Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease

Autores
Rejc, Luka; Gómez Vallejo, Vanessa; Joya, Ana; Moreno, Oscar; Egimendia, Ander; Castellnou, Pilar; Ríos Anglada, Xabier; Cossío, Unai; Zuriñe, Baz; Passannante, Rossana; Tobalina Larrea, Ignacio; Ramos Cabrer, Pedro; Giralt, Albert; Sastre, Magdalena; Capetillo Zarate, Estibaliz; Koak, Urban; Knez, Damijan; Gobec, Stanislav; Marder, Nora Mariel; Martin, Abraham; Llop, Jordi
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: The increase in butyrylcholinesterase (BChE) activity in the brain of Alzheimer disease (AD) patients and animal models of AD position this enzyme as a potential biomarker of the disease. However, the information on the ability of BChE to serve as AD biomarker is contradicting, also due to scarce longitudinal studies of BChE activity abundance. Here, we report 11C-labeling, in vivo stability, biodistribution, and longitudinal study on BChE abundance in the brains of control and 5xFAD (AD model) animals, using a potent BChE selective inhibitor, [11C]4, and positron emission tomography (PET) in combination with computerised tomography (CT). We correlate the results with in vivo amyloid beta (Aβ) deposition, longitudinally assessed by [18F]florbetaben-PET imaging. Methods: [11C]4 was radiolabelled through 11C-methylation. Metabolism studies were performed on blood and brain samples of female wild type (WT) mice. Biodistribution studies were performed in female WT mice using dynamic PET-CT imaging. Specific binding was demonstrated by ex vivo and in vivo PET imaging blocking studies in female WT and 5xFAD mice at the age of 7 months. Longitudinal PET imaging of BChE was conducted in female 5xFAD mice at 4, 6, 8, 10 and 12 months of age and compared to age-matched control animals. Additionally, Aβ plaque distribution was assessed in the same mice using [18F]florbetaben at the ages of 2, 5, 7 and 11 months. The results were validated by ex vivo staining of BChE at 4, 8, and 12 months and Aβ at 12 months on brain samples. Results: [11C]4 was produced in sufficient radiochemical yield and molar activity for the use in PET imaging. Metabolism and biodistribution studies confirmed sufficient stability in vivo, the ability of [11C]4 to cross the blood brain barrier (BBB) and rapid washout from the brain. Blocking studies confirmed specificity of the binding. Longitudinal PET studies showed increased levels of BChE in the cerebral cortex, hippocampus, striatum, thalamus, cerebellum and brain stem in aged AD mice compared to WT littermates. [18F]Florbetaben-PET imaging showed similar trend of Aβ plaques accumulation in the cerebral cortex and the hippocampus of AD animals as the one observed for BChE at ages 4 to 8 months. Contrarily to the results obtained by ex vivo staining, lower abundance of BChE was observed in vivo at 10 and 12 months than at 8 months of age. Conclusions: The BChE inhibitor [11C]4 crosses the BBB and is quickly washed out of the brain of WT mice. Comparison between AD and WT mice shows accumulation of the radiotracer in the AD-affected areas of the brain over time during the early disease progression. The results correspond well with Aβ accumulation, suggesting that BChE is a promising early biomarker for incipient AD.
