Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex

Autores
Villalta, Jorge Ignacio; Landi, Sofía Mariana; Fló, Ana; Della Maggiore, Valeria Monica
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Savings is a fundamental property of learning. In motor adaptation, it refers to the improvement in learning observed when adaptation to a perturbation A (A1) is followed by re-adaptation to the same perturbation (A2). A common procedure to equate the initial level of error across sessions consists of restoring native sensorimotor coordinates by inserting null—unperturbed—trials (N) just before re-adaptation (washout). Here, we hypothesized that the washout is not innocuous but interferes with the expression of the new memory at recall. To assess this possibility, we measured savings following the A1NA2 protocol, where A was a 40° visual rotation. In Experiment 1, we increased the time window between N and A2 from 1 min to 24 h. This manipulation increased the amount of savings during middle to late phases of adaptation, suggesting that N interfered with the retrieval of A. In Experiment 2, we used repetitive TMS to evaluate if this interference was partly mediated by the sensorimotor cortex (SM). We conclude that the washout does not just restore the unperturbed sensorimotor coordinates, but inhibits the expression of the recently acquired visuomotor map through a mechanism involving SM. Our results resemble the phenomenon of extinction in classical conditioning.
Fil: Villalta, Jorge Ignacio. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Landi, Sofía Mariana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fló, Ana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Della Maggiore, Valeria Monica. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Adaptation
Anterograde Interference
Motor Learning
Null Trials
Sensorimotor Cortex
Transcranial Magnetic Stimulation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15358
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortexVillalta, Jorge IgnacioLandi, Sofía MarianaFló, AnaDella Maggiore, Valeria MonicaAdaptationAnterograde InterferenceMotor LearningNull TrialsSensorimotor CortexTranscranial Magnetic Stimulationhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Savings is a fundamental property of learning. In motor adaptation, it refers to the improvement in learning observed when adaptation to a perturbation A (A1) is followed by re-adaptation to the same perturbation (A2). A common procedure to equate the initial level of error across sessions consists of restoring native sensorimotor coordinates by inserting null—unperturbed—trials (N) just before re-adaptation (washout). Here, we hypothesized that the washout is not innocuous but interferes with the expression of the new memory at recall. To assess this possibility, we measured savings following the A1NA2 protocol, where A was a 40° visual rotation. In Experiment 1, we increased the time window between N and A2 from 1 min to 24 h. This manipulation increased the amount of savings during middle to late phases of adaptation, suggesting that N interfered with the retrieval of A. In Experiment 2, we used repetitive TMS to evaluate if this interference was partly mediated by the sensorimotor cortex (SM). We conclude that the washout does not just restore the unperturbed sensorimotor coordinates, but inhibits the expression of the recently acquired visuomotor map through a mechanism involving SM. Our results resemble the phenomenon of extinction in classical conditioning.Fil: Villalta, Jorge Ignacio. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Landi, Sofía Mariana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fló, Ana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Della Maggiore, Valeria Monica. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaOxford University Press2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15358Villalta, Jorge Ignacio; Landi, Sofía Mariana; Fló, Ana; Della Maggiore, Valeria Monica; Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex; Oxford University Press; Cerebral Cortex; 25; 6; 6-2015; 1535-15431047-32111460-2199enginfo:eu-repo/semantics/altIdentifier/doi/10.1093/cercor/bht346info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bht346info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:36Zoai:ri.conicet.gov.ar:11336/15358instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:37.217CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex
title Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex
spellingShingle Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex
Villalta, Jorge Ignacio
Adaptation
Anterograde Interference
Motor Learning
Null Trials
Sensorimotor Cortex
Transcranial Magnetic Stimulation
title_short Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex
title_full Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex
title_fullStr Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex
title_full_unstemmed Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex
title_sort Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex
dc.creator.none.fl_str_mv Villalta, Jorge Ignacio
Landi, Sofía Mariana
Fló, Ana
Della Maggiore, Valeria Monica
author Villalta, Jorge Ignacio
author_facet Villalta, Jorge Ignacio
Landi, Sofía Mariana
Fló, Ana
Della Maggiore, Valeria Monica
author_role author
author2 Landi, Sofía Mariana
Fló, Ana
Della Maggiore, Valeria Monica
author2_role author
author
author
dc.subject.none.fl_str_mv Adaptation
Anterograde Interference
Motor Learning
Null Trials
Sensorimotor Cortex
Transcranial Magnetic Stimulation
topic Adaptation
Anterograde Interference
Motor Learning
Null Trials
Sensorimotor Cortex
Transcranial Magnetic Stimulation
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Savings is a fundamental property of learning. In motor adaptation, it refers to the improvement in learning observed when adaptation to a perturbation A (A1) is followed by re-adaptation to the same perturbation (A2). A common procedure to equate the initial level of error across sessions consists of restoring native sensorimotor coordinates by inserting null—unperturbed—trials (N) just before re-adaptation (washout). Here, we hypothesized that the washout is not innocuous but interferes with the expression of the new memory at recall. To assess this possibility, we measured savings following the A1NA2 protocol, where A was a 40° visual rotation. In Experiment 1, we increased the time window between N and A2 from 1 min to 24 h. This manipulation increased the amount of savings during middle to late phases of adaptation, suggesting that N interfered with the retrieval of A. In Experiment 2, we used repetitive TMS to evaluate if this interference was partly mediated by the sensorimotor cortex (SM). We conclude that the washout does not just restore the unperturbed sensorimotor coordinates, but inhibits the expression of the recently acquired visuomotor map through a mechanism involving SM. Our results resemble the phenomenon of extinction in classical conditioning.
Fil: Villalta, Jorge Ignacio. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Landi, Sofía Mariana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fló, Ana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Della Maggiore, Valeria Monica. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Savings is a fundamental property of learning. In motor adaptation, it refers to the improvement in learning observed when adaptation to a perturbation A (A1) is followed by re-adaptation to the same perturbation (A2). A common procedure to equate the initial level of error across sessions consists of restoring native sensorimotor coordinates by inserting null—unperturbed—trials (N) just before re-adaptation (washout). Here, we hypothesized that the washout is not innocuous but interferes with the expression of the new memory at recall. To assess this possibility, we measured savings following the A1NA2 protocol, where A was a 40° visual rotation. In Experiment 1, we increased the time window between N and A2 from 1 min to 24 h. This manipulation increased the amount of savings during middle to late phases of adaptation, suggesting that N interfered with the retrieval of A. In Experiment 2, we used repetitive TMS to evaluate if this interference was partly mediated by the sensorimotor cortex (SM). We conclude that the washout does not just restore the unperturbed sensorimotor coordinates, but inhibits the expression of the recently acquired visuomotor map through a mechanism involving SM. Our results resemble the phenomenon of extinction in classical conditioning.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15358
Villalta, Jorge Ignacio; Landi, Sofía Mariana; Fló, Ana; Della Maggiore, Valeria Monica; Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex; Oxford University Press; Cerebral Cortex; 25; 6; 6-2015; 1535-1543
1047-3211
1460-2199
url http://hdl.handle.net/11336/15358
identifier_str_mv Villalta, Jorge Ignacio; Landi, Sofía Mariana; Fló, Ana; Della Maggiore, Valeria Monica; Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex; Oxford University Press; Cerebral Cortex; 25; 6; 6-2015; 1535-1543
1047-3211
1460-2199
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/cercor/bht346
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bht346
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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