Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial

Autores
Saadmaan, Gazi; Dalmasso, Maria Carolina; Ramirez, Alfredo; Hiltunen, Mikko; Kemppainen, Nina; Lehtisalo, Jenni; Mangialasche, Francesca; Ngandu, Tiia; Rinne, Juha; Soininen, Hilkka; Stephen, Ruth; Kivipelto, Miia; Solomon, Alina
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
INTRODUCTION:We assessed a genetic risk score for Alzheimer’s disease (AD-GRS) and apolipoprotein E (APOE4) in an exploratory neuroimaging substudy of the FINGER trial.METHODS: 1260 at-risk older individuals without dementia were randomized to multidomain lifestyle intervention or health advice. N = 126 participants underwent magnetic resonance imaging (MRI), and N = 47 positron emission tomography (PET) scans (Pittsburgh Compund B [PiB], Fluorodeoxyglucose) at baseline; N = 107 and N = 38 had repeated 2-year scans.RESULTS: The APOE4 allele, but not AD-GRS, was associated with baseline lower hippocampus volume (β = −0.27, p = 0.001), greater amyloid deposition (β = 0.48, p = 0.001), 2-year decline in hippocampus (β=−0.27, p = 0.01), total gray matter volume (β = −0.25, p = 0.01), and cortical thickness (β = −0.28, p = 0.003). In analyses stratified by AD-GRS (below vs above median), the PiB composite score increased less in intervention versus control in the higher AD-GRS group (β=−0.60, p = 0.03). DISCUSSION: AD-GRS and APOE4 may have different impacts on potential intervention effects on amyloid, that is, less accumulation in the higher-risk group (AD-GRS) versus lower-risk group (APOE).
Fil: Saadmaan, Gazi. University Of Eastern Finland.; Finlandia
Fil: Dalmasso, Maria Carolina. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Ramirez, Alfredo. University Hospital Bonn; Alemania
Fil: Hiltunen, Mikko. University Of Eastern Finland.; Finlandia
Fil: Kemppainen, Nina. University Of Turku; Finlandia
Fil: Lehtisalo, Jenni. University Of Eastern Finland.; Finlandia
Fil: Mangialasche, Francesca. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Ngandu, Tiia. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Rinne, Juha. University Of Turku; Finlandia
Fil: Soininen, Hilkka. University Of Eastern Finland.; Finlandia
Fil: Stephen, Ruth. University Of Eastern Finland.; Finlandia
Fil: Kivipelto, Miia. University Of Eastern Finland.; Finlandia
Fil: Solomon, Alina. University Of Eastern Finland.; Finlandia
Materia
ALZHEIMER'S DISEASE
APOE4
CLINICAL TRIAL
DEMENTIA
GENETIC RISK SCORE
NEUROIMAGING
BIOMARKER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/267601
Acceder
id CONICETDig_f16feea754e316a03f779038f8d2d626
oai_identifier_str oai:ri.conicet.gov.ar:11336/267601
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trialSaadmaan, GaziDalmasso, Maria CarolinaRamirez, AlfredoHiltunen, MikkoKemppainen, NinaLehtisalo, JenniMangialasche, FrancescaNgandu, TiiaRinne, JuhaSoininen, HilkkaStephen, RuthKivipelto, MiiaSolomon, AlinaALZHEIMER'S DISEASEAPOE4CLINICAL TRIALDEMENTIAGENETIC RISK SCORENEUROIMAGINGBIOMARKERhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3INTRODUCTION:We assessed a genetic risk score for Alzheimer’s disease (AD-GRS) and apolipoprotein E (APOE4) in an exploratory neuroimaging substudy of the FINGER trial.METHODS: 1260 at-risk older individuals without dementia were randomized to multidomain lifestyle intervention or health advice. N = 126 participants underwent magnetic resonance imaging (MRI), and N = 47 positron emission tomography (PET) scans (Pittsburgh Compund B [PiB], Fluorodeoxyglucose) at baseline; N = 107 and N = 38 had repeated 2-year scans.RESULTS: The APOE4 allele, but not AD-GRS, was associated with baseline lower hippocampus volume (β = −0.27, p = 0.001), greater amyloid deposition (β = 0.48, p = 0.001), 2-year decline in hippocampus (β=−0.27, p = 0.01), total gray matter volume (β = −0.25, p = 0.01), and cortical thickness (β = −0.28, p = 0.003). In analyses stratified by AD-GRS (below vs above median), the PiB composite score increased less in intervention versus control in the higher AD-GRS group (β=−0.60, p = 0.03). DISCUSSION: AD-GRS and APOE4 may have different impacts on potential intervention effects on amyloid, that is, less accumulation in the higher-risk group (AD-GRS) versus lower-risk group (APOE).Fil: Saadmaan, Gazi. University Of Eastern Finland.; FinlandiaFil: Dalmasso, Maria Carolina. