Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases

Autores
Alvar, Jorge; Alves, Fabiana; Bucheton, Bruno; Burrows, Louise; Büscher, Philippe; Carrillo, Eugenia; Felger, Ingrid; Hübner, Marc P.; Moreno, Javier; Pinazo, Maria Jesus; Ribeiro, Isabela; Sosa-Estani, Sergio Alejandro; Specht, Sabine; Tarral, Antoine; Strub Wourgaft, Nathalie; Bilbe, Graeme
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Progress has been made in the control or elimination of tropical diseases, with a significant reduction of incidence. However, there is a risk of re-emergence if the factors fueling transmission are not dealt with. Although it is essential to understand these underlying factors for each disease, asymptomatic carriers are a common element that may promote resurgence; their impact in terms of proportion in the population and role in transmission needs to be determined. In this paper, we review the current evidence on whether or not to treat asymptomatic carriers given the relevance of their role in the transmission of a specific disease, the efficacy and toxicity of existing drugs, the Public Health interest, and the benefit at an individual level, for example, in Chagas disease, to prevent irreversible organ damage. In the absence of other control tools such as vaccines, there is a need for safer drugs with good risk/benefit profiles in order to change the paradigm so that it addresses the complete infectious process beyond manifest disease to include treatment of non-symptomatic infected persons.
Fil: Alvar, Jorge. Drugs For Neglected Diseases Initiative; Suiza
Fil: Alves, Fabiana. Drugs For Neglected Diseases Initiative; Suiza
Fil: Bucheton, Bruno. Université Montpellier II; Francia
Fil: Burrows, Louise. Drugs For Neglected Diseases Initiative; Suiza
Fil: Büscher, Philippe. Institute Of Tropical Medicine; Bélgica
Fil: Carrillo, Eugenia. Universidad Carlos III de Madrid. Instituto de Salud; España
Fil: Felger, Ingrid. Swiss Tropical And Public Health Institute; Suiza
Fil: Hübner, Marc P.. Universitat Bonn; Alemania
Fil: Moreno, Javier. Universidad Carlos III de Madrid. Instituto de Salud; España
Fil: Pinazo, Maria Jesus. Instituto de Salud Global de Barcelona; España
Fil: Ribeiro, Isabela. Drugs For Neglected Diseases Initiative; Suiza
Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Specht, Sabine. Drugs For Neglected Diseases Initiative; Suiza
Fil: Tarral, Antoine. Drugs For Neglected Diseases Initiative; Suiza
Fil: Strub Wourgaft, Nathalie. Drugs For Neglected Diseases Initiative; Suiza
Fil: Bilbe, Graeme. Drugs For Neglected Diseases Initiative; Suiza
Materia
ASYMPTOMATIC
CHAGAS DISEASE
FILARIASIS
HUMAN AFRICAN TRYPANOSOMIASIS
LEISHMANIASIS
MALARIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/142513
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/142513
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Implications of asymptomatic infection for the natural history of selected parasitic tropical diseasesAlvar, JorgeAlves, FabianaBucheton, BrunoBurrows, LouiseBüscher, PhilippeCarrillo, EugeniaFelger, IngridHübner, Marc P.Moreno, JavierPinazo, Maria JesusRibeiro, IsabelaSosa-Estani, Sergio AlejandroSpecht, SabineTarral, AntoineStrub Wourgaft, NathalieBilbe, GraemeASYMPTOMATICCHAGAS DISEASEFILARIASISHUMAN AFRICAN TRYPANOSOMIASISLEISHMANIASISMALARIAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Progress has been made in the control or elimination of tropical diseases, with a significant reduction of incidence. However, there is a risk of re-emergence if the factors fueling transmission are not dealt with. Although it is essential to understand these underlying factors for each disease, asymptomatic carriers are a common element that may promote resurgence; their impact in terms of proportion