Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice

Autores
Alvarez, Gladis Susana; Herrero, Claudia; Bru Chauve, Elena Magdalena; Perdigon, Gabriela del Valle
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pseudomonas aeruginosa is an opportunistic pathogen that rarely causes pulmonary disease in normal hosts but one that is an important cause of acute pneumonia in immunocompromised patients, including neonates, and of chronic pneumonia in patients with cystic fibrosis. The aim of this work was to study the effect of oral administration of Lactobacillus casei and yogurt on prevention of P. aeruginosa lung infection in young mice (3 weeks old). This study demonstrates that oral administration of L. casei or yogurt to young mice enhanced lung clearance of P. aeruginosa and phagocytic activity of alveolar macrophages through a dose-dependent effect. There were, however, no significant differences in white blood cell (WBC) differential counts. Furthermore, it was observed that previous administration of L. casei or yogurt induced a significant increase in IgA and IgM levels in bronchoalveolar lavages (BALs) after a P. aeruginosa infection, although there was no relationship with the serum values.
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
Fil: Herrero, Claudia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Bru Chauve, Elena Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Materia
Pseudomona Aeruginosa
Pathogen
Pulmonary Disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55019
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young miceAlvarez, Gladis SusanaHerrero, ClaudiaBru Chauve, Elena MagdalenaPerdigon, Gabriela del VallePseudomona AeruginosaPathogenPulmonary Diseasehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Pseudomonas aeruginosa is an opportunistic pathogen that rarely causes pulmonary disease in normal hosts but one that is an important cause of acute pneumonia in immunocompromised patients, including neonates, and of chronic pneumonia in patients with cystic fibrosis. The aim of this work was to study the effect of oral administration of Lactobacillus casei and yogurt on prevention of P. aeruginosa lung infection in young mice (3 weeks old). This study demonstrates that oral administration of L. casei or yogurt to young mice enhanced lung clearance of P. aeruginosa and phagocytic activity of alveolar macrophages through a dose-dependent effect. There were, however, no significant differences in white blood cell (WBC) differential counts. Furthermore, it was observed that previous administration of L. casei or yogurt induced a significant increase in IgA and IgM levels in bronchoalveolar lavages (BALs) after a P. aeruginosa infection, although there was no relationship with the serum values.Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; ArgentinaFil: Herrero, Claudia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Bru Chauve, Elena Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaInt Assoc Food Protection2001-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55019Alvarez, Gladis Susana; Herrero, Claudia; Bru Chauve, Elena Magdalena; Perdigon, Gabriela del Valle; Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice; Int Assoc Food Protection; Journal of Food Protection; 64; 11; 11-2001; 1768-17740362-028X1944-9097CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jfoodprotection.org/doi/pdf/10.4315/0362-028X-64.11.1768info:eu-repo/semantics/altIdentifier/url/http://jfoodprotection.org/toc/food/64/11info:eu-repo/semantics/altIdentifier/doi/10.4315/0362-028X-64.11.1768info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:14:29Zoai:ri.conicet.gov.ar:11336/55019instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:14:29.873CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice
title Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice
spellingShingle Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice
Alvarez, Gladis Susana
Pseudomona Aeruginosa
Pathogen
Pulmonary Disease
title_short Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice
title_full Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice
title_fullStr Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice
title_full_unstemmed Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice
title_sort Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice
dc.creator.none.fl_str_mv Alvarez, Gladis Susana
Herrero, Claudia
Bru Chauve, Elena Magdalena
Perdigon, Gabriela del Valle
author Alvarez, Gladis Susana
author_facet Alvarez, Gladis Susana
Herrero, Claudia
Bru Chauve, Elena Magdalena
Perdigon, Gabriela del Valle
author_role author
author2 Herrero, Claudia
Bru Chauve, Elena Magdalena
Perdigon, Gabriela del Valle
author2_role author
author
author
dc.subject.none.fl_str_mv Pseudomona Aeruginosa
Pathogen
Pulmonary Disease
topic Pseudomona Aeruginosa
Pathogen
Pulmonary Disease
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Pseudomonas aeruginosa is an opportunistic pathogen that rarely causes pulmonary disease in normal hosts but one that is an important cause of acute pneumonia in immunocompromised patients, including neonates, and of chronic pneumonia in patients with cystic fibrosis. The aim of this work was to study the effect of oral administration of Lactobacillus casei and yogurt on prevention of P. aeruginosa lung infection in young mice (3 weeks old). This study demonstrates that oral administration of L. casei or yogurt to young mice enhanced lung clearance of P. aeruginosa and phagocytic activity of alveolar macrophages through a dose-dependent effect. There were, however, no significant differences in white blood cell (WBC) differential counts. Furthermore, it was observed that previous administration of L. casei or yogurt induced a significant increase in IgA and IgM levels in bronchoalveolar lavages (BALs) after a P. aeruginosa infection, although there was no relationship with the serum values.
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
Fil: Herrero, Claudia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Bru Chauve, Elena Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
description Pseudomonas aeruginosa is an opportunistic pathogen that rarely causes pulmonary disease in normal hosts but one that is an important cause of acute pneumonia in immunocompromised patients, including neonates, and of chronic pneumonia in patients with cystic fibrosis. The aim of this work was to study the effect of oral administration of Lactobacillus casei and yogurt on prevention of P. aeruginosa lung infection in young mice (3 weeks old). This study demonstrates that oral administration of L. casei or yogurt to young mice enhanced lung clearance of P. aeruginosa and phagocytic activity of alveolar macrophages through a dose-dependent effect. There were, however, no significant differences in white blood cell (WBC) differential counts. Furthermore, it was observed that previous administration of L. casei or yogurt induced a significant increase in IgA and IgM levels in bronchoalveolar lavages (BALs) after a P. aeruginosa infection, although there was no relationship with the serum values.
publishDate 2001
dc.date.none.fl_str_mv 2001-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55019
Alvarez, Gladis Susana; Herrero, Claudia; Bru Chauve, Elena Magdalena; Perdigon, Gabriela del Valle; Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice; Int Assoc Food Protection; Journal of Food Protection; 64; 11; 11-2001; 1768-1774
0362-028X
1944-9097
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55019
identifier_str_mv Alvarez, Gladis Susana; Herrero, Claudia; Bru Chauve, Elena Magdalena; Perdigon, Gabriela del Valle; Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice; Int Assoc Food Protection; Journal of Food Protection; 64; 11; 11-2001; 1768-1774
0362-028X
1944-9097
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://jfoodprotection.org/doi/pdf/10.4315/0362-028X-64.11.1768
info:eu-repo/semantics/altIdentifier/url/http://jfoodprotection.org/toc/food/64/11
info:eu-repo/semantics/altIdentifier/doi/10.4315/0362-028X-64.11.1768
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Int Assoc Food Protection
publisher.none.fl_str_mv Int Assoc Food Protection
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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