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; ArgentinaFil: Ramirez, Alfredo. University Hospital Bonn; AlemaniaFil: Hiltunen, Mikko. University Of Eastern Finland.; FinlandiaFil: Kemppainen, Nina. University Of Turku; FinlandiaFil: Lehtisalo, Jenni. University Of Eastern Finland.; FinlandiaFil: Mangialasche, Francesca. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Ngandu, Tiia. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Rinne, Juha. University Of Turku; FinlandiaFil: Soininen, Hilkka. University Of Eastern Finland.; FinlandiaFil: Stephen, Ruth. University Of Eastern Finland.; FinlandiaFil: Kivipelto, Miia. University Of Eastern Finland.; FinlandiaFil: Solomon, Alina. University Of Eastern Finland.; FinlandiaWiley2024-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/267601Saadmaan, Gazi; Dalmasso, Maria Carolina; Ramirez, Alfredo; Hiltunen, Mikko; Kemppainen, Nina; et al.; Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial; Wiley; Alzheimers & Dementia; 20; 6; 4-2024; 4345-43501552-5260CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13843info:eu-repo/semantics/altIdentifier/doi/10.1002/alz.13843info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:10:03Zoai:ri.conicet.gov.ar:11336/267601instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:10:03.255CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
title Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
spellingShingle Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
Saadmaan, Gazi
ALZHEIMER'S DISEASE
APOE4
CLINICAL TRIAL
DEMENTIA
GENETIC RISK SCORE
NEUROIMAGING
BIOMARKER
title_short Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
title_full Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
title_fullStr Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
title_full_unstemmed Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
title_sort Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
dc.creator.none.fl_str_mv Saadmaan, Gazi
Dalmasso, Maria Carolina
Ramirez, Alfredo
Hiltunen, Mikko
Kemppainen, Nina
Lehtisalo, Jenni
Mangialasche, Francesca
Ngandu, Tiia
Rinne, Juha
Soininen, Hilkka
Stephen, Ruth
Kivipelto, Miia
Solomon, Alina
author Saadmaan, Gazi
author_facet Saadmaan, Gazi
Dalmasso, Maria Carolina
Ramirez, Alfredo
Hiltunen, Mikko
Kemppainen, Nina
Lehtisalo, Jenni
Mangialasche, Francesca
Ngandu, Tiia
Rinne, Juha
Soininen, Hilkka
Stephen, Ruth
Kivipelto, Miia
Solomon, Alina
author_role author
author2 Dalmasso, Maria Carolina
Ramirez, Alfredo
Hiltunen, Mikko
Kemppainen, Nina
Lehtisalo, Jenni
Mangialasche, Francesca
Ngandu, Tiia
Rinne, Juha
Soininen, Hilkka
Stephen, Ruth
Kivipelto, Miia
Solomon, Alina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALZHEIMER'S DISEASE
APOE4
CLINICAL TRIAL
DEMENTIA
GENETIC RISK SCORE
NEUROIMAGING
BIOMARKER
topic ALZHEIMER'S DISEASE
APOE4
CLINICAL TRIAL
DEMENTIA
GENETIC RISK SCORE
NEUROIMAGING
BIOMARKER
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv INTRODUCTION:We assessed a genetic risk score for Alzheimer’s disease (AD-GRS) and apolipoprotein E (APOE4) in an exploratory neuroimaging substudy of the FINGER trial.METHODS: 1260 at-risk older individuals without dementia were randomized to multidomain lifestyle intervention or health advice. N = 126 participants underwent magnetic resonance imaging (MRI), and N = 47 positron emission tomography (PET) scans (Pittsburgh Compund B [PiB], Fluorodeoxyglucose) at baseline; N = 107 and N = 38 had repeated 2-year scans.RESULTS: The APOE4 allele, but not AD-GRS, was associated with baseline lower hippocampus volume (β = −0.27, p = 0.001), greater amyloid deposition (β = 0.48, p = 0.001), 2-year decline in hippocampus (β=−0.27, p = 0.01), total gray matter volume (β = −0.25, p = 0.01), and cortical thickness (β = −0.28, p = 0.003). In analyses stratified by AD-GRS (below vs above median), the PiB composite score increased less in intervention versus control in the higher AD-GRS group (β=−0.60, p = 0.03). DISCUSSION: AD-GRS and APOE4 may have different impacts on potential intervention effects on amyloid, that is, less accumulation in the higher-risk group (AD-GRS) versus lower-risk group (APOE).
