Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia

Autores
Couto, Juan Blas Marcos; Manes, Facundo Francisco; Montañés, Patricia; Matallana, Diana; Reyes, Pablo; Velasquez, Marcela; Yoris Magnago, Adrián Ezequiel; Báez Buitrago, Sandra Jimena; Ibáñez Barassi, Agustín Mariano
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Social cognition impairments are pervasive in the frontotemporal dementias (FTD). These deficits would be triggered by (a) basic emotion and face recognition processes as well as by (b) higher level social cognition (e.g., theory of mind, ToM). Both emotional processing and social cognition impairments have been previously reported in the behavioral variant of FTD (bvFTD) and also in other versions of FTDs, including primary progressive aphasia. However, no neuroanatomic comparison between different FTD variants has been performed. We report selective behavioral impairments of face recognition, emotion recognition, and ToM in patients with bvFTD and progressive non-fluent aphasia (PNFA) when compared to controls. Voxel-based morphometry (VBM) shows a classical impairment of mainly orbitofrontal (OFC), anterior cingulate (ACC), insula and lateral temporal cortices in patients. Comparative analysis of regional gray matter related to social cognition deficits (VBM) reveals a differential pattern of fronto-insulo-temporal atrophy in bvFTD and an insulo-temporal involvement in PNFA group. Results suggest that in spite of similar social cognition impairments reported in bvFTD and PNFA, the former represents an inherent ToM affectation whereas in the PNFA these deficits could be related to more basic processes of face and emotion recognition. These results are interpreted in the frame of the fronto-insulo-temporal social context network model (SCNM).
Fil: Couto, Juan Blas Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Montañés, Patricia. Pontificia Universidad Javeriana; Colombia
Fil: Matallana, Diana. Pontificia Universidad Javeriana; Colombia
Fil: Reyes, Pablo. Pontificia Universidad Javeriana; Colombia
Fil: Velasquez, Marcela. Universidad Favaloro; Argentina
Fil: Yoris Magnago, Adrián Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Báez Buitrago, Sandra Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; Chile
Materia
BVFTD
FRONTO-INSULO-TEMPORAL NETWORK
PNFA
SOCIAL CONTEXT NETWORK MODEL
THEORY OF MIND
VOXEL-BASED MORPHOMETRY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/86417
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/86417
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementiaCouto, Juan Blas MarcosManes, Facundo FranciscoMontañés, PatriciaMatallana, DianaReyes, PabloVelasquez, MarcelaYoris Magnago, Adrián EzequielBáez Buitrago, Sandra JimenaIbáñez Barassi, Agustín MarianoBVFTDFRONTO-INSULO-TEMPORAL NETWORKPNFASOCIAL CONTEXT NETWORK MODELTHEORY OF MINDVOXEL-BASED MORPHOMETRYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Social cognition impairments are pervasive in the frontotemporal dementias (FTD). These deficits would be triggered by (a) basic emotion and face recognition processes as well as by (b) higher level social cognition (e.g., theory of mind, ToM). Both emotional processing and social cognition impairments have been previously reported in the behavioral variant of FTD (bvFTD) and also in other versions of FTDs, including primary progressive aphasia. However, no neuroanatomic comparison between different FTD variants has been performed. We report selective behavioral impairments of face recognition, emotion recognition, and ToM in patients with bvFTD and progressive non-fluent aphasia (PNFA) when compared to controls. Voxel-based morphometry (VBM) shows a classical impairment of mainly orbitofrontal (OFC), anterior cingulate (ACC), insula and lateral temporal cortices in patients. Comparative analysis of regional gray matter related to social cognition deficits (VBM) reveals a differential pattern of fronto-insulo-temporal atrophy in bvFTD and an insulo-temporal involvement in PNFA group. Results suggest that in spite of similar social cognition impairments reported in bvFTD and PNFA, the former represents an inherent ToM affectation whereas in the PNFA these deficits could be related to more basic processes of face and emotion recognition. These results are interpreted in the frame of the fronto-insulo-temporal social context network model (SCNM).Fil: Couto, Juan Blas Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Montañés, Patricia. Pontificia Universidad Javeriana; ColombiaFil: Matallana, Diana. Pontificia Universidad Javeriana; ColombiaFil: Reyes, Pablo. Pontificia Universidad Javeriana; ColombiaFil: Velasquez, Marcela. Universidad Favaloro; ArgentinaFil: Yoris Magnago, Adrián Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Báez Buitrago, Sandra Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; ChileFrontiers Research Foundation2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86417Couto, Juan Blas Marcos; Manes, Facundo Francisco; Montañés, Patricia; Matallana, Diana; Reyes, Pablo; et al.; Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia; Frontiers Research Foundation; Frontiers In Human Neuroscience; 7; Aug.; 8-2013; 1-111662-5161CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fnhum.2013.00467info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnhum.2013.00467info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:38Zoai:ri.conicet.gov.ar:11336/86417instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:38.381CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia
title Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia
spellingShingle Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia
Couto, Juan Blas Marcos
BVFTD
FRONTO-INSULO-TEMPORAL NETWORK
PNFA
