Gravity and Telomeres

Autores
Aquilano, Roberto Oscar; Blasco, M
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Telomere shortening is a well-known process that is proposed to influence the pace of aging in every living being. On the other hand, telomere lengthening seems to be restricted to pluripotent cells and adult stem cell population, and it is mainly mediated by the enzyme telomerase. However, how is telomerase activation regulated in these compartments is largely unknown. Telomerase is also aberrantly upregulated in the vast majority of cancer cell where it allows for indefinite cell division. In previous papers, it has been put forth that time asymmetry is important to understand the cellular world, especially stem cells and cancer. This process could also be the cause of the telomerase activation and the corresponding telomere lengthening, but this stress mechanism described in the aforementioned articles could be extended to changes produced by the effects of gravity and the lack of gravity (weightlessness). This paper intends to expand on those previous papers.
Fil: Aquilano, Roberto Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; Argentina
Materia
Asymmetry of time
Cells
Molecular
Gravitation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/93975
Acceder
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spelling Gravity and TelomeresAquilano, Roberto OscarBlasco, MAsymmetry of timeCellsMolecularGravitationhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Telomere shortening is a well-known process that is proposed to influence the pace of aging in every living being. On the other hand, telomere lengthening seems to be restricted to pluripotent cells and adult stem cell population, and it is mainly mediated by the enzyme telomerase. However, how is telomerase activation regulated in these compartments is largely unknown. Telomerase is also aberrantly upregulated in the vast majority of cancer cell where it allows for indefinite cell division. In previous papers, it has been put forth that time asymmetry is important to understand the cellular world, especially stem cells and cancer. This process could also be the cause of the telomerase activation and the corresponding telomere lengthening, but this stress mechanism described in the aforementioned articles could be extended to changes produced by the effects of gravity and the lack of gravity (weightlessness). This paper intends to expand on those previous papers.Fil: Aquilano, Roberto Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaAustin Publishing Group2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93975Aquilano, Roberto Oscar; Blasco, M; Gravity and Telomeres; Austin Publishing Group; Austin Biochemistry; 3; 1019; 8-2018; 1-32578-9481CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.austinpublishinggroup.com/biochemistry/fulltext/biochemistry-v3-id1019.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:44Zoai:ri.conicet.gov.ar:11336/93975instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:44.904CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gravity and Telomeres
title Gravity and Telomeres
spellingShingle Gravity and Telomeres
Aquilano, Roberto Oscar
Asymmetry of time
Cells
Molecular
Gravitation
title_short Gravity and Telomeres
title_full Gravity and Telomeres
title_fullStr Gravity and Telomeres
title_full_unstemmed Gravity and Telomeres
title_sort Gravity and Telomeres
dc.creator.none.fl_str_mv Aquilano, Roberto Oscar
Blasco, M
author Aquilano, Roberto Oscar
author_facet Aquilano, Roberto Oscar
Blasco, M
author_role author
author2 Blasco, M
author2_role author
dc.subject.none.fl_str_mv Asymmetry of time
Cells
Molecular
Gravitation
topic Asymmetry of time
Cells
Molecular
Gravitation
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Telomere shortening is a well-known process that is proposed to influence the pace of aging in every living being. On the other hand, telomere lengthening seems to be restricted to pluripotent cells and adult stem cell population, and it is mainly mediated by the enzyme telomerase. However, how is telomerase activation regulated in these compartments is largely unknown. Telomerase is also aberrantly upregulated in the vast majority of cancer cell where it allows for indefinite cell division. In previous papers, it has been put forth that time asymmetry is important to understand the cellular world, especially stem cells and cancer. This process could also be the cause of the telomerase activation and the corresponding telomere lengthening, but this stress mechanism described in the aforementioned articles could be extended to changes produced by the effects of gravity and the lack of gravity (weightlessness). This paper intends to expand on those previous papers.
Fil: Aquilano, Roberto Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; Argentina
description Telomere shortening is a well-known process that is proposed to influence the pace of aging in every living being. On the other hand, telomere lengthening seems to be restricted to pluripotent cells and adult stem cell population, and it is mainly mediated by the enzyme telomerase. However, how is telomerase activation regulated in these compartments is largely unknown. Telomerase is also aberrantly upregulated in the vast majority of cancer cell where it allows for indefinite cell division. In previous papers, it has been put forth that time asymmetry is important to understand the cellular world, especially stem cells and cancer. This process could also be the cause of the telomerase activation and the corresponding telomere lengthening, but this stress mechanism described in the aforementioned articles could be extended to changes produced by the effects of gravity and the lack of gravity (weightlessness). This paper intends to expand on those previous papers.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93975
Aquilano, Roberto Oscar; Blasco, M; Gravity and Telomeres; Austin Publishing Group; Austin Biochemistry; 3; 1019; 8-2018; 1-3
2578-9481
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93975
identifier_str_mv Aquilano, Roberto Oscar; Blasco, M; Gravity and Telomeres; Austin Publishing Group; Austin Biochemistry; 3; 1019; 8-2018; 1-3
2578-9481
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.austinpublishinggroup.com/biochemistry/fulltext/biochemistry-v3-id1019.php
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Austin Publishing Group
publisher.none.fl_str_mv Austin Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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