Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis

Autores
Antunes Rodrigues, J.; Ruginsk, S. G.; Mecawi, A. S.; Margatho, L. O.; Cruz, J. C.; Vilhena Franco, T.; Reis, W. L.; Ventura, R. R.; Reis, L. C.; Vivas, Laura Marta; Elias, L. L. K.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Several forebrain and brainstem neurochemical circuitries interact with peripheral neural and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Although much progress has been made over the past decades in the understanding of complex mechanisms underlying neuroendocrine control of hydromineral homeostasis, several issues still remain to be clarified. The use of techniques such as molecular biology, neuronal tracing, electrophysiology, immunohistochemistry, and microinfusions has significantly improved our ability to identify neuronal phenotypes and their signals, including those related to neuron-glia interactions. Accordingly, neurons have been shown to produce and release a large number of chemical mediators (neurotransmitters, neurohormones and neuromodulators) into the interstitial space, which include not only classic neurotransmitters, such as acetylcholine, amines (noradrenaline, serotonin) and amino acids (glutamate, GABA), but also gaseous (nitric oxide, carbon monoxide and hydrogen sulfide) and lipid-derived (endocannabinoids) mediators. This efferent response, initiated within the neuronal environment, recruits several peripheral effectors, such as hormones (glucocorticoids, angiotensin II, estrogen), which in turn modulate central nervous system responsiveness to systemic challenges. Therefore, in this review, we shall evaluate in an integrated manner the physiological control of body fluid homeostasis from the molecular aspects to the systemic and integrated responses.
Fil: Antunes Rodrigues, J.. Universidade de Sao Paulo; Brasil
Fil: Ruginsk, S. G.. Universidade de Sao Paulo; Brasil
Fil: Mecawi, A. S.. Universidade de Sao Paulo; Brasil
Fil: Margatho, L. O.. Universidade de Sao Paulo; Brasil
Fil: Cruz, J. C.. Universidade de Sao Paulo; Brasil
Fil: Vilhena Franco, T.. Universidade de Sao Paulo; Brasil
Fil: Reis, W. L.. Georgia Health Sciences University; Estados Unidos
Fil: Ventura, R. R.. Universidade Federal de Alfenas; Brasil
Fil: Reis, L. C.. Universidade Federal Rural do Rio de Janeiro; Brasil
Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Elias, L. L. K.. Universidade de Sao Paulo; Brasil
Materia
Hypothalamus
Gaseous Neuromodulators
Neuropeptides
Endocannabinoids
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25521
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasisAntunes Rodrigues, J.Ruginsk, S. G.Mecawi, A. S.Margatho, L. O.Cruz, J. C.Vilhena Franco, T.Reis, W. L.Ventura, R. R.Reis, L. C.Vivas, Laura MartaElias, L. L. K.HypothalamusGaseous NeuromodulatorsNeuropeptidesEndocannabinoidshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Several forebrain and brainstem neurochemical circuitries interact with peripheral neural and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Although much progress has been made over the past decades in the understanding of complex mechanisms underlying neuroendocrine control of hydromineral homeostasis, several issues still remain to be clarified. The use of techniques such as molecular biology, neuronal tracing, electrophysiology, immunohistochemistry, and microinfusions has significantly improved our ability to identify neuronal phenotypes and their signals, including those related to neuron-glia interactions. Accordingly, neurons have been shown to produce and release a large number of chemical mediators (neurotransmitters, neurohormones and neuromodulators) into the interstitial space, which include not only classic neurotransmitters, such as acetylcholine, amines (noradrenaline, serotonin) and amino acids (glutamate, GABA), but also gaseous (nitric oxide, carbon monoxide and hydrogen sulfide) and lipid-derived (endocannabinoids) mediators. This efferent response, initiated within the neuronal environment, recruits several peripheral effectors, such as hormones (glucocorticoids, angiotensin II, estrogen), which in turn modulate central nervous system responsiveness to systemic challenges. Therefore, in this review, we shall evaluate in an integrated manner the physiological control of body fluid homeostasis from the molecular aspects to the systemic and integrated responses.Fil: Antunes Rodrigues, J.. Universidade de Sao Paulo; BrasilFil: Ruginsk, S. G.. Universidade de Sao Paulo; BrasilFil: Mecawi, A. S.. Universidade de Sao Paulo; BrasilFil: Margatho, L. O.. Universidade de Sao Paulo; BrasilFil: Cruz, J. C.. Universidade de Sao Paulo; BrasilFil: Vilhena Franco, T.. Universidade de Sao Paulo; BrasilFil: Reis, W. L.. Georgia Health Sciences University; Estados UnidosFil: Ventura, R. R.. Universidade Federal de Alfenas; BrasilFil: Reis, L. C.. Universidade Federal Rural do Rio de Janeiro; BrasilFil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Elias, L. L. K.. Universidade de Sao Paulo; BrasilAssociação Brasileira de Divulgação Científica2013-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25521Antunes Rodrigues, J.; Ruginsk, S. G.; Mecawi, A. S.; Margatho, L. O.; Cruz, J. C.; et al.; Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis; Associação Brasileira de Divulgação Científica; Brazilian Journal Of Medical And Biological Research; 46; 4; 4-2013; 1-121414-431XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1590/1414-431X20132788info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/n6xbqminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:07:15Zoai:ri.conicet.gov.ar:11336/25521instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:07:16.037CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis
title Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis
spellingShingle Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis
Antunes Rodrigues, J.
