Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus

Autores
Acosta , Helena; Lopez, Silvia Liliana; Revinski, Diego Raul; Carrasco, Andres Eduardo
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and alsocontains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of β-catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises β-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain. © 2011. Published by The Company of Biologists Ltd.
Fil: Acosta , Helena. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina
Fil: Lopez, Silvia Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina
Fil: Revinski, Diego Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina
Fil: Carrasco, Andres Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina
Materia
Β-CATENIN
BCNE
BRAIN
DORSAL-ANTERIOR DEVELOPMENT
NOTCH
XENOPUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67259
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/67259
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Notch destabilises maternal β-catenin and restricts dorsal-anterior development in XenopusAcosta , HelenaLopez, Silvia LilianaRevinski, Diego RaulCarrasco, Andres EduardoΒ-CATENINBCNEBRAINDORSAL-ANTERIOR DEVELOPMENTNOTCHXENOPUShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and alsocontains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of β-catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises β-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain. © 2011. Published by The Company of Biologists Ltd.Fil: Acosta , Helena. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; ArgentinaFil: Lopez, Silvia Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Revinski, Diego Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Carrasco, Andres Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; ArgentinaCompany of Biologists2011-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67259Acosta , Helena; Lopez, Silvia Liliana; Revinski, Diego Raul; Carrasco, Andres Eduardo; Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus; Company of Biologists; Development; 138; 12; 6-2011; 2567-25790950-1991CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1242/dev.061143info:eu-repo/semantics/altIdentifier/url/http://dev.biologists.org/content/138/12/2567info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:34:03Zoai:ri.conicet.gov.ar:11336/67259instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:34:03.806CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus
title Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus
spellingShingle Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus
Acosta , Helena
Β-CATENIN
BCNE
BRAIN
DORSAL-ANTERIOR DEVELOPMENT
NOTCH
XENOPUS
title_short Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus
title_full Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus
title_fullStr Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus
title_full_unstemmed Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus
title_sort Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus
dc.creator.none.fl_str_mv Acosta , Helena
Lopez, Silvia Liliana
Revinski, Diego Raul
Carrasco, Andres Eduardo
author Acosta , Helena
author_facet Acosta , Helena
Lopez, Silvia Liliana
Revinski, Diego Raul
Carrasco, Andres Eduardo
author_role author
author2 Lopez, Silvia Liliana
Revinski, Diego Raul
Carrasco, Andres Eduardo
author2_role author
author
author
dc.subject.none.fl_str_mv Β-CATENIN
BCNE
BRAIN
DORSAL-ANTERIOR DEVELOPMENT
NOTCH
XENOPUS
topic Β-CATENIN
BCNE
BRAIN
DORSAL-ANTERIOR DEVELOPMENT
NOTCH
XENOPUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and alsocontains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of β-catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises β-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain. © 2011. Published by The Company of Biologists Ltd.
Fil: Acosta , Helena. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina
Fil: Lopez, Silvia Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina
Fil: Revinski, Diego Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina
Fil: Carrasco, Andres Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina
description The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and alsocontains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of β-catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises β-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain. © 2011. Published by The Company of Biologists Ltd.
publishDate 2011
dc.date.none.fl_str_mv 2011-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67259
Acosta , Helena; Lopez, Silvia Liliana; Revinski, Diego Raul; Carrasco, Andres Eduardo; Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus; Company of Biologists; Development; 138; 12; 6-2011; 2567-2579
0950-1991
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67259
identifier_str_mv Acosta , Helena; Lopez, Silvia Liliana; Revinski, Diego Raul; Carrasco, Andres Eduardo; Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus; Company of Biologists; Development; 138; 12; 6-2011; 2567-2579
0950-1991
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1242/dev.061143
info:eu-repo/semantics/altIdentifier/url/http://dev.biologists.org/content/138/12/2567
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1848597097854533632
score 12.976206

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