Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever

Autores
Chiappero, Marina Beatriz; Piacenza, Maria Florencia; Provensal, María Cecilia; Calderón, Gladys Ethel; Gardenal, Cristina Noemi; Polop, Jaime Jose
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Argentine hemorrhagic fever (AHF) is a serious endemic disease in Argentina, produced by Junín virus, whose host is the Sigmodontinae rodent Calomys musculinus. Within the endemic area, human incidence and proportion of infected rodents remains high for 5-10 years after the first appearance of the disease (epidemic [E] zone) and then gradually declines to sporadic cases (historic [H] zone). We tested the hypothesis that host populations within the E zone are large and well connected by gene flow, facilitating the transmission and maintenance of the virus, whereas those in the H and nonendemic (NE) zones are small and isolated, with the opposite effect. We estimated parameters affected by levels of gene flow and population size in 14 populations of C. musculinus: population effective size (Ne), genetic variability, and mean relatedness. Our hypothesis was not supported: the lowest levels of variability and of Ne and the highest genetic relatedness among individuals were found in the H zone. Populations from the NE zone displayed opposite results, whereas those in the E zone showed intermediate values. If we consider that populations are first NE, then E, and finally H, a correlative decrease in Ne was observed. Chronically infected females have a low reproductive success. We propose that this would lower Ne because each cohort would originate from a fraction of females of the previous generation, and affect other factors such as proportion of individuals that develop acute infection, probability of viral transmission, and evolution of virulence, which would explain, at least partly, the changing incidence of AHF.
Fil: Chiappero, Marina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina
Fil: Piacenza, Maria Florencia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Ciencias Naturales; Argentina
Fil: Provensal, María Cecilia. Universidad Nacional de Río Cuarto; Argentina
Fil: Calderón, Gladys Ethel. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui; Argentina
Fil: Gardenal, Cristina Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina
Fil: Polop, Jaime Jose. Universidad Nacional de Río Cuarto; Argentina
Materia
ARGENTINE HEMORRHAGIC FEVER
CALOMYS MUSCULINUS
POPULATION EFFECTIVE SIZE
VIRAL TRANSMISSION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/88612
Acceder
id CONICETDig_f10b252015effd0a8523d5d45e2fd1fb
oai_identifier_str oai:ri.conicet.gov.ar:11336/88612
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic feverChiappero, Marina BeatrizPiacenza, Maria FlorenciaProvensal, María CeciliaCalderón, Gladys EthelGardenal, Cristina NoemiPolop, Jaime JoseARGENTINE HEMORRHAGIC FEVERCALOMYS MUSCULINUSPOPULATION EFFECTIVE SIZEVIRAL TRANSMISSIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Argentine hemorrhagic fever (AHF) is a serious endemic disease in Argentina, produced by Junín virus, whose host is the Sigmodontinae rodent Calomys musculinus. Within the endemic area, human incidence and proportion of infected rodents remains high for 5-10 years after the first appearance of the disease (epidemic [E] zone) and then gradually declines to sporadic cases (historic [H] zone). We tested the hypothesis that host populations within the E zone are large and well connected by gene flow, facilitating the transmission and maintenance of the virus, whereas those in the H and nonendemic (NE) zones are small and isolated, with the opposite effect. We estimated parameters affected by levels of gene flow and population size in 14 populations of C. musculinus: population effective size (Ne), genetic variability, and mean relatedness. Our hypothesis was not supported: the lowest levels of variability and of Ne and the highest genetic relatedness among individuals were found in the H zone. Populations from the NE zone displayed opposite results, whereas those in the E zone showed intermediate values. If we consider that populations are first NE, then E, and finally H, a correlative decrease in Ne was observed. Chronically infected females have a low reproductive success. We propose that this would lower Ne because each cohort would originate from a fraction of females of the previous generation, and affect other factors such as proportion of individuals that develop acute infection, probability of viral transmission, and evolution of virulence, which would explain, at least partly, the changing incidence of AHF.Fil: Chiappero, Marina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; ArgentinaFil: Piacenza, Maria Florencia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Ciencias Naturales; ArgentinaFil: Provensal, María Cecilia. Universidad Nacional de Río Cuarto; ArgentinaFil: Calderón, Gladys Ethel. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui; ArgentinaFil: Gardenal, Cristina Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; ArgentinaFil: Polop, Jaime Jose. Universidad Nacional de Río Cuarto; ArgentinaAmerican Society of Tropical Medicine and Hygiene2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/88612Chiappero, Marina Beatriz; Piacenza, Maria Florencia; Provensal, María Cecilia; Calderón, Gladys Ethel; Gardenal, Cristina Noemi; et al.; Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 99; 2; 10-2018; 445-4500002-96371476-1645CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.17-0838info:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.17-0838info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:01:15Zoai:ri.conicet.gov.ar:11336/88612instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:01:15.689CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever
title Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever
spellingShingle Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever
Chiappero, Marina Beatriz
