Polymeric microparticles containing indomethacin for inhalatory administration

Autores
Ceschan, Nazareth Eliana; Bucala, Veronica; Ramírez Rigo, María Veronica
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Indomethacin (IN) is a non-steroidal antiinflammatory drug. It reduces pain and inflammation in rheumatoid arthritis but its use is associated with high incidence of undesirable gastrointestinal side effects. In addition, its low solubility in water limits its oral bioavailability. In this work, microparticles based on an IN-polylysine (PL) complex were obtained by spray drying. The system is intended to deliver the drug through the inhalatory route for both local and systemic treatments. Several formulations, varying the relative composition IN/PL-dextrine (DX) and the total solid content of the feed solutions, were tested. The process performance (yield, air outlet temperature), product properties (IN load efficiency, moisture content, crystallinity, glass transition temperature, density, morphology and particle size distribution), the IN- polylysine ionic interaction (assessed by FT-infrared spectroscopy, powder X-ray diffraction and thermal analysis), and in vitro IN release were studied. Powders exhibited high load efficiencies and low moisture contents, and remained in the amorphous state after nine months of storage. The particle systems with 50 % of the polylysine amino groups neutralized by IN were the more attractive ones for pulmonary treatment,since they were easily processed using a Homogeneous aqueous feed, had relatively high IN contents and high cumulative fraction of respirable particles.
Fil: Ceschan, Nazareth Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Materia
Polyelectrolyte-Drug Complexes
Pulmonary Route
Non-Steroidal Antiinflammatory Drug
Spray Drying
Polylysine
Particle Engineering
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13467
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Polymeric microparticles containing indomethacin for inhalatory administrationCeschan, Nazareth ElianaBucala, VeronicaRamírez Rigo, María VeronicaPolyelectrolyte-Drug ComplexesPulmonary RouteNon-Steroidal Antiinflammatory DrugSpray DryingPolylysineParticle Engineeringhttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2Indomethacin (IN) is a non-steroidal antiinflammatory drug. It reduces pain and inflammation in rheumatoid arthritis but its use is associated with high incidence of undesirable gastrointestinal side effects. In addition, its low solubility in water limits its oral bioavailability. In this work, microparticles based on an IN-polylysine (PL) complex were obtained by spray drying. The system is intended to deliver the drug through the inhalatory route for both local and systemic treatments. Several formulations, varying the relative composition IN/PL-dextrine (DX) and the total solid content of the feed solutions, were tested. The process performance (yield, air outlet temperature), product properties (IN load efficiency, moisture content, crystallinity, glass transition temperature, density, morphology and particle size distribution), the IN- polylysine ionic interaction (assessed by FT-infrared spectroscopy, powder X-ray diffraction and thermal analysis), and in vitro IN release were studied. Powders exhibited high load efficiencies and low moisture contents, and remained in the amorphous state after nine months of storage. The particle systems with 50 % of the polylysine amino groups neutralized by IN were the more attractive ones for pulmonary treatment,since they were easily processed using a Homogeneous aqueous feed, had relatively high IN contents and high cumulative fraction of respirable particles.Fil: Ceschan, Nazareth Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; ArgentinaFil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; ArgentinaFil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaElsevier Science2015-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13467Ceschan, Nazareth Eliana; Bucala, Veronica; Ramírez Rigo, María Veronica; Polymeric microparticles containing indomethacin for inhalatory administration; Elsevier Science; Powder Technology; 285; 2-2015; 51-610032-5910enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0032591015001114info:eu-repo/semantics/altIdentifier/doi/10.1016/j.powtec.2015.02.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:05:42Zoai:ri.conicet.gov.ar:11336/13467instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:05:42.557CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Polymeric microparticles containing indomethacin for inhalatory administration
title Polymeric microparticles containing indomethacin for inhalatory administration
spellingShingle Polymeric microparticles containing indomethacin for inhalatory administration
Ceschan, Nazareth Eliana
Polyelectrolyte-Drug Complexes
Pulmonary Route
Non-Steroidal Antiinflammatory Drug
