Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies

Autores
Ramirez, Maria Soledad; Xie, G.; Marshall, S. H.; Hujer, K. M.; Chain, P. S. G.; Bonomo, R. A.; Tolmasky, Marcelo E.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Comparison of genome-wide, high-resolution restriction maps of Klebsiella pneumoniae clinical isolates, including an NDM-1 producer, and in silico-generated restriction maps of sequenced genomes revealed a highly heterogeneous region we designated the ‘high heterogeneity zone’ (HHZ). The HHZ consists of several regions, including a ‘hot spot’ prone to insertions and other rearrangements. The HHZ is a characteristic genomic area that can be used in the identification and tracking of outbreak-causing strains.
Fil: Ramirez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. California State University; Estados Unidos
Fil: Xie, G.. Los Alamos National Laboratory; Estados Unidos. United States Department of Energy. Joint Genome Institute; Estados Unidos
Fil: Marshall, S. H.. Veteran ffairs Medical Center; Estados Unidos
Fil: Hujer, K. M.. Veteran ffairs Medical Center; Estados Unidos
Fil: Chain, P. S. G.. Los Alamos National Laboratory; Estados Unidos. United States Department of Energy. Joint Genome Institute; Estados Unidos
Fil: Bonomo, R. A.. Veteran ffairs Medical Center; Estados Unidos. Case Western Reserve University; Estados Unidos
Fil: Tolmasky, Marcelo E.. California State University; Estados Unidos
Materia
KLEBSIELLA PNEUMONIAE
MAPA OPTICO
EPIDEMIOLOGIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/272577
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studiesRamirez, Maria SoledadXie, G.Marshall, S. H.Hujer, K. M.Chain, P. S. G.Bonomo, R. A.Tolmasky, Marcelo E.KLEBSIELLA PNEUMONIAEMAPA OPTICOEPIDEMIOLOGIAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Comparison of genome-wide, high-resolution restriction maps of Klebsiella pneumoniae clinical isolates, including an NDM-1 producer, and in silico-generated restriction maps of sequenced genomes revealed a highly heterogeneous region we designated the ‘high heterogeneity zone’ (HHZ). The HHZ consists of several regions, including a ‘hot spot’ prone to insertions and other rearrangements. The HHZ is a characteristic genomic area that can be used in the identification and tracking of outbreak-causing strains.Fil: Ramirez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. California State University; Estados UnidosFil: Xie, G.. Los Alamos National Laboratory; Estados Unidos. United States Department of Energy. Joint Genome Institute; Estados UnidosFil: Marshall, S. H.. Veteran ffairs Medical Center; Estados UnidosFil: Hujer, K. M.. Veteran ffairs Medical Center; Estados UnidosFil: Chain, P. S. G.. Los Alamos National Laboratory; Estados Unidos. United States Department of Energy. Joint Genome Institute; Estados UnidosFil: Bonomo, R. A.. Veteran ffairs Medical Center; Estados Unidos. Case Western Reserve University; Estados UnidosFil: Tolmasky, Marcelo E.. California State University; Estados UnidosWiley Blackwell Publishing, Inc2012-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/272577Ramirez, Maria Soledad; Xie, G.; Marshall, S. H.; Hujer, K. M.; Chain, P. S. G.; et al.; Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies; Wiley Blackwell Publishing, Inc; Clinical Microbiology And Infection; 18; 7; 7-2012; 254-2581198-743XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1198743X14645869info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1469-0691.2012.03886.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:43:47Zoai:ri.conicet.gov.ar:11336/272577instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:43:47.959CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies
title Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies
spellingShingle Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies
Ramirez, Maria Soledad
KLEBSIELLA PNEUMONIAE
MAPA OPTICO
EPIDEMIOLOGIA
title_short Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies
title_full Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies
title_fullStr Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies
title_full_unstemmed Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies
title_sort Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies
dc.creator.none.fl_str_mv Ramirez, Maria Soledad
Xie, G.
Marshall, S. H.
Hujer, K. M.
Chain, P. S. G.
Bonomo, R. A.
Tolmasky, Marcelo E.
author Ramirez, Maria Soledad
author_facet Ramirez, Maria Soledad
Xie, G.
Marshall, S. H.
Hujer, K. M.
Chain, P. S. G.
Bonomo, R. A.
Tolmasky, Marcelo E.
author_role author
author2 Xie, G.
Marshall, S. H.
Hujer, K. M.
Chain, P. S. G.
Bonomo, R. A.
Tolmasky, Marcelo E.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv KLEBSIELLA PNEUMONIAE
MAPA OPTICO
EPIDEMIOLOGIA
topic KLEBSIELLA PNEUMONIAE
MAPA OPTICO
EPIDEMIOLOGIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Comparison of genome-wide, high-resolution restriction maps of Klebsiella pneumoniae clinical isolates, including an NDM-1 producer, and in silico-generated restriction maps of sequenced genomes revealed a highly heterogeneous region we designated the ‘high heterogeneity zone’ (HHZ). The HHZ consists of several regions, including a ‘hot spot’ prone to insertions and other rearrangements. The HHZ is a characteristic genomic area that can be used in the identification and tracking of outbreak-causing strains.
Fil: Ramirez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. California State University; Estados Unidos
Fil: Xie, G.. Los Alamos National Laboratory; Estados Unidos. United States Department of Energy. Joint Genome Institute; Estados Unidos
Fil: Marshall, S. H.. Veteran ffairs Medical Center; Estados Unidos
Fil: Hujer, K. M.. Veteran ffairs Medical Center; Estados Unidos
Fil: Chain, P. S. G.. Los Alamos National Laboratory; Estados Unidos. United States Department of Energy. Joint Genome Institute; Estados Unidos
Fil: Bonomo, R. A.. Veteran ffairs Medical Center; Estados Unidos. Case Western Reserve University; Estados Unidos
Fil: Tolmasky, Marcelo E.. California State University; Estados Unidos
description Comparison of genome-wide, high-resolution restriction maps of Klebsiella pneumoniae clinical isolates, including an NDM-1 producer, and in silico-generated restriction maps of sequenced genomes revealed a highly heterogeneous region we designated the ‘high heterogeneity zone’ (HHZ). The HHZ consists of several regions, including a ‘hot spot’ prone to insertions and other rearrangements. The HHZ is a characteristic genomic area that can be used in the identification and tracking of outbreak-causing strains.
publishDate 2012
dc.date.none.fl_str_mv 2012-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/272577
Ramirez, Maria Soledad; Xie, G.; Marshall, S. H.; Hujer, K. M.; Chain, P. S. G.; et al.; Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies; Wiley Blackwell Publishing, Inc; Clinical Microbiology And Infection; 18; 7; 7-2012; 254-258
1198-743X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/272577
identifier_str_mv Ramirez, Maria Soledad; Xie, G.; Marshall, S. H.; Hujer, K. M.; Chain, P. S. G.; et al.; Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies; Wiley Blackwell Publishing, Inc; Clinical Microbiology And Infection; 18; 7; 7-2012; 254-258
1198-743X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1198743X14645869
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1469-0691.2012.03886.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.087074

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