SOCIAL CONTEXT NETWORK MODEL
THEORY OF MIND
VOXEL-BASED MORPHOMETRY
title_short Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia
title_full Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia
title_fullStr Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia
title_full_unstemmed Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia
title_sort Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia
dc.creator.none.fl_str_mv Couto, Juan Blas Marcos
Manes, Facundo Francisco
Montañés, Patricia
Matallana, Diana
Reyes, Pablo
Velasquez, Marcela
Yoris Magnago, Adrián Ezequiel
Báez Buitrago, Sandra Jimena
Ibáñez Barassi, Agustín Mariano
author Couto, Juan Blas Marcos
author_facet Couto, Juan Blas Marcos
Manes, Facundo Francisco
Montañés, Patricia
Matallana, Diana
Reyes, Pablo
Velasquez, Marcela
Yoris Magnago, Adrián Ezequiel
Báez Buitrago, Sandra Jimena
Ibáñez Barassi, Agustín Mariano
author_role author
author2 Manes, Facundo Francisco
Montañés, Patricia
Matallana, Diana
Reyes, Pablo
Velasquez, Marcela
Yoris Magnago, Adrián Ezequiel
Báez Buitrago, Sandra Jimena
Ibáñez Barassi, Agustín Mariano
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BVFTD
FRONTO-INSULO-TEMPORAL NETWORK
PNFA
SOCIAL CONTEXT NETWORK MODEL
THEORY OF MIND
VOXEL-BASED MORPHOMETRY
topic BVFTD
FRONTO-INSULO-TEMPORAL NETWORK
PNFA
SOCIAL CONTEXT NETWORK MODEL
THEORY OF MIND
VOXEL-BASED MORPHOMETRY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Social cognition impairments are pervasive in the frontotemporal dementias (FTD). These deficits would be triggered by (a) basic emotion and face recognition processes as well as by (b) higher level social cognition (e.g., theory of mind, ToM). Both emotional processing and social cognition impairments have been previously reported in the behavioral variant of FTD (bvFTD) and also in other versions of FTDs, including primary progressive aphasia. However, no neuroanatomic comparison between different FTD variants has been performed. We report selective behavioral impairments of face recognition, emotion recognition, and ToM in patients with bvFTD and progressive non-fluent aphasia (PNFA) when compared to controls. Voxel-based morphometry (VBM) shows a classical impairment of mainly orbitofrontal (OFC), anterior cingulate (ACC), insula and lateral temporal cortices in patients. Comparative analysis of regional gray matter related to social cognition deficits (VBM) reveals a differential pattern of fronto-insulo-temporal atrophy in bvFTD and an insulo-temporal involvement in PNFA group. Results suggest that in spite of similar social cognition impairments reported in bvFTD and PNFA, the former represents an inherent ToM affectation whereas in the PNFA these deficits could be related to more basic processes of face and emotion recognition. These results are interpreted in the frame of the fronto-insulo-temporal social context network model (SCNM).
Fil: Couto, Juan Blas Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Montañés, Patricia. Pontificia Universidad Javeriana; Colombia
Fil: Matallana, Diana. Pontificia Universidad Javeriana; Colombia
Fil: Reyes, Pablo. Pontificia Universidad Javeriana; Colombia
Fil: Velasquez, Marcela. Universidad Favaloro; Argentina
Fil: Yoris Magnago, Adrián Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Báez Buitrago, Sandra Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; Chile
description Social cognition impairments are pervasive in the frontotemporal dementias (FTD). These deficits would be triggered by (a) basic emotion and face recognition processes as well as by (b) higher level social cognition (e.g., theory of mind, ToM). Both emotional processing and social cognition impairments have been previously reported in the behavioral variant of FTD (bvFTD) and also in other versions of FTDs, including primary progressive aphasia. However, no neuroanatomic comparison between different FTD variants has been performed. We report selective behavioral impairments of face recognition, emotion recognition, and ToM in patients with bvFTD and progressive non-fluent aphasia (PNFA) when compared to controls. Voxel-based morphometry (VBM) shows a classical impairment of mainly orbitofrontal (OFC), anterior cingulate (ACC), insula and lateral temporal cortices in patients. Comparative analysis of regional gray matter related to social cognition deficits (VBM) reveals a differential pattern of fronto-insulo-temporal atrophy in bvFTD and an insulo-temporal involvement in PNFA group. Results suggest that in spite of similar social cognition impairments reported in bvFTD and PNFA, the former represents an inherent ToM affectation whereas in the PNFA these deficits could be related to more basic processes of face and emotion recognition. These results are interpreted in the frame of the fronto-insulo-temporal social context network model (SCNM).
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/86417
Couto, Juan Blas Marcos; Manes, Facundo Francisco; Montañés, Patricia; Matallana, Diana; Reyes, Pablo; et al.; Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia; Frontiers Research Foundation; Frontiers In Human Neuroscience; 7; Aug.; 8-2013; 1-11
1662-5161
CONICET Digital
CONICET
url http://hdl.handle.net/11336/86417
identifier_str_mv Couto, Juan Blas Marcos; Manes, Facundo Francisco; Montañés, Patricia; Matallana, Diana; Reyes, Pablo; et al.; Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia; Frontiers Research Foundation; Frontiers In Human Neuroscience; 7; Aug.; 8-2013; 1-11
1662-5161
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fnhum.2013.00467
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnhum.2013.00467
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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