A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis

Autores
Motrich, Ruben Darío; van Etten, Evelyne; Baeke, Femke; Riera, Clelia Maria; Mathieu, Chantal; Rivero, Virginia Elena
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: An autoimmune etiology is proposed in some patients with chronic nonbacterial prostatitis since they show interferon-γ secreting lymphocytes specific to prostate antigens in the periphery and increased interferon-γ in seminal plasma. We investigated the involvement of interferon-γ in an animal model of autoimmune prostatitis. Materials and Methods: Experimental autoimmune prostatitis was studied in the no-obese diabetic and C57Bl/6 (Harlan, Zeist, The Netherlands) susceptible mouse strains, and in the IRF-1 KO and STAT-1 KO mouse strains deficient in transcription factors involved in interferon-γ signaling. Results: Experimental autoimmune prostatitis was characterized by prostate specific interferon-γ secreting cells in the periphery and by T-helper 1 related cytokines in the target organ. Increased interferon-γ and interleukin-12 were observed in the prostate of autoimmune animals while interleukin-10 and interleukin-4 were decreased and unaltered, respectively. The absence of transcription factors involved in the interferon-γ signaling cascade, IRF-1 and STAT-1, made mice resistant to experimental autoimmune prostatitis. IRF-1 KO and STAT-1 KO mice immunized with prostate antigens did not show infiltration or alterations in the prostate. They did not have the typical prostate specific autoimmune response and showed decreased interferon-γ, interleukin-12 and interleukin-10, and augmented interleukin-4 in the prostate. Conclusions: Our results argue for a crucial role of interferon-γ as a key factor in the pathogenesis of the disease. Intense research is promptly required to identify the pathogenic mechanisms underlying chronic prostatitis/chronic pelvic pain syndrome to find a more rational therapy.
Fil: Motrich, Ruben Darío. Universidad Nacional de Córdoba; Argentina
Fil: van Etten, Evelyne. Katholikie Universiteit Leuven; Bélgica
Fil: Baeke, Femke. Katholikie Universiteit Leuven; Bélgica
Fil: Riera, Clelia Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Mathieu, Chantal. Katholikie Universiteit Leuven; Bélgica
Fil: Rivero, Virginia Elena. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Materia
AUTOIMMUNITY
MICE
PAIN
PROSTATE
PROSTATITIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/186541
Acceder
id CONICETDig_eb4d50437e3654494e5382fab6af59f0
oai_identifier_str oai:ri.conicet.gov.ar:11336/186541
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A Crucial Role of INF-gamma in Experimental Autoimmune ProstatitisMotrich, Ruben Daríovan Etten, EvelyneBaeke, FemkeRiera, Clelia MariaMathieu, ChantalRivero, Virginia ElenaAUTOIMMUNITYMICEPAINPROSTATEPROSTATITIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Purpose: An autoimmune etiology is proposed in some patients with chronic nonbacterial prostatitis since they show interferon-γ secreting lymphocytes specific to prostate antigens in the periphery and increased interferon-γ in seminal plasma. We investigated the involvement of interferon-γ in an animal model of autoimmune prostatitis. Materials and Methods: Experimental autoimmune prostatitis was studied in the no-obese diabetic and C57Bl/6 (Harlan, Zeist, The Netherlands) susceptible mouse strains, and in the IRF-1 KO and STAT-1 KO mouse strains deficient in transcription factors involved in interferon-γ signaling. Results: Experimental autoimmune prostatitis was characterized by prostate specific interferon-γ secreting cells in the periphery and by T-helper 1 related cytokines in the target organ. Increased interferon-γ and interleukin-12 were observed in the prostate of autoimmune animals while interleukin-10 and interleukin-4 were decreased and unaltered, respectively. The absence of transcription factors involved in the interferon-γ signaling cascade, IRF-1 and STAT-1, made mice resistant to experimental autoimmune prostatitis. IRF-1 KO and STAT-1 KO mice immunized with prostate antigens did not show infiltration or alterations in the prostate. They did not have the typical prostate specific autoimmune response and showed decreased interferon-γ, interleukin-12 and interleukin-10, and augmented interleukin-4 in the prostate. Conclusions: Our results argue for a crucial role of interferon-γ as a key factor in the pathogenesis of the disease. Intense research is promptly required to identify the pathogenic mechanisms underlying chronic prostatitis/chronic pelvic pain syndrome to find a more rational therapy.Fil: Motrich, Ruben Darío. Universidad Nacional de Córdoba; ArgentinaFil: van Etten, Evelyne. Katholikie Universiteit Leuven; BélgicaFil: Baeke, Femke. Katholikie Universiteit Leuven; BélgicaFil: Riera, Clelia Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Mathieu, Chantal. Katholikie Universiteit Leuven; BélgicaFil: Rivero, Virginia Elena. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaElsevier Science Inc.2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/186541Motrich, Ruben Darío; van Etten, Evelyne; Baeke, Femke; Riera, Clelia Maria; Mathieu, Chantal; et al.; A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis; Elsevier Science Inc.; Journal of Urology; 183; 3; 3-2010; 1213-12200022-5347CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.juro.2009.11.008info:eu-repo/semantics/altIdentifier/url/https://www.auajournals.org/doi/10.1016/j.juro.2009.11.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:49Zoai:ri.conicet.gov.ar:11336/186541instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:49.479CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis
title A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis
spellingShingle A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis
Motrich, Ruben Darío
AUTOIMMUNITY
MICE
PAIN
PROSTATE
PROSTATITIS
title_short A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis
title_full A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis
title_fullStr A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis
title_full_unstemmed A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis
title_sort A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis
dc.creator.none.fl_str_mv Motrich, Ruben Darío
van Etten, Evelyne
Baeke, Femke
Riera, Clelia Maria
Mathieu, Chantal
Rivero, Virginia Elena
author Motrich, Ruben Darío
author_facet Motrich, Ruben Darío
van Etten, Evelyne
Baeke, Femke
Riera, Clelia Maria
Mathieu, Chantal
Rivero, Virginia Elena
author_role author
author2 van Etten, Evelyne
Baeke, Femke
Riera, Clelia Maria
Mathieu, Chantal
Rivero, Virginia Elena
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv AUTOIMMUNITY
MICE
PAIN
PROSTATE
PROSTATITIS
topic AUTOIMMUNITY
MICE
PAIN
PROSTATE
PROSTATITIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose: An autoimmune etiology is proposed in some patients with chronic nonbacterial prostatitis since they show interferon-γ secreting lymphocytes specific to prostate antigens in the periphery and increased interferon-γ in seminal plasma. We investigated the involvement of interferon-γ in an animal model of autoimmune prostatitis. Materials and Methods: Experimental autoimmune prostatitis was studied in the no-obese diabetic and C57Bl/6 (Harlan, Zeist, The Netherlands) susceptible mouse strains, and in the IRF-1 KO and STAT-1 KO mouse strains deficient in transcription factors involved in interferon-γ signaling. Results: Experimental autoimmune prostatitis was characterized by prostate specific interferon-γ secreting cells in the periphery and by T-helper 1 related cytokines in the target organ. Increased interferon-γ and interleukin-12 were observed in the prostate of autoimmune animals while interleukin-10 and interleukin-4 were decreased and unaltered, respectively. The absence of transcription factors involved in the interferon-γ signaling cascade, IRF-1 and STAT-1, made mice resistant to experimental autoimmune prostatitis. IRF-1 KO and STAT-1 KO mice immunized with prostate antigens did not show infiltration or alterations in the prostate. They did not have the typical prostate specific autoimmune response and showed decreased interferon-γ, interleukin-12 and interleukin-10, and augmented interleukin-4 in the prostate. Conclusions: Our results argue for a crucial role of interferon-γ as a key factor in the pathogenesis of the disease. Intense research is promptly required to identify the pathogenic mechanisms underlying chronic prostatitis/chronic pelvic pain syndrome to find a more rational therapy.
Fil: Motrich, Ruben Darío. Universidad Nacional de Córdoba; Argentina
Fil: van Etten, Evelyne. Katholikie Universiteit Leuven; Bélgica
Fil: Baeke, Femke. Katholikie Universiteit Leuven; Bélgica
Fil: Riera, Clelia Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Mathieu, Chantal. Katholikie Universiteit Leuven; Bélgica
Fil: Rivero, Virginia Elena. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
description Purpose: An autoimmune etiology is proposed in some patients with chronic nonbacterial prostatitis since they show interferon-γ secreting lymphocytes specific to prostate antigens in the periphery and increased interferon-γ in seminal plasma. We investigated the involvement of interferon-γ in an animal model of autoimmune prostatitis. Materials and Methods: Experimental autoimmune prostatitis was studied in the no-obese diabetic and C57Bl/6 (Harlan, Zeist, The Netherlands) susceptible mouse strains, and in the IRF-1 KO and STAT-1 KO mouse strains deficient in transcription factors involved in interferon-γ signaling. Results: Experimental autoimmune prostatitis was characterized by prostate specific interferon-γ secreting cells in the periphery and by T-helper 1 related cytokines in the target organ. Increased interferon-γ and interleukin-12 were observed in the prostate of autoimmune animals while interleukin-10 and interleukin-4 were decreased and unaltered, respectively. The absence of transcription factors involved in the interferon-γ signaling cascade, IRF-1 and STAT-1, made mice resistant to experimental autoimmune prostatitis. IRF-1 KO and STAT-1 KO mice immunized with prostate antigens did not show infiltration or alterations in the prostate. They did not have the typical prostate specific autoimmune response and showed decreased interferon-γ, interleukin-12 and interleukin-10, and augmented interleukin-4 in the prostate. Conclusions: Our results argue for a crucial role of interferon-γ as a key factor in the pathogenesis of the disease. Intense research is promptly required to identify the pathogenic mechanisms underlying chronic prostatitis/chronic pelvic pain syndrome to find a more rational therapy.
publishDate 2010
dc.date.none.fl_str_mv 2010-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/186541
Motrich, Ruben Darío; van Etten, Evelyne; Baeke, Femke; Riera, Clelia Maria; Mathieu, Chantal; et al.; A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis; Elsevier Science Inc.; Journal of Urology; 183; 3; 3-2010; 1213-1220
0022-5347
CONICET Digital
CONICET
url http://hdl.handle.net/11336/186541
identifier_str_mv Motrich, Ruben Darío; van Etten, Evelyne; Baeke, Femke; Riera, Clelia Maria; Mathieu, Chantal; et al.; A Crucial Role of INF-gamma in Experimental Autoimmune Prostatitis; Elsevier Science Inc.; Journal of Urology; 183; 3; 3-2010; 1213-1220
0022-5347
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.juro.2009.11.008
info:eu-repo/semantics/altIdentifier/url/https://www.auajournals.org/doi/10.1016/j.juro.2009.11.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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