Circadian control of a sex-specific behaviour in Drosophila

Autores
Riva, Sabrina Carla; Ceriani, Maria Fernanda; Risau Gusman, Sebastian Luis; Franco, Diana Lorena
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
An endogenous circadian clock controls many of the behavioral traits of Drosophila melanogaster. This “clock” relies on the activity of interconnected clusters of neurons that harbor the clock machinery. The hierarchy among clusters involved in the control of restactivity cycles has been extensively studied. Sexually dimorphic behaviors, on the other hand, have received less attention. Even though egg-laying, a female characteristic behavior, has been shown to be rhythmic, it remains largely unexplored possibly due to metholodological constraints. The current study provides the first steps towards determining the neural substrates underlying the circadian control of egg-laying. We show that, whereas the lateral ventral neurons (LNvs) and the dorsal neurons (DNs) are dispensable, the lateral dorsal neurons (LNds) are necessary for rhythmic egg-laying. Systematically probing the Drosophila connectome for contacts between circadian clusters and oviposition-related neurons, we found no evidence of direct connections between LNvs or DNs and neurons recruited during oviposition. Conversely, we did find bidirectional connections between Cryptochrome (Cry) expressing LNd (Cry+ LNds) and oviposition related neurons. Taken together, these results reveal that Cry+ LNd neurons have a leading role in the control of the egg-laying rhythm in Drosophila females.
Fil: Riva, Sabrina Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Ceriani, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Risau Gusman, Sebastian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Franco, Diana Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica; Argentina
Materia
OVIPOSITION
CIRCADIAN RHYTHM
DROSOPHILA MELANOGASTER
FEMALES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/253356
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Circadian control of a sex-specific behaviour in DrosophilaRiva, Sabrina CarlaCeriani, Maria FernandaRisau Gusman, Sebastian LuisFranco, Diana LorenaOVIPOSITIONCIRCADIAN RHYTHMDROSOPHILA MELANOGASTERFEMALEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1An endogenous circadian clock controls many of the behavioral traits of Drosophila melanogaster. This “clock” relies on the activity of interconnected clusters of neurons that harbor the clock machinery. The hierarchy among clusters involved in the control of restactivity cycles has been extensively studied. Sexually dimorphic behaviors, on the other hand, have received less attention. Even though egg-laying, a female characteristic behavior, has been shown to be rhythmic, it remains largely unexplored possibly due to metholodological constraints. The current study provides the first steps towards determining the neural substrates underlying the circadian control of egg-laying. We show that, whereas the lateral ventral neurons (LNvs) and the dorsal neurons (DNs) are dispensable, the lateral dorsal neurons (LNds) are necessary for rhythmic egg-laying. Systematically probing the Drosophila connectome for contacts between circadian clusters and oviposition-related neurons, we found no evidence of direct connections between LNvs or DNs and neurons recruited during oviposition. Conversely, we did find bidirectional connections between Cryptochrome (Cry) expressing LNd (Cry+ LNds) and oviposition related neurons. Taken together, these results reveal that Cry+ LNd neurons have a leading role in the control of the egg-laying rhythm in Drosophila females.Fil: Riva, Sabrina Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Ceriani, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Risau Gusman, Sebastian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Franco, Diana Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica; ArgentinaeLife Sciences Publications2024-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/253356Riva, Sabrina Carla; Ceriani, Maria Fernanda; Risau Gusman, Sebastian Luis; Franco, Diana Lorena; Circadian control of a sex-specific behaviour in Drosophila; eLife Sciences Publications; elife; 1; 12-2024; 1-302050-084XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.103359.1info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/reviewed-preprints/103359v1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:03Zoai:ri.conicet.gov.ar:11336/253356instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:03.455CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Circadian control of a sex-specific behaviour in Drosophila
title Circadian control of a sex-specific behaviour in Drosophila
spellingShingle Circadian control of a sex-specific behaviour in Drosophila
Riva, Sabrina Carla
OVIPOSITION
CIRCADIAN RHYTHM
DROSOPHILA MELANOGASTER
FEMALES
title_short Circadian control of a sex-specific behaviour in Drosophila
