Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis

Autores
Acquier, Andrea Beatriz; de Couto Pita, Alejandra Karina; Busch, Lucila; Sanchez, Gabriel A.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: Free radicals play an important role in the onset and progression of many diseases. The aim ofthis study was to investigate the contribution of oxidative stress in the pathology of aggressive (AgP) andchronic (CP) periodontitis and its relation with the clinical periodontal status.Methods: Eighty subjects were divided into two groups: 20 patients with AgP and 20 patients with CP withtheir 20 corresponding matched controls, based on clinical attachment loss (CAL), probing pocket depth(PPD), and bleeding on probing (BOP). Saliva reactive oxygen species (ROS), lipid peroxidation, and nonenzymaticantioxidant defences were measured by luminol-dependent chemiluminescence assay, asthiobarbituric acid-reactive substances (TBARs) and total radical-trapping antioxidant potential (TRAP),respectively. Pearson?s correlation and multivariate analysis were used to determine the relationshipbetween ROS and TBARs and the clinical parameters.Results: ROS and TBARs were increased in AgP while TRAP was decreased, comparing with CP. In AgP, astrong and positive correlation was observed between ROS and TBARs and they were closely associatedwith CAL and PPD.Discussion: In AgP, but not in CP, oxidative stress is a high contributor to periodontal pathology and it isclosely associated with the clinical periodontal status.
Fil: Acquier, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: de Couto Pita, Alejandra Karina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Busch, Lucila. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Sanchez, Gabriel A.. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Biofísica; Argentina
Materia
Oxidative Stress
ROS
TRAP
TBARs
Aggressive periodontitis
Chronic periodontitis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/48577
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/48577
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitisAcquier, Andrea Beatrizde Couto Pita, Alejandra KarinaBusch, LucilaSanchez, Gabriel A.Oxidative StressROSTRAPTBARsAggressive periodontitisChronic periodontitishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objectives: Free radicals play an important role in the onset and progression of many diseases. The aim ofthis study was to investigate the contribution of oxidative stress in the pathology of aggressive (AgP) andchronic (CP) periodontitis and its relation with the clinical periodontal status.Methods: Eighty subjects were divided into two groups: 20 patients with AgP and 20 patients with CP withtheir 20 corresponding matched controls, based on clinical attachment loss (CAL), probing pocket depth(PPD), and bleeding on probing (BOP). Saliva reactive oxygen species (ROS), lipid peroxidation, and nonenzymaticantioxidant defences were measured by luminol-dependent chemiluminescence assay, asthiobarbituric acid-reactive substances (TBARs) and total radical-trapping antioxidant potential (TRAP),respectively. Pearson?s correlation and multivariate analysis were used to determine the relationshipbetween ROS and TBARs and the clinical parameters.Results: ROS and TBARs were increased in AgP while TRAP was decreased, comparing with CP. In AgP, astrong and positive correlation was observed between ROS and TBARs and they were closely associatedwith CAL and PPD.Discussion: In AgP, but not in CP, oxidative stress is a high contributor to periodontal pathology and it isclosely associated with the clinical periodontal status.Fil: Acquier, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: de Couto Pita, Alejandra Karina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; ArgentinaFil: Busch, Lucila. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; ArgentinaFil: Sanchez, Gabriel A.. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Biofísica; ArgentinaManey Publishing2016-06-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48577Acquier, Andrea Beatriz; de Couto Pita, Alejandra Karina; Busch, Lucila; Sanchez, Gabriel A.; Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis; Maney Publishing; Redox Report; 22; 3; 20-6-2016; 119-1261351-00021743-2928CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/13510002.2016.1198104info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/13510002.2016.1198104?scroll=top&needAccess=trueinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:17Zoai:ri.conicet.gov.ar:11336/48577instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:17.853CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis
title Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis
spellingShingle Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis
Acquier, Andrea Beatriz
Oxidative Stress
ROS
TRAP
TBARs
Aggressive periodontitis
Chronic periodontitis
title_short Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis
title_full Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis
title_fullStr Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis
title_full_unstemmed Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis
title_sort Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis
dc.creator.none.fl_str_mv Acquier, Andrea Beatriz
de Couto Pita, Alejandra Karina
Busch, Lucila
Sanchez, Gabriel A.