Fil: Saadmaan, Gazi. University Of Eastern Finland.; Finlandia
Fil: Dalmasso, Maria Carolina. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Ramirez, Alfredo. University Hospital Bonn; Alemania
Fil: Hiltunen, Mikko. University Of Eastern Finland.; Finlandia
Fil: Kemppainen, Nina. University Of Turku; Finlandia
Fil: Lehtisalo, Jenni. University Of Eastern Finland.; Finlandia
Fil: Mangialasche, Francesca. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Ngandu, Tiia. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Rinne, Juha. University Of Turku; Finlandia
Fil: Soininen, Hilkka. University Of Eastern Finland.; Finlandia
Fil: Stephen, Ruth. University Of Eastern Finland.; Finlandia
Fil: Kivipelto, Miia. University Of Eastern Finland.; Finlandia
Fil: Solomon, Alina. University Of Eastern Finland.; Finlandia
description INTRODUCTION:We assessed a genetic risk score for Alzheimer’s disease (AD-GRS) and apolipoprotein E (APOE4) in an exploratory neuroimaging substudy of the FINGER trial.METHODS: 1260 at-risk older individuals without dementia were randomized to multidomain lifestyle intervention or health advice. N = 126 participants underwent magnetic resonance imaging (MRI), and N = 47 positron emission tomography (PET) scans (Pittsburgh Compund B [PiB], Fluorodeoxyglucose) at baseline; N = 107 and N = 38 had repeated 2-year scans.RESULTS: The APOE4 allele, but not AD-GRS, was associated with baseline lower hippocampus volume (β = −0.27, p = 0.001), greater amyloid deposition (β = 0.48, p = 0.001), 2-year decline in hippocampus (β=−0.27, p = 0.01), total gray matter volume (β = −0.25, p = 0.01), and cortical thickness (β = −0.28, p = 0.003). In analyses stratified by AD-GRS (below vs above median), the PiB composite score increased less in intervention versus control in the higher AD-GRS group (β=−0.60, p = 0.03). DISCUSSION: AD-GRS and APOE4 may have different impacts on potential intervention effects on amyloid, that is, less accumulation in the higher-risk group (AD-GRS) versus lower-risk group (APOE).
publishDate 2024
dc.date.none.fl_str_mv 2024-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/267601
Saadmaan, Gazi; Dalmasso, Maria Carolina; Ramirez, Alfredo; Hiltunen, Mikko; Kemppainen, Nina; et al.; Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial; Wiley; Alzheimers & Dementia; 20; 6; 4-2024; 4345-4350
1552-5260
CONICET Digital
CONICET
url http://hdl.handle.net/11336/267601
identifier_str_mv Saadmaan, Gazi; Dalmasso, Maria Carolina; Ramirez, Alfredo; Hiltunen, Mikko; Kemppainen, Nina; et al.; Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial; Wiley; Alzheimers & Dementia; 20; 6; 4-2024; 4345-4350
1552-5260
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13843
info:eu-repo/semantics/altIdentifier/doi/10.1002/alz.13843
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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