Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory

Autores
Lobos de Ponga, Jacquelina Claudia; Piña, Juliana; Cotabarren, Ivana María
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The understanding of granule growth mechanisms and the effects of formulation and operating conditions over product quality and process performance in fluidized bed co-melt granulation is nowadays of great interest. In this sense, this work systematically studies the combined effects of binder content (WPEG) and fluidization air flowrate (FA) and temperature (TA) on granules’ quality and process-related variables (product mass (MP), elutriated fines (Mf), mass stuck on walls (MW)) by using a Box–Behnken-type design of experiments (DoE), as it is a statistical tool suggested by the Quality by Design (QbD) initiative. It was found that the granules’ size and powder flowability are significantly affected by WPEG (higher WPEG, higher granule size and better flowability). Interestingly, TA is the process variable that significantly affects MP, enhancing process performance at high temperature values. Regarding FA, it significantly affects d10, promoting the formation of small particles due to breakage at high flowrates and the presence of non-elutriated powder at low flowrates. As a consequence, intermediate FA is the optimum for obtaining higher MP. Regarding regime map studies, most runs experienced a rapid growth regime, which is in accordance with the granules’ high pore saturation. This result agrees with the observed high increment in particle size and the morphology of the final granules, allowing researchers to validate and extend existing previous maps.
Fil: Lobos de Ponga, Jacquelina Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
Fil: Piña, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
Fil: Cotabarren, Ivana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
Materia
FLUIDIZED-BED GRANULATION
CO-MELT
REGIME MAP
BOX-BEHNEKEN
LACTOSE
POLYEHTYLENE GLICOL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/231268
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map TheoryLobos de Ponga, Jacquelina ClaudiaPiña, JulianaCotabarren, Ivana MaríaFLUIDIZED-BED GRANULATIONCO-MELTREGIME MAPBOX-BEHNEKENLACTOSEPOLYEHTYLENE GLICOLhttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2The understanding of granule growth mechanisms and the effects of formulation and operating conditions over product quality and process performance in fluidized bed co-melt granulation is nowadays of great interest. In this sense, this work systematically studies the combined effects of binder content (WPEG) and fluidization air flowrate (FA) and temperature (TA) on granules’ quality and process-related variables (product mass (MP), elutriated fines (Mf), mass stuck on walls (MW)) by using a Box–Behnken-type design of experiments (DoE), as it is a statistical tool suggested by the Quality by Design (QbD) initiative. It was found that the granules’ size and powder flowability are significantly affected by WPEG (higher WPEG, higher granule size and better flowability). Interestingly, TA is the process variable that significantly affects MP, enhancing process performance at high temperature values. Regarding FA, it significantly affects d10, promoting the formation of small particles due to breakage at high flowrates and the presence of non-elutriated powder at low flowrates. As a consequence, intermediate FA is the optimum for obtaining higher MP. Regarding regime map studies, most runs experienced a rapid growth regime, which is in accordance with the granules’ high pore saturation. This result agrees with the observed high increment in particle size and the morphology of the final granules, allowing researchers to validate and extend existing previous maps.Fil: Lobos de Ponga, Jacquelina Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; ArgentinaFil: Piña, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; ArgentinaFil: Cotabarren, Ivana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; ArgentinaMultidisciplinary Digital Publishing Institute2023-09-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/231268Lobos de Ponga, Jacquelina Claudia; Piña, Juliana; Cotabarren, Ivana María; Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory; Multidisciplinary Digital Publishing Institute; Powders; 2; 3; 15-9-2023; 639-6582674-0516CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2674-0516/2/3/40info:eu-repo/semantics/altIdentifier/doi/10.3390/powders2030040info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:42:02Zoai:ri.conicet.gov.ar:11336/231268instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:42:03.169CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory
title Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory
spellingShingle Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory
Lobos de Ponga, Jacquelina Claudia
FLUIDIZED-BED GRANULATION
CO-MELT
REGIME MAP
BOX-BEHNEKEN