Fil: Rejc, Luka. University Of Ljubljana; Eslovenia
Fil: Gómez Vallejo, Vanessa. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Joya, Ana. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Moreno, Oscar. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Egimendia, Ander. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Castellnou, Pilar. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Ríos Anglada, Xabier. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Cossío, Unai. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Zuriñe, Baz. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Passannante, Rossana. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Tobalina Larrea, Ignacio. Universidad del País Vasco; España
Fil: Ramos Cabrer, Pedro. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Giralt, Albert. Universitat Autònoma de Barcelona; España
Fil: Sastre, Magdalena. Imperial College. London Institute Of Medical Sciences.;
Fil: Capetillo Zarate, Estibaliz. Universidad del País Vasco; España
Fil: Koak, Urban. University Of Ljubljana; Eslovenia
Fil: Knez, Damijan. University Of Ljubljana; Eslovenia
Fil: Gobec, Stanislav. University Of Ljubljana; Eslovenia
Fil: Marder, Nora Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Martin, Abraham. No especifíca;
Fil: Llop, Jordi. Centro de Investigacion Cooperativa En Biomateriales.; España
Materia
ALZHEIMER DISEASE
AMYLOID BETA
BUTYRYLCHOLINESTERASE
PET
POSITRON EMISSION TOMOGRAPHY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/180929

id CONICETDig_eb6a5fc057387adfa474fe11a3920457
oai_identifier_str oai:ri.conicet.gov.ar:11336/180929
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer diseaseRejc, LukaGómez Vallejo, VanessaJoya, AnaMoreno, OscarEgimendia, AnderCastellnou, PilarRíos Anglada, XabierCossío, UnaiZuriñe, BazPassannante, RossanaTobalina Larrea, IgnacioRamos Cabrer, PedroGiralt, AlbertSastre, MagdalenaCapetillo Zarate, EstibalizKoak, UrbanKnez, DamijanGobec, StanislavMarder, Nora MarielMartin, AbrahamLlop, JordiALZHEIMER DISEASEAMYLOID BETABUTYRYLCHOLINESTERASEPETPOSITRON EMISSION TOMOGRAPHYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Purpose: The increase in butyrylcholinesterase (BChE) activity in the brain of Alzheimer disease (AD) patients and animal models of AD position this enzyme as a potential biomarker of the disease. However, the information on the ability of BChE to serve as AD biomarker is contradicting, also due to scarce longitudinal studies of BChE activity abundance. Here, we report 11C-labeling, in vivo stability, biodistribution, and longitudinal study on BChE abundance in the brains of control and 5xFAD (AD model) animals, using a potent BChE selective inhibitor, [11C]4, and positron emission tomography (PET) in combination with computerised tomography (CT). We correlate the results with in vivo amyloid beta (Aβ) deposition, longitudinally assessed by [18F]florbetaben-PET imaging. Methods: [11C]4 was radiolabelled through 11C-methylation. Metabolism studies were performed on blood and brain samples of female wild type (WT) mice. Biodistribution studies were performed in female WT mice using dynamic PET-CT imaging. Specific binding was demonstrated by ex vivo and in vivo PET imaging blocking studies in female WT and 5xFAD mice at the age of 7 months. Longitudinal PET imaging of BChE was conducted in female 5xFAD mice at 4, 6, 8, 10 and 12 months of age and compared to age-matched control animals. Additionally, Aβ plaque distribution was assessed in the same mice using [18F]florbetaben at the ages of 2, 5, 7 and 11 months. The results were validated by ex vivo staining of BChE at 4, 8, and 12 months and Aβ at 12 months on brain samples. Results: [11C]4 was produced in sufficient radiochemical yield and molar activity for the use in PET imaging. Metabolism and biodistribution studies confirmed sufficient stability in vivo, the ability of [11C]4 to cross the blood brain barrier (BBB) and rapid washout