Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)

Autores
Ibañez, Agustin Mariano; Urquina Sánchez, Hugo Fernando; Petroni, Agustín; Báez Buitrago, Sandra Jimena; Lopez, Vladimir; Do Nascimento, Micaela; Herrera, Eduar; Guex, Raphael; Hurtado, Esteban; Blenkmann, Alejandro Omar; Beltrachini, Leandro; Gelormini Lezama, Carlos; Sigman, Mariano; Lischinsky, Alicia Graciela; Torralva, Teresa; Torrente, Fernando Manuel; Cetkovich Bakmas, Marcelo Gustavo; Manes, Facundo Francisco
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology/Principal Findings: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face . word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind). Conclusions/Significance: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; Chile
Fil: Urquina Sánchez, Hugo Fernando. Universidad Favaloro; Argentina. Universidad Surcolombiana; Colombia
Fil: Petroni, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Báez Buitrago, Sandra Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Lopez, Vladimir. Universidad Católica de Chile; Chile
Fil: Do Nascimento, Micaela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Herrera, Eduar. Universidad Autónoma del Caribe; Colombia
Fil: Guex, Raphael. University Of Geneva (ug);
Fil: Hurtado, Esteban. Universidad Católica de Chile; Chile
Fil: Blenkmann, Alejandro Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; Argentina. Universidad de Buenos Aires; Argentina
Fil: Beltrachini, Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; Argentina
Fil: Gelormini Lezama, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Lischinsky, Alicia Graciela. Universidad Favaloro; Argentina
Fil: Torralva, Teresa. Universidad Favaloro; Argentina
Fil: Torrente, Fernando Manuel. Universidad Favaloro; Argentina
Fil: Cetkovich Bakmas, Marcelo Gustavo. Universidad Favaloro; Argentina
Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Materia
Bipolar Disorder
Theory of Mind
Neural Processing
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/280555
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)Ibañez, Agustin MarianoUrquina Sánchez, Hugo FernandoPetroni, AgustínBáez Buitrago, Sandra JimenaLopez, VladimirDo Nascimento, MicaelaHerrera, EduarGuex, RaphaelHurtado, EstebanBlenkmann, Alejandro OmarBeltrachini, LeandroGelormini Lezama, CarlosSigman, MarianoLischinsky, Alicia GracielaTorralva, TeresaTorrente, Fernando ManuelCetkovich Bakmas, Marcelo GustavoManes, Facundo FranciscoBipolar DisorderTheory of MindNeural Processinghttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology/Principal Findings: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face . word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind). Conclusions/Significance: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; ChileFil: Urquina Sánchez, Hugo Fernando. Universidad Favaloro; Argentina. Universidad Surcolombiana; ColombiaFil: Petroni, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Báez Buitrago, Sandra Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; ArgentinaFil: Lopez, Vladimir. Universidad Católica de Chile; ChileFil: Do Nascimento, Micaela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Herrera, Eduar. Universidad Autónoma del Caribe; ColombiaFil: Guex, Raphael. University Of Geneva (ug);Fil: Hurtado, Esteban. Universidad Católica de Chile; ChileFil: Blenkmann, Alejandro Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; Argentina. Universidad de Buenos Aires; ArgentinaFil: Beltrachini, Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; ArgentinaFil: Gelormini Lezama, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Lischinsky, Alicia Graciela. Universidad Favaloro; ArgentinaFil: Torralva, Teresa. Universidad Favaloro; ArgentinaFil: Torrente, Fernando Manuel. Universidad Favaloro; ArgentinaFil: Cetkovich Bakmas, Marcelo Gustavo. Universidad Favaloro; ArgentinaFil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaPublic Library of Science2012-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/280555Ibañez, Agustin Mariano; Urquina Sánchez, Hugo Fernando; Petroni, Agustín; Báez Buitrago, Sandra Jimena; Lopez, Vladimir; et al.; Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM); Public Library of Science; Plos One; 7; 10; 10-2012; 1-121932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046877info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0046877info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:30:26Zoai:ri.conicet.gov.ar:11336/280555instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:30:26.69CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)
title Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)
spellingShingle Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)
Ibañez, Agustin Mariano
Bipolar Disorder
Theory of Mind
Neural Processing
title_short Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)
title_full Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)
title_fullStr Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)
title_full_unstemmed Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)
title_sort Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)
dc.creator.none.fl_str_mv Ibañez, Agustin Mariano
Urquina Sánchez, Hugo Fernando
Petroni, Agustín
Báez Buitrago, Sandra Jimena
Lopez, Vladimir
Do Nascimento, Micaela
Herrera, Eduar
Guex, Raphael
Hurtado, Esteban
Blenkmann, Alejandro Omar
Beltrachini, Leandro
Gelormini Lezama, Carlos
Sigman, Mariano
Lischinsky, Alicia Graciela
Torralva, Teresa
Torrente, Fernando Manuel
Cetkovich Bakmas, Marcelo Gustavo
Manes, Facundo Francisco
author Ibañez, Agustin Mariano
author_facet Ibañez, Agustin Mariano
Urquina Sánchez, Hugo Fernando
Petroni, Agustín
Báez Buitrago, Sandra Jimena
Lopez, Vladimir
Do Nascimento, Micaela
Herrera, Eduar
Guex, Raphael
Hurtado, Esteban
Blenkmann, Alejandro Omar
Beltrachini, Leandro
Gelormini Lezama, Carlos
Sigman, Mariano
Lischinsky, Alicia Graciela
Torralva, Teresa
Torrente, Fernando Manuel
Cetkovich Bakmas, Marcelo Gustavo
Manes, Facundo Francisco
author_role author
author2 Urquina Sánchez, Hugo Fernando
Petroni, Agustín
Báez Buitrago, Sandra Jimena
Lopez, Vladimir
Do Nascimento, Micaela
Herrera, Eduar
Guex, Raphael
Hurtado, Esteban
Blenkmann, Alejandro Omar
Beltrachini, Leandro
Gelormini Lezama, Carlos
Sigman, Mariano
Lischinsky, Alicia Graciela
Torralva, Teresa
Torrente, Fernando Manuel
Cetkovich Bakmas, Marcelo Gustavo
Manes, Facundo Francisco
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bipolar Disorder
Theory of Mind
Neural Processing
topic Bipolar Disorder
Theory of Mind
Neural Processing
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology/Principal Findings: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face . word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind). Conclusions/Significance: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; Chile
Fil: Urquina Sánchez, Hugo Fernando. Universidad Favaloro; Argentina. Universidad Surcolombiana; Colombia
Fil: Petroni, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Báez Buitrago, Sandra Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Lopez, Vladimir. Universidad Católica de Chile; Chile
Fil: Do Nascimento, Micaela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Herrera, Eduar. Universidad Autónoma del Caribe; Colombia
Fil: Guex, Raphael. University Of Geneva (ug);
Fil: Hurtado, Esteban. Universidad Católica de Chile; Chile
Fil: Blenkmann, Alejandro Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; Argentina. Universidad de Buenos Aires; Argentina
Fil: Beltrachini, Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; Argentina
Fil: Gelormini Lezama, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Lischinsky, Alicia Graciela. Universidad Favaloro; Argentina
Fil: Torralva, Teresa. Universidad Favaloro; Argentina
Fil: Torrente, Fernando Manuel. Universidad Favaloro; Argentina
Fil: Cetkovich Bakmas, Marcelo Gustavo. Universidad Favaloro; Argentina
Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
description Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology/Principal Findings: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face . word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind). Conclusions/Significance: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.
publishDate 2012
dc.date.none.fl_str_mv 2012-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/280555
Ibañez, Agustin Mariano; Urquina Sánchez, Hugo Fernando; Petroni, Agustín; Báez Buitrago, Sandra Jimena; Lopez, Vladimir; et al.; Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM); Public Library of Science; Plos One; 7; 10; 10-2012; 1-12
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/280555
identifier_str_mv Ibañez, Agustin Mariano; Urquina Sánchez, Hugo Fernando; Petroni, Agustín; Báez Buitrago, Sandra Jimena; Lopez, Vladimir; et al.; Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM); Public Library of Science; Plos One; 7; 10; 10-2012; 1-12
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0046877
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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