title_full Circadian control of a sex-specific behaviour in Drosophila
title_fullStr Circadian control of a sex-specific behaviour in Drosophila
title_full_unstemmed Circadian control of a sex-specific behaviour in Drosophila
title_sort Circadian control of a sex-specific behaviour in Drosophila
dc.creator.none.fl_str_mv Riva, Sabrina Carla
Ceriani, Maria Fernanda
Risau Gusman, Sebastian Luis
Franco, Diana Lorena
author Riva, Sabrina Carla
author_facet Riva, Sabrina Carla
Ceriani, Maria Fernanda
Risau Gusman, Sebastian Luis
Franco, Diana Lorena
author_role author
author2 Ceriani, Maria Fernanda
Risau Gusman, Sebastian Luis
Franco, Diana Lorena
author2_role author
author
author
dc.subject.none.fl_str_mv OVIPOSITION
CIRCADIAN RHYTHM
DROSOPHILA MELANOGASTER
FEMALES
topic OVIPOSITION
CIRCADIAN RHYTHM
DROSOPHILA MELANOGASTER
FEMALES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv An endogenous circadian clock controls many of the behavioral traits of Drosophila melanogaster. This “clock” relies on the activity of interconnected clusters of neurons that harbor the clock machinery. The hierarchy among clusters involved in the control of restactivity cycles has been extensively studied. Sexually dimorphic behaviors, on the other hand, have received less attention. Even though egg-laying, a female characteristic behavior, has been shown to be rhythmic, it remains largely unexplored possibly due to metholodological constraints. The current study provides the first steps towards determining the neural substrates underlying the circadian control of egg-laying. We show that, whereas the lateral ventral neurons (LNvs) and the dorsal neurons (DNs) are dispensable, the lateral dorsal neurons (LNds) are necessary for rhythmic egg-laying. Systematically probing the Drosophila connectome for contacts between circadian clusters and oviposition-related neurons, we found no evidence of direct connections between LNvs or DNs and neurons recruited during oviposition. Conversely, we did find bidirectional connections between Cryptochrome (Cry) expressing LNd (Cry+ LNds) and oviposition related neurons. Taken together, these results reveal that Cry+ LNd neurons have a leading role in the control of the egg-laying rhythm in Drosophila females.
Fil: Riva, Sabrina Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Ceriani, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Risau Gusman, Sebastian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Franco, Diana Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica; Argentina
description An endogenous circadian clock controls many of the behavioral traits of Drosophila melanogaster. This “clock” relies on the activity of interconnected clusters of neurons that harbor the clock machinery. The hierarchy among clusters involved in the control of restactivity cycles has been extensively studied. Sexually dimorphic behaviors, on the other hand, have received less attention. Even though egg-laying, a female characteristic behavior, has been shown to be rhythmic, it remains largely unexplored possibly due to metholodological constraints. The current study provides the first steps towards determining the neural substrates underlying the circadian control of egg-laying. We show that, whereas the lateral ventral neurons (LNvs) and the dorsal neurons (DNs) are dispensable, the lateral dorsal neurons (LNds) are necessary for rhythmic egg-laying. Systematically probing the Drosophila connectome for contacts between circadian clusters and oviposition-related neurons, we found no evidence of direct connections between LNvs or DNs and neurons recruited during oviposition. Conversely, we did find bidirectional connections between Cryptochrome (Cry) expressing LNd (Cry+ LNds) and oviposition related neurons. Taken together, these results reveal that Cry+ LNd neurons have a leading role in the control of the egg-laying rhythm in Drosophila females.
publishDate 2024
dc.date.none.fl_str_mv 2024-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/253356
Riva, Sabrina Carla; Ceriani, Maria Fernanda; Risau Gusman, Sebastian Luis; Franco, Diana Lorena; Circadian control of a sex-specific behaviour in Drosophila; eLife Sciences Publications; elife; 1; 12-2024; 1-30
2050-084X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/253356
identifier_str_mv Riva, Sabrina Carla; Ceriani, Maria Fernanda; Risau Gusman, Sebastian Luis; Franco, Diana Lorena; Circadian control of a sex-specific behaviour in Drosophila; eLife Sciences Publications; elife; 1; 12-2024; 1-30
2050-084X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.103359.1
info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/reviewed-preprints/103359v1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv eLife Sciences Publications
publisher.none.fl_str_mv eLife Sciences Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268899275440128
score 13.13397

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