Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator

Autores
Cortina, María Eugenia; Litwin, Silvana; Rial Hawila, María Rocío; Miranda, Silvia Esther
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Problem: Multiparity increased the number of trophoblast cells in decidua of both low and high fetal loss mouse models. However, they differ in fetal survival rate and maternal thymocyte subpopulations, suggesting that trophoblast invasiveness is not equivalent. Our aim was to explore the involved mechanism. Method of study: We studied placentae from primiparous and multiparous females of low and high fetal loss models. We investigated invasiveness in vitro, expression of plasminogen, and its activators: tissue type (tPA)‐urokinase type (uPA), and activity and expression of matrix metalloproteinases (MMP)‐2 and MMP‐9. Results: Placental invasiveness is upregulated by multiparity, but lesser in the high fetal loss model. Multiparous animals showed elevated expression of plasminogen and uPA. However, the high fetal loss combination showed higher expression of a short and less active fragment of uPA (LMW‐uPA). MMP‐2, MMP‐9, and tPA were unaffected. Conclusion: uPA would participate in the increased multiparity‐associated placental invasiveness.
Fil: Cortina, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Litwin, Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Rial Hawila, María Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Miranda, Silvia Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Materia
Parity
Placenta
Plasminogen
Upa/Plau
Mouse
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41642
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/41642
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Multiparity upregulates placental plasminogen and urokinase-type plasminogen activatorCortina, María EugeniaLitwin, SilvanaRial Hawila, María RocíoMiranda, Silvia EstherParityPlacentaPlasminogenUpa/PlauMousehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Problem: Multiparity increased the number of trophoblast cells in decidua of both low and high fetal loss mouse models. However, they differ in fetal survival rate and maternal thymocyte subpopulations, suggesting that trophoblast invasiveness is not equivalent. Our aim was to explore the involved mechanism. Method of study: We studied placentae from primiparous and multiparous females of low and high fetal loss models. We investigated invasiveness in vitro, expression of plasminogen, and its activators: tissue type (tPA)‐urokinase type (uPA), and activity and expression of matrix metalloproteinases (MMP)‐2 and MMP‐9. Results: Placental invasiveness is upregulated by multiparity, but lesser in the high fetal loss model. Multiparous animals showed elevated expression of plasminogen and uPA. However, the high fetal loss combination showed higher expression of a short and less active fragment of uPA (LMW‐uPA). MMP‐2, MMP‐9, and tPA were unaffected. Conclusion: uPA would participate in the increased multiparity‐associated placental invasiveness.Fil: Cortina, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Litwin, Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Rial Hawila, María Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Miranda, Silvia Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaWiley Blackwell Publishing, Inc2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41642Cortina, María Eugenia; Litwin, Silvana; Rial Hawila, María Rocío; Miranda, Silvia Esther; Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator; Wiley Blackwell Publishing, Inc; American Journal of Reproductive Immunology; 77; 4; 4-2017; 1-10; e126331046-7408CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/aji.12633info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/aji.12633info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:30Zoai:ri.conicet.gov.ar:11336/41642instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:30.422CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator
title Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator
spellingShingle Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator
Cortina, María Eugenia
Parity
Placenta
Plasminogen
Upa/Plau
Mouse
title_short Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator
title_full Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator
title_fullStr Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator
title_full_unstemmed Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator
title_sort Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator
dc.creator.none.fl_str_mv Cortina, María Eugenia
Litwin, Silvana
Rial Hawila, María Rocío
Miranda, Silvia Esther
author Cortina, María Eugenia
author_facet Cortina, María Eugenia
Litwin, Silvana
Rial Hawila, María Rocío
Miranda, Silvia Esther
author_role author
author2 Litwin, Silvana
Rial Hawila, María Rocío
Miranda, Silvia Esther
author2_role author
author
author
dc.subject.none.fl_str_mv Parity
Placenta
Plasminogen
Upa/Plau
Mouse
topic Parity
Placenta
Plasminogen
Upa/Plau
Mouse
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Problem: Multiparity increased the number of trophoblast cells in decidua of both low and high fetal loss mouse models. However, they differ in fetal survival rate and maternal thymocyte subpopulations, suggesting that trophoblast invasiveness is not equivalent. Our aim was to explore the involved mechanism. Method of study: We studied placentae from primiparous and multiparous females of low and high fetal loss models. We investigated invasiveness in vitro, expression of plasminogen, and its activators: tissue type (tPA)‐urokinase type (uPA), and activity and expression of matrix metalloproteinases (MMP)‐2 and MMP‐9. Results: Placental invasiveness is upregulated by multiparity, but lesser in the high fetal loss model. Multiparous animals showed elevated expression of plasminogen and uPA. However, the high fetal loss combination showed higher expression of a short and less active fragment of uPA (LMW‐uPA). MMP‐2, MMP‐9, and tPA were unaffected. Conclusion: uPA would participate in the increased multiparity‐associated placental invasiveness.
Fil: Cortina, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Litwin, Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Rial Hawila, María Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Miranda, Silvia Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
description Problem: Multiparity increased the number of trophoblast cells in decidua of both low and high fetal loss mouse models. However, they differ in fetal survival rate and maternal thymocyte subpopulations, suggesting that trophoblast invasiveness is not equivalent. Our aim was to explore the involved mechanism. Method of study: We studied placentae from primiparous and multiparous females of low and high fetal loss models. We investigated invasiveness in vitro, expression of plasminogen, and its activators: tissue type (tPA)‐urokinase type (uPA), and activity and expression of matrix metalloproteinases (MMP)‐2 and MMP‐9. Results: Placental invasiveness is upregulated by multiparity, but lesser in the high fetal loss model. Multiparous animals showed elevated expression of plasminogen and uPA. However, the high fetal loss combination showed higher expression of a short and less active fragment of uPA (LMW‐uPA). MMP‐2, MMP‐9, and tPA were unaffected. Conclusion: uPA would participate in the increased multiparity‐associated placental invasiveness.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41642
Cortina, María Eugenia; Litwin, Silvana; Rial Hawila, María Rocío; Miranda, Silvia Esther; Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator; Wiley Blackwell Publishing, Inc; American Journal of Reproductive Immunology; 77; 4; 4-2017; 1-10; e12633
1046-7408
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41642
identifier_str_mv Cortina, María Eugenia; Litwin, Silvana; Rial Hawila, María Rocío; Miranda, Silvia Esther; Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator; Wiley Blackwell Publishing, Inc; American Journal of Reproductive Immunology; 77; 4; 4-2017; 1-10; e12633
1046-7408
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/aji.12633
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/aji.12633
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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