An updated review on the neuropsychological profile of subjects with bipolar disorder

Autores
Szmulewicz, Alejandro G.; Samame, Cecilia; Martino, Diego Javier; Strejilevich, Sergio
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: In recent years, growing interest in the neuropsychology of bipolar disorder has emerged, giving rise to the accumulation of a robust body of evidence on this topic and to several related questions. Objective: To provide a state-of-the-art overview of the neuropsychological profile of bipolar disorder. Method: A thorough literature search was performed. Published research evidence was summarized and organized along three key pathways: findings from cross-sectional studies of cognition in bipolar patients, cognitive heterogeneity among affected subjects, and trajectory of neuropsychological deficits. Results: At least two thirds of bipolar patients display neuropsychological deficits, even in euthymia. Although bipolar disorder was found to be associated with an increased risk of dementia, data from elderly subjects and longitudinal research do not support a worsening of cognitive performance over time. Discussion: Cognitive dysfunctions are part of the clinical conceptualization of bipolar illness. However, they may not be present in all affected subjects and their course appears to be stable in most cases. Available evidence may be highlighting the fact that bipolar disorder is characterized by remarkable heterogeneity regarding cognitive outcomes. Different variables may be related to such heterogeneity and should be the focus of therapeutic approaches and further research.
Fil: Szmulewicz, Alejandro G.. Universidad Favaloro; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Emergencias Psiquiáicas ; Argentina
Fil: Samame, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad de Buenos Aires; Argentina
Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Strejilevich, Sergio. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina
Materia
BIPOLAR DISORDER
EVOLUTION
HETEROGENEITY
NEUROPSYCHOLOGICAL FUNCTIONING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/61417
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An updated review on the neuropsychological profile of subjects with bipolar disorderSzmulewicz, Alejandro G.Samame, CeciliaMartino, Diego JavierStrejilevich, SergioBIPOLAR DISORDEREVOLUTIONHETEROGENEITYNEUROPSYCHOLOGICAL FUNCTIONINGhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: In recent years, growing interest in the neuropsychology of bipolar disorder has emerged, giving rise to the accumulation of a robust body of evidence on this topic and to several related questions. Objective: To provide a state-of-the-art overview of the neuropsychological profile of bipolar disorder. Method: A thorough literature search was performed. Published research evidence was summarized and organized along three key pathways: findings from cross-sectional studies of cognition in bipolar patients, cognitive heterogeneity among affected subjects, and trajectory of neuropsychological deficits. Results: At least two thirds of bipolar patients display neuropsychological deficits, even in euthymia. Although bipolar disorder was found to be associated with an increased risk of dementia, data from elderly subjects and longitudinal research do not support a worsening of cognitive performance over time. Discussion: Cognitive dysfunctions are part of the clinical conceptualization of bipolar illness. However, they may not be present in all affected subjects and their course appears to be stable in most cases. Available evidence may be highlighting the fact that bipolar disorder is characterized by remarkable heterogeneity regarding cognitive outcomes. Different variables may be related to such heterogeneity and should be the focus of therapeutic approaches and further research.Fil: Szmulewicz, Alejandro G.. Universidad Favaloro; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Emergencias Psiquiáicas ; ArgentinaFil: Samame, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad de Buenos Aires; ArgentinaFil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Strejilevich, Sergio. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; ArgentinaUniversidade de São Paulo2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/61417Szmulewicz, Alejandro G.; Samame, Cecilia; Martino, Diego Javier; Strejilevich, Sergio; An updated review on the neuropsychological profile of subjects with bipolar disorder; Universidade de São Paulo; Archives of Clinical Psychiatry; 42; 5; 9-2015; 139-1461806-938XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1590/0101-60830000000064info:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-60832015000500139&lng=en&nrm=iso&tlng=eninfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:28Zoai:ri.conicet.gov.ar:11336/61417instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:28.977CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An updated review on the neuropsychological profile of subjects with bipolar disorder
title An updated review on the neuropsychological profile of subjects with bipolar disorder
spellingShingle An updated review on the neuropsychological profile of subjects with bipolar disorder
Szmulewicz, Alejandro G.
