A model for the assembly of nicotinic receptors based on subunit-subunit interactions

Autores
Ortells, Marcelo Oscar; Barrantes, Georgina Elida
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neuronal ion-channels are complex multimeric proteins. Within a given family, the variability of their pharmacological responses depends on subunit composition and subunit arrangement. We report here that protein assembly in the pentameric nicotinic acetylcholine receptor family, the best characterized of all neuronal receptors, can be predicted using information derived from homology modeled surface to surface subunit interactions based on the atomic structure of a snail acetylcholine-binding protein. An empirical assembly model is able to establish both subunit stoichiometry and subunit arrangement of known neuronal and muscle nicotinic receptors. This contribution to the understanding of nicotinic receptor assembly and variability might be extended to other types of ion-channels.
Fil: Ortells, Marcelo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Morón; Argentina
Fil: Barrantes, Georgina Elida. Universidad de Morón; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
molecular modeling
nicotinic receptors
5HT3 receptors
assembly
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/248264
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/248264
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A model for the assembly of nicotinic receptors based on subunit-subunit interactionsOrtells, Marcelo OscarBarrantes, Georgina Elidamolecular modelingnicotinic receptors5HT3 receptorsassemblyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Neuronal ion-channels are complex multimeric proteins. Within a given family, the variability of their pharmacological responses depends on subunit composition and subunit arrangement. We report here that protein assembly in the pentameric nicotinic acetylcholine receptor family, the best characterized of all neuronal receptors, can be predicted using information derived from homology modeled surface to surface subunit interactions based on the atomic structure of a snail acetylcholine-binding protein. An empirical assembly model is able to establish both subunit stoichiometry and subunit arrangement of known neuronal and muscle nicotinic receptors. This contribution to the understanding of nicotinic receptor assembly and variability might be extended to other types of ion-channels.Fil: Ortells, Marcelo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Morón; ArgentinaFil: Barrantes, Georgina Elida. Universidad de Morón; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley-liss, div John Wiley & Sons Inc.2007-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/248264Ortells, Marcelo Oscar; Barrantes, Georgina Elida; A model for the assembly of nicotinic receptors based on subunit-subunit interactions; Wiley-liss, div John Wiley & Sons Inc.; Proteins: Structure, Function And Genetics; 70; 2; 8-2007; 473-4880887-3585CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/prot.21529info:eu-repo/semantics/altIdentifier/doi/10.1002/prot.21529info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:17:00Zoai:ri.conicet.gov.ar:11336/248264instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:17:01.095CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A model for the assembly of nicotinic receptors based on subunit-subunit interactions
title A model for the assembly of nicotinic receptors based on subunit-subunit interactions
spellingShingle A model for the assembly of nicotinic receptors based on subunit-subunit interactions
Ortells, Marcelo Oscar
molecular modeling
nicotinic receptors
5HT3 receptors
assembly
title_short A model for the assembly of nicotinic receptors based on subunit-subunit interactions
title_full A model for the assembly of nicotinic receptors based on subunit-subunit interactions
title_fullStr A model for the assembly of nicotinic receptors based on subunit-subunit interactions
title_full_unstemmed A model for the assembly of nicotinic receptors based on subunit-subunit interactions
title_sort A model for the assembly of nicotinic receptors based on subunit-subunit interactions
dc.creator.none.fl_str_mv Ortells, Marcelo Oscar
Barrantes, Georgina Elida
author Ortells, Marcelo Oscar
author_facet Ortells, Marcelo Oscar
Barrantes, Georgina Elida
author_role author
author2 Barrantes, Georgina Elida
author2_role author
dc.subject.none.fl_str_mv molecular modeling
nicotinic receptors
5HT3 receptors
assembly
topic molecular modeling
nicotinic receptors
5HT3 receptors
assembly
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Neuronal ion-channels are complex multimeric proteins. Within a given family, the variability of their pharmacological responses depends on subunit composition and subunit arrangement. We report here that protein assembly in the pentameric nicotinic acetylcholine receptor family, the best characterized of all neuronal receptors, can be predicted using information derived from homology modeled surface to surface subunit interactions based on the atomic structure of a snail acetylcholine-binding protein. An empirical assembly model is able to establish both subunit stoichiometry and subunit arrangement of known neuronal and muscle nicotinic receptors. This contribution to the understanding of nicotinic receptor assembly and variability might be extended to other types of ion-channels.
Fil: Ortells, Marcelo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Morón; Argentina
Fil: Barrantes, Georgina Elida. Universidad de Morón; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Neuronal ion-channels are complex multimeric proteins. Within a given family, the variability of their pharmacological responses depends on subunit composition and subunit arrangement. We report here that protein assembly in the pentameric nicotinic acetylcholine receptor family, the best characterized of all neuronal receptors, can be predicted using information derived from homology modeled surface to surface subunit interactions based on the atomic structure of a snail acetylcholine-binding protein. An empirical assembly model is able to establish both subunit stoichiometry and subunit arrangement of known neuronal and muscle nicotinic receptors. This contribution to the understanding of nicotinic receptor assembly and variability might be extended to other types of ion-channels.
publishDate 2007
dc.date.none.fl_str_mv 2007-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/248264
Ortells, Marcelo Oscar; Barrantes, Georgina Elida; A model for the assembly of nicotinic receptors based on subunit-subunit interactions; Wiley-liss, div John Wiley & Sons Inc.; Proteins: Structure, Function And Genetics; 70; 2; 8-2007; 473-488
0887-3585
CONICET Digital
CONICET
url http://hdl.handle.net/11336/248264
identifier_str_mv Ortells, Marcelo Oscar; Barrantes, Georgina Elida; A model for the assembly of nicotinic receptors based on subunit-subunit interactions; Wiley-liss, div John Wiley & Sons Inc.; Proteins: Structure, Function And Genetics; 70; 2; 8-2007; 473-488
0887-3585
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/prot.21529
info:eu-repo/semantics/altIdentifier/doi/10.1002/prot.21529
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, div John Wiley & Sons Inc.
publisher.none.fl_str_mv Wiley-liss, div John Wiley & Sons Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980929380810752
score 12.993085

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