Adenoviral vector-mediated gene therapy for gliomas: coming of age
- Autores
- Castro, María G.; Candolfi, Marianela; Wilson, Thomas J.; Calinescu, Alexandra; Paran, Christopher; Kamran, Neha; Koschmann, Carl; Moreno Ayala, Mariela Alejandra; Assi, Hikmat; Lowenstein, Pedro R.
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- INTRODUCTION: Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and it carries a dismal prognosis. Adenoviral vector (Ad)-mediated gene transfer is being developed as a promising therapeutic strategy for GBM. Preclinical studies have demonstrated safety and efficacy of adenovirus administration into the brain and tumor mass in rodents and into the non-human primates' brain. Importantly, Ads have been safely administered within the tumor resection cavity in humans. AREAS COVERED: This review gives background on GBM and Ads; we describe gene therapy strategies for GBM and discuss the value of combination approaches. Finally, we discuss the results of the human clinical trials for GBM that have used Ads. EXPERT OPINION: The transduction characteristics of Ads, and their safety profile, added to their capacity to achieve high levels of transgene expression have made them powerful vectors for the treatment of GBM. Recent gene therapy successes in the treatment of retinal diseases and systemic brain metabolic diseases encourage the development of gene therapy for malignant glioma. Exciting clinical trials are currently recruiting patients; although, it is the large randomized Phase III controlled clinical trials that will provide the final decision on the success of gene therapy for the treatment of GBM.
Fil: Castro, María G.. University of Michigan; Estados Unidos
Fil: Candolfi, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Wilson, Thomas J.. University of Michigan; Estados Unidos
Fil: Calinescu, Alexandra. University of Michigan; Estados Unidos
Fil: Paran, Christopher. University of Michigan; Estados Unidos
Fil: Kamran, Neha. University of Michigan; Estados Unidos
Fil: Koschmann, Carl. University of Michigan; Estados Unidos
Fil: Moreno Ayala, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Assi, Hikmat. University Of Michigan Medical School;
Fil: Lowenstein, Pedro R.. University of Michigan; Estados Unidos - Materia
-
DENDRITIC CELLS
FMS-LIKE TYROSINE KINASE 3 LIGAND
GLIOBLASTOMA MULTIFORME
HIGH CAPACITY ADENOVIRUS
HSV1-TK
IMMUNOTHERAPY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/15324
Ver los metadatos del registro completo
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Adenoviral vector-mediated gene therapy for gliomas: coming of ageCastro, María G.Candolfi, MarianelaWilson, Thomas J.Calinescu, AlexandraParan, ChristopherKamran, NehaKoschmann, CarlMoreno Ayala, Mariela AlejandraAssi, HikmatLowenstein, Pedro R.DENDRITIC CELLSFMS-LIKE TYROSINE KINASE 3 LIGANDGLIOBLASTOMA MULTIFORMEHIGH CAPACITY ADENOVIRUSHSV1-TKIMMUNOTHERAPYhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3INTRODUCTION: Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and it carries a dismal prognosis. Adenoviral vector (Ad)-mediated gene transfer is being developed as a promising therapeutic strategy for GBM. Preclinical studies have demonstrated safety and efficacy of adenovirus administration into the brain and tumor mass in rodents and into the non-human primates' brain. Importantly, Ads have been safely administered within the tumor resection cavity in humans. AREAS COVERED: This review gives background on GBM and Ads; we describe gene therapy strategies for GBM and discuss the value of combination approaches. Finally, we discuss the results of the human clinical trials for GBM that have used Ads. EXPERT OPINION: The transduction characteristics of Ads, and their safety profile, added to their capacity to achieve high levels of transgene expression have made them powerful vectors for the treatment of GBM. Recent gene therapy successes in the treatment of retinal diseases and systemic brain metabolic diseases encourage the development of gene therapy for malignant glioma. Exciting clinical trials are currently recruiting patients; although, it is the large randomized Phase III controlled clinical trials that will provide the final decision on the success of gene therapy for the treatment of GBM.Fil: Castro, María G.. University of Michigan; Estados UnidosFil: Candolfi, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Wilson, Thomas J.. University of Michigan; Estados UnidosFil: Calinescu, Alexandra. University of Michigan; Estados UnidosFil: Paran, Christopher. University of Michigan; Estados UnidosFil: Kamran, Neha. University of Michigan; Estados UnidosFil: Koschmann, Carl. University of Michigan; Estados UnidosFil: Moreno Ayala, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Assi, Hikmat. University Of Michigan Medical School;Fil: Lowenstein, Pedro R.. University of Michigan; Estados UnidosTaylor & Francis2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15324Castro, María G.; Candolfi, Marianela; Wilson, Thomas J.; Calinescu, Alexandra; Paran, Christopher; et al.; Adenoviral vector-mediated gene therapy for gliomas: coming of age; Taylor & Francis; Expert Opinion On Biological Therapy; 14; 9; 9-2014; 1241-12571471-2598enginfo:eu-repo/semantics/altIdentifier/doi/10.1517/14712598.2014.915307info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.1517/14712598.2014.915307info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:18Zoai:ri.conicet.gov.ar:11336/15324instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:18.367CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Adenoviral vector-mediated gene therapy for gliomas: coming of age |
title |
Adenoviral vector-mediated gene therapy for gliomas: coming of age |
spellingShingle |
