Melatonin, immune function and cancer

Autores
Srinivasan, Venkatramanujam; Pandi Perumal, Seithikurippu R.; Brzezinsk, Amnon; Bhatnagar, Kunwar P.; Cardinali, Daniel Pedro
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Melatonin is a natural substance ubiquitous in distribution and present in almost all species ranging from unicellular organisms to humans. In mammals, melatonin is synthesized not only in the pineal gland but also in many other parts of the body, including the eyes, bone marrow, gastrointestinal tract, skin and lymphocytes. Melatonin influences almost every cell and can be traced in membrane, cytoplasmic, mitochondrial and nuclear compartments of the cell. The decline in the production of melatonin with age has been suggested as one of the major contributors to immunosenescence and development of neoplastic diseases. Melatonin is a natural antioxidant with immunoenhancing properties. T-helper cells play an important role for protection against malignancy and melatonin has been shown to enhance T-helper cell response by releasing interleukin-2, interleukin-10 and interferon-��. Melatonin is effective in suppressing neoplastic growth in a variety of tumors like melanoma, breast and prostate cancer, and ovarian and colorectal cancer. As an adjuvant therapy, melatonin can be beneficial in treating patients suffering from breast cancer, hepatocellular carcinoma or melanoma. In this paper, a brief review of recent patents on melatonin and cancer has also been presented.
Fil: Srinivasan, Venkatramanujam. Karpagam Academy Of Higher Education; India. Sri Sathya Sai Medical Educational And Research Foundation; India
Fil: Pandi Perumal, Seithikurippu R.. No especifíca;
Fil: Brzezinsk, Amnon. The Hebrew University of Jerusalem; Israel
Fil: Bhatnagar, Kunwar P.. University of Louisville; Estados Unidos
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
BREAST CANCER
COLORECTAL CANCER
CYTOKINES
GASTROINTESTINAL CANCER
IMMUNE THERAPY
MELANOMA
MELATONIN
OXIDATIVE STRESS
PROSTATE CANCER
T-HELPER CELLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/193896
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/193896
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Melatonin, immune function and cancerSrinivasan, VenkatramanujamPandi Perumal, Seithikurippu R.Brzezinsk, AmnonBhatnagar, Kunwar P.Cardinali, Daniel PedroBREAST CANCERCOLORECTAL CANCERCYTOKINESGASTROINTESTINAL CANCERIMMUNE THERAPYMELANOMAMELATONINOXIDATIVE STRESSPROSTATE CANCERT-HELPER CELLShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Melatonin is a natural substance ubiquitous in distribution and present in almost all species ranging from unicellular organisms to humans. In mammals, melatonin is synthesized not only in the pineal gland but also in many other parts of the body, including the eyes, bone marrow, gastrointestinal tract, skin and lymphocytes. Melatonin influences almost every cell and can be traced in membrane, cytoplasmic, mitochondrial and nuclear compartments of the cell. The decline in the production of melatonin with age has been suggested as one of the major contributors to immunosenescence and development of neoplastic diseases. Melatonin is a natural antioxidant with immunoenhancing properties. T-helper cells play an important role for protection against malignancy and melatonin has been shown to enhance T-helper cell response by releasing interleukin-2, interleukin-10 and interferon-��. Melatonin is effective in suppressing neoplastic growth in a variety of tumors like melanoma, breast and prostate cancer, and ovarian and colorectal cancer. As an adjuvant therapy, melatonin can be beneficial in treating patients suffering from breast cancer, hepatocellular carcinoma or melanoma. In this paper, a brief review of recent patents on melatonin and cancer has also been presented.Fil: Srinivasan, Venkatramanujam. Karpagam Academy Of Higher Education; India. Sri Sathya Sai Medical Educational And Research Foundation; IndiaFil: Pandi Perumal, Seithikurippu R.. No especifíca;Fil: Brzezinsk, Amnon. The Hebrew University of Jerusalem; IsraelFil: Bhatnagar, Kunwar P.. University of Louisville; Estados UnidosFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaBentham Science Publishers2011-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/193896Srinivasan, Venkatramanujam; Pandi Perumal, Seithikurippu R.; Brzezinsk, Amnon; Bhatnagar, Kunwar P.; Cardinali, Daniel Pedro; Melatonin, immune function and cancer; Bentham Science Publishers; Recent Patents on Endocrine, Metabolic & Immune Drug Discovery; 5; 2; 11-2011; 109-1231872-2148CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://benthamscience.com/article/39396#:~:text=Melatonin%20is%20effective%20in%20suppressing,cancer%2C%20hepatocellular%20carcinoma%20or%20melanoma.info:eu-repo/semantics/altIdentifier/doi/10.2174/187221411799015408info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:02:41Zoai:ri.conicet.gov.ar:11336/193896instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:02:41.295CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Melatonin, immune function and cancer
title Melatonin, immune function and cancer
spellingShingle Melatonin, immune function and cancer
Srinivasan, Venkatramanujam
BREAST CANCER
COLORECTAL CANCER
CYTOKINES
GASTROINTESTINAL CANCER
IMMUNE THERAPY
MELANOMA
MELATONIN
OXIDATIVE STRESS
PROSTATE CANCER
T-HELPER CELLS
title_short Melatonin, immune function and cancer
title_full Melatonin, immune function and cancer
title_fullStr Melatonin, immune function and cancer
title_full_unstemmed Melatonin, immune function and cancer
title_sort Melatonin, immune function and cancer
dc.creator.none.fl_str_mv Srinivasan, Venkatramanujam
Pandi Perumal, Seithikurippu R.
