Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter

Autores
Cuenca, Victor E.; Pedroni, Viviana Isabel; Morini, Marcela Ana
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The present study investigates a multicomponent lipid system that simulates the neuronalgrey matter membrane, employing molecular acoustics as a precise, straightforward, andcost-effective methodology. Given the significance of omega-3 polyunsaturated fatty acids in thefunctionality of cellular membranes, this research examines the effects of reducing 1-palmitoyl-2-docosahexaenoylphosphatylcholine (PDPC) content on the compressibility and elasticity of theproposed membrane under physiological conditions. Our results align with bibliographic data obtainedthrough other techniques, showing that as the proportion of PDPC increases in the grey mattermembrane model, the system’s compressibility decreases, and the membrane’s elasticity increases, asevidenced by the reduction in the bulk modulus. These results could be interpreted in light of theemerging model of lipid rafts, in which esterified DHA infiltrates and remodels their architecture.We contend that the results obtained may serve as a bridge between biophysics and cellular biology.
Fil: Cuenca, Victor E.. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Pedroni, Viviana Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Morini, Marcela Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Materia
MODEL MEMBRANE
GREY MATTER
DOCOSAHEXAENOIC ACID
LIPID RAFT
MOLECULAR ACOUSTIC
ZETA POTENTIAL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/260543
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Role of DHA in a Physicochemical Study of a Model Membrane of Grey MatterCuenca, Victor E.Pedroni, Viviana IsabelMorini, Marcela AnaMODEL MEMBRANEGREY MATTERDOCOSAHEXAENOIC ACIDLIPID RAFTMOLECULAR ACOUSTICZETA POTENTIALhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The present study investigates a multicomponent lipid system that simulates the neuronalgrey matter membrane, employing molecular acoustics as a precise, straightforward, andcost-effective methodology. Given the significance of omega-3 polyunsaturated fatty acids in thefunctionality of cellular membranes, this research examines the effects of reducing 1-palmitoyl-2-docosahexaenoylphosphatylcholine (PDPC) content on the compressibility and elasticity of theproposed membrane under physiological conditions. Our results align with bibliographic data obtainedthrough other techniques, showing that as the proportion of PDPC increases in the grey mattermembrane model, the system’s compressibility decreases, and the membrane’s elasticity increases, asevidenced by the reduction in the bulk modulus. These results could be interpreted in light of theemerging model of lipid rafts, in which esterified DHA infiltrates and remodels their architecture.We contend that the results obtained may serve as a bridge between biophysics and cellular biology.Fil: Cuenca, Victor E.. Universidad Nacional del Sur. Departamento de Química; ArgentinaFil: Pedroni, Viviana Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Morini, Marcela Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaMDPI2024-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/260543Cuenca, Victor E.; Pedroni, Viviana Isabel; Morini, Marcela Ana; Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter; MDPI; Membranes; 14; 12; 12-2024; 256-2732077-0375CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2077-0375/14/12/256info:eu-repo/semantics/altIdentifier/doi/10.3390/membranes14120256info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:11:31Zoai:ri.conicet.gov.ar:11336/260543instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:11:31.563CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter
title Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter
spellingShingle Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter
Cuenca, Victor E.
MODEL MEMBRANE
GREY MATTER
DOCOSAHEXAENOIC ACID
LIPID RAFT
MOLECULAR ACOUSTIC
ZETA POTENTIAL
title_short Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter
title_full Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter
title_fullStr Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter
title_full_unstemmed Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter
title_sort Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter
dc.creator.none.fl_str_mv Cuenca, Victor E.
Pedroni, Viviana Isabel
Morini, Marcela Ana
author Cuenca, Victor E.
author_facet Cuenca, Victor E.
Pedroni, Viviana Isabel
Morini, Marcela Ana
author_role author
author2 Pedroni, Viviana Isabel
Morini, Marcela Ana
author2_role author
author
dc.subject.none.fl_str_mv MODEL MEMBRANE
GREY MATTER
DOCOSAHEXAENOIC ACID
LIPID RAFT
MOLECULAR ACOUSTIC
ZETA POTENTIAL
topic MODEL MEMBRANE
GREY MATTER
DOCOSAHEXAENOIC ACID
LIPID RAFT
MOLECULAR ACOUSTIC
ZETA POTENTIAL
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The present study investigates a multicomponent lipid system that simulates the neuronalgrey matter membrane, employing molecular acoustics as a precise, straightforward, andcost-effective methodology. Given the significance of omega-3 polyunsaturated fatty acids in thefunctionality of cellular membranes, this research examines the effects of reducing 1-palmitoyl-2-docosahexaenoylphosphatylcholine (PDPC) content on the compressibility and elasticity of theproposed membrane under physiological conditions. Our results align with bibliographic data obtainedthrough other techniques, showing that as the proportion of PDPC increases in the grey mattermembrane model, the system’s compressibility decreases, and the membrane’s elasticity increases, asevidenced by the reduction in the bulk modulus. These results could be interpreted in light of theemerging model of lipid rafts, in which esterified DHA infiltrates and remodels their architecture.We contend that the results obtained may serve as a bridge between biophysics and cellular biology.
Fil: Cuenca, Victor E.. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Pedroni, Viviana Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Morini, Marcela Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description The present study investigates a multicomponent lipid system that simulates the neuronalgrey matter membrane, employing molecular acoustics as a precise, straightforward, andcost-effective methodology. Given the significance of omega-3 polyunsaturated fatty acids in thefunctionality of cellular membranes, this research examines the effects of reducing 1-palmitoyl-2-docosahexaenoylphosphatylcholine (PDPC) content on the compressibility and elasticity of theproposed membrane under physiological conditions. Our results align with bibliographic data obtainedthrough other techniques, showing that as the proportion of PDPC increases in the grey mattermembrane model, the system’s compressibility decreases, and the membrane’s elasticity increases, asevidenced by the reduction in the bulk modulus. These results could be interpreted in light of theemerging model of lipid rafts, in which esterified DHA infiltrates and remodels their architecture.We contend that the results obtained may serve as a bridge between biophysics and cellular biology.
publishDate 2024
dc.date.none.fl_str_mv 2024-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/260543
Cuenca, Victor E.; Pedroni, Viviana Isabel; Morini, Marcela Ana; Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter; MDPI; Membranes; 14; 12; 12-2024; 256-273
2077-0375
CONICET Digital
CONICET
url http://hdl.handle.net/11336/260543
identifier_str_mv Cuenca, Victor E.; Pedroni, Viviana Isabel; Morini, Marcela Ana; Role of DHA in a Physicochemical Study of a Model Membrane of Grey Matter; MDPI; Membranes; 14; 12; 12-2024; 256-273
2077-0375
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2077-0375/14/12/256
info:eu-repo/semantics/altIdentifier/doi/10.3390/membranes14120256
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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