Can we heal Chagas infection?

Autores
Vega Royero, Shirlene Patricia; Sibona, Gustavo Javier
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We present a model for the parasite-antibody dynamical competition between Trypanosoma rangeli and its antibodies during the acute phase of an infection in a mammal host. The model reproduces experimental data from murine models found in the literature and allows us to demonstrate that a preinfection with T. rangeli induces a temporary protective effect against Chagas disease. As the mammal immune system is able to eliminate a single T. rangeli infection, the host high antibody levels, needed to resist the Chagas infection, are reduced with time, returning the system to the initial healthy state. Our results suggest that a preinfection with T. rangeli could be used to reduce the in-house vectorial parasitemia through repeated vaccination of domestic animals.
Fil: Vega Royero, Shirlene Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Sibona, Gustavo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Materia
CHAGAS DISEASE
MATHEMATICAL MODELING
TRYPANOSOMA CRUZI
TRYPANOSOMA RANGELI
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/185841
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Can we heal Chagas infection?Vega Royero, Shirlene PatriciaSibona, Gustavo JavierCHAGAS DISEASEMATHEMATICAL MODELINGTRYPANOSOMA CRUZITRYPANOSOMA RANGELIhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1We present a model for the parasite-antibody dynamical competition between Trypanosoma rangeli and its antibodies during the acute phase of an infection in a mammal host. The model reproduces experimental data from murine models found in the literature and allows us to demonstrate that a preinfection with T. rangeli induces a temporary protective effect against Chagas disease. As the mammal immune system is able to eliminate a single T. rangeli infection, the host high antibody levels, needed to resist the Chagas infection, are reduced with time, returning the system to the initial healthy state. Our results suggest that a preinfection with T. rangeli could be used to reduce the in-house vectorial parasitemia through repeated vaccination of domestic animals.Fil: Vega Royero, Shirlene Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Sibona, Gustavo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaAcademic Press Ltd - Elsevier Science Ltd2014-01-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/185841Vega Royero, Shirlene Patricia; Sibona, Gustavo Javier; Can we heal Chagas infection?; Academic Press Ltd - Elsevier Science Ltd; Journal of Theoretical Biology; 340; 7-1-2014; 23-290022-51931095-8541CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022519313004232info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jtbi.2013.09.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:04:31Zoai:ri.conicet.gov.ar:11336/185841instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:04:31.504CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Can we heal Chagas infection?
title Can we heal Chagas infection?
spellingShingle Can we heal Chagas infection?
Vega Royero, Shirlene Patricia
CHAGAS DISEASE
MATHEMATICAL MODELING
TRYPANOSOMA CRUZI
TRYPANOSOMA RANGELI
title_short Can we heal Chagas infection?
title_full Can we heal Chagas infection?
title_fullStr Can we heal Chagas infection?
title_full_unstemmed Can we heal Chagas infection?
title_sort Can we heal Chagas infection?
dc.creator.none.fl_str_mv Vega Royero, Shirlene Patricia
Sibona, Gustavo Javier
author Vega Royero, Shirlene Patricia
author_facet Vega Royero, Shirlene Patricia
Sibona, Gustavo Javier
author_role author
author2 Sibona, Gustavo Javier
author2_role author
dc.subject.none.fl_str_mv CHAGAS DISEASE
MATHEMATICAL MODELING
TRYPANOSOMA CRUZI
TRYPANOSOMA RANGELI
topic CHAGAS DISEASE
MATHEMATICAL MODELING
TRYPANOSOMA CRUZI
TRYPANOSOMA RANGELI
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We present a model for the parasite-antibody dynamical competition between Trypanosoma rangeli and its antibodies during the acute phase of an infection in a mammal host. The model reproduces experimental data from murine models found in the literature and allows us to demonstrate that a preinfection with T. rangeli induces a temporary protective effect against Chagas disease. As the mammal immune system is able to eliminate a single T. rangeli infection, the host high antibody levels, needed to resist the Chagas infection, are reduced with time, returning the system to the initial healthy state. Our results suggest that a preinfection with T. rangeli could be used to reduce the in-house vectorial parasitemia through repeated vaccination of domestic animals.
Fil: Vega Royero, Shirlene Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Sibona, Gustavo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
description We present a model for the parasite-antibody dynamical competition between Trypanosoma rangeli and its antibodies during the acute phase of an infection in a mammal host. The model reproduces experimental data from murine models found in the literature and allows us to demonstrate that a preinfection with T. rangeli induces a temporary protective effect against Chagas disease. As the mammal immune system is able to eliminate a single T. rangeli infection, the host high antibody levels, needed to resist the Chagas infection, are reduced with time, returning the system to the initial healthy state. Our results suggest that a preinfection with T. rangeli could be used to reduce the in-house vectorial parasitemia through repeated vaccination of domestic animals.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/185841
Vega Royero, Shirlene Patricia; Sibona, Gustavo Javier; Can we heal Chagas infection?; Academic Press Ltd - Elsevier Science Ltd; Journal of Theoretical Biology; 340; 7-1-2014; 23-29
0022-5193
1095-8541
CONICET Digital
CONICET
url http://hdl.handle.net/11336/185841
identifier_str_mv Vega Royero, Shirlene Patricia; Sibona, Gustavo Javier; Can we heal Chagas infection?; Academic Press Ltd - Elsevier Science Ltd; Journal of Theoretical Biology; 340; 7-1-2014; 23-29
0022-5193
1095-8541
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022519313004232
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jtbi.2013.09.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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