Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, traf...

Autores
Asensio, Cristian Jorge Alejandro
Año de publicación
2022
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
C23/NCL has multiple domains, PTMs, polyanionic stretches, repeats, functions and subcellular locations and without signal peptide is enriched on cancer cells surface acting as co-receptor, alarmin, etc. Its study is also difficulted by lack of full-length C23 expression in bacteria. C23 integrates multiple aspects of DNA and RNA metabolism and cell cycle/metabolism and senses environmental cues in cell surface, cytosol and nucleus. Its diverse PTMs coordinate interactions with proteins, nucleic acids, carbohydrates, cations, LPS and lipids as well as the trafficking from nucleolus to nucleoplasm, cytosol, microtubules, vesicles, membrane and back again. It is unconventionally secreted, clustering on membranes with receptors, extracellular factors, matrix, cations and pathogens. Most steps on its trafficking, interaction partners, or if the diverse PTMs are hierarchical and/or alternative are unclear. Understanding mechanisms should help testing anti-C23 drugs to prevent viruses/bacteria entry, to target cancer and for diagnostics. Articles have dispersed on different roles and cells, so bibliometric/bioinformatic approaches might help better in making sense on PTMs diversity. Thus, we aimed to recollect C23 PTMs from several databases, curating data by impacts on subcellular location, functions/interactomes, frequency, etc. We detected ~180 PTMs (some alternative) involving phosphoryl, acetyl, succinyl, ubiquitin, sumo, glycosyl, NO and methyl groups plus cleavage. Enzyme crosstalk data and 7 known PTMs were absent. We conclude that a curated PTM database might help in experiment and drug design and in knowledge gap identification. Studies are needed on: a) expansion of sequence/folding diversity by cleavage, isomerization, oligomerization and charge density, b) finding PTMs in cytosolic C23 as markers of shuttling to or from membranes, c) interaction motif identification, d) modeling impacts on folding, e) searching any PTM-code and epigenetic/signaling roles.
Fil: Asensio, Cristian Jorge Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología; 3° Congreso Franco-Argentino de Inmunología; Reunión Anual de la Sociedad Argentina de Fisiología
Mar del Plata
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Sociedad Argentina de Fisiología
Materia
BIOINFORMATIC
BIBLIOMETRIC
NCL
POST-TRANSLATIONAL
PTM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/222472
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretionAsensio, Cristian Jorge AlejandroBIOINFORMATICBIBLIOMETRICNCLPOST-TRANSLATIONALPTMhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1C23/NCL has multiple domains, PTMs, polyanionic stretches, repeats, functions and subcellular locations and without signal peptide is enriched on cancer cells surface acting as co-receptor, alarmin, etc. Its study is also difficulted by lack of full-length C23 expression in bacteria. C23 integrates multiple aspects of DNA and RNA metabolism and cell cycle/metabolism and senses environmental cues in cell surface, cytosol and nucleus. Its diverse PTMs coordinate interactions with proteins, nucleic acids, carbohydrates, cations, LPS and lipids as well as the trafficking from nucleolus to nucleoplasm, cytosol, microtubules, vesicles, membrane and back again. It is unconventionally secreted, clustering on membranes with receptors, extracellular factors, matrix, cations and pathogens. Most steps on its trafficking, interaction partners, or if the diverse PTMs are hierarchical and/or alternative are unclear. Understanding mechanisms should help testing anti-C23 drugs to prevent viruses/bacteria entry, to target cancer and for diagnostics. Articles have dispersed on different roles and cells, so bibliometric/bioinformatic approaches might help better in making sense on PTMs diversity. Thus, we aimed to recollect C23 PTMs from several databases, curating data by impacts on subcellular location, functions/interactomes, frequency, etc. We detected ~180 PTMs (some alternative) involving phosphoryl, acetyl, succinyl, ubiquitin, sumo, glycosyl, NO and methyl groups plus cleavage. Enzyme crosstalk data and 7 known PTMs were absent. We conclude that a curated PTM database might help in experiment and drug design and in knowledge gap identification. Studies are needed on: a) expansion of sequence/folding diversity by cleavage, isomerization, oligomerization and charge density, b) finding PTMs in cytosolic C23 as markers of shuttling to or from membranes, c) interaction motif identification, d) modeling impacts on folding, e) searching any PTM-code and epigenetic/signaling roles.Fil: Asensio, Cristian Jorge Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaLXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología; 3° Congreso Franco-Argentino de Inmunología; Reunión Anual de la Sociedad Argentina de FisiologíaMar del PlataArgentinaSociedad Argentina de Investigación ClínicaSociedad Argentina de InmunologíaSociedad Argentina de FisiologíaFundación Revista Medicina2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/222472Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion; LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología; 3° Congreso Franco-Argentino de Inmunología; Reunión Anual de la Sociedad Argentina de Fisiología; Mar del Plata; Argentina; 2022; 181-1810025-76801669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.medicinabuenosaires.com/PMID/36368022.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:17:39Zoai:ri.conicet.gov.ar:11336/222472instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:17:40.238CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion
title Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion
spellingShingle Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion
Asensio, Cristian Jorge Alejandro
BIOINFORMATIC
BIBLIOMETRIC
NCL
POST-TRANSLATIONAL
PTM
title_short Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion
title_full Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion
title_fullStr Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion
title_full_unstemmed Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion
title_sort Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion
dc.creator.none.fl_str_mv Asensio, Cristian Jorge Alejandro
author Asensio, Cristian Jorge Alejandro
author_facet Asensio, Cristian Jorge Alejandro
author_role author
dc.subject.none.fl_str_mv BIOINFORMATIC
BIBLIOMETRIC
NCL
POST-TRANSLATIONAL
PTM
topic BIOINFORMATIC
BIBLIOMETRIC
NCL
POST-TRANSLATIONAL
PTM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv C23/NCL has multiple domains, PTMs, polyanionic stretches, repeats, functions and subcellular locations and without signal peptide is enriched on cancer cells surface acting as co-receptor, alarmin, etc. Its study is also difficulted by lack of full-length C23 expression in bacteria. C23 integrates multiple aspects of DNA and RNA metabolism and cell cycle/metabolism and senses environmental cues in cell surface, cytosol and nucleus. Its diverse PTMs coordinate interactions with proteins, nucleic acids, carbohydrates, cations, LPS and lipids as well as the trafficking from nucleolus to nucleoplasm, cytosol, microtubules, vesicles, membrane and back again. It is unconventionally secreted, clustering on membranes with receptors, extracellular factors, matrix, cations and pathogens. Most steps on its trafficking, interaction partners, or if the diverse PTMs are hierarchical and/or alternative are unclear. Understanding mechanisms should help testing anti-C23 drugs to prevent viruses/bacteria entry, to target cancer and for diagnostics. Articles have dispersed on different roles and cells, so bibliometric/bioinformatic approaches might help better in making sense on PTMs diversity. Thus, we aimed to recollect C23 PTMs from several databases, curating data by impacts on subcellular location, functions/interactomes, frequency, etc. We detected ~180 PTMs (some alternative) involving phosphoryl, acetyl, succinyl, ubiquitin, sumo, glycosyl, NO and methyl groups plus cleavage. Enzyme crosstalk data and 7 known PTMs were absent. We conclude that a curated PTM database might help in experiment and drug design and in knowledge gap identification. Studies are needed on: a) expansion of sequence/folding diversity by cleavage, isomerization, oligomerization and charge density, b) finding PTMs in cytosolic C23 as markers of shuttling to or from membranes, c) interaction motif identification, d) modeling impacts on folding, e) searching any PTM-code and epigenetic/signaling roles.
Fil: Asensio, Cristian Jorge Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología; 3° Congreso Franco-Argentino de Inmunología; Reunión Anual de la Sociedad Argentina de Fisiología
Mar del Plata
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Sociedad Argentina de Fisiología
description C23/NCL has multiple domains, PTMs, polyanionic stretches, repeats, functions and subcellular locations and without signal peptide is enriched on cancer cells surface acting as co-receptor, alarmin, etc. Its study is also difficulted by lack of full-length C23 expression in bacteria. C23 integrates multiple aspects of DNA and RNA metabolism and cell cycle/metabolism and senses environmental cues in cell surface, cytosol and nucleus. Its diverse PTMs coordinate interactions with proteins, nucleic acids, carbohydrates, cations, LPS and lipids as well as the trafficking from nucleolus to nucleoplasm, cytosol, microtubules, vesicles, membrane and back again. It is unconventionally secreted, clustering on membranes with receptors, extracellular factors, matrix, cations and pathogens. Most steps on its trafficking, interaction partners, or if the diverse PTMs are hierarchical and/or alternative are unclear. Understanding mechanisms should help testing anti-C23 drugs to prevent viruses/bacteria entry, to target cancer and for diagnostics. Articles have dispersed on different roles and cells, so bibliometric/bioinformatic approaches might help better in making sense on PTMs diversity. Thus, we aimed to recollect C23 PTMs from several databases, curating data by impacts on subcellular location, functions/interactomes, frequency, etc. We detected ~180 PTMs (some alternative) involving phosphoryl, acetyl, succinyl, ubiquitin, sumo, glycosyl, NO and methyl groups plus cleavage. Enzyme crosstalk data and 7 known PTMs were absent. We conclude that a curated PTM database might help in experiment and drug design and in knowledge gap identification. Studies are needed on: a) expansion of sequence/folding diversity by cleavage, isomerization, oligomerization and charge density, b) finding PTMs in cytosolic C23 as markers of shuttling to or from membranes, c) interaction motif identification, d) modeling impacts on folding, e) searching any PTM-code and epigenetic/signaling roles.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
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http://purl.org/coar/resource_type/c_5794
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status_str publishedVersion
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dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/222472
Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion; LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología; 3° Congreso Franco-Argentino de Inmunología; Reunión Anual de la Sociedad Argentina de Fisiología; Mar del Plata; Argentina; 2022; 181-181
0025-7680
1669-9106
CONICET Digital
CONICET
url http://hdl.handle.net/11336/222472
identifier_str_mv Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion; LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología; 3° Congreso Franco-Argentino de Inmunología; Reunión Anual de la Sociedad Argentina de Fisiología; Mar del Plata; Argentina; 2022; 181-181
0025-7680
1669-9106
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.medicinabuenosaires.com/PMID/36368022.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Fundación Revista Medicina
publisher.none.fl_str_mv Fundación Revista Medicina
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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