d-Chiro-Inositol in Clinical Practice: a perspective from the Experts Group on Inositol in Basic and Clinical Research (EGOI)

• Autores: Dinicola, Simona; Unfer, Vittorio; Soulage, Christophe O.; Yap Garcia, Maria Isidora Margarita; Bevilacqua, Arturo Miguel; Benvenga, Salvatore; Barbaro, Daniele; Wdowiak, Artur; Nordio, Maurizio; Dewailly, Didier; Appetecchia, Marialuisa; Aragona, Cesare; Bezerra Espinola, Maria Salomé; Bizzarri, Mariano; Cavalli, Pietro; Colao, Annamaria; D'Anna, Rosario; Vazquez, Monica Hebe; Hernández Marín, Imelda; Kamenov, Zdravko; Laganà, Antonio Simone; Monastra, Giovanni; Montanino Oliva, Mario; Cenk Özay, Ali; Pintaudi, Basilio; Porcaro, Giuseppina; Pustotina, Olga; Pkhaladze, Lali; Prapas, Nikos; Roseff, Scott; Salehpour, Saghar; Stringaro, Annarita; Tugushev, Marat; Unfer, Virginia; Vucenik, Ivana; Facchinetti, Fabio
• Año de publicación: 2024
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: REPRODUCTION; INFERTILITY; INOSITOLS; REVIEW
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

D-Chiro-inositol is a natural molecule that, in association with its well-studied isomer myo-inositol, may play a role in treating various metabolic and gynecological disorders.This perspective seeks to explore the mechanisms and functions of d-chiro-inositol, laying the foundations to discuss its use in clinical practice, across dysmetabolism, obesity, and hormonal dysregulation. A narrative review of all the relevant papers known to the authors was conducted.d-Chiro-inositol acts through a variety of mechanisms, acting as an insulin sensitizer, inhibiting the transcription of aromatase, in addition to modulating white adipose tissue/brown adipose tissue transdifferentiation. These different modes of action have potential applications in a variety of therapeutic fields, including PCOS, dysmetabolism, obesity, hypoestrogenic/hyperandrogenic disorders, and bone health.
Fil: Dinicola, Simona. Experts Group on Inositol in Basic and Clinical Research; Italia. Università degli Studi di Roma "La Sapienza"; Italia
Fil: Unfer, Vittorio. Experts Group on Inositol in Basic and Clinical Research; Italia. Università UniCamillus. Saint Camillus International University of Health and Medical Sciences; Italia
Fil: Soulage, Christophe O.. Experts Group on Inositol in Basic and Clinical Research; Italia. Inserm; Francia. Institut National des Sciences Appliquées de Lyion; Francia. Université Claude Bernard Lyon 1; Francia
Fil: Yap Garcia, Maria Isidora Margarita. Experts Group on Inositol in Basic and Clinical Research; Italia. St. Luke’s Medical Center College of Medicine. William H. Quasha Memorial; Filipinas
Fil: Bevilacqua, Arturo Miguel. Università degli Studi di Roma "La Sapienza"; Italia. Experts Group on Inositol in Basic and Clinical Research; Italia
Fil: Benvenga, Salvatore. Experts Group on Inositol in Basic and Clinical Research; Italia. Università degli Studi di Messina. Dipartimento di Medicina Clinica e Sperimentale; Italia
Fil: Barbaro, Daniele. Experts Group on Inositol in Basic and Clinical Research; Italia. Ospedale di Livorno; Italia
Fil: Wdowiak, Artur. Experts Group on Inositol in Basic and Clinical Research; Italia. Medical University Of Lublin (medical University Of Lublin);
Fil: Nordio, Maurizio. Experts Group on Inositol in Basic and Clinical Research; Italia. Azienda Sanitaria Locale Roma; Italia
Fil: Dewailly, Didier. Experts Group on Inositol in Basic and Clinical Research; Italia. Université de Lille; Francia
Fil: Appetecchia, Marialuisa. Experts Group on Inositol in Basic and Clinical Research; Italia. Istituto Nazionale Tumori Regina Elena; Italia
Fil: Aragona, Cesare. Experts Group on Inositol in Basic and Clinical Research; Italia. Università degli Studi di Roma "La Sapienza"; Italia