in the population and role in transmission needs to be determined. In this paper, we review the current evidence on whether or not to treat asymptomatic carriers given the relevance of their role in the transmission of a specific disease, the efficacy and toxicity of existing drugs, the Public Health interest, and the benefit at an individual level, for example, in Chagas disease, to prevent irreversible organ damage. In the absence of other control tools such as vaccines, there is a need for safer drugs with good risk/benefit profiles in order to change the paradigm so that it addresses the complete infectious process beyond manifest disease to include treatment of non-symptomatic infected persons.Fil: Alvar, Jorge. Drugs For Neglected Diseases Initiative; SuizaFil: Alves, Fabiana. Drugs For Neglected Diseases Initiative; SuizaFil: Bucheton, Bruno. Université Montpellier II; FranciaFil: Burrows, Louise. Drugs For Neglected Diseases Initiative; SuizaFil: Büscher, Philippe. Institute Of Tropical Medicine; BélgicaFil: Carrillo, Eugenia. Universidad Carlos III de Madrid. Instituto de Salud; EspañaFil: Felger, Ingrid. Swiss Tropical And Public Health Institute; SuizaFil: Hübner, Marc P.. Universitat Bonn; AlemaniaFil: Moreno, Javier. Universidad Carlos III de Madrid. Instituto de Salud; EspañaFil: Pinazo, Maria Jesus. Instituto de Salud Global de Barcelona; EspañaFil: Ribeiro, Isabela. Drugs For Neglected Diseases Initiative; SuizaFil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Specht, Sabine. Drugs For Neglected Diseases Initiative; SuizaFil: Tarral, Antoine. Drugs For Neglected Diseases Initiative; SuizaFil: Strub Wourgaft, Nathalie. Drugs For Neglected Diseases Initiative; SuizaFil: Bilbe, Graeme. Drugs For Neglected Diseases Initiative; SuizaSpringer2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/142513Alvar, Jorge; Alves, Fabiana; Bucheton, Bruno; Burrows, Louise; Büscher, Philippe; et al.; Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases; Springer; Seminars in Immunopathology; 42; 3; 3-2020; 231-2461863-2297CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s00281-020-00796-yinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00281-020-00796-yinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:19:54Zoai:ri.conicet.gov.ar:11336/142513instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:19:54.401CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases
title Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases
spellingShingle Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases
Alvar, Jorge
ASYMPTOMATIC
CHAGAS DISEASE
FILARIASIS
HUMAN AFRICAN TRYPANOSOMIASIS
LEISHMANIASIS
MALARIA
title_short Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases
title_full Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases
title_fullStr Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases
title_full_unstemmed Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases
title_sort Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases
dc.creator.none.fl_str_mv Alvar, Jorge
Alves, Fabiana
Bucheton, Bruno
Burrows, Louise
Büscher, Philippe
Carrillo, Eugenia
Felger, Ingrid
Hübner, Marc P.
Moreno, Javier
Pinazo, Maria Jesus
Ribeiro, Isabela
Sosa-Estani, Sergio Alejandro
Specht, Sabine
Tarral, Antoine
Strub Wourgaft, Nathalie
Bilbe, Graeme
author Alvar, Jorge
author_facet Alvar, Jorge
Alves, Fabiana
Bucheton, Bruno
Burrows, Louise
Büscher, Philippe
Carrillo, Eugenia
Felger, Ingrid
Hübner, Marc P.
Moreno, Javier
Pinazo, Maria Jesus
Ribeiro, Isabela
Sosa-Estani, Sergio Alejandro
Specht, Sabine
Tarral, Antoine
Strub Wourgaft, Nathalie
Bilbe, Graeme
author_role author
author2 Alves, Fabiana
Bucheton, Bruno
Burrows, Louise
Büscher, Philippe
Carrillo, Eugenia
Felger, Ingrid
Hübner, Marc P.
