[177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies

Autores
Audicio, Paola F.; Castellano, Gustavo Eugenio; Tassano, Marcos R.; Rezzano, Maria E.; Fernandez, Marcelo; Riva, Eloisa; Robles, Ana; Cabral, Pablo; Balter, Henia; Oliver, Patricia
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Anti-CD20 (Rituximab®), a specific chimeric monoclonal antibody used in CD20-positive Non-Hodgkin’s Lymphoma, was conjugated to a bifunctional quelate (DOTA) and radiolabeled with 177Lu through a simple method. [177Lu]-DOTA-anti-CD20 was obtained with a radiochemical purity higher than 97%, and showed good chemical and biological stability, maintaining its biospecificity to CD20 antigens. MonteCarlo simulation showed high doses deposited on a spheroid tumor mass model. This method shows to be an appropiate alternative for the production of [177Lu]-DOTA-anti-CD20 as therapeutic radiopharmaceutical.
Fil: Audicio, Paola F.. Universidad de la República; Uruguay
Fil: Castellano, Gustavo Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Tassano, Marcos R.. Universidad de la República; Uruguay
Fil: Rezzano, Maria E.. Universidad de la República; Uruguay
Fil: Fernandez, Marcelo. Universidad de la República; Uruguay
Fil: Riva, Eloisa. Hospital de Clínicas; Uruguay
Fil: Robles, Ana. Universidad de la República; Uruguay
Fil: Cabral, Pablo. Universidad de la República; Uruguay
Fil: Balter, Henia. Universidad de la República; Uruguay
Fil: Oliver, Patricia. Universidad de la República; Uruguay
Materia
CD20
Non-Hodgkin Lymphoma
177Lu
Radioimmunotherapy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/271298
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studiesAudicio, Paola F.Castellano, Gustavo EugenioTassano, Marcos R.Rezzano, Maria E.Fernandez, MarceloRiva, EloisaRobles, AnaCabral, PabloBalter, HeniaOliver, PatriciaCD20Non-Hodgkin Lymphoma177LuRadioimmunotherapyhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Anti-CD20 (Rituximab®), a specific chimeric monoclonal antibody used in CD20-positive Non-Hodgkin’s Lymphoma, was conjugated to a bifunctional quelate (DOTA) and radiolabeled with 177Lu through a simple method. [177Lu]-DOTA-anti-CD20 was obtained with a radiochemical purity higher than 97%, and showed good chemical and biological stability, maintaining its biospecificity to CD20 antigens. MonteCarlo simulation showed high doses deposited on a spheroid tumor mass model. This method shows to be an appropiate alternative for the production of [177Lu]-DOTA-anti-CD20 as therapeutic radiopharmaceutical.Fil: Audicio, Paola F.. Universidad de la República; UruguayFil: Castellano, Gustavo Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Tassano, Marcos R.. Universidad de la República; UruguayFil: Rezzano, Maria E.. Universidad de la República; UruguayFil: Fernandez, Marcelo. Universidad de la República; UruguayFil: Riva, Eloisa. Hospital de Clínicas; UruguayFil: Robles, Ana. Universidad de la República; UruguayFil: Cabral, Pablo. Universidad de la República; UruguayFil: Balter, Henia. Universidad de la República; UruguayFil: Oliver, Patricia. Universidad de la República; UruguayPergamon-Elsevier Science Ltd2011-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/271298Audicio, Paola F.; Castellano, Gustavo Eugenio; Tassano, Marcos R.; Rezzano, Maria E.; Fernandez, Marcelo; et al.; [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 69; 7; 7-2011; 924-9280969-8043CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969804311000406info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2011.01.026info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:05Zoai:ri.conicet.gov.ar:11336/271298instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:05.891CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies
title [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies
spellingShingle [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies
Audicio, Paola F.