Fil: Bezerra Espinola, Maria Salomé. Experts Group on Inositol in Basic and Clinical Research; Italia. Università degli Studi di Roma "La Sapienza"; Italia
Fil: Bizzarri, Mariano. Experts Group on Inositol in Basic and Clinical Research; Italia. Università degli Studi di Roma "La Sapienza"; Italia
Fil: Cavalli, Pietro. Experts Group on Inositol in Basic and Clinical Research; Italia. Istituto di Ricovero e Cura a Carattere Scientifico. Istituto Clinico Humanitas; Italia
Fil: Colao, Annamaria. Experts Group on Inositol in Basic and Clinical Research; Italia. Università degli Studi di Napoli Federico II; Italia
Fil: D'Anna, Rosario. Experts Group on Inositol in Basic and Clinical Research; Italia. Università degli Studi di Messina. Dipartimento di Patologia Umana; Italia
Fil: Vazquez, Monica Hebe. Experts Group on Inositol in Basic and Clinical Research; Italia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Hernández Marín, Imelda. Experts Group on Inositol in Basic and Clinical Research; Italia. Universidad Nacional Autónoma de México; México. Hospital Juarez de México. Departamento de Reproducción Humana; México
Fil: Kamenov, Zdravko. Experts Group on Inositol in Basic and Clinical Research; Italia. University Hospital Alexandrovska; Bulgaria
Fil: Laganà, Antonio Simone. Experts Group on Inositol in Basic and Clinical Research; Italia. Università degli Studi di Palermo; Italia
Fil: Monastra, Giovanni. Experts Group on Inositol in Basic and Clinical Research; Italia
Fil: Montanino Oliva, Mario. Experts Group on Inositol in Basic and Clinical Research; Italia. Servizio Sanitario Regionale. Ospedale Santo Spirito In Sassia; Italia
Fil: Cenk Özay, Ali. Experts Group on Inositol in Basic and Clinical Research; Italia. Cyprus International University; Chipre
Fil: Pintaudi, Basilio. Experts Group on Inositol in Basic and Clinical Research; Italia. ASST Grande Ospedale Metropolitano Niguarda; Italia
Fil: Porcaro, Giuseppina. Experts Group on Inositol in Basic and Clinical Research; Italia. Servicio Sanitario Regionale. USL Umbria 2. Azienda Ospedaliera Universitaria "Santa Maria" Terni, Centro per la salute delle donne; Italia
Fil: Pustotina, Olga. Experts Group on Inositol in Basic and Clinical Research; Italia. Saint Petersburg State University. Faculty of Medicine. Department of Obstetrics and Gynaecology; Rusia
Fil: Pkhaladze, Lali. Experts Group on Inositol in Basic and Clinical Research; Italia. Prof. Zhordania and Prof. Khomasuridze Institute of Reproductology; Georgia
Fil: Prapas, Nikos. Experts Group on Inositol in Basic and Clinical Research; Italia. Aristotle University of Thessaloniki; Grecia. IAKENTRO Fertility Centre; Grecia
Fil: Roseff, Scott. Experts Group on Inositol in Basic and Clinical Research; Italia. South Florida Institute for Reproductive Medicine; Estados Unidos
Fil: Salehpour, Saghar. Experts Group on Inositol in Basic and Clinical Research; Italia. Shahid Beheshti University of Medical Sciences; Irán
Fil: Stringaro, Annarita. Experts Group on Inositol in Basic and Clinical Research; Italia. Istituto Superiore di Sanità; Italia
Fil: Tugushev, Marat. Experts Group on Inositol in Basic and Clinical Research; Italia. Samara University. Samara State Medical University. Department of Reproductive Medicine, Clinical Embryology and Genetics; Rusia
Fil: Unfer, Virginia. Experts Group on Inositol in Basic and Clinical Research; Italia. Università Europea di Roma; Italia
Fil: Vucenik, Ivana. Experts Group on Inositol in Basic and Clinical Research; Italia. University of Maryland; Estados Unidos
Fil: Facchinetti, Fabio. Experts Group on Inositol in Basic and Clinical Research; Italia. Università di Modena e Reggio Emilia; Italia