Brzezinsk, Amnon
Bhatnagar, Kunwar P.
Cardinali, Daniel Pedro
author Srinivasan, Venkatramanujam
author_facet Srinivasan, Venkatramanujam
Pandi Perumal, Seithikurippu R.
Brzezinsk, Amnon
Bhatnagar, Kunwar P.
Cardinali, Daniel Pedro
author_role author
author2 Pandi Perumal, Seithikurippu R.
Brzezinsk, Amnon
Bhatnagar, Kunwar P.
Cardinali, Daniel Pedro
author2_role author
author
author
author
dc.subject.none.fl_str_mv BREAST CANCER
COLORECTAL CANCER
CYTOKINES
GASTROINTESTINAL CANCER
IMMUNE THERAPY
MELANOMA
MELATONIN
OXIDATIVE STRESS
PROSTATE CANCER
T-HELPER CELLS
topic BREAST CANCER
COLORECTAL CANCER
CYTOKINES
GASTROINTESTINAL CANCER
IMMUNE THERAPY
MELANOMA
MELATONIN
OXIDATIVE STRESS
PROSTATE CANCER
T-HELPER CELLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Melatonin is a natural substance ubiquitous in distribution and present in almost all species ranging from unicellular organisms to humans. In mammals, melatonin is synthesized not only in the pineal gland but also in many other parts of the body, including the eyes, bone marrow, gastrointestinal tract, skin and lymphocytes. Melatonin influences almost every cell and can be traced in membrane, cytoplasmic, mitochondrial and nuclear compartments of the cell. The decline in the production of melatonin with age has been suggested as one of the major contributors to immunosenescence and development of neoplastic diseases. Melatonin is a natural antioxidant with immunoenhancing properties. T-helper cells play an important role for protection against malignancy and melatonin has been shown to enhance T-helper cell response by releasing interleukin-2, interleukin-10 and interferon-��. Melatonin is effective in suppressing neoplastic growth in a variety of tumors like melanoma, breast and prostate cancer, and ovarian and colorectal cancer. As an adjuvant therapy, melatonin can be beneficial in treating patients suffering from breast cancer, hepatocellular carcinoma or melanoma. In this paper, a brief review of recent patents on melatonin and cancer has also been presented.
Fil: Srinivasan, Venkatramanujam. Karpagam Academy Of Higher Education; India. Sri Sathya Sai Medical Educational And Research Foundation; India
Fil: Pandi Perumal, Seithikurippu R.. No especifíca;
Fil: Brzezinsk, Amnon. The Hebrew University of Jerusalem; Israel
Fil: Bhatnagar, Kunwar P.. University of Louisville; Estados Unidos
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Melatonin is a natural substance ubiquitous in distribution and present in almost all species ranging from unicellular organisms to humans. In mammals, melatonin is synthesized not only in the pineal gland but also in many other parts of the body, including the eyes, bone marrow, gastrointestinal tract, skin and lymphocytes. Melatonin influences almost every cell and can be traced in membrane, cytoplasmic, mitochondrial and nuclear compartments of the cell. The decline in the production of melatonin with age has been suggested as one of the major contributors to immunosenescence and development of neoplastic diseases. Melatonin is a natural antioxidant with immunoenhancing properties. T-helper cells play an important role for protection against malignancy and melatonin has been shown to enhance T-helper cell response by releasing interleukin-2, interleukin-10 and interferon-��. Melatonin is effective in suppressing neoplastic growth in a variety of tumors like melanoma, breast and prostate cancer, and ovarian and colorectal cancer. As an adjuvant therapy, melatonin can be beneficial in treating patients suffering from breast cancer, hepatocellular carcinoma or melanoma. In this paper, a brief review of recent patents on melatonin and cancer has also been presented.
publishDate 2011
dc.date.none.fl_str_mv 2011-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/193896
Srinivasan, Venkatramanujam; Pandi Perumal, Seithikurippu R.; Brzezinsk, Amnon; Bhatnagar, Kunwar P.; Cardinali, Daniel Pedro; Melatonin, immune function and cancer; Bentham Science Publishers; Recent Patents on Endocrine, Metabolic & Immune Drug Discovery; 5; 2; 11-2011; 109-123
1872-2148
CONICET Digital
CONICET
url http://hdl.handle.net/11336/193896
identifier_str_mv Srinivasan, Venkatramanujam; Pandi Perumal, Seithikurippu R.; Brzezinsk, Amnon; Bhatnagar, Kunwar P.; Cardinali, Daniel Pedro; Melatonin, immune function and cancer; Bentham Science Publishers; Recent Patents on Endocrine, Metabolic & Immune Drug Discovery; 5; 2; 11-2011; 109-123
1872-2148
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://benthamscience.com/article/39396#:~:text=Melatonin%20is%20effective%20in%20suppressing,cancer%2C%20hepatocellular%20carcinoma%20or%20melanoma.
info:eu-repo/semantics/altIdentifier/doi/10.2174/187221411799015408
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613834368614400
score 13.069144

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