Adenoviral vector-mediated gene therapy for gliomas: coming of age Castro, María G. DENDRITIC CELLS FMS-LIKE TYROSINE KINASE 3 LIGAND GLIOBLASTOMA MULTIFORME HIGH CAPACITY ADENOVIRUS HSV1-TK IMMUNOTHERAPY |
title_short |
Adenoviral vector-mediated gene therapy for gliomas: coming of age |
title_full |
Adenoviral vector-mediated gene therapy for gliomas: coming of age |
title_fullStr |
Adenoviral vector-mediated gene therapy for gliomas: coming of age |
title_full_unstemmed |
Adenoviral vector-mediated gene therapy for gliomas: coming of age |
title_sort |
Adenoviral vector-mediated gene therapy for gliomas: coming of age |
dc.creator.none.fl_str_mv |
Castro, María G. Candolfi, Marianela Wilson, Thomas J. Calinescu, Alexandra Paran, Christopher Kamran, Neha Koschmann, Carl Moreno Ayala, Mariela Alejandra Assi, Hikmat Lowenstein, Pedro R. |
author |
Castro, María G. |
author_facet |
Castro, María G. Candolfi, Marianela Wilson, Thomas J. Calinescu, Alexandra Paran, Christopher Kamran, Neha Koschmann, Carl Moreno Ayala, Mariela Alejandra Assi, Hikmat Lowenstein, Pedro R. |
author_role |
author |
author2 |
Candolfi, Marianela Wilson, Thomas J. Calinescu, Alexandra Paran, Christopher Kamran, Neha Koschmann, Carl Moreno Ayala, Mariela Alejandra Assi, Hikmat Lowenstein, Pedro R. |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
DENDRITIC CELLS FMS-LIKE TYROSINE KINASE 3 LIGAND GLIOBLASTOMA MULTIFORME HIGH CAPACITY ADENOVIRUS HSV1-TK IMMUNOTHERAPY |
topic |
DENDRITIC CELLS FMS-LIKE TYROSINE KINASE 3 LIGAND GLIOBLASTOMA MULTIFORME HIGH CAPACITY ADENOVIRUS HSV1-TK IMMUNOTHERAPY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.4 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
INTRODUCTION: Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and it carries a dismal prognosis. Adenoviral vector (Ad)-mediated gene transfer is being developed as a promising therapeutic strategy for GBM. Preclinical studies have demonstrated safety and efficacy of adenovirus administration into the brain and tumor mass in rodents and into the non-human primates' brain. Importantly, Ads have been safely administered within the tumor resection cavity in humans. AREAS COVERED: This review gives background on GBM and Ads; we describe gene therapy strategies for GBM and discuss the value of combination approaches. Finally, we discuss the results of the human clinical trials for GBM that have used Ads. EXPERT OPINION: The transduction characteristics of Ads, and their safety profile, added to their capacity to achieve high levels of transgene expression have made them powerful vectors for the treatment of GBM. Recent gene therapy successes in the treatment of retinal diseases and systemic brain metabolic diseases encourage the development of gene therapy for malignant glioma. Exciting clinical trials are currently recruiting patients; although, it is the large randomized Phase III controlled clinical trials that will provide the final decision on the success of gene therapy for the treatment of GBM. Fil: Castro, María G.. University of Michigan; Estados Unidos Fil: Candolfi, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Wilson, Thomas J.. University of Michigan; Estados Unidos Fil: Calinescu, Alexandra. University of Michigan; Estados Unidos Fil: Paran, Christopher. University of Michigan; Estados Unidos Fil: Kamran, Neha. University of Michigan; Estados Unidos Fil: Koschmann, Carl. University of Michigan; Estados Unidos Fil: Moreno Ayala, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Assi, Hikmat. University Of Michigan Medical School; Fil: Lowenstein, Pedro R.. University of Michigan; Estados Unidos |
description |
INTRODUCTION: Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and it carries a dismal prognosis. Adenoviral vector (Ad)-mediated gene transfer is being developed as a promising therapeutic strategy for GBM. Preclinical studies have demonstrated safety and efficacy of adenovirus administration into the brain and tumor mass in rodents and into the non-human primates' brain. Importantly, Ads have been safely administered within the tumor resection cavity in humans. AREAS COVERED: This review gives background on GBM and Ads; we describe gene therapy strategies for GBM and discuss the value of combination approaches. Finally, we discuss the results of the human clinical trials for GBM that have used Ads. EXPERT OPINION: The transduction characteristics of Ads, and their safety profile, added to their capacity to achieve high levels of transgene expression have made them powerful vectors for the treatment of GBM. Recent gene therapy successes in the treatment of retinal diseases and systemic brain metabolic diseases encourage the development of gene therapy for malignant glioma. Exciting clinical trials are currently recruiting patients; although, it is the large randomized Phase III controlled clinical trials that will provide the final decision on the success of gene therapy for the treatment of GBM. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/15324 Castro, María G.; Candolfi, Marianela; Wilson, Thomas J.; Calinescu, Alexandra; Paran, Christopher; et al.; Adenoviral vector-mediated gene therapy for gliomas: coming of age; Taylor & Francis; Expert Opinion On Biological Therapy; 14; 9; 9-2014; 1241-1257 1471-2598 |
url |
http://hdl.handle.net/11336/15324 |
identifier_str_mv |
Castro, María G.; Candolfi, Marianela; Wilson, Thomas J.; Calinescu, Alexandra; Paran, Christopher; et al.; Adenoviral vector-mediated gene therapy for gliomas: coming of age; Taylor & Francis; Expert Opinion On Biological Therapy; 14; 9; 9-2014; 1241-1257 1471-2598 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1517/14712598.2014.915307 info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.1517/14712598.2014.915307 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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score |
13.070432 |