from the brain. Blocking studies confirmed specificity of the binding. Longitudinal PET studies showed increased levels of BChE in the cerebral cortex, hippocampus, striatum, thalamus, cerebellum and brain stem in aged AD mice compared to WT littermates. [18F]Florbetaben-PET imaging showed similar trend of Aβ plaques accumulation in the cerebral cortex and the hippocampus of AD animals as the one observed for BChE at ages 4 to 8 months. Contrarily to the results obtained by ex vivo staining, lower abundance of BChE was observed in vivo at 10 and 12 months than at 8 months of age. Conclusions: The BChE inhibitor [11C]4 crosses the BBB and is quickly washed out of the brain of WT mice. Comparison between AD and WT mice shows accumulation of the radiotracer in the AD-affected areas of the brain over time during the early disease progression. The results correspond well with Aβ accumulation, suggesting that BChE is a promising early biomarker for incipient AD.Fil: Rejc, Luka. University Of Ljubljana; EsloveniaFil: Gómez Vallejo, Vanessa. Centro de Investigacion Cooperativa En Biomateriales.; EspañaFil: Joya, Ana. Centro de Investigacion Cooperativa En Biomateriales.; EspañaFil: Moreno, Oscar. Centro de Investigacion Cooperativa En Biomateriales.; EspañaFil: Egimendia, Ander. Centro de Investigacion Cooperativa En Biomateriales.; EspañaFil: Castellnou, Pilar. Centro de Investigacion Cooperativa En Biomateriales.; EspañaFil: Ríos Anglada, Xabier. Centro de Investigacion Cooperativa En Biomateriales.; EspañaFil: Cossío, Unai. Centro de Investigacion Cooperativa En Biomateriales.; EspañaFil: Zuriñe, Baz. Centro de Investigacion Cooperativa En Biomateriales.; EspañaFil: Passannante, Rossana. Centro de Investigacion Cooperativa En Biomateriales.; EspañaFil: Tobalina Larrea, Ignacio. Universidad del País Vasco; EspañaFil: Ramos Cabrer, Pedro. Centro de Investigacion Cooperativa En Biomateriales.; EspañaFil: Giralt, Albert. Universitat Autònoma de Barcelona; EspañaFil: Sastre, Magdalena. Imperial College. London Institute Of Medical Sciences.;Fil: Capetillo Zarate, Estibaliz. Universidad del País Vasco; EspañaFil: Koak, Urban. University Of Ljubljana; EsloveniaFil: Knez, Damijan. University Of Ljubljana; EsloveniaFil: Gobec, Stanislav. University Of Ljubljana; EsloveniaFil: Marder, Nora Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Martin, Abraham. No especifíca;Fil: Llop, Jordi. Centro de Investigacion Cooperativa En Biomateriales.; EspañaIvyspring International Publisher2021-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/180929Rejc, Luka; Gómez Vallejo, Vanessa; Joya, Ana; Moreno, Oscar; Egimendia, Ander; et al.; Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease; Ivyspring International Publisher; Theranostics; 11; 13; 3-2021; 6542-65591838-7640CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.7150/thno.54589info:eu-repo/semantics/altIdentifier/url/https://www.thno.org/v11p6542.htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:48:20Zoai:ri.conicet.gov.ar:11336/180929instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:48:21.162CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease
title Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease
spellingShingle Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease
Rejc, Luka
ALZHEIMER DISEASE
AMYLOID BETA
BUTYRYLCHOLINESTERASE
PET
POSITRON EMISSION TOMOGRAPHY
title_short Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease
title_full Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease
title_fullStr Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease
title_full_unstemmed Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease
title_sort Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease
dc.creator.none.fl_str_mv Rejc, Luka
Gómez Vallejo, Vanessa
Joya, Ana
Moreno, Oscar
Egimendia, Ander
Castellnou, Pilar
Ríos Anglada, Xabier
Cossío, Unai
Zuriñe, Baz
Passannante, Rossana
Tobalina Larrea, Ignacio
Ramos Cabrer, Pedro
