Determination of the frequency and direct cost of the adverse drug events in Argentina

Autores
Izquierdo, Estela Juana; Rodríguez, Néstor Claudio; Pampliega, Eneas; Filinger, Ester Julia
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To determine the frequency and the direct costs of adverse drug reactions, in an ambulatory population of the City of Buenos Aires, Argentina and its area of influence. A retrospective study was done during a period of three months on approximately 300.000 residents of the Buenos Aires area, gathering data according to the selected variables by means of the electronic capture of prescriptions dispensed in pharmacies of the area. This method enables the detection and registration of potential conflicts that may arise between a prescribed drug and factors such as: patient's demographic, clinical and drug profile. The analysis unit was defined as the happening of a moderate or severe adverse event reported by the system. The selected variables were the incidence of these effects and the direct cost was calculated as the value of the drugs that induced the adverse event. The events were classified according to the following interactions: a) drug- drug, b) drug-pediatrics, c) drug- gender, d) drug- pregnancy and abuse of controlled substances. The observed frequency shows great variability and the shortage of available data for ambulatory populations. We found 6.74% of reported events over the total of processed items, which generated an additional cost equivalent to 4.58% of the total pharmaceutical expenses. This study has only evaluated the cost occured by the use of a drug that will lead to an adverse reaction. Moderate and severe reactions were included regardless of the important indirect costs, hospitalization costs, tests, physician fees, etc.
Fil: Izquierdo, Estela Juana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Rodríguez, Néstor Claudio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Pampliega, Eneas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Filinger, Ester Julia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
ADVERSE DRUG REACTIONS
DIRECT COST
DRUG INTERACTIONS
FREQUENCY OF ADVERSE EVENTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/114996
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/114996
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Determination of the frequency and direct cost of the adverse drug events in ArgentinaIzquierdo, Estela JuanaRodríguez, Néstor ClaudioPampliega, EneasFilinger, Ester JuliaADVERSE DRUG REACTIONSDIRECT COSTDRUG INTERACTIONSFREQUENCY OF ADVERSE EVENTShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3To determine the frequency and the direct costs of adverse drug reactions, in an ambulatory population of the City of Buenos Aires, Argentina and its area of influence. A retrospective study was done during a period of three months on approximately 300.000 residents of the Buenos Aires area, gathering data according to the selected variables by means of the electronic capture of prescriptions dispensed in pharmacies of the area. This method enables the detection and registration of potential conflicts that may arise between a prescribed drug and factors such as: patient's demographic, clinical and drug profile. The analysis unit was defined as the happening of a moderate or severe adverse event reported by the system. The selected variables were the incidence of these effects and the direct cost was calculated as the value of the drugs that induced the adverse event. The events were classified according to the following interactions: a) drug- drug, b) drug-pediatrics, c) drug- gender, d) drug- pregnancy and abuse of controlled substances. The observed frequency shows great variability and the shortage of available data for ambulatory populations. We found 6.74% of reported events over the total of processed items, which generated an additional cost equivalent to 4.58% of the total pharmaceutical expenses. This study has only evaluated the cost occured by the use of a drug that will lead to an adverse reaction. Moderate and severe reactions were included regardless of the important indirect costs, hospitalization costs, tests, physician fees, etc.Fil: Izquierdo, Estela Juana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Rodríguez, Néstor Claudio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Pampliega, Eneas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Filinger, Ester Julia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaBentham Science Publishers2009-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/114996Izquierdo, Estela Juana; Rodríguez, Néstor Claudio; Pampliega, Eneas; Filinger, Ester Julia; Determination of the frequency and direct cost of the adverse drug events in Argentina; Bentham Science Publishers; Current Drug Safety; 4; 2; 4-2009; 103-1061574-8863CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/157488609788173017info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/69105/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:35:20Zoai:ri.conicet.gov.ar:11336/114996instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:35:20.597CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Determination of the frequency and direct cost of the adverse drug events in Argentina
title Determination of the frequency and direct cost of the adverse drug events in Argentina
spellingShingle Determination of the frequency and direct cost of the adverse drug events in Argentina
Izquierdo, Estela Juana
ADVERSE DRUG REACTIONS
DIRECT COST
