Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
- Autores
- Toni, Nicolas; Schinder, Alejandro Fabian
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA)3 region, and receive glutamatergic and γ-aminobutyric acid (GABA)ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.
Fil: Toni, Nicolas. Universite de Lausanne; Suiza
Fil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina - Materia
-
Neurogenesis
Granule Cells
Functional Integration
Structural Studies - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/9656
Ver los metadatos del registro completo
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Maturation and Functional Integration of New Granule Cells into the Adult HippocampusToni, NicolasSchinder, Alejandro FabianNeurogenesisGranule CellsFunctional IntegrationStructural Studieshttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA)3 region, and receive glutamatergic and γ-aminobutyric acid (GABA)ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.Fil: Toni, Nicolas. Universite de Lausanne; SuizaFil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; ArgentinaCold Spring Harbor Laboratory Press2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/9656Toni, Nicolas; Schinder, Alejandro Fabian; Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus; Cold Spring Harbor Laboratory Press; Cold Spring Harbor Perspectives in Biology; 8; 1; 12-20151943-0264enginfo:eu-repo/semantics/altIdentifier/url/http://cshperspectives.cshlp.org/content/8/1/a018903info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1101/cshperspect.a018903info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:00Zoai:ri.conicet.gov.ar:11336/9656instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:01.026CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus |
title |
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus |
spellingShingle |
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus Toni, Nicolas Neurogenesis Granule Cells Functional Integration Structural Studies |
title_short |
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus |
title_full |
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus |
title_fullStr |
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus |
title_full_unstemmed |
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus |
title_sort |
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus |
dc.creator.none.fl_str_mv |
Toni, Nicolas Schinder, Alejandro Fabian |
author |
Toni, Nicolas |
author_facet |
Toni, Nicolas Schinder, Alejandro Fabian |
author_role |
author |
author2 |
Schinder, Alejandro Fabian |
author2_role |
author |
dc.subject.none.fl_str_mv |
Neurogenesis Granule Cells Functional Integration Structural Studies |
topic |
Neurogenesis Granule Cells Functional Integration Structural Studies |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.5 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.5 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA)3 region, and receive glutamatergic and γ-aminobutyric acid (GABA)ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function. Fil: Toni, Nicolas. Universite de Lausanne; Suiza Fil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina |
description |
The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA)3 region, and receive glutamatergic and γ-aminobutyric acid (GABA)ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/9656 Toni, Nicolas; Schinder, Alejandro Fabian; Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus; Cold Spring Harbor Laboratory Press; Cold Spring Harbor Perspectives in Biology; 8; 1; 12-2015 1943-0264 |
url |
http://hdl.handle.net/11336/9656 |
identifier_str_mv |
Toni, Nicolas; Schinder, Alejandro Fabian; Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus; Cold Spring Harbor Laboratory Press; Cold Spring Harbor Perspectives in Biology; 8; 1; 12-2015 1943-0264 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://cshperspectives.cshlp.org/content/8/1/a018903 info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1101/cshperspect.a018903 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Cold Spring Harbor Laboratory Press |
publisher.none.fl_str_mv |
Cold Spring Harbor Laboratory Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |