A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility

Autores
Alejandro, Gabriela; Longhino, Juan Manuel; Alvarez, Nadia Roxana; Pawlak, Eva; Butera, Alejandro Ricardo
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Standard commercial L-alanine pellets and specially prepared natural lithium formate monohydrate powder samples of specific granulometry were irradiated in a 60Co gamma-ray irradiation plant and in the mixed field (thermal neutrons and gamma photons) of a boron neutron capture therapy (BNCT) experimental facility. The γ-doses applied with the 60Co source range from 0.1 to 50 kGy, while those in the BNCT facility go from ∼7 Gy to 150 Gy. The thermal neutron fluences range from 1012 neutrons cm-2 to 2 1013 neutrons cm-2. The irradiation of materials promotes the creation of stable electronic defects (generally free radicals) which constitute paramagnetic centers that can be detected and quantified by electron paramagnetic resonance (EPR). After irradiation, the EPR characterization of the samples was performed by determining the EPR intensity of the spectrum relative to a reference standard constituted by Mn2+ impurities diluted into a MgO single crystal. As expected, L-alanine has revealed to be largely insensitive to thermal neutrons fluence in the investigated range. On the contrary, it is shown that the EPR intensity of irradiated natural lithium formate monohydrate powders is clearly sensitive to thermal neutrons and has a linear dependence with the γ-dose. We propose a dual dosimeter by combining L-alanine pellets and formate powders that would allow to determine the γ-dose and thermal neutron fluence in a selected position of the BNCT irradiation facility. Moreover, we demonstrate that the 6Li enrichment that has been proposed in the literature to enhance the performance of lithium-based EPR dosimeters is not crucial in our case. Instead, the natural isotopic abundance of lithium is large enough to obtain a satisfactory sensibility to thermal neutrons in our BNCT facility for fluencies >1012 neutrons cm-2.
Fil: Alejandro, Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina
Fil: Longhino, Juan Manuel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina
Fil: Alvarez, Nadia Roxana. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear; Argentina
Fil: Pawlak, Eva. Comisión Nacional de Energía Atómica; Argentina
Fil: Butera, Alejandro Ricardo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina
Materia
BORON NEUTRON CAPTURE THERAPY
ELECTRON PARAMAGNETIC RESONANCE DOSIMETRY
L-ALAINE
LITHIUM FORMATE
MIXED RADIATION FIELDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/146132

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oai_identifier_str oai:ri.conicet.gov.ar:11336/146132
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facilityAlejandro, GabrielaLonghino, Juan ManuelAlvarez, Nadia RoxanaPawlak, EvaButera, Alejandro RicardoBORON NEUTRON CAPTURE THERAPYELECTRON PARAMAGNETIC RESONANCE DOSIMETRYL-ALAINELITHIUM FORMATEMIXED RADIATION FIELDShttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Standard commercial L-alanine pellets and specially prepared natural lithium formate monohydrate powder samples of specific granulometry were irradiated in a 60Co gamma-ray irradiation plant and in the mixed field (thermal neutrons and gamma photons) of a boron neutron capture therapy (BNCT) experimental facility. The γ-doses applied with the 60Co source range from 0.1 to 50 kGy, while those in the BNCT facility go from ∼7 Gy to 150 Gy. The thermal neutron fluences range from 1012 neutrons cm-2 to 2 1013 neutrons cm-2. The irradiation of materials promotes the creation of stable electronic defects (generally free radicals) which constitute paramagnetic centers that can be detected and quantified by electron paramagnetic resonance (EPR). After irradiation, the EPR characterization of the samples was performed by determining the EPR intensity of the spectrum relative to a reference standard constituted by Mn2+ impurities diluted into a MgO single crystal. As expected, L-alanine has revealed to be largely insensitive to thermal neutrons fluence in the investigated range. On the contrary, it is shown that the EPR intensity of irradiated natural lithium formate monohydrate powders is clearly sensitive to thermal neutrons and has a linear dependence with the γ-dose. We propose a dual dosimeter by combining L-alanine pellets and formate powders that would allow to determine the γ-dose and thermal neutron fluence in a selected position of the BNCT irradiation facility. Moreover, we demonstrate that the 6Li enrichment that has been proposed in the literature to enhance the performance of lithium-based EPR dosimeters is not crucial in our case. Instead, the natural isotopic abundance of lithium is large enough to obtain a satisfactory sensibility to thermal neutrons in our BNCT facility for fluencies >1012 neutrons cm-2.Fil: Alejandro, Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; ArgentinaFil: Longhino, Juan Manuel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; ArgentinaFil: Alvarez, Nadia Roxana. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear; ArgentinaFil: Pawlak, Eva. Comisión Nacional de Energía Atómica; ArgentinaFil: Butera, Alejandro Ricardo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; ArgentinaIOP Publishing2020-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/146132Alejandro, Gabriela; Longhino, Juan Manuel; Alvarez, Nadia Roxana; Pawlak, Eva; Butera, Alejandro Ricardo; A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility; IOP Publishing; Journal of Physics D: Applied Physics; 53; 16; 4-2020; 1-100022-3727CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1088/1361-6463/ab6e45info:eu-repo/semantics/altIdentifier/url/https://iopscience.iop.org/article/10.1088/1361-6463/ab6e45info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:52:22Zoai:ri.conicet.gov.ar:11336/146132instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:52:22.355CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility
title A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility
spellingShingle A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility
Alejandro, Gabriela
BORON NEUTRON CAPTURE THERAPY
ELECTRON PARAMAGNETIC RESONANCE DOSIMETRY
L-ALAINE
LITHIUM FORMATE
MIXED RADIATION FIELDS
title_short A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility
title_full A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility
title_fullStr A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility
title_full_unstemmed A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility
title_sort A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility
dc.creator.none.fl_str_mv Alejandro, Gabriela
Longhino, Juan Manuel
Alvarez, Nadia Roxana
Pawlak, Eva
Butera, Alejandro Ricardo
author Alejandro, Gabriela
author_facet Alejandro, Gabriela
Longhino, Juan Manuel
Alvarez, Nadia Roxana
Pawlak, Eva
Butera, Alejandro Ricardo
author_role author
author2 Longhino, Juan Manuel
Alvarez, Nadia Roxana
Pawlak, Eva
Butera, Alejandro Ricardo
author2_role author
author
author
author
dc.subject.none.fl_str_mv BORON NEUTRON CAPTURE THERAPY
ELECTRON PARAMAGNETIC RESONANCE DOSIMETRY
L-ALAINE
LITHIUM FORMATE
MIXED RADIATION FIELDS
topic BORON NEUTRON CAPTURE THERAPY
ELECTRON PARAMAGNETIC RESONANCE DOSIMETRY
L-ALAINE
LITHIUM FORMATE
MIXED RADIATION FIELDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Standard commercial L-alanine pellets and specially prepared natural lithium formate monohydrate powder samples of specific granulometry were irradiated in a 60Co gamma-ray irradiation plant and in the mixed field (thermal neutrons and gamma photons) of a boron neutron capture therapy (BNCT) experimental facility. The γ-doses applied with the 60Co source range from 0.1 to 50 kGy, while those in the BNCT facility go from ∼7 Gy to 150 Gy. The thermal neutron fluences range from 1012 neutrons cm-2 to 2 1013 neutrons cm-2. The irradiation of materials promotes the creation of stable electronic defects (generally free radicals) which constitute paramagnetic centers that can be detected and quantified by electron paramagnetic resonance (EPR). After irradiation, the EPR characterization of the samples was performed by determining the EPR intensity of the spectrum relative to a reference standard constituted by Mn2+ impurities diluted into a MgO single crystal. As expected, L-alanine has revealed to be largely insensitive to thermal neutrons fluence in the investigated range. On the contrary, it is shown that the EPR intensity of irradiated natural lithium formate monohydrate powders is clearly sensitive to thermal neutrons and has a linear dependence with the γ-dose. We propose a dual dosimeter by combining L-alanine pellets and formate powders that would allow to determine the γ-dose and thermal neutron fluence in a selected position of the BNCT irradiation facility. Moreover, we demonstrate that the 6Li enrichment that has been proposed in the literature to enhance the performance of lithium-based EPR dosimeters is not crucial in our case. Instead, the natural isotopic abundance of lithium is large enough to obtain a satisfactory sensibility to thermal neutrons in our BNCT facility for fluencies >1012 neutrons cm-2.