LACTOSE
POLYEHTYLENE GLICOL
title_short Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory
title_full Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory
title_fullStr Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory
title_full_unstemmed Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory
title_sort Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory
dc.creator.none.fl_str_mv Lobos de Ponga, Jacquelina Claudia
Piña, Juliana
Cotabarren, Ivana María
author Lobos de Ponga, Jacquelina Claudia
author_facet Lobos de Ponga, Jacquelina Claudia
Piña, Juliana
Cotabarren, Ivana María
author_role author
author2 Piña, Juliana
Cotabarren, Ivana María
author2_role author
author
dc.subject.none.fl_str_mv FLUIDIZED-BED GRANULATION
CO-MELT
REGIME MAP
BOX-BEHNEKEN
LACTOSE
POLYEHTYLENE GLICOL
topic FLUIDIZED-BED GRANULATION
CO-MELT
REGIME MAP
BOX-BEHNEKEN
LACTOSE
POLYEHTYLENE GLICOL
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The understanding of granule growth mechanisms and the effects of formulation and operating conditions over product quality and process performance in fluidized bed co-melt granulation is nowadays of great interest. In this sense, this work systematically studies the combined effects of binder content (WPEG) and fluidization air flowrate (FA) and temperature (TA) on granules’ quality and process-related variables (product mass (MP), elutriated fines (Mf), mass stuck on walls (MW)) by using a Box–Behnken-type design of experiments (DoE), as it is a statistical tool suggested by the Quality by Design (QbD) initiative. It was found that the granules’ size and powder flowability are significantly affected by WPEG (higher WPEG, higher granule size and better flowability). Interestingly, TA is the process variable that significantly affects MP, enhancing process performance at high temperature values. Regarding FA, it significantly affects d10, promoting the formation of small particles due to breakage at high flowrates and the presence of non-elutriated powder at low flowrates. As a consequence, intermediate FA is the optimum for obtaining higher MP. Regarding regime map studies, most runs experienced a rapid growth regime, which is in accordance with the granules’ high pore saturation. This result agrees with the observed high increment in particle size and the morphology of the final granules, allowing researchers to validate and extend existing previous maps.
Fil: Lobos de Ponga, Jacquelina Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
Fil: Piña, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
Fil: Cotabarren, Ivana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
description The understanding of granule growth mechanisms and the effects of formulation and operating conditions over product quality and process performance in fluidized bed co-melt granulation is nowadays of great interest. In this sense, this work systematically studies the combined effects of binder content (WPEG) and fluidization air flowrate (FA) and temperature (TA) on granules’ quality and process-related variables (product mass (MP), elutriated fines (Mf), mass stuck on walls (MW)) by using a Box–Behnken-type design of experiments (DoE), as it is a statistical tool suggested by the Quality by Design (QbD) initiative. It was found that the granules’ size and powder flowability are significantly affected by WPEG (higher WPEG, higher granule size and better flowability). Interestingly, TA is the process variable that significantly affects MP, enhancing process performance at high temperature values. Regarding FA, it significantly affects d10, promoting the formation of small particles due to breakage at high flowrates and the presence of non-elutriated powder at low flowrates. As a consequence, intermediate FA is the optimum for obtaining higher MP. Regarding regime map studies, most runs experienced a rapid growth regime, which is in accordance with the granules’ high pore saturation. This result agrees with the observed high increment in particle size and the morphology of the final granules, allowing researchers to validate and extend existing previous maps.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/231268
Lobos de Ponga, Jacquelina Claudia; Piña, Juliana; Cotabarren, Ivana María; Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory; Multidisciplinary Digital Publishing Institute; Powders; 2; 3; 15-9-2023; 639-658
2674-0516
CONICET Digital
CONICET
url http://hdl.handle.net/11336/231268
identifier_str_mv Lobos de Ponga, Jacquelina Claudia; Piña, Juliana; Cotabarren, Ivana María; Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory; Multidisciplinary Digital Publishing Institute; Powders; 2; 3; 15-9-2023; 639-658
2674-0516
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2674-0516/2/3/40
info:eu-repo/semantics/altIdentifier/doi/10.3390/powders2030040
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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