ARGENTINE HEMORRHAGIC FEVER
CALOMYS MUSCULINUS
POPULATION EFFECTIVE SIZE
VIRAL TRANSMISSION
title_short Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever
title_full Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever
title_fullStr Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever
title_full_unstemmed Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever
title_sort Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever
dc.creator.none.fl_str_mv Chiappero, Marina Beatriz
Piacenza, Maria Florencia
Provensal, María Cecilia
Calderón, Gladys Ethel
Gardenal, Cristina Noemi
Polop, Jaime Jose
author Chiappero, Marina Beatriz
author_facet Chiappero, Marina Beatriz
Piacenza, Maria Florencia
Provensal, María Cecilia
Calderón, Gladys Ethel
Gardenal, Cristina Noemi
Polop, Jaime Jose
author_role author
author2 Piacenza, Maria Florencia
Provensal, María Cecilia
Calderón, Gladys Ethel
Gardenal, Cristina Noemi
Polop, Jaime Jose
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ARGENTINE HEMORRHAGIC FEVER
CALOMYS MUSCULINUS
POPULATION EFFECTIVE SIZE
VIRAL TRANSMISSION
topic ARGENTINE HEMORRHAGIC FEVER
CALOMYS MUSCULINUS
POPULATION EFFECTIVE SIZE
VIRAL TRANSMISSION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Argentine hemorrhagic fever (AHF) is a serious endemic disease in Argentina, produced by Junín virus, whose host is the Sigmodontinae rodent Calomys musculinus. Within the endemic area, human incidence and proportion of infected rodents remains high for 5-10 years after the first appearance of the disease (epidemic [E] zone) and then gradually declines to sporadic cases (historic [H] zone). We tested the hypothesis that host populations within the E zone are large and well connected by gene flow, facilitating the transmission and maintenance of the virus, whereas those in the H and nonendemic (NE) zones are small and isolated, with the opposite effect. We estimated parameters affected by levels of gene flow and population size in 14 populations of C. musculinus: population effective size (Ne), genetic variability, and mean relatedness. Our hypothesis was not supported: the lowest levels of variability and of Ne and the highest genetic relatedness among individuals were found in the H zone. Populations from the NE zone displayed opposite results, whereas those in the E zone showed intermediate values. If we consider that populations are first NE, then E, and finally H, a correlative decrease in Ne was observed. Chronically infected females have a low reproductive success. We propose that this would lower Ne because each cohort would originate from a fraction of females of the previous generation, and affect other factors such as proportion of individuals that develop acute infection, probability of viral transmission, and evolution of virulence, which would explain, at least partly, the changing incidence of AHF.
Fil: Chiappero, Marina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina
Fil: Piacenza, Maria Florencia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Ciencias Naturales; Argentina
Fil: Provensal, María Cecilia. Universidad Nacional de Río Cuarto; Argentina
Fil: Calderón, Gladys Ethel. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui; Argentina
Fil: Gardenal, Cristina Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina
Fil: Polop, Jaime Jose. Universidad Nacional de Río Cuarto; Argentina
description Argentine hemorrhagic fever (AHF) is a serious endemic disease in Argentina, produced by Junín virus, whose host is the Sigmodontinae rodent Calomys musculinus. Within the endemic area, human incidence and proportion of infected rodents remains high for 5-10 years after the first appearance of the disease (epidemic [E] zone) and then gradually declines to sporadic cases (historic [H] zone). We tested the hypothesis that host populations within the E zone are large and well connected by gene flow, facilitating the transmission and maintenance of the virus, whereas those in the H and nonendemic (NE) zones are small and isolated, with the opposite effect. We estimated parameters affected by levels of gene flow and population size in 14 populations of C. musculinus: population effective size (Ne), genetic variability, and mean relatedness. Our hypothesis was not supported: the lowest levels of variability and of Ne and the highest genetic relatedness among individuals were found in the H zone. Populations from the NE zone displayed opposite results, whereas those in the E zone showed intermediate values. If we consider that populations are first NE, then E, and finally H, a correlative decrease in Ne was observed. Chronically infected females have a low reproductive success. We propose that this would lower Ne because each cohort would originate from a fraction of females of the previous generation, and affect other factors such as proportion of individuals that develop acute infection, probability of viral transmission, and evolution of virulence, which would explain, at least partly, the changing incidence of AHF.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/88612
Chiappero, Marina Beatriz; Piacenza, Maria Florencia; Provensal, María Cecilia; Calderón, Gladys Ethel; Gardenal, Cristina Noemi; et al.; Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 99; 2; 10-2018; 445-450
0002-9637
1476-1645
CONICET Digital
CONICET
url http://hdl.handle.net/11336/88612
identifier_str_mv Chiappero, Marina Beatriz; Piacenza, Maria Florencia; Provensal, María Cecilia; Calderón, Gladys Ethel; Gardenal, Cristina Noemi; et al.; Effective population size differences in calomys musculinus, the host of Junín Virus: Their relationship with the epidemiological history of argentine hemorrhagic fever; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 99; 2; 10-2018; 445-450
0002-9637
1476-1645
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.17-0838
info:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.17-0838
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842979936715931648
score 12.48226

Publicaciones similares