BIPOLAR DISORDER
EVOLUTION
HETEROGENEITY
NEUROPSYCHOLOGICAL FUNCTIONING
title_short An updated review on the neuropsychological profile of subjects with bipolar disorder
title_full An updated review on the neuropsychological profile of subjects with bipolar disorder
title_fullStr An updated review on the neuropsychological profile of subjects with bipolar disorder
title_full_unstemmed An updated review on the neuropsychological profile of subjects with bipolar disorder
title_sort An updated review on the neuropsychological profile of subjects with bipolar disorder
dc.creator.none.fl_str_mv Szmulewicz, Alejandro G.
Samame, Cecilia
Martino, Diego Javier
Strejilevich, Sergio
author Szmulewicz, Alejandro G.
author_facet Szmulewicz, Alejandro G.
Samame, Cecilia
Martino, Diego Javier
Strejilevich, Sergio
author_role author
author2 Samame, Cecilia
Martino, Diego Javier
Strejilevich, Sergio
author2_role author
author
author
dc.subject.none.fl_str_mv BIPOLAR DISORDER
EVOLUTION
HETEROGENEITY
NEUROPSYCHOLOGICAL FUNCTIONING
topic BIPOLAR DISORDER
EVOLUTION
HETEROGENEITY
NEUROPSYCHOLOGICAL FUNCTIONING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: In recent years, growing interest in the neuropsychology of bipolar disorder has emerged, giving rise to the accumulation of a robust body of evidence on this topic and to several related questions. Objective: To provide a state-of-the-art overview of the neuropsychological profile of bipolar disorder. Method: A thorough literature search was performed. Published research evidence was summarized and organized along three key pathways: findings from cross-sectional studies of cognition in bipolar patients, cognitive heterogeneity among affected subjects, and trajectory of neuropsychological deficits. Results: At least two thirds of bipolar patients display neuropsychological deficits, even in euthymia. Although bipolar disorder was found to be associated with an increased risk of dementia, data from elderly subjects and longitudinal research do not support a worsening of cognitive performance over time. Discussion: Cognitive dysfunctions are part of the clinical conceptualization of bipolar illness. However, they may not be present in all affected subjects and their course appears to be stable in most cases. Available evidence may be highlighting the fact that bipolar disorder is characterized by remarkable heterogeneity regarding cognitive outcomes. Different variables may be related to such heterogeneity and should be the focus of therapeutic approaches and further research.
Fil: Szmulewicz, Alejandro G.. Universidad Favaloro; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Emergencias Psiquiáicas ; Argentina
Fil: Samame, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad de Buenos Aires; Argentina
Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Strejilevich, Sergio. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina
description Background: In recent years, growing interest in the neuropsychology of bipolar disorder has emerged, giving rise to the accumulation of a robust body of evidence on this topic and to several related questions. Objective: To provide a state-of-the-art overview of the neuropsychological profile of bipolar disorder. Method: A thorough literature search was performed. Published research evidence was summarized and organized along three key pathways: findings from cross-sectional studies of cognition in bipolar patients, cognitive heterogeneity among affected subjects, and trajectory of neuropsychological deficits. Results: At least two thirds of bipolar patients display neuropsychological deficits, even in euthymia. Although bipolar disorder was found to be associated with an increased risk of dementia, data from elderly subjects and longitudinal research do not support a worsening of cognitive performance over time. Discussion: Cognitive dysfunctions are part of the clinical conceptualization of bipolar illness. However, they may not be present in all affected subjects and their course appears to be stable in most cases. Available evidence may be highlighting the fact that bipolar disorder is characterized by remarkable heterogeneity regarding cognitive outcomes. Different variables may be related to such heterogeneity and should be the focus of therapeutic approaches and further research.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/61417
Szmulewicz, Alejandro G.; Samame, Cecilia; Martino, Diego Javier; Strejilevich, Sergio; An updated review on the neuropsychological profile of subjects with bipolar disorder; Universidade de São Paulo; Archives of Clinical Psychiatry; 42; 5; 9-2015; 139-146
1806-938X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/61417
identifier_str_mv Szmulewicz, Alejandro G.; Samame, Cecilia; Martino, Diego Javier; Strejilevich, Sergio; An updated review on the neuropsychological profile of subjects with bipolar disorder; Universidade de São Paulo; Archives of Clinical Psychiatry; 42; 5; 9-2015; 139-146
1806-938X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1590/0101-60830000000064
info:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-60832015000500139&lng=en&nrm=iso&tlng=en
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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