:eu-repo/semantics/altIdentifier/url/https://iopscience.iop.org/article/10.1088/1361-6463/ab6e45 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
IOP Publishing |
publisher.none.fl_str_mv |
IOP Publishing |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1846083051585536000 |
score |
13.22299 |