Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus

Autores
Toni, Nicolas; Schinder, Alejandro Fabian
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA)3 region, and receive glutamatergic and γ-aminobutyric acid (GABA)ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.
Fil: Toni, Nicolas. Universite de Lausanne; Suiza
Fil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Materia
Neurogenesis
Granule Cells
Functional Integration
Structural Studies
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/9656
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/9656
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Maturation and Functional Integration of New Granule Cells into the Adult HippocampusToni, NicolasSchinder, Alejandro FabianNeurogenesisGranule CellsFunctional IntegrationStructural Studieshttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA)3 region, and receive glutamatergic and γ-aminobutyric acid (GABA)ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.Fil: Toni, Nicolas. Universite de Lausanne; SuizaFil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; ArgentinaCold Spring Harbor Laboratory Press2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/9656Toni, Nicolas; Schinder, Alejandro Fabian; Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus; Cold Spring Harbor Laboratory Press; Cold Spring Harbor Perspectives in Biology; 8; 1; 12-20151943-0264enginfo:eu-repo/semantics/altIdentifier/url/http://cshperspectives.cshlp.org/content/8/1/a018903info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1101/cshperspect.a018903info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:18:27Zoai:ri.conicet.gov.ar:11336/9656instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:18:27.914CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
title Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
spellingShingle Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
Toni, Nicolas
Neurogenesis
Granule Cells
Functional Integration
Structural Studies
title_short Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
title_full Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
title_fullStr Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
title_full_unstemmed Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
title_sort Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
dc.creator.none.fl_str_mv Toni, Nicolas
Schinder, Alejandro Fabian
author Toni, Nicolas
author_facet Toni, Nicolas
Schinder, Alejandro Fabian
author_role author
author2 Schinder, Alejandro Fabian
author2_role author
dc.subject.none.fl_str_mv Neurogenesis
Granule Cells
Functional Integration
Structural Studies
topic Neurogenesis
Granule Cells
Functional Integration
Structural Studies
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA)3 region, and receive glutamatergic and γ-aminobutyric acid (GABA)ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.
Fil: Toni, Nicolas. Universite de Lausanne; Suiza
Fil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
description The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA)3 region, and receive glutamatergic and γ-aminobutyric acid (GABA)ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/9656
Toni, Nicolas; Schinder, Alejandro Fabian; Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus; Cold Spring Harbor Laboratory Press; Cold Spring Harbor Perspectives in Biology; 8; 1; 12-2015
1943-0264
url http://hdl.handle.net/11336/9656
identifier_str_mv Toni, Nicolas; Schinder, Alejandro Fabian; Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus; Cold Spring Harbor Laboratory Press; Cold Spring Harbor Perspectives in Biology; 8; 1; 12-2015
1943-0264
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://cshperspectives.cshlp.org/content/8/1/a018903
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1101/cshperspect.a018903
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781647982166016
score 12.982451

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