author Acquier, Andrea Beatriz
author_facet Acquier, Andrea Beatriz
de Couto Pita, Alejandra Karina
Busch, Lucila
Sanchez, Gabriel A.
author_role author
author2 de Couto Pita, Alejandra Karina
Busch, Lucila
Sanchez, Gabriel A.
author2_role author
author
author
dc.subject.none.fl_str_mv Oxidative Stress
ROS
TRAP
TBARs
Aggressive periodontitis
Chronic periodontitis
topic Oxidative Stress
ROS
TRAP
TBARs
Aggressive periodontitis
Chronic periodontitis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Objectives: Free radicals play an important role in the onset and progression of many diseases. The aim ofthis study was to investigate the contribution of oxidative stress in the pathology of aggressive (AgP) andchronic (CP) periodontitis and its relation with the clinical periodontal status.Methods: Eighty subjects were divided into two groups: 20 patients with AgP and 20 patients with CP withtheir 20 corresponding matched controls, based on clinical attachment loss (CAL), probing pocket depth(PPD), and bleeding on probing (BOP). Saliva reactive oxygen species (ROS), lipid peroxidation, and nonenzymaticantioxidant defences were measured by luminol-dependent chemiluminescence assay, asthiobarbituric acid-reactive substances (TBARs) and total radical-trapping antioxidant potential (TRAP),respectively. Pearson?s correlation and multivariate analysis were used to determine the relationshipbetween ROS and TBARs and the clinical parameters.Results: ROS and TBARs were increased in AgP while TRAP was decreased, comparing with CP. In AgP, astrong and positive correlation was observed between ROS and TBARs and they were closely associatedwith CAL and PPD.Discussion: In AgP, but not in CP, oxidative stress is a high contributor to periodontal pathology and it isclosely associated with the clinical periodontal status.
Fil: Acquier, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: de Couto Pita, Alejandra Karina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Busch, Lucila. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Sanchez, Gabriel A.. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Biofísica; Argentina
description Objectives: Free radicals play an important role in the onset and progression of many diseases. The aim ofthis study was to investigate the contribution of oxidative stress in the pathology of aggressive (AgP) andchronic (CP) periodontitis and its relation with the clinical periodontal status.Methods: Eighty subjects were divided into two groups: 20 patients with AgP and 20 patients with CP withtheir 20 corresponding matched controls, based on clinical attachment loss (CAL), probing pocket depth(PPD), and bleeding on probing (BOP). Saliva reactive oxygen species (ROS), lipid peroxidation, and nonenzymaticantioxidant defences were measured by luminol-dependent chemiluminescence assay, asthiobarbituric acid-reactive substances (TBARs) and total radical-trapping antioxidant potential (TRAP),respectively. Pearson?s correlation and multivariate analysis were used to determine the relationshipbetween ROS and TBARs and the clinical parameters.Results: ROS and TBARs were increased in AgP while TRAP was decreased, comparing with CP. In AgP, astrong and positive correlation was observed between ROS and TBARs and they were closely associatedwith CAL and PPD.Discussion: In AgP, but not in CP, oxidative stress is a high contributor to periodontal pathology and it isclosely associated with the clinical periodontal status.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-20
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/48577
Acquier, Andrea Beatriz; de Couto Pita, Alejandra Karina; Busch, Lucila; Sanchez, Gabriel A.; Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis; Maney Publishing; Redox Report; 22; 3; 20-6-2016; 119-126
1351-0002
1743-2928
CONICET Digital
CONICET
url http://hdl.handle.net/11336/48577
identifier_str_mv Acquier, Andrea Beatriz; de Couto Pita, Alejandra Karina; Busch, Lucila; Sanchez, Gabriel A.; Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis; Maney Publishing; Redox Report; 22; 3; 20-6-2016; 119-126
1351-0002
1743-2928
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/13510002.2016.1198104
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/13510002.2016.1198104?scroll=top&needAccess=true
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Maney Publishing
publisher.none.fl_str_mv Maney Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269513877291008
score 13.13397

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