Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performance

Autores
Llabot, Juan Manuel; Manzo, Ruben Hilario; Allemandi, Daniel Alberto
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mucoadhesive tablets containing nystatin (10 mg) were evaluated in vivo. The assays were carried out with 12 healthy volunteers and the concentration of nystatin in saliva was determined at different times. Tablets remained attached to the buccal mucosa during 270 min ± 30 min. No evidence of ulceration or bleeding was observed. Typical appearance of intact human buccal mucosa was seen before and after contact with the tablet. The tablets were well accepted by the volunteers, although most of the volunteers reported a light bitter taste, probably due to nystatin. Concentration of nystatin in saliva was several times higher than MIC over a period of approximately 4.5 h, which was in agreement with the behavior observed in vitro. These results allow us to infer that the administration of these mucoadhesive tablets could be advantageous compared to conventional formulations and mucoadhesive extended-release tablets might produce better therapeutic performance than conventional formulations in the treatment of oral candidosis.
Fil: Llabot, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Materia
BIOAVAILABILITY
BUCCAL
FORMULATION
POLYMERIC DRUG DELIVERY SYSTEMS
SOLID DOSAGE FORM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/134072
Acceder
id CONICETDig_eb94ca119948d4806d32191d67d487ae
oai_identifier_str oai:ri.conicet.gov.ar:11336/134072
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performanceLlabot, Juan ManuelManzo, Ruben HilarioAllemandi, Daniel AlbertoBIOAVAILABILITYBUCCALFORMULATIONPOLYMERIC DRUG DELIVERY SYSTEMSSOLID DOSAGE FORMhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Mucoadhesive tablets containing nystatin (10 mg) were evaluated in vivo. The assays were carried out with 12 healthy volunteers and the concentration of nystatin in saliva was determined at different times. Tablets remained attached to the buccal mucosa during 270 min ± 30 min. No evidence of ulceration or bleeding was observed. Typical appearance of intact human buccal mucosa was seen before and after contact with the tablet. The tablets were well accepted by the volunteers, although most of the volunteers reported a light bitter taste, probably due to nystatin. Concentration of nystatin in saliva was several times higher than MIC over a period of approximately 4.5 h, which was in agreement with the behavior observed in vitro. These results allow us to infer that the administration of these mucoadhesive tablets could be advantageous compared to conventional formulations and mucoadhesive extended-release tablets might produce better therapeutic performance than conventional formulations in the treatment of oral candidosis.Fil: Llabot, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaJohn Wiley & Sons Inc2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/134072Llabot, Juan Manuel; Manzo, Ruben Hilario; Allemandi, Daniel Alberto; Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performance; John Wiley & Sons Inc; Journal of Pharmaceutical Sciences; 98; 5; 12-2009; 1871-18760022-35491520-6017CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/18803261/info:eu-repo/semantics/altIdentifier/doi/10.1002/jps.21513info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:18Zoai:ri.conicet.gov.ar:11336/134072instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:18.526CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performance
title Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performance
spellingShingle Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performance
Llabot, Juan Manuel
BIOAVAILABILITY
BUCCAL
FORMULATION
POLYMERIC DRUG DELIVERY SYSTEMS
SOLID DOSAGE FORM
title_short Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performance
title_full Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performance
title_fullStr Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performance
title_full_unstemmed Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performance
title_sort Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performance
dc.creator.none.fl_str_mv Llabot, Juan Manuel
Manzo, Ruben Hilario
Allemandi, Daniel Alberto
author Llabot, Juan Manuel
author_facet Llabot, Juan Manuel
Manzo, Ruben Hilario
Allemandi, Daniel Alberto
author_role author
author2 Manzo, Ruben Hilario
Allemandi, Daniel Alberto
author2_role author
author
dc.subject.none.fl_str_mv BIOAVAILABILITY
BUCCAL
FORMULATION
POLYMERIC DRUG DELIVERY SYSTEMS
SOLID DOSAGE FORM
topic BIOAVAILABILITY
BUCCAL
FORMULATION
POLYMERIC DRUG DELIVERY SYSTEMS
SOLID DOSAGE FORM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Mucoadhesive tablets containing nystatin (10 mg) were evaluated in vivo. The assays were carried out with 12 healthy volunteers and the concentration of nystatin in saliva was determined at different times. Tablets remained attached to the buccal mucosa during 270 min ± 30 min. No evidence of ulceration or bleeding was observed. Typical appearance of intact human buccal mucosa was seen before and after contact with the tablet. The tablets were well accepted by the volunteers, although most of the volunteers reported a light bitter taste, probably due to nystatin. Concentration of nystatin in saliva was several times higher than MIC over a period of approximately 4.5 h, which was in agreement with the behavior observed in vitro. These results allow us to infer that the administration of these mucoadhesive tablets could be advantageous compared to conventional formulations and mucoadhesive extended-release tablets might produce better therapeutic performance than conventional formulations in the treatment of oral candidosis.
Fil: Llabot, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
description Mucoadhesive tablets containing nystatin (10 mg) were evaluated in vivo. The assays were carried out with 12 healthy volunteers and the concentration of nystatin in saliva was determined at different times. Tablets remained attached to the buccal mucosa during 270 min ± 30 min. No evidence of ulceration or bleeding was observed. Typical appearance of intact human buccal mucosa was seen before and after contact with the tablet. The tablets were well accepted by the volunteers, although most of the volunteers reported a light bitter taste, probably due to nystatin. Concentration of nystatin in saliva was several times higher than MIC over a period of approximately 4.5 h, which was in agreement with the behavior observed in vitro. These results allow us to infer that the administration of these mucoadhesive tablets could be advantageous compared to conventional formulations and mucoadhesive extended-release tablets might produce better therapeutic performance than conventional formulations in the treatment of oral candidosis.
publishDate 2009
dc.date.none.fl_str_mv 2009-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/134072
Llabot, Juan Manuel; Manzo, Ruben Hilario; Allemandi, Daniel Alberto; Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performance; John Wiley & Sons Inc; Journal of Pharmaceutical Sciences; 98; 5; 12-2009; 1871-1876
0022-3549
1520-6017
CONICET Digital
CONICET
url http://hdl.handle.net/11336/134072
identifier_str_mv Llabot, Juan Manuel; Manzo, Ruben Hilario; Allemandi, Daniel Alberto; Novel mucoadhesive extended release tablets for treatment of oral candidosis: "In vivo" evaluation of the biopharmaceutical performance; John Wiley & Sons Inc; Journal of Pharmaceutical Sciences; 98; 5; 12-2009; 1871-1876
0022-3549
1520-6017
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/18803261/
info:eu-repo/semantics/altIdentifier/doi/10.1002/jps.21513
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Inc
publisher.none.fl_str_mv John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614106618789888
score 13.070432

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