Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed

Autores
Azcona, Florencia; Molina, Antonio; Demyda-Peyrás, Sebastián
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Analyzing genetic variability and inbreeding trends is essential for effective breed management in animal populations. To this, the characterization of runs of homozygosity (ROH) provides a good genomic approach to study the phenomena. The Polo Argentino (PA) breed, globally recognized as the best adapted to playing polo, is known for its strong influence of Thoroughbreds, intense selective breeding, and extensive use of reproductive biotechnologies. This study investigates the PA’s genomic variability, by characterizing the ROH landscape and identifying ROH islands (ROHi) as potential genomic footprints for the breed. PA horses (n = 506) were genotyped using EquineGGP™ array v5 (70 k). We calculated the inbreeding coefficient based on ROH (FROH—ancestral and recent) using a chromosomal approach. Finally, we identified genomic regions with increased ROH frequency (ROHi) and their associated genes. An average of 79.5 ROH per horse was detected, with a mean length of 4.6 Mb. The average FROH was 0.151, but most of them (54%) corresponded to ancestral inbreeding (ROH < 5.5 Mb). However, 4 ROHi were identified in ECA 1, 3, 7 and 17, containing 67 genes, some of which were related to behavior, neurodevelopment, and metabolic functions. This genomic analysis determined, for the first time, the length and location of homozygosity segments in the PA breed and identified ROHi associated with potential genomic regions and genes for positive selection in the breed.
Fil: Azcona, Florencia. Catedra de Genetica de Poblaciones y Mejoramiento Animal ; Departamento de Produccion Animal ; Facultad de Cs.veterinarias ; Universidad Nacional de la Plata; . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Molina, Antonio. Universidad de Córdoba; España
Fil: Demyda-Peyrás, Sebastián. Universidad de Córdoba; España
Materia
runs of homozygosity
genomic footprints
ROH island
polo horses
equine genetics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/256181
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse BreedAzcona, FlorenciaMolina, AntonioDemyda-Peyrás, Sebastiánruns of homozygositygenomic footprintsROH islandpolo horsesequine geneticshttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Analyzing genetic variability and inbreeding trends is essential for effective breed management in animal populations. To this, the characterization of runs of homozygosity (ROH) provides a good genomic approach to study the phenomena. The Polo Argentino (PA) breed, globally recognized as the best adapted to playing polo, is known for its strong influence of Thoroughbreds, intense selective breeding, and extensive use of reproductive biotechnologies. This study investigates the PA’s genomic variability, by characterizing the ROH landscape and identifying ROH islands (ROHi) as potential genomic footprints for the breed. PA horses (n = 506) were genotyped using EquineGGP™ array v5 (70 k). We calculated the inbreeding coefficient based on ROH (FROH—ancestral and recent) using a chromosomal approach. Finally, we identified genomic regions with increased ROH frequency (ROHi) and their associated genes. An average of 79.5 ROH per horse was detected, with a mean length of 4.6 Mb. The average FROH was 0.151, but most of them (54%) corresponded to ancestral inbreeding (ROH < 5.5 Mb). However, 4 ROHi were identified in ECA 1, 3, 7 and 17, containing 67 genes, some of which were related to behavior, neurodevelopment, and metabolic functions. This genomic analysis determined, for the first time, the length and location of homozygosity segments in the PA breed and identified ROHi associated with potential genomic regions and genes for positive selection in the breed.Fil: Azcona, Florencia. Catedra de Genetica de Poblaciones y Mejoramiento Animal ; Departamento de Produccion Animal ; Facultad de Cs.veterinarias ; Universidad Nacional de la Plata; . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Molina, Antonio. Universidad de Córdoba; EspañaFil: Demyda-Peyrás, Sebastián. Universidad de Córdoba; EspañaMolecular Diversity Preservation International2024-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/256181Azcona, Florencia; Molina, Antonio; Demyda-Peyrás, Sebastián; Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 26; 1; 12-2024; 1-141422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/26/1/26info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms26010026info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:12:59Zoai:ri.conicet.gov.ar:11336/256181instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:13:00.065CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed
title Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed
spellingShingle Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed
Azcona, Florencia
runs of homozygosity