Fil: Alejandro, Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina
Fil: Longhino, Juan Manuel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina
Fil: Alvarez, Nadia Roxana. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear; Argentina
Fil: Pawlak, Eva. Comisión Nacional de Energía Atómica; Argentina
Fil: Butera, Alejandro Ricardo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Bariloche.; Argentina
description Standard commercial L-alanine pellets and specially prepared natural lithium formate monohydrate powder samples of specific granulometry were irradiated in a 60Co gamma-ray irradiation plant and in the mixed field (thermal neutrons and gamma photons) of a boron neutron capture therapy (BNCT) experimental facility. The γ-doses applied with the 60Co source range from 0.1 to 50 kGy, while those in the BNCT facility go from ∼7 Gy to 150 Gy. The thermal neutron fluences range from 1012 neutrons cm-2 to 2 1013 neutrons cm-2. The irradiation of materials promotes the creation of stable electronic defects (generally free radicals) which constitute paramagnetic centers that can be detected and quantified by electron paramagnetic resonance (EPR). After irradiation, the EPR characterization of the samples was performed by determining the EPR intensity of the spectrum relative to a reference standard constituted by Mn2+ impurities diluted into a MgO single crystal. As expected, L-alanine has revealed to be largely insensitive to thermal neutrons fluence in the investigated range. On the contrary, it is shown that the EPR intensity of irradiated natural lithium formate monohydrate powders is clearly sensitive to thermal neutrons and has a linear dependence with the γ-dose. We propose a dual dosimeter by combining L-alanine pellets and formate powders that would allow to determine the γ-dose and thermal neutron fluence in a selected position of the BNCT irradiation facility. Moreover, we demonstrate that the 6Li enrichment that has been proposed in the literature to enhance the performance of lithium-based EPR dosimeters is not crucial in our case. Instead, the natural isotopic abundance of lithium is large enough to obtain a satisfactory sensibility to thermal neutrons in our BNCT facility for fluencies >1012 neutrons cm-2.
publishDate 2020
dc.date.none.fl_str_mv 2020-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/146132
Alejandro, Gabriela; Longhino, Juan Manuel; Alvarez, Nadia Roxana; Pawlak, Eva; Butera, Alejandro Ricardo; A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility; IOP Publishing; Journal of Physics D: Applied Physics; 53; 16; 4-2020; 1-10
0022-3727
CONICET Digital
CONICET
url http://hdl.handle.net/11336/146132
identifier_str_mv Alejandro, Gabriela; Longhino, Juan Manuel; Alvarez, Nadia Roxana; Pawlak, Eva; Butera, Alejandro Ricardo; A dual natural lithium formate/L-alanine EPR dosimeter for a mixed radiation field in a boron neutron capture therapy irradiation facility; IOP Publishing; Journal of Physics D: Applied Physics; 53; 16; 4-2020; 1-10
0022-3727
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1088/1361-6463/ab6e45
info:eu-repo/semantics/altIdentifier/url/https://iopscience.iop.org/article/10.1088/1361-6463/ab6e45
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOP Publishing
publisher.none.fl_str_mv IOP Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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