DRUG INTERACTIONS
FREQUENCY OF ADVERSE EVENTS
title_short Determination of the frequency and direct cost of the adverse drug events in Argentina
title_full Determination of the frequency and direct cost of the adverse drug events in Argentina
title_fullStr Determination of the frequency and direct cost of the adverse drug events in Argentina
title_full_unstemmed Determination of the frequency and direct cost of the adverse drug events in Argentina
title_sort Determination of the frequency and direct cost of the adverse drug events in Argentina
dc.creator.none.fl_str_mv Izquierdo, Estela Juana
Rodríguez, Néstor Claudio
Pampliega, Eneas
Filinger, Ester Julia
author Izquierdo, Estela Juana
author_facet Izquierdo, Estela Juana
Rodríguez, Néstor Claudio
Pampliega, Eneas
Filinger, Ester Julia
author_role author
author2 Rodríguez, Néstor Claudio
Pampliega, Eneas
Filinger, Ester Julia
author2_role author
author
author
dc.subject.none.fl_str_mv ADVERSE DRUG REACTIONS
DIRECT COST
DRUG INTERACTIONS
FREQUENCY OF ADVERSE EVENTS
topic ADVERSE DRUG REACTIONS
DIRECT COST
DRUG INTERACTIONS
FREQUENCY OF ADVERSE EVENTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv To determine the frequency and the direct costs of adverse drug reactions, in an ambulatory population of the City of Buenos Aires, Argentina and its area of influence. A retrospective study was done during a period of three months on approximately 300.000 residents of the Buenos Aires area, gathering data according to the selected variables by means of the electronic capture of prescriptions dispensed in pharmacies of the area. This method enables the detection and registration of potential conflicts that may arise between a prescribed drug and factors such as: patient's demographic, clinical and drug profile. The analysis unit was defined as the happening of a moderate or severe adverse event reported by the system. The selected variables were the incidence of these effects and the direct cost was calculated as the value of the drugs that induced the adverse event. The events were classified according to the following interactions: a) drug- drug, b) drug-pediatrics, c) drug- gender, d) drug- pregnancy and abuse of controlled substances. The observed frequency shows great variability and the shortage of available data for ambulatory populations. We found 6.74% of reported events over the total of processed items, which generated an additional cost equivalent to 4.58% of the total pharmaceutical expenses. This study has only evaluated the cost occured by the use of a drug that will lead to an adverse reaction. Moderate and severe reactions were included regardless of the important indirect costs, hospitalization costs, tests, physician fees, etc.
Fil: Izquierdo, Estela Juana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Rodríguez, Néstor Claudio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Pampliega, Eneas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Filinger, Ester Julia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description To determine the frequency and the direct costs of adverse drug reactions, in an ambulatory population of the City of Buenos Aires, Argentina and its area of influence. A retrospective study was done during a period of three months on approximately 300.000 residents of the Buenos Aires area, gathering data according to the selected variables by means of the electronic capture of prescriptions dispensed in pharmacies of the area. This method enables the detection and registration of potential conflicts that may arise between a prescribed drug and factors such as: patient's demographic, clinical and drug profile. The analysis unit was defined as the happening of a moderate or severe adverse event reported by the system. The selected variables were the incidence of these effects and the direct cost was calculated as the value of the drugs that induced the adverse event. The events were classified according to the following interactions: a) drug- drug, b) drug-pediatrics, c) drug- gender, d) drug- pregnancy and abuse of controlled substances. The observed frequency shows great variability and the shortage of available data for ambulatory populations. We found 6.74% of reported events over the total of processed items, which generated an additional cost equivalent to 4.58% of the total pharmaceutical expenses. This study has only evaluated the cost occured by the use of a drug that will lead to an adverse reaction. Moderate and severe reactions were included regardless of the important indirect costs, hospitalization costs, tests, physician fees, etc.
publishDate 2009
dc.date.none.fl_str_mv 2009-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/114996
Izquierdo, Estela Juana; Rodríguez, Néstor Claudio; Pampliega, Eneas; Filinger, Ester Julia; Determination of the frequency and direct cost of the adverse drug events in Argentina; Bentham Science Publishers; Current Drug Safety; 4; 2; 4-2009; 103-106
1574-8863
CONICET Digital
CONICET
url http://hdl.handle.net/11336/114996
identifier_str_mv Izquierdo, Estela Juana; Rodríguez, Néstor Claudio; Pampliega, Eneas; Filinger, Ester Julia; Determination of the frequency and direct cost of the adverse drug events in Argentina; Bentham Science Publishers; Current Drug Safety; 4; 2; 4-2009; 103-106
1574-8863
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/157488609788173017
info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/69105/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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