genomic footprints
ROH island
polo horses
equine genetics
title_short Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed
title_full Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed
title_fullStr Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed
title_full_unstemmed Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed
title_sort Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed
dc.creator.none.fl_str_mv Azcona, Florencia
Molina, Antonio
Demyda-Peyrás, Sebastián
author Azcona, Florencia
author_facet Azcona, Florencia
Molina, Antonio
Demyda-Peyrás, Sebastián
author_role author
author2 Molina, Antonio
Demyda-Peyrás, Sebastián
author2_role author
author
dc.subject.none.fl_str_mv runs of homozygosity
genomic footprints
ROH island
polo horses
equine genetics
topic runs of homozygosity
genomic footprints
ROH island
polo horses
equine genetics
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Analyzing genetic variability and inbreeding trends is essential for effective breed management in animal populations. To this, the characterization of runs of homozygosity (ROH) provides a good genomic approach to study the phenomena. The Polo Argentino (PA) breed, globally recognized as the best adapted to playing polo, is known for its strong influence of Thoroughbreds, intense selective breeding, and extensive use of reproductive biotechnologies. This study investigates the PA’s genomic variability, by characterizing the ROH landscape and identifying ROH islands (ROHi) as potential genomic footprints for the breed. PA horses (n = 506) were genotyped using EquineGGP™ array v5 (70 k). We calculated the inbreeding coefficient based on ROH (FROH—ancestral and recent) using a chromosomal approach. Finally, we identified genomic regions with increased ROH frequency (ROHi) and their associated genes. An average of 79.5 ROH per horse was detected, with a mean length of 4.6 Mb. The average FROH was 0.151, but most of them (54%) corresponded to ancestral inbreeding (ROH < 5.5 Mb). However, 4 ROHi were identified in ECA 1, 3, 7 and 17, containing 67 genes, some of which were related to behavior, neurodevelopment, and metabolic functions. This genomic analysis determined, for the first time, the length and location of homozygosity segments in the PA breed and identified ROHi associated with potential genomic regions and genes for positive selection in the breed.
Fil: Azcona, Florencia. Catedra de Genetica de Poblaciones y Mejoramiento Animal ; Departamento de Produccion Animal ; Facultad de Cs.veterinarias ; Universidad Nacional de la Plata; . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Molina, Antonio. Universidad de Córdoba; España
Fil: Demyda-Peyrás, Sebastián. Universidad de Córdoba; España
description Analyzing genetic variability and inbreeding trends is essential for effective breed management in animal populations. To this, the characterization of runs of homozygosity (ROH) provides a good genomic approach to study the phenomena. The Polo Argentino (PA) breed, globally recognized as the best adapted to playing polo, is known for its strong influence of Thoroughbreds, intense selective breeding, and extensive use of reproductive biotechnologies. This study investigates the PA’s genomic variability, by characterizing the ROH landscape and identifying ROH islands (ROHi) as potential genomic footprints for the breed. PA horses (n = 506) were genotyped using EquineGGP™ array v5 (70 k). We calculated the inbreeding coefficient based on ROH (FROH—ancestral and recent) using a chromosomal approach. Finally, we identified genomic regions with increased ROH frequency (ROHi) and their associated genes. An average of 79.5 ROH per horse was detected, with a mean length of 4.6 Mb. The average FROH was 0.151, but most of them (54%) corresponded to ancestral inbreeding (ROH < 5.5 Mb). However, 4 ROHi were identified in ECA 1, 3, 7 and 17, containing 67 genes, some of which were related to behavior, neurodevelopment, and metabolic functions. This genomic analysis determined, for the first time, the length and location of homozygosity segments in the PA breed and identified ROHi associated with potential genomic regions and genes for positive selection in the breed.
publishDate 2024
dc.date.none.fl_str_mv 2024-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/256181
Azcona, Florencia; Molina, Antonio; Demyda-Peyrás, Sebastián; Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 26; 1; 12-2024; 1-14
1422-0067
CONICET Digital
CONICET
url http://hdl.handle.net/11336/256181
identifier_str_mv Azcona, Florencia; Molina, Antonio; Demyda-Peyrás, Sebastián; Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 26; 1; 12-2024; 1-14
1422-0067
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/26/1/26
info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms26010026
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781531521024000
score 12.982451

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