Moreno, Javier
Pinazo, Maria Jesus
Ribeiro, Isabela
Sosa-Estani, Sergio Alejandro
Specht, Sabine
Tarral, Antoine
Strub Wourgaft, Nathalie
Bilbe, Graeme
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ASYMPTOMATIC
CHAGAS DISEASE
FILARIASIS
HUMAN AFRICAN TRYPANOSOMIASIS
LEISHMANIASIS
MALARIA
topic ASYMPTOMATIC
CHAGAS DISEASE
FILARIASIS
HUMAN AFRICAN TRYPANOSOMIASIS
LEISHMANIASIS
MALARIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Progress has been made in the control or elimination of tropical diseases, with a significant reduction of incidence. However, there is a risk of re-emergence if the factors fueling transmission are not dealt with. Although it is essential to understand these underlying factors for each disease, asymptomatic carriers are a common element that may promote resurgence; their impact in terms of proportion in the population and role in transmission needs to be determined. In this paper, we review the current evidence on whether or not to treat asymptomatic carriers given the relevance of their role in the transmission of a specific disease, the efficacy and toxicity of existing drugs, the Public Health interest, and the benefit at an individual level, for example, in Chagas disease, to prevent irreversible organ damage. In the absence of other control tools such as vaccines, there is a need for safer drugs with good risk/benefit profiles in order to change the paradigm so that it addresses the complete infectious process beyond manifest disease to include treatment of non-symptomatic infected persons.
Fil: Alvar, Jorge. Drugs For Neglected Diseases Initiative; Suiza
Fil: Alves, Fabiana. Drugs For Neglected Diseases Initiative; Suiza
Fil: Bucheton, Bruno. Université Montpellier II; Francia
Fil: Burrows, Louise. Drugs For Neglected Diseases Initiative; Suiza
Fil: Büscher, Philippe. Institute Of Tropical Medicine; Bélgica
Fil: Carrillo, Eugenia. Universidad Carlos III de Madrid. Instituto de Salud; España
Fil: Felger, Ingrid. Swiss Tropical And Public Health Institute; Suiza
Fil: Hübner, Marc P.. Universitat Bonn; Alemania
Fil: Moreno, Javier. Universidad Carlos III de Madrid. Instituto de Salud; España
Fil: Pinazo, Maria Jesus. Instituto de Salud Global de Barcelona; España
Fil: Ribeiro, Isabela. Drugs For Neglected Diseases Initiative; Suiza
Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Specht, Sabine. Drugs For Neglected Diseases Initiative; Suiza
Fil: Tarral, Antoine. Drugs For Neglected Diseases Initiative; Suiza
Fil: Strub Wourgaft, Nathalie. Drugs For Neglected Diseases Initiative; Suiza
Fil: Bilbe, Graeme. Drugs For Neglected Diseases Initiative; Suiza
description Progress has been made in the control or elimination of tropical diseases, with a significant reduction of incidence. However, there is a risk of re-emergence if the factors fueling transmission are not dealt with. Although it is essential to understand these underlying factors for each disease, asymptomatic carriers are a common element that may promote resurgence; their impact in terms of proportion in the population and role in transmission needs to be determined. In this paper, we review the current evidence on whether or not to treat asymptomatic carriers given the relevance of their role in the transmission of a specific disease, the efficacy and toxicity of existing drugs, the Public Health interest, and the benefit at an individual level, for example, in Chagas disease, to prevent irreversible organ damage. In the absence of other control tools such as vaccines, there is a need for safer drugs with good risk/benefit profiles in order to change the paradigm so that it addresses the complete infectious process beyond manifest disease to include treatment of non-symptomatic infected persons.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/142513
Alvar, Jorge; Alves, Fabiana; Bucheton, Bruno; Burrows, Louise; Büscher, Philippe; et al.; Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases; Springer; Seminars in Immunopathology; 42; 3; 3-2020; 231-246
1863-2297
CONICET Digital
CONICET
url http://hdl.handle.net/11336/142513
identifier_str_mv Alvar, Jorge; Alves, Fabiana; Bucheton, Bruno; Burrows, Louise; Büscher, Philippe; et al.; Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases; Springer; Seminars in Immunopathology; 42; 3; 3-2020; 231-246
1863-2297
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s00281-020-00796-y
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00281-020-00796-y
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782641610686464
score 12.982451

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