Spray Drying
Polylysine
Particle Engineering
title_short Polymeric microparticles containing indomethacin for inhalatory administration
title_full Polymeric microparticles containing indomethacin for inhalatory administration
title_fullStr Polymeric microparticles containing indomethacin for inhalatory administration
title_full_unstemmed Polymeric microparticles containing indomethacin for inhalatory administration
title_sort Polymeric microparticles containing indomethacin for inhalatory administration
dc.creator.none.fl_str_mv Ceschan, Nazareth Eliana
Bucala, Veronica
Ramírez Rigo, María Veronica
author Ceschan, Nazareth Eliana
author_facet Ceschan, Nazareth Eliana
Bucala, Veronica
Ramírez Rigo, María Veronica
author_role author
author2 Bucala, Veronica
Ramírez Rigo, María Veronica
author2_role author
author
dc.subject.none.fl_str_mv Polyelectrolyte-Drug Complexes
Pulmonary Route
Non-Steroidal Antiinflammatory Drug
Spray Drying
Polylysine
Particle Engineering
topic Polyelectrolyte-Drug Complexes
Pulmonary Route
Non-Steroidal Antiinflammatory Drug
Spray Drying
Polylysine
Particle Engineering
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Indomethacin (IN) is a non-steroidal antiinflammatory drug. It reduces pain and inflammation in rheumatoid arthritis but its use is associated with high incidence of undesirable gastrointestinal side effects. In addition, its low solubility in water limits its oral bioavailability. In this work, microparticles based on an IN-polylysine (PL) complex were obtained by spray drying. The system is intended to deliver the drug through the inhalatory route for both local and systemic treatments. Several formulations, varying the relative composition IN/PL-dextrine (DX) and the total solid content of the feed solutions, were tested. The process performance (yield, air outlet temperature), product properties (IN load efficiency, moisture content, crystallinity, glass transition temperature, density, morphology and particle size distribution), the IN- polylysine ionic interaction (assessed by FT-infrared spectroscopy, powder X-ray diffraction and thermal analysis), and in vitro IN release were studied. Powders exhibited high load efficiencies and low moisture contents, and remained in the amorphous state after nine months of storage. The particle systems with 50 % of the polylysine amino groups neutralized by IN were the more attractive ones for pulmonary treatment,since they were easily processed using a Homogeneous aqueous feed, had relatively high IN contents and high cumulative fraction of respirable particles.
Fil: Ceschan, Nazareth Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
description Indomethacin (IN) is a non-steroidal antiinflammatory drug. It reduces pain and inflammation in rheumatoid arthritis but its use is associated with high incidence of undesirable gastrointestinal side effects. In addition, its low solubility in water limits its oral bioavailability. In this work, microparticles based on an IN-polylysine (PL) complex were obtained by spray drying. The system is intended to deliver the drug through the inhalatory route for both local and systemic treatments. Several formulations, varying the relative composition IN/PL-dextrine (DX) and the total solid content of the feed solutions, were tested. The process performance (yield, air outlet temperature), product properties (IN load efficiency, moisture content, crystallinity, glass transition temperature, density, morphology and particle size distribution), the IN- polylysine ionic interaction (assessed by FT-infrared spectroscopy, powder X-ray diffraction and thermal analysis), and in vitro IN release were studied. Powders exhibited high load efficiencies and low moisture contents, and remained in the amorphous state after nine months of storage. The particle systems with 50 % of the polylysine amino groups neutralized by IN were the more attractive ones for pulmonary treatment,since they were easily processed using a Homogeneous aqueous feed, had relatively high IN contents and high cumulative fraction of respirable particles.
publishDate 2015
dc.date.none.fl_str_mv 2015-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13467
Ceschan, Nazareth Eliana; Bucala, Veronica; Ramírez Rigo, María Veronica; Polymeric microparticles containing indomethacin for inhalatory administration; Elsevier Science; Powder Technology; 285; 2-2015; 51-61
0032-5910
url http://hdl.handle.net/11336/13467
identifier_str_mv Ceschan, Nazareth Eliana; Bucala, Veronica; Ramírez Rigo, María Veronica; Polymeric microparticles containing indomethacin for inhalatory administration; Elsevier Science; Powder Technology; 285; 2-2015; 51-61
0032-5910
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0032591015001114
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.powtec.2015.02.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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