Hypothalamus
Gaseous Neuromodulators
Neuropeptides
Endocannabinoids
title_short Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis
title_full Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis
title_fullStr Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis
title_full_unstemmed Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis
title_sort Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis
dc.creator.none.fl_str_mv Antunes Rodrigues, J.
Ruginsk, S. G.
Mecawi, A. S.
Margatho, L. O.
Cruz, J. C.
Vilhena Franco, T.
Reis, W. L.
Ventura, R. R.
Reis, L. C.
Vivas, Laura Marta
Elias, L. L. K.
author Antunes Rodrigues, J.
author_facet Antunes Rodrigues, J.
Ruginsk, S. G.
Mecawi, A. S.
Margatho, L. O.
Cruz, J. C.
Vilhena Franco, T.
Reis, W. L.
Ventura, R. R.
Reis, L. C.
Vivas, Laura Marta
Elias, L. L. K.
author_role author
author2 Ruginsk, S. G.
Mecawi, A. S.
Margatho, L. O.
Cruz, J. C.
Vilhena Franco, T.
Reis, W. L.
Ventura, R. R.
Reis, L. C.
Vivas, Laura Marta
Elias, L. L. K.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hypothalamus
Gaseous Neuromodulators
Neuropeptides
Endocannabinoids
topic Hypothalamus
Gaseous Neuromodulators
Neuropeptides
Endocannabinoids
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Several forebrain and brainstem neurochemical circuitries interact with peripheral neural and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Although much progress has been made over the past decades in the understanding of complex mechanisms underlying neuroendocrine control of hydromineral homeostasis, several issues still remain to be clarified. The use of techniques such as molecular biology, neuronal tracing, electrophysiology, immunohistochemistry, and microinfusions has significantly improved our ability to identify neuronal phenotypes and their signals, including those related to neuron-glia interactions. Accordingly, neurons have been shown to produce and release a large number of chemical mediators (neurotransmitters, neurohormones and neuromodulators) into the interstitial space, which include not only classic neurotransmitters, such as acetylcholine, amines (noradrenaline, serotonin) and amino acids (glutamate, GABA), but also gaseous (nitric oxide, carbon monoxide and hydrogen sulfide) and lipid-derived (endocannabinoids) mediators. This efferent response, initiated within the neuronal environment, recruits several peripheral effectors, such as hormones (glucocorticoids, angiotensin II, estrogen), which in turn modulate central nervous system responsiveness to systemic challenges. Therefore, in this review, we shall evaluate in an integrated manner the physiological control of body fluid homeostasis from the molecular aspects to the systemic and integrated responses.
Fil: Antunes Rodrigues, J.. Universidade de Sao Paulo; Brasil
Fil: Ruginsk, S. G.. Universidade de Sao Paulo; Brasil
Fil: Mecawi, A. S.. Universidade de Sao Paulo; Brasil
Fil: Margatho, L. O.. Universidade de Sao Paulo; Brasil
Fil: Cruz, J. C.. Universidade de Sao Paulo; Brasil
Fil: Vilhena Franco, T.. Universidade de Sao Paulo; Brasil
Fil: Reis, W. L.. Georgia Health Sciences University; Estados Unidos
Fil: Ventura, R. R.. Universidade Federal de Alfenas; Brasil
Fil: Reis, L. C.. Universidade Federal Rural do Rio de Janeiro; Brasil
Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Elias, L. L. K.. Universidade de Sao Paulo; Brasil
description Several forebrain and brainstem neurochemical circuitries interact with peripheral neural and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Although much progress has been made over the past decades in the understanding of complex mechanisms underlying neuroendocrine control of hydromineral homeostasis, several issues still remain to be clarified. The use of techniques such as molecular biology, neuronal tracing, electrophysiology, immunohistochemistry, and microinfusions has significantly improved our ability to identify neuronal phenotypes and their signals, including those related to neuron-glia interactions. Accordingly, neurons have been shown to produce and release a large number of chemical mediators (neurotransmitters, neurohormones and neuromodulators) into the interstitial space, which include not only classic neurotransmitters, such as acetylcholine, amines (noradrenaline, serotonin) and amino acids (glutamate, GABA), but also gaseous (nitric oxide, carbon monoxide and hydrogen sulfide) and lipid-derived (endocannabinoids) mediators. This efferent response, initiated within the neuronal environment, recruits several peripheral effectors, such as hormones (glucocorticoids, angiotensin II, estrogen), which in turn modulate central nervous system responsiveness to systemic challenges. Therefore, in this review, we shall evaluate in an integrated manner the physiological control of body fluid homeostasis from the molecular aspects to the systemic and integrated responses.
publishDate 2013
dc.date.none.fl_str_mv 2013-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25521
Antunes Rodrigues, J.; Ruginsk, S. G.; Mecawi, A. S.; Margatho, L. O.; Cruz, J. C.; et al.; Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis; Associação Brasileira de Divulgação Científica; Brazilian Journal Of Medical And Biological Research; 46; 4; 4-2013; 1-12
1414-431X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25521
identifier_str_mv Antunes Rodrigues, J.; Ruginsk, S. G.; Mecawi, A. S.; Margatho, L. O.; Cruz, J. C.; et al.; Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis; Associação Brasileira de Divulgação Científica; Brazilian Journal Of Medical And Biological Research; 46; 4; 4-2013; 1-12
1414-431X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1590/1414-431X20132788
info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/n6xbqm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.176822

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