Giralt, Albert
Sastre, Magdalena
Capetillo Zarate, Estibaliz
Koak, Urban
Knez, Damijan
Gobec, Stanislav
Marder, Nora Mariel
Martin, Abraham
Llop, Jordi
author Rejc, Luka
author_facet Rejc, Luka
Gómez Vallejo, Vanessa
Joya, Ana
Moreno, Oscar
Egimendia, Ander
Castellnou, Pilar
Ríos Anglada, Xabier
Cossío, Unai
Zuriñe, Baz
Passannante, Rossana
Tobalina Larrea, Ignacio
Ramos Cabrer, Pedro
Giralt, Albert
Sastre, Magdalena
Capetillo Zarate, Estibaliz
Koak, Urban
Knez, Damijan
Gobec, Stanislav
Marder, Nora Mariel
Martin, Abraham
Llop, Jordi
author_role author
author2 Gómez Vallejo, Vanessa
Joya, Ana
Moreno, Oscar
Egimendia, Ander
Castellnou, Pilar
Ríos Anglada, Xabier
Cossío, Unai
Zuriñe, Baz
Passannante, Rossana
Tobalina Larrea, Ignacio
Ramos Cabrer, Pedro
Giralt, Albert
Sastre, Magdalena
Capetillo Zarate, Estibaliz
Koak, Urban
Knez, Damijan
Gobec, Stanislav
Marder, Nora Mariel
Martin, Abraham
Llop, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALZHEIMER DISEASE
AMYLOID BETA
BUTYRYLCHOLINESTERASE
PET
POSITRON EMISSION TOMOGRAPHY
topic ALZHEIMER DISEASE
AMYLOID BETA
BUTYRYLCHOLINESTERASE
PET
POSITRON EMISSION TOMOGRAPHY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Purpose: The increase in butyrylcholinesterase (BChE) activity in the brain of Alzheimer disease (AD) patients and animal models of AD position this enzyme as a potential biomarker of the disease. However, the information on the ability of BChE to serve as AD biomarker is contradicting, also due to scarce longitudinal studies of BChE activity abundance. Here, we report 11C-labeling, in vivo stability, biodistribution, and longitudinal study on BChE abundance in the brains of control and 5xFAD (AD model) animals, using a potent BChE selective inhibitor, [11C]4, and positron emission tomography (PET) in combination with computerised tomography (CT). We correlate the results with in vivo amyloid beta (Aβ) deposition, longitudinally assessed by [18F]florbetaben-PET imaging. Methods: [11C]4 was radiolabelled through 11C-methylation. Metabolism studies were performed on blood and brain samples of female wild type (WT) mice. Biodistribution studies were performed in female WT mice using dynamic PET-CT imaging. Specific binding was demonstrated by ex vivo and in vivo PET imaging blocking studies in female WT and 5xFAD mice at the age of 7 months. Longitudinal PET imaging of BChE was conducted in female 5xFAD mice at 4, 6, 8, 10 and 12 months of age and compared to age-matched control animals. Additionally, Aβ plaque distribution was assessed in the same mice using [18F]florbetaben at the ages of 2, 5, 7 and 11 months. The results were validated by ex vivo staining of BChE at 4, 8, and 12 months and Aβ at 12 months on brain samples. Results: [11C]4 was produced in sufficient radiochemical yield and molar activity for the use in PET imaging. Metabolism and biodistribution studies confirmed sufficient stability in vivo, the ability of [11C]4 to cross the blood brain barrier (BBB) and rapid washout from the brain. Blocking studies confirmed specificity of the binding. Longitudinal PET studies showed increased levels of BChE in the cerebral cortex, hippocampus, striatum, thalamus, cerebellum and brain stem in aged AD mice compared to WT littermates. [18F]Florbetaben-PET imaging showed similar trend of Aβ plaques accumulation in the cerebral cortex and the hippocampus of AD animals as the one observed for BChE at ages 4 to 8 months. Contrarily to the results obtained by ex vivo staining, lower abundance of BChE was observed in vivo at 10 and 12 months than at 8 months of age. Conclusions: The BChE inhibitor [11C]4 crosses the BBB and is quickly washed out of the brain of WT mice. Comparison between AD and WT mice shows accumulation of the radiotracer in the AD-affected areas of the brain over time during the early disease progression. The results correspond well with Aβ accumulation, suggesting that BChE is a promising early biomarker for incipient AD.
