Bioactive properties of peptides obtained by enzymatic hydrolysis from protein

Autores
Cian, Raúl Esteban; Martínez Augustin, Olga; Drago, Silvina Rosa
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The traditional method to obtain phycocolloids from seaweeds implies successive extraction steps with cold and hot water. The first cold water extract has no phycocolloids but is rich in proteins and is considered a waste. Four hydrolysates were obtained using trypsin, alcalase and a combination of both sequentially added from a first cold water protein extract (PF) derived from Porphyra columbina. PF hydrolysates (PFH) were enriched in peptides with low molecular weight containing Asp, Ala and Glu. Both PF and PFH showed immunosuppressive effects on rat splenocytes as they enhanced IL-10 production while the production of TNFa and IFNg was inhibited. These immunosuppressive effects were higher for PFH. PFH had antihypertensive activity (> 35% of ACE inhibition) and antioxidant capacity (DPPH, TEAC, ORAC and copper-chelating activity). The hydrolysis could be used as a mean to obtain bioactive peptides from algae protein byproducts and to add value to the phycocolloids extraction process.
Fil: Cian, Raúl Esteban. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Martínez Augustin, Olga. Universidad de Granada; España
Fil: Drago, Silvina Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Materia
ACE INHIBITION
ANTIOXIDANT CAPACITY
HYDROLYSATES
IMMUNOMODULATION
RED SEAWEEDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/198201
Acceder
id CONICETDig_eff1511bf348d7f4e04d7a94936c3e17
oai_identifier_str oai:ri.conicet.gov.ar:11336/198201
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Bioactive properties of peptides obtained by enzymatic hydrolysis from proteinCian, Raúl EstebanMartínez Augustin, OlgaDrago, Silvina RosaACE INHIBITIONANTIOXIDANT CAPACITYHYDROLYSATESIMMUNOMODULATIONRED SEAWEEDShttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2The traditional method to obtain phycocolloids from seaweeds implies successive extraction steps with cold and hot water. The first cold water extract has no phycocolloids but is rich in proteins and is considered a waste. Four hydrolysates were obtained using trypsin, alcalase and a combination of both sequentially added from a first cold water protein extract (PF) derived from Porphyra columbina. PF hydrolysates (PFH) were enriched in peptides with low molecular weight containing Asp, Ala and Glu. Both PF and PFH showed immunosuppressive effects on rat splenocytes as they enhanced IL-10 production while the production of TNFa and IFNg was inhibited. These immunosuppressive effects were higher for PFH. PFH had antihypertensive activity (> 35% of ACE inhibition) and antioxidant capacity (DPPH, TEAC, ORAC and copper-chelating activity). The hydrolysis could be used as a mean to obtain bioactive peptides from algae protein byproducts and to add value to the phycocolloids extraction process.Fil: Cian, Raúl Esteban. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Martínez Augustin, Olga. Universidad de Granada; EspañaFil: Drago, Silvina Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaElsevier Science2012-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/198201Cian, Raúl Esteban; Martínez Augustin, Olga; Drago, Silvina Rosa; Bioactive properties of peptides obtained by enzymatic hydrolysis from protein; Elsevier Science; Food Research International; 49; 1; 11-2012; 364-3720963-9969CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0963996912002438info:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodres.2012.07.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T10:53:39Zoai:ri.conicet.gov.ar:11336/198201instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 10:53:39.376CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bioactive properties of peptides obtained by enzymatic hydrolysis from protein
title Bioactive properties of peptides obtained by enzymatic hydrolysis from protein
spellingShingle Bioactive properties of peptides obtained by enzymatic hydrolysis from protein
Cian, Raúl Esteban
ACE INHIBITION
ANTIOXIDANT CAPACITY
HYDROLYSATES
IMMUNOMODULATION
RED SEAWEEDS
title_short Bioactive properties of peptides obtained by enzymatic hydrolysis from protein
title_full Bioactive properties of peptides obtained by enzymatic hydrolysis from protein
title_fullStr Bioactive properties of peptides obtained by enzymatic hydrolysis from protein
title_full_unstemmed Bioactive properties of peptides obtained by enzymatic hydrolysis from protein
title_sort Bioactive properties of peptides obtained by enzymatic hydrolysis from protein
dc.creator.none.fl_str_mv Cian, Raúl Esteban
Martínez Augustin, Olga
Drago, Silvina Rosa
author Cian, Raúl Esteban
author_facet Cian, Raúl Esteban
Martínez Augustin, Olga
Drago, Silvina Rosa
author_role author
author2 Martínez Augustin, Olga
Drago, Silvina Rosa
author2_role author
author
dc.subject.none.fl_str_mv ACE INHIBITION
ANTIOXIDANT CAPACITY
HYDROLYSATES
IMMUNOMODULATION
RED SEAWEEDS
topic ACE INHIBITION
ANTIOXIDANT CAPACITY
HYDROLYSATES
IMMUNOMODULATION
RED SEAWEEDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The traditional method to obtain phycocolloids from seaweeds implies successive extraction steps with cold and hot water. The first cold water extract has no phycocolloids but is rich in proteins and is considered a waste. Four hydrolysates were obtained using trypsin, alcalase and a combination of both sequentially added from a first cold water protein extract (PF) derived from Porphyra columbina. PF hydrolysates (PFH) were enriched in peptides with low molecular weight containing Asp, Ala and Glu. Both PF and PFH showed immunosuppressive effects on rat splenocytes as they enhanced IL-10 production while the production of TNFa and IFNg was inhibited. These immunosuppressive effects were higher for PFH. PFH had antihypertensive activity (> 35% of ACE inhibition) and antioxidant capacity (DPPH, TEAC, ORAC and copper-chelating activity). The hydrolysis could be used as a mean to obtain bioactive peptides from algae protein byproducts and to add value to the phycocolloids extraction process.
Fil: Cian, Raúl Esteban. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Martínez Augustin, Olga. Universidad de Granada; España
Fil: Drago, Silvina Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
description The traditional method to obtain phycocolloids from seaweeds implies successive extraction steps with cold and hot water. The first cold water extract has no phycocolloids but is rich in proteins and is considered a waste. Four hydrolysates were obtained using trypsin, alcalase and a combination of both sequentially added from a first cold water protein extract (PF) derived from Porphyra columbina. PF hydrolysates (PFH) were enriched in peptides with low molecular weight containing Asp, Ala and Glu. Both PF and PFH showed immunosuppressive effects on rat splenocytes as they enhanced IL-10 production while the production of TNFa and IFNg was inhibited. These immunosuppressive effects were higher for PFH. PFH had antihypertensive activity (> 35% of ACE inhibition) and antioxidant capacity (DPPH, TEAC, ORAC and copper-chelating activity). The hydrolysis could be used as a mean to obtain bioactive peptides from algae protein byproducts and to add value to the phycocolloids extraction process.
publishDate 2012
dc.date.none.fl_str_mv 2012-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/198201
Cian, Raúl Esteban; Martínez Augustin, Olga; Drago, Silvina Rosa; Bioactive properties of peptides obtained by enzymatic hydrolysis from protein; Elsevier Science; Food Research International; 49; 1; 11-2012; 364-372
0963-9969
CONICET Digital
CONICET
url http://hdl.handle.net/11336/198201
identifier_str_mv Cian, Raúl Esteban; Martínez Augustin, Olga; Drago, Silvina Rosa; Bioactive properties of peptides obtained by enzymatic hydrolysis from protein; Elsevier Science; Food Research International; 49; 1; 11-2012; 364-372
0963-9969
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0963996912002438
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodres.2012.07.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.000565

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