CD20
Non-Hodgkin Lymphoma
177Lu
Radioimmunotherapy
title_short [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies
title_full [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies
title_fullStr [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies
title_full_unstemmed [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies
title_sort [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies
dc.creator.none.fl_str_mv Audicio, Paola F.
Castellano, Gustavo Eugenio
Tassano, Marcos R.
Rezzano, Maria E.
Fernandez, Marcelo
Riva, Eloisa
Robles, Ana
Cabral, Pablo
Balter, Henia
Oliver, Patricia
author Audicio, Paola F.
author_facet Audicio, Paola F.
Castellano, Gustavo Eugenio
Tassano, Marcos R.
Rezzano, Maria E.
Fernandez, Marcelo
Riva, Eloisa
Robles, Ana
Cabral, Pablo
Balter, Henia
Oliver, Patricia
author_role author
author2 Castellano, Gustavo Eugenio
Tassano, Marcos R.
Rezzano, Maria E.
Fernandez, Marcelo
Riva, Eloisa
Robles, Ana
Cabral, Pablo
Balter, Henia
Oliver, Patricia
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CD20
Non-Hodgkin Lymphoma
177Lu
Radioimmunotherapy
topic CD20
Non-Hodgkin Lymphoma
177Lu
Radioimmunotherapy
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Anti-CD20 (Rituximab®), a specific chimeric monoclonal antibody used in CD20-positive Non-Hodgkin’s Lymphoma, was conjugated to a bifunctional quelate (DOTA) and radiolabeled with 177Lu through a simple method. [177Lu]-DOTA-anti-CD20 was obtained with a radiochemical purity higher than 97%, and showed good chemical and biological stability, maintaining its biospecificity to CD20 antigens. MonteCarlo simulation showed high doses deposited on a spheroid tumor mass model. This method shows to be an appropiate alternative for the production of [177Lu]-DOTA-anti-CD20 as therapeutic radiopharmaceutical.
Fil: Audicio, Paola F.. Universidad de la República; Uruguay
Fil: Castellano, Gustavo Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Tassano, Marcos R.. Universidad de la República; Uruguay
Fil: Rezzano, Maria E.. Universidad de la República; Uruguay
Fil: Fernandez, Marcelo. Universidad de la República; Uruguay
Fil: Riva, Eloisa. Hospital de Clínicas; Uruguay
Fil: Robles, Ana. Universidad de la República; Uruguay
Fil: Cabral, Pablo. Universidad de la República; Uruguay
Fil: Balter, Henia. Universidad de la República; Uruguay
Fil: Oliver, Patricia. Universidad de la República; Uruguay
description Anti-CD20 (Rituximab®), a specific chimeric monoclonal antibody used in CD20-positive Non-Hodgkin’s Lymphoma, was conjugated to a bifunctional quelate (DOTA) and radiolabeled with 177Lu through a simple method. [177Lu]-DOTA-anti-CD20 was obtained with a radiochemical purity higher than 97%, and showed good chemical and biological stability, maintaining its biospecificity to CD20 antigens. MonteCarlo simulation showed high doses deposited on a spheroid tumor mass model. This method shows to be an appropiate alternative for the production of [177Lu]-DOTA-anti-CD20 as therapeutic radiopharmaceutical.
publishDate 2011
dc.date.none.fl_str_mv 2011-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/271298
Audicio, Paola F.; Castellano, Gustavo Eugenio; Tassano, Marcos R.; Rezzano, Maria E.; Fernandez, Marcelo; et al.; [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 69; 7; 7-2011; 924-928
0969-8043
CONICET Digital
CONICET
url http://hdl.handle.net/11336/271298
identifier_str_mv Audicio, Paola F.; Castellano, Gustavo Eugenio; Tassano, Marcos R.; Rezzano, Maria E.; Fernandez, Marcelo; et al.; [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 69; 7; 7-2011; 924-928
0969-8043
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969804311000406
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2011.01.026
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614178189344768
score 13.070432

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