Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, traf...
- Autores
- Asensio, Cristian Jorge Alejandro
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- C23/NCL has multiple domains, PTMs, polyanionic stretches, repeats, functions and subcellular locations and without signal peptide is enriched on cancer cells surface acting as co-receptor, alarmin, etc. Its study is also difficulted by lack of full-length C23 expression in bacteria. C23 integrates multiple aspects of DNA and RNA metabolism and cell cycle/metabolism and senses environmental cues in cell surface, cytosol and nucleus. Its diverse PTMs coordinate interactions with proteins, nucleic acids, carbohydrates, cations, LPS and lipids as well as the trafficking from nucleolus to nucleoplasm, cytosol, microtubules, vesicles, membrane and back again. It is unconventionally secreted, clustering on membranes with receptors, extracellular factors, matrix, cations and pathogens. Most steps on its trafficking, interaction partners, or if the diverse PTMs are hierarchical and/or alternative are unclear. Understanding mechanisms should help testing anti-C23 drugs to prevent viruses/bacteria entry, to target cancer and for diagnostics. Articles have dispersed on different roles and cells, so bibliometric/bioinformatic approaches might help better in making sense on PTMs diversity. Thus, we aimed to recollect C23 PTMs from several databases, curating data by impacts on subcellular location, functions/interactomes, frequency, etc. We detected ~180 PTMs (some alternative) involving phosphoryl, acetyl, succinyl, ubiquitin, sumo, glycosyl, NO and methyl groups plus cleavage. Enzyme crosstalk data and 7 known PTMs were absent. We conclude that a curated PTM database might help in experiment and drug design and in knowledge gap identification. Studies are needed on: a) expansion of sequence/folding diversity by cleavage, isomerization, oligomerization and charge density, b) finding PTMs in cytosolic C23 as markers of shuttling to or from membranes, c) interaction motif identification, d) modeling impacts on folding, e) searching any PTM-code and epigenetic/signaling roles.
Fil: Asensio, Cristian Jorge Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología; 3° Congreso Franco-Argentino de Inmunología; Reunión Anual de la Sociedad Argentina de Fisiología
Mar del Plata
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Sociedad Argentina de Fisiología - Materia
-
BIOINFORMATIC
BIBLIOMETRIC
NCL
POST-TRANSLATIONAL
PTM - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/222472
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Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretionAsensio, Cristian Jorge AlejandroBIOINFORMATICBIBLIOMETRICNCLPOST-TRANSLATIONALPTMhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1C23/NCL has multiple domains, PTMs, polyanionic stretches, repeats, functions and subcellular locations and without signal peptide is enriched on cancer cells surface acting as co-receptor, alarmin, etc. Its study is also difficulted by lack of full-length C23 expression in bacteria. C23 integrates multiple aspects of DNA and RNA metabolism and cell cycle/metabolism and senses environmental cues in cell surface, cytosol and nucleus. Its diverse PTMs coordinate interactions with proteins, nucleic acids, carbohydrates, cations, LPS and lipids as well as the trafficking from nucleolus to nucleoplasm, cytosol, microtubules, vesicles, membrane and back again. It is unconventionally secreted, clustering on membranes with receptors, extracellular factors, matrix, cations and pathogens. Most steps on its trafficking, interaction partners, or if the diverse PTMs are hierarchical and/or alternative are unclear. Understanding mechanisms should help testing anti-C23 drugs to prevent viruses/bacteria entry, to target cancer and for diagnostics. Articles have dispersed on different roles and cells, so bibliometric/bioinformatic approaches might help better in making sense on PTMs diversity. Thus, we aimed to recollect C23 PTMs from several databases, curating data by impacts on subcellular location, functions/interactomes, frequency, etc. We detected ~180 PTMs (some alternative) involving phosphoryl, acetyl, succinyl, ubiquitin, sumo, glycosyl, NO and methyl groups plus cleavage. Enzyme crosstalk data and 7 known PTMs were absent. We conclude that a curated PTM database might help in experiment and drug design and in knowledge gap identification. Studies are needed on: a) expansion of sequence/folding diversity by cleavage, isomerization, oligomerization and charge density, b) finding PTMs in cytosolic C23 as markers of shuttling to or from membranes, c) interaction motif identification, d) modeling impacts on folding, e) searching any PTM-code and epigenetic/signaling roles.Fil: Asensio, Cristian Jorge Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaLXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología; 3° Congreso Franco-Argentino de Inmunología; Reunión Anual de la Sociedad Argentina de FisiologíaMar del PlataArgentinaSociedad Argentina de Investigación ClínicaSociedad Argentina de InmunologíaSociedad Argentina de FisiologíaFundación Revista Medicina2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/222472Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion; LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología; 3° Congreso Franco-Argentino de Inmunología; Reunión Anual de la Sociedad Argentina de Fisiología; Mar del Plata; Argentina; 2022; 181-1810025-76801669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.medicinabuenosaires.com/PMID/36368022.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:28Zoai:ri.conicet.gov.ar:11336/222472instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:28.582CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion |
title |
Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion |
spellingShingle |
Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion Asensio, Cristian Jorge Alejandro BIOINFORMATIC BIBLIOMETRIC NCL POST-TRANSLATIONAL PTM |
title_short |
Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion |
title_full |
Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion |
title_fullStr |
Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion |
title_full_unstemmed |
Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion |
title_sort |
Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion |
dc.creator.none.fl_str_mv |
Asensio, Cristian Jorge Alejandro |
author |
Asensio, Cristian Jorge Alejandro |
author_facet |
Asensio, Cristian Jorge Alejandro |
author_role |
author |
dc.subject.none.fl_str_mv |
BIOINFORMATIC BIBLIOMETRIC NCL POST-TRANSLATIONAL PTM |
topic |
BIOINFORMATIC BIBLIOMETRIC NCL POST-TRANSLATIONAL PTM |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
C23/NCL has multiple domains, PTMs, polyanionic stretches, repeats, functions and subcellular locations and without signal peptide is enriched on cancer cells surface acting as co-receptor, alarmin, etc. Its study is also difficulted by lack of full-length C23 expression in bacteria. C23 integrates multiple aspects of DNA and RNA metabolism and cell cycle/metabolism and senses environmental cues in cell surface, cytosol and nucleus. Its diverse PTMs coordinate interactions with proteins, nucleic acids, carbohydrates, cations, LPS and lipids as well as the trafficking from nucleolus to nucleoplasm, cytosol, microtubules, vesicles, membrane and back again. It is unconventionally secreted, clustering on membranes with receptors, extracellular factors, matrix, cations and pathogens. Most steps on its trafficking, interaction partners, or if the diverse PTMs are hierarchical and/or alternative are unclear. Understanding mechanisms should help testing anti-C23 drugs to prevent viruses/bacteria entry, to target cancer and for diagnostics. Articles have dispersed on different roles and cells, so bibliometric/bioinformatic approaches might help better in making sense on PTMs diversity. Thus, we aimed to recollect C23 PTMs from several databases, curating data by impacts on subcellular location, functions/interactomes, frequency, etc. We detected ~180 PTMs (some alternative) involving phosphoryl, acetyl, succinyl, ubiquitin, sumo, glycosyl, NO and methyl groups plus cleavage. Enzyme crosstalk data and 7 known PTMs were absent. We conclude that a curated PTM database might help in experiment and drug design and in knowledge gap identification. Studies are needed on: a) expansion of sequence/folding diversity by cleavage, isomerization, oligomerization and charge density, b) finding PTMs in cytosolic C23 as markers of shuttling to or from membranes, c) interaction motif identification, d) modeling impacts on folding, e) searching any PTM-code and epigenetic/signaling roles. Fil: Asensio, Cristian Jorge Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología; 3° Congreso Franco-Argentino de Inmunología; Reunión Anual de la Sociedad Argentina de Fisiología Mar del Plata Argentina Sociedad Argentina de Investigación Clínica Sociedad Argentina de Inmunología Sociedad Argentina de Fisiología |
description |
C23/NCL has multiple domains, PTMs, polyanionic stretches, repeats, functions and subcellular locations and without signal peptide is enriched on cancer cells surface acting as co-receptor, alarmin, etc. Its study is also difficulted by lack of full-length C23 expression in bacteria. C23 integrates multiple aspects of DNA and RNA metabolism and cell cycle/metabolism and senses environmental cues in cell surface, cytosol and nucleus. Its diverse PTMs coordinate interactions with proteins, nucleic acids, carbohydrates, cations, LPS and lipids as well as the trafficking from nucleolus to nucleoplasm, cytosol, microtubules, vesicles, membrane and back again. It is unconventionally secreted, clustering on membranes with receptors, extracellular factors, matrix, cations and pathogens. Most steps on its trafficking, interaction partners, or if the diverse PTMs are hierarchical and/or alternative are unclear. Understanding mechanisms should help testing anti-C23 drugs to prevent viruses/bacteria entry, to target cancer and for diagnostics. Articles have dispersed on different roles and cells, so bibliometric/bioinformatic approaches might help better in making sense on PTMs diversity. Thus, we aimed to recollect C23 PTMs from several databases, curating data by impacts on subcellular location, functions/interactomes, frequency, etc. We detected ~180 PTMs (some alternative) involving phosphoryl, acetyl, succinyl, ubiquitin, sumo, glycosyl, NO and methyl groups plus cleavage. Enzyme crosstalk data and 7 known PTMs were absent. We conclude that a curated PTM database might help in experiment and drug design and in knowledge gap identification. Studies are needed on: a) expansion of sequence/folding diversity by cleavage, isomerization, oligomerization and charge density, b) finding PTMs in cytosolic C23 as markers of shuttling to or from membranes, c) interaction motif identification, d) modeling impacts on folding, e) searching any PTM-code and epigenetic/signaling roles. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/222472 Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion; LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología; 3° Congreso Franco-Argentino de Inmunología; Reunión Anual de la Sociedad Argentina de Fisiología; Mar del Plata; Argentina; 2022; 181-181 0025-7680 1669-9106 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/222472 |
identifier_str_mv |
Towards an integrative bioinformatic and bibliometric analysis of C23/NCL post-translational modifications diversity. data curation by implications on molecular size, folding, trafficking, interactions, functions and unconventional secretion; LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología; 3° Congreso Franco-Argentino de Inmunología; Reunión Anual de la Sociedad Argentina de Fisiología; Mar del Plata; Argentina; 2022; 181-181 0025-7680 1669-9106 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/altIdentifier/url/https://www.medicinabuenosaires.com/PMID/36368022.pdf |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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Fundación Revista Medicina |
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Fundación Revista Medicina |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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