Genomic approaches to studying human-specific developmental traits
- Autores
- Franchini, Lucia Florencia; Pollard, Katherine S.
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Changes in developmental regulatory programs drive both disease and phenotypic differences among species. Linking human-specific traits to alterations in development is challenging, because we have lacked the tools to assay and manipulate regulatory networks in human and primate embryonic cells. This field was transformed by the sequencing of hundreds of genomes - human and non-human - that can be compared to discover the regulatory machinery of genes involved in human development. This approach has identified thousands of human-specific genome alterations in developmental genes and their regulatory regions. With recent advances in stem cell techniques, genome engineering, and genomics, we can now test these sequences for effects on developmental gene regulation and downstream phenotypes in human cells and tissues.
Fil: Franchini, Lucia Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
Fil: Pollard, Katherine S.. Gladstone Institutes; Estados Unidos. University of California. Department of Epidemiology & Biostatistics. Institute for Human Genetics; Estados Unidos - Materia
-
Evolution
Humans
Brain
Primates - Nivel de accesibilidad
- acceso embargado
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/4002
Ver los metadatos del registro completo
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Genomic approaches to studying human-specific developmental traitsFranchini, Lucia FlorenciaPollard, Katherine S.EvolutionHumansBrainPrimateshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Changes in developmental regulatory programs drive both disease and phenotypic differences among species. Linking human-specific traits to alterations in development is challenging, because we have lacked the tools to assay and manipulate regulatory networks in human and primate embryonic cells. This field was transformed by the sequencing of hundreds of genomes - human and non-human - that can be compared to discover the regulatory machinery of genes involved in human development. This approach has identified thousands of human-specific genome alterations in developmental genes and their regulatory regions. With recent advances in stem cell techniques, genome engineering, and genomics, we can now test these sequences for effects on developmental gene regulation and downstream phenotypes in human cells and tissues.Fil: Franchini, Lucia Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; ArgentinaFil: Pollard, Katherine S.. Gladstone Institutes; Estados Unidos. University of California. Department of Epidemiology & Biostatistics. Institute for Human Genetics; Estados UnidosCompany of Biologists2015-09info:eu-repo/date/embargoEnd/2016-10-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4002Franchini, Lucia Florencia; Pollard, Katherine S.; Genomic approaches to studying human-specific developmental traits; Company of Biologists; Development; 142; 9-2015; 3100-31120950-1991enginfo:eu-repo/semantics/altIdentifier/url/http://dev.biologists.org/content/142/18/3100.longinfo:eu-repo/semantics/altIdentifier/doi/doi:10.1242/dev.120048info:eu-repo/semantics/altIdentifier/issn/0950-1991info:eu-repo/semantics/embargoedAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:08:47Zoai:ri.conicet.gov.ar:11336/4002instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:08:47.373CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Genomic approaches to studying human-specific developmental traits |
title |
Genomic approaches to studying human-specific developmental traits |
spellingShingle |
Genomic approaches to studying human-specific developmental traits Franchini, Lucia Florencia Evolution Humans Brain Primates |
title_short |
Genomic approaches to studying human-specific developmental traits |
title_full |
Genomic approaches to studying human-specific developmental traits |
title_fullStr |
Genomic approaches to studying human-specific developmental traits |
title_full_unstemmed |
Genomic approaches to studying human-specific developmental traits |
title_sort |
Genomic approaches to studying human-specific developmental traits |
dc.creator.none.fl_str_mv |
Franchini, Lucia Florencia Pollard, Katherine S. |
author |
Franchini, Lucia Florencia |
author_facet |
Franchini, Lucia Florencia Pollard, Katherine S. |
author_role |
author |
author2 |
Pollard, Katherine S. |
author2_role |
author |
dc.subject.none.fl_str_mv |
Evolution Humans Brain Primates |
topic |
Evolution Humans Brain Primates |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Changes in developmental regulatory programs drive both disease and phenotypic differences among species. Linking human-specific traits to alterations in development is challenging, because we have lacked the tools to assay and manipulate regulatory networks in human and primate embryonic cells. This field was transformed by the sequencing of hundreds of genomes - human and non-human - that can be compared to discover the regulatory machinery of genes involved in human development. This approach has identified thousands of human-specific genome alterations in developmental genes and their regulatory regions. With recent advances in stem cell techniques, genome engineering, and genomics, we can now test these sequences for effects on developmental gene regulation and downstream phenotypes in human cells and tissues. Fil: Franchini, Lucia Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina Fil: Pollard, Katherine S.. Gladstone Institutes; Estados Unidos. University of California. Department of Epidemiology & Biostatistics. Institute for Human Genetics; Estados Unidos |
description |
Changes in developmental regulatory programs drive both disease and phenotypic differences among species. Linking human-specific traits to alterations in development is challenging, because we have lacked the tools to assay and manipulate regulatory networks in human and primate embryonic cells. This field was transformed by the sequencing of hundreds of genomes - human and non-human - that can be compared to discover the regulatory machinery of genes involved in human development. This approach has identified thousands of human-specific genome alterations in developmental genes and their regulatory regions. With recent advances in stem cell techniques, genome engineering, and genomics, we can now test these sequences for effects on developmental gene regulation and downstream phenotypes in human cells and tissues. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09 info:eu-repo/date/embargoEnd/2016-10-31 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/4002 Franchini, Lucia Florencia; Pollard, Katherine S.; Genomic approaches to studying human-specific developmental traits; Company of Biologists; Development; 142; 9-2015; 3100-3112 0950-1991 |
url |
http://hdl.handle.net/11336/4002 |
identifier_str_mv |
Franchini, Lucia Florencia; Pollard, Katherine S.; Genomic approaches to studying human-specific developmental traits; Company of Biologists; Development; 142; 9-2015; 3100-3112 0950-1991 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://dev.biologists.org/content/142/18/3100.long info:eu-repo/semantics/altIdentifier/doi/doi:10.1242/dev.120048 info:eu-repo/semantics/altIdentifier/issn/0950-1991 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/embargoedAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
embargoedAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Company of Biologists |
publisher.none.fl_str_mv |
Company of Biologists |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613958669959168 |
score |
13.070432 |