Fil: Rejc, Luka. University Of Ljubljana; Eslovenia
Fil: Gómez Vallejo, Vanessa. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Joya, Ana. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Moreno, Oscar. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Egimendia, Ander. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Castellnou, Pilar. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Ríos Anglada, Xabier. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Cossío, Unai. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Zuriñe, Baz. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Passannante, Rossana. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Tobalina Larrea, Ignacio. Universidad del País Vasco; España
Fil: Ramos Cabrer, Pedro. Centro de Investigacion Cooperativa En Biomateriales.; España
Fil: Giralt, Albert. Universitat Autònoma de Barcelona; España
Fil: Sastre, Magdalena. Imperial College. London Institute Of Medical Sciences.;
Fil: Capetillo Zarate, Estibaliz. Universidad del País Vasco; España
Fil: Koak, Urban. University Of Ljubljana; Eslovenia
Fil: Knez, Damijan. University Of Ljubljana; Eslovenia
Fil: Gobec, Stanislav. University Of Ljubljana; Eslovenia
Fil: Marder, Nora Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Martin, Abraham. No especifíca;
Fil: Llop, Jordi. Centro de Investigacion Cooperativa En Biomateriales.; España
description Purpose: The increase in butyrylcholinesterase (BChE) activity in the brain of Alzheimer disease (AD) patients and animal models of AD position this enzyme as a potential biomarker of the disease. However, the information on the ability of BChE to serve as AD biomarker is contradicting, also due to scarce longitudinal studies of BChE activity abundance. Here, we report 11C-labeling, in vivo stability, biodistribution, and longitudinal study on BChE abundance in the brains of control and 5xFAD (AD model) animals, using a potent BChE selective inhibitor, [11C]4, and positron emission tomography (PET) in combination with computerised tomography (CT). We correlate the results with in vivo amyloid beta (Aβ) deposition, longitudinally assessed by [18F]florbetaben-PET imaging. Methods: [11C]4 was radiolabelled through 11C-methylation. Metabolism studies were performed on blood and brain samples of female wild type (WT) mice. Biodistribution studies were performed in female WT mice using dynamic PET-CT imaging. Specific binding was demonstrated by ex vivo and in vivo PET imaging blocking studies in female WT and 5xFAD mice at the age of 7 months. Longitudinal PET imaging of BChE was conducted in female 5xFAD mice at 4, 6, 8, 10 and 12 months of age and compared to age-matched control animals. Additionally, Aβ plaque distribution was assessed in the same mice using [18F]florbetaben at the ages of 2, 5, 7 and 11 months. The results were validated by ex vivo staining of BChE at 4, 8, and 12 months and Aβ at 12 months on brain samples. Results: [11C]4 was produced in sufficient radiochemical yield and molar activity for the use in PET imaging. Metabolism and biodistribution studies confirmed sufficient stability in vivo, the ability of [11C]4 to cross the blood brain barrier (BBB) and rapid washout from the brain. Blocking studies confirmed specificity of the binding. Longitudinal PET studies showed increased levels of BChE in the cerebral cortex, hippocampus, striatum, thalamus, cerebellum and brain stem in aged AD mice compared to WT littermates. [18F]Florbetaben-PET imaging showed similar trend of Aβ plaques accumulation in the cerebral cortex and the hippocampus of AD animals as the one observed for BChE at ages 4 to 8 months. Contrarily to the results obtained by ex vivo staining, lower abundance of BChE was observed in vivo at 10 and 12 months than at 8 months of age. Conclusions: The BChE inhibitor [11C]4 crosses the BBB and is quickly washed out of the brain of WT mice. Comparison between AD and WT mice shows accumulation of the radiotracer in the AD-affected areas of the brain over time during the early disease progression. The results correspond well with Aβ accumulation, suggesting that BChE is a promising early biomarker for incipient AD.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/180929
Rejc, Luka; Gómez Vallejo, Vanessa; Joya, Ana; Moreno, Oscar; Egimendia, Ander; et al.; Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease; Ivyspring International Publisher; Theranostics; 11; 13; 3-2021; 6542-6559
1838-7640
CONICET Digital
CONICET
url http://hdl.handle.net/11336/180929
identifier_str_mv Rejc, Luka; Gómez Vallejo, Vanessa; Joya, Ana; Moreno, Oscar; Egimendia, Ander; et al.; Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease; Ivyspring International Publisher; Theranostics; 11; 13; 3-2021; 6542-6559
1838-7640
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.7150/thno.54589
info:eu-repo/semantics/altIdentifier/url/https://www.thno.org/v11p6542.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Ivyspring International Publisher
publisher.none.fl_str